Handbook of Process Chromatography

Handbook of Process Chromatography
Author: Gunter Jagschies,Gail K. Sofer,Lars Hagel
Publsiher: Elsevier
Total Pages: 382
Release: 2007-12-08
ISBN 10: 9780080554518
ISBN 13: 0080554512
Language: EN, FR, DE, ES & NL

Handbook of Process Chromatography Book Review:

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design

Handbook of Process Chromatography

Handbook of Process Chromatography
Author: Gail K. Sofer,Lars Hagel
Publsiher: Academic Press
Total Pages: 387
Release: 1997-07-08
ISBN 10:
ISBN 13: STANFORD:36105019357438
Language: EN, FR, DE, ES & NL

Handbook of Process Chromatography Book Review:

With examples from companies with establised processes and approved biotherapeutics, this pack considers the entire scope of process chromatography, including scale-up, regulatory issues, equipment, evaluation studies, scheduling and cost effectiveness.

Handbook of Separation Process Technology

Handbook of Separation Process Technology
Author: Ronald W. Rousseau
Publsiher: John Wiley & Sons
Total Pages: 1024
Release: 1987-05-13
ISBN 10: 9780471895589
ISBN 13: 047189558X
Language: EN, FR, DE, ES & NL

Handbook of Separation Process Technology Book Review:

Surveys the selection, design, and operation of most of the industrially important separation processes. Discusses the underlying principles on which the processes are based, and provides illustrative examples of the use of the processes in a modern context. Features thorough treatment of newer separation processes based on membranes, adsorption, chromatography, ion exchange, and chemical complexation. Includes a review of historically important separation processes such as distillation, absorption, extraction, leaching, and crystallization and considers these techniques in light of recent developments affecting them.

Handbook of Biogeneric Therapeutic Proteins

Handbook of Biogeneric Therapeutic Proteins
Author: Sarfaraz K. Niazi
Publsiher: CRC Press
Total Pages: 584
Release: 2002-08-15
ISBN 10: 1000611329
ISBN 13: 9781000611328
Language: EN, FR, DE, ES & NL

Handbook of Biogeneric Therapeutic Proteins Book Review:

More than 20 billion dollars worth of biopharmaceuticals are scheduled to go off-patent by 2006. Given the strong political impetus and the development of technological tools that can answer the questions regulatory authorities may raise, it is inevitable that the FDA and EMEA will allow biogeneric or biosimilar products. Even with all the regulato

Handbook of Bioseparations

Handbook of Bioseparations
Author: Satinder Ahuja
Publsiher: Elsevier
Total Pages: 722
Release: 2000-06-23
ISBN 10: 9780080507798
ISBN 13: 0080507794
Language: EN, FR, DE, ES & NL

Handbook of Bioseparations Book Review:

It is generally recognized that the commercial success of biotechnology products is highly dependent on the successful development and application of high-powered separation and purification methods. In this practical and authoritative handbook, the separation of proteins, nucleic acids, and oligonucleotides from biological matrices is covered from analytical to process scales. Also included in a chapter on the separation of monoclonal antibodies, which have found numerous uses as therapeutic and diagnostic agents. Analytical techniques include an interesting montage of chromatographic methods, capillary electrophoresis, isoelectric focusing, and mass spectrometry. Among separation and purification methods, liquid-liquid distribution, displacement chromatography, expanded bed adsorption, membrane chromatography, and simulated moving bed chromatography are covered at length. Regulatory and economic considerations are addressed, as are plant and process equipment and engineering process control. A chapter on future developments highlights the application of DNA chip arrays as well as evolving methodologies for a large number of drugs that are under development for treatment of cancer, AIDS, rheumatoid arthritis, and Alzheimer's disease. Handbook of Bioseparations serves as an essential reference and guidebook for separation scientists working in the pharmaceutical and biotechnology industries, academia, and government laboratories. Key Features * Covers bioseparations of proteins, nucleic acids, and monoclonal antibodies * Encompasses both analytical and process-scale methods * Elucidates the importance of engineering process control * Details selection of plant and process equipment * Addresses economic considerations * Discusses future developments

A Practical Handbook of Preparative HPLC

A Practical Handbook of Preparative HPLC
Author: Donald A Wellings
Publsiher: Elsevier
Total Pages: 176
Release: 2011-04-18
ISBN 10: 9780080458854
ISBN 13: 0080458858
Language: EN, FR, DE, ES & NL

A Practical Handbook of Preparative HPLC Book Review:

This book is a distillation of twenty years of practical experience of the high pressure liquid chromatography (HPLC) process. Deliberately steering clear of complex theoretical aspects, this book concentrates on the everyday problems associated with the technique, making it perfect for frequent use in the laboratory and for those in the pharmaceutical, agrochemical and biotechnology industries for the analysis and purification of drugs, small molecules, proteins and DNA. This book... •Provides practical, hands-on advice based on years of experience •Will help ensure optimal design, equipment and separation results for your particular task •Presents system layouts from laboratory to process scale •Will help you to devise or improve record-keeping and documentation systems ·Provides practical, hands-on advice based on years of experience ·Will help ensure optimal design, equipment and separation results for your particular task ·Presents system layouts from laboratory to process scale ·Will help you to devise or improve record-keeping and documentation systems

Process Chromatography

Process Chromatography
Author: Gail K. Sofer,L. E.E. Nystrom
Publsiher: Academic Press
Total Pages: 96
Release: 2015-09-02
ISBN 10: 1483289176
ISBN 13: 9781483289175
Language: EN, FR, DE, ES & NL

Process Chromatography Book Review:

Research and development into biological products for therapeutic use has increased dramatically over the last 10 years. With this, strict regulatory requirements have been imposed by authorities such as the U.S. Food & Drug Administration, so that today validation has become a key issue in the biopharmaceutical industry. This concise book addresses validation issues in the chromatography of biotherapeutics. It covers process design, qualification and validation, including an overview of analytical techniques commonly used in the validation of processes. A concluding section comments on product changeover and presents four case studies.

Handbook of Methods and Instrumentation in Separation Science

Handbook of Methods and Instrumentation in Separation Science
Author: Anonim
Publsiher: Academic Press
Total Pages: 880
Release: 2009-11-11
ISBN 10: 9780123757272
ISBN 13: 0123757274
Language: EN, FR, DE, ES & NL

Handbook of Methods and Instrumentation in Separation Science Book Review:

Handbook of Methods and Instrumentation in Separation Science, Volume 1 provides concise overviews and summaries of the main methods used for separation. It is based on the Encyclopedia of Separation Science. The handbook focuses on the principles of methods and instrumentation. It provides general concepts concerning the subject matter; it does not present specific procedures. This volume discusses the separation processes including affinity methods, analytical ultracentrifugation, centrifugation, chromatography, and use of decanter centrifuge and dye. Each methodology is defined and compared with other separation processes. It also provides specific techniques, principles, and theories concerning each process. Furthermore, the handbook presents the applications, benefits, and validation of the processes described in this book. This handbook is an excellent reference for biomedical researchers, environmental and production chemists, flavor and fragrance technologists, food and beverage technologists, academic and industrial librarians, and nuclear researchers. Students and novices will also find this handbook useful for practice and learning. One-stop source for information on separation methods General overviews for quick orientation Ease of use for finding results fast Expert coverage of major separation methods Coverage of techniques for all sizes of samples, pico-level to kilo-level

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies
Author: Stefan Dübel,Janice M. Reichert
Publsiher: John Wiley & Sons
Total Pages: 2544
Release: 2014-12-03
ISBN 10: 3527329374
ISBN 13: 9783527329373
Language: EN, FR, DE, ES & NL

Handbook of Therapeutic Antibodies Book Review:

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Handbook of Process Stream Analysis

Handbook of Process Stream Analysis
Author: Kenneth J. Clevett
Publsiher: Ellis Horwood
Total Pages: 470
Release: 1974
ISBN 10:
ISBN 13: STANFORD:36105030288562
Language: EN, FR, DE, ES & NL

Handbook of Process Stream Analysis Book Review:

Handbook of Advanced Chromatography Mass Spectrometry Techniques

Handbook of Advanced Chromatography  Mass Spectrometry Techniques
Author: Michal Holcapek,Wm. Craig Byrdwell
Publsiher: Elsevier
Total Pages: 520
Release: 2017-09-07
ISBN 10: 0128117338
ISBN 13: 9780128117330
Language: EN, FR, DE, ES & NL

Handbook of Advanced Chromatography Mass Spectrometry Techniques Book Review:

Handbook of Advanced Chromatography /Mass Spectrometry Techniques is a compendium of new and advanced analytical techniques that have been developed in recent years for analysis of all types of molecules in a variety of complex matrices, from foods to fuel to pharmaceuticals and more. Focusing on areas that are becoming widely used or growing rapidly, this is a comprehensive volume that describes both theoretical and practical aspects of advanced methods for analysis. Written by authors who have published the foundational works in the field, the chapters have an emphasis on lipids, but reach a broader audience by including advanced analytical techniques applied to a variety of fields. Handbook of Advanced Chromatography / Mass Spectrometry Techniques is the ideal reference for those just entering the analytical fields covered, but also for those experienced analysts who want a combination of an overview of the techniques plus specific and pragmatic details not often covered in journal reports. The authors provide, in one source, a synthesis of knowledge that is scattered across a multitude of literature articles. The combination of pragmatic hints and tips with theoretical concepts and demonstrated applications provides both breadth and depth to produce a valuable and enduring reference manual. It is well suited for advanced analytical instrumentation students as well as for analysts seeking additional knowledge or a deeper understanding of familiar techniques. Includes UHPLC, HILIC, nano-liquid chromatographic separations, two-dimensional LC-MS (LCxLC), multiple parallel MS, 2D-GC (GCxGC) methodologies for lipids analysis, and more Contains both practical and theoretical knowledge, providing core understanding for implementing modern chromatographic and mass spectrometric techniques Presents chapters on the most popular and fastest-growing new techniques being implemented in diverse areas of research

Expanded Bed Chromatography

Expanded Bed Chromatography
Author: B. Mattiasson
Publsiher: Springer Science & Business Media
Total Pages: 271
Release: 1999-12-31
ISBN 10: 9780792361237
ISBN 13: 0792361237
Language: EN, FR, DE, ES & NL

Expanded Bed Chromatography Book Review:

Expanded bed adsorption chromatography is a novel processing technique for the purification of biomolecules, combining clarification, concentration and initial purification in one step. By such an integration it is possible to reduce the number of steps in the purification process, to shorten the processing time and to improve the yields. The technology is new, and interesting developments have taken place concerning the adsorbents, the processing technology and potential applications. Both small-scale laboratory processes and larger industrial processes are being developed. Expanded bed chromatography is one of the most exciting new developments in downstream processing in recent years. The technology will be a standard procedure when new biotechnological processes are being developed.

Purification of Alpha 1 antitrypsin Using a Three step Chromatography Process

Purification of Alpha 1 antitrypsin Using a Three step Chromatography Process
Author: Elizabeth Zapalac
Publsiher: Anonim
Total Pages: 346
Release: 2003
ISBN 10:
ISBN 13: UCAL:X66421
Language: EN, FR, DE, ES & NL

Purification of Alpha 1 antitrypsin Using a Three step Chromatography Process Book Review:

Handbook of Downstream Processing

Handbook of Downstream Processing
Author: E. Goldberg
Publsiher: Springer Science & Business Media
Total Pages: 720
Release: 2012-12-06
ISBN 10: 9400915632
ISBN 13: 9789400915633
Language: EN, FR, DE, ES & NL

Handbook of Downstream Processing Book Review:

The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

Handbook of Membrane Separations

Handbook of Membrane Separations
Author: Anil Kumar Pabby,Syed S.H. Rizvi,Ana Maria Sastre Requena
Publsiher: CRC Press
Total Pages: 1184
Release: 2008-07-07
ISBN 10: 1420009486
ISBN 13: 9781420009484
Language: EN, FR, DE, ES & NL

Handbook of Membrane Separations Book Review:

The Handbook of Membrane Separations: Chemical, Pharmaceutical, and Biotechnological Applications provides detailed information on membrane separation technologies as they have evolved over the past decades. To provide a basic understanding of membrane technology, this book documents the developments dealing with these technologies. It explo

Ewing s Analytical Instrumentation Handbook Fourth Edition

Ewing s Analytical Instrumentation Handbook  Fourth Edition
Author: Nelu Grinberg,Sonia Rodriguez
Publsiher: CRC Press
Total Pages: 975
Release: 2019-02-21
ISBN 10: 1351644319
ISBN 13: 9781351644310
Language: EN, FR, DE, ES & NL

Ewing s Analytical Instrumentation Handbook Fourth Edition Book Review:

This handbook is a guide for workers in analytical chemistry who need a starting place for information about a specific instrumental technique. It gives a basic introduction to the techniques and provides leading references on the theory and methodology for an instrumental technique. This edition thoroughly expands and updates the chapters to include concepts, applications, and key references from recent literature. It also contains a new chapter on process analytical technology.

Handbook of Batch Process Design

Handbook of Batch Process Design
Author: P.N. Sharratt
Publsiher: Springer Science & Business Media
Total Pages: 320
Release: 1997-09-30
ISBN 10: 9780751403695
ISBN 13: 0751403695
Language: EN, FR, DE, ES & NL

Handbook of Batch Process Design Book Review:

Batch processes are used to manufacture many fine organic chemicals, and as such they can be considered to underpin much of the modern chemical industry. Despite widespread use and a consequent huge contribution to wealth creation, batch processes have attracted limited attention outside the user industries. Batch chemicals processing uses a number of core techniques and technologies, such as scheduling and sequence control, agitation and batch filtration. The combination of these technologies with often complex chemistry, the multi-purpose nature of much of this type of plant, the distinctive safety and environmental issues, and a fast moving commercial environment makes the development of a successful batch process a considerable challenge for the chemist or engineer. The literature on the topics covered in this book is fragmented and often not easily accessible, so this handbook has been written to address this problem and to bring together design and process analysis methods in the core areas of batch process design. By combining the science and pragmatism required in the development of successful batch processes this new book provides answers to real problems in an accessible and concise way. Written by an international team of authors drawn from industry, consulting and academe, this book is an essential part of the library of any chemist, technologist or engineer working on the development of new or existing batch processes.

Column Handbook for Size Exclusion Chromatography

Column Handbook for Size Exclusion Chromatography
Author: Chi-san Wu
Publsiher: Elsevier
Total Pages: 637
Release: 1999-03-19
ISBN 10: 0080529399
ISBN 13: 9780080529394
Language: EN, FR, DE, ES & NL

Column Handbook for Size Exclusion Chromatography Book Review:

Column Handbook for Size Exclusion Chromatography is the first comprehensive reference to provide everything one needs to know about commercial analytical and preparative columns for size exclusion and gel filtration chromatography (SEC and GFC). SEC is now widely used as a quality assurance method in the polymer industry (both synthetic and biopolymers) to determine molecular weight and molecular weight distribution. The Handbook contains contributions from every column manufacturer around the world and from many experienced column users. It covers the technology, characterization, application, evaluation, maintenance, and quality control of analytical and preparative columns for SEC and GFC. Also included are columns for two closely related techniques, hydrodynamic chromatography and high osmotic pressure chromatography. Key Features * Evaluate and select columns with confidence for specific applications * Optimize separations and improve the ruggedness of analytical methods * Extend the service time of a column * Establish a quality-control program to ensure consistency in column performance * Avoid the expense of column damage or purchases that do not give the expected results

Handbook of Solid Phase Microextraction

Handbook of Solid Phase Microextraction
Author: Janusz Pawliszyn
Publsiher: Elsevier
Total Pages: 496
Release: 2011-11-29
ISBN 10: 0123914493
ISBN 13: 9780123914491
Language: EN, FR, DE, ES & NL

Handbook of Solid Phase Microextraction Book Review:

The relatively new technique of solid phase microextraction (SPME) is an important tool to prepare samples both in the lab and on-site. SPME is a "green" technology because it eliminates organic solvents from analytical laboratory and can be used in environmental, food and fragrance, and forensic and drug analysis. This handbook offers a thorough background of the theory and practical implementation of SPME. SPME protocols are presented outlining each stage of the method and providing useful tips and potential pitfalls. In addition, devices and fiber coatings, automated SPME systems, SPME method development, and In Vivo applications are discussed. This handbook is essential for its discussion of the latest SPME developments as well as its in depth information on the history, theory, and practical application of the method. Practical application of Solid Phase Microextraction methods including detailed steps Provides history of extraction methods to better understand the process Suitable for all levels, from beginning student to experienced practitioner

Handbook of Affinity Chromatography

Handbook of Affinity Chromatography
Author: David S. Hage,Jack Cazes
Publsiher: CRC Press
Total Pages: 968
Release: 2005-07-19
ISBN 10: 9780824751982
ISBN 13: 0824751981
Language: EN, FR, DE, ES & NL

Handbook of Affinity Chromatography Book Review:

This essential handbook guides investigators in the theory, applications, and practical use of affinity chromatography in a variety of fields including biotechnology, biochemistry, molecular biology, analytical chemistry, proteomics, pharmaceutical science, environmental analysis, and clinical chemistry. The Handbook of Affinity Chromatograph