Handbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine
Author: Sandosh Padmanabhan
Publsiher: Academic Press
Total Pages: 1118
Release: 2014-04-28
ISBN 10: 0123868831
ISBN 13: 9780123868831
Language: EN, FR, DE, ES & NL

Handbook of Pharmacogenomics and Stratified Medicine Book Review:

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Handbook of Personalized Medicine

Handbook of Personalized Medicine
Author: Ioannis S. Vizirianakis
Publsiher: CRC Press
Total Pages: 1560
Release: 2014-02-12
ISBN 10: 9814411205
ISBN 13: 9789814411202
Language: EN, FR, DE, ES & NL

Handbook of Personalized Medicine Book Review:

This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
Author: Claudio Carini,Mark Fidock,Alain van Gool
Publsiher: CRC Press
Total Pages: 631
Release: 2019-04-16
ISBN 10: 0429574622
ISBN 13: 9780429574627
Language: EN, FR, DE, ES & NL

Handbook of Biomarkers and Precision Medicine Book Review:

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods
Author: Amitava Dasgupta
Publsiher: Springer Science & Business Media
Total Pages: 445
Release: 2007-10-23
ISBN 10: 1588297802
ISBN 13: 9781588297808
Language: EN, FR, DE, ES & NL

Handbook of Drug Monitoring Methods Book Review:

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Toward Precision Medicine

Toward Precision Medicine
Author: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publsiher: National Academies Press
Total Pages: 142
Release: 2012-01-16
ISBN 10: 0309222222
ISBN 13: 9780309222228
Language: EN, FR, DE, ES & NL

Toward Precision Medicine Book Review:

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Handbook of Clinical Adult Genetics and Genomics

Handbook of Clinical Adult Genetics and Genomics
Author: Shweta Dhar,Sandesh Sreenath Chakravarthy Nagamani,Tanya Eble
Publsiher: Academic Press
Total Pages: 534
Release: 2020-04-10
ISBN 10: 0128173459
ISBN 13: 9780128173459
Language: EN, FR, DE, ES & NL

Handbook of Clinical Adult Genetics and Genomics Book Review:

Handbook of Clinical Adult Genetics and Genomics: A Practice-Based Approach provides a thorough overview of genetic disorders that are commonly encountered in adult populations and supports the full translation of adult genetic and genomic modalities into clinical practice. Expert chapter authors supplement foundational knowledge with case-based strategies for the evaluation and management of genetic disorders in each organ system and specialty area. Topics discussed include employing genetic testing technologies, reporting test results, genetic counseling for adult patients, medical genetics referrals, issues of complex inheritance, gene therapy, and diagnostic and treatment criteria for developmental, cardiovascular, gastrointestinal, neuropsychiatric, pulmonary issues, and much more. Employs clinical case studies to demonstrate how to evaluate, diagnosis and treat adult patients with genetic disorders Offers a practical framework for establishing an adult genetics clinic, addressing infrastructure, billing, counseling, and challenges unique to adult clinical genetics Features chapter contributions from authors at leading adult genetics institutions in the US and abroad

Textbook of Personalized Medicine

Textbook of Personalized Medicine
Author: Kewal K. Jain
Publsiher: Springer Science & Business Media
Total Pages: 430
Release: 2009-08-29
ISBN 10: 9781441907691
ISBN 13: 1441907696
Language: EN, FR, DE, ES & NL

Textbook of Personalized Medicine Book Review:

Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic. There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine, summarizes the author’s efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.

Cancer Genetics and Genomics for Personalized Medicine

Cancer Genetics and Genomics for Personalized Medicine
Author: Il-Jin Kim
Publsiher: CRC Press
Total Pages: 286
Release: 2017-04-11
ISBN 10: 1315341107
ISBN 13: 9781315341101
Language: EN, FR, DE, ES & NL

Cancer Genetics and Genomics for Personalized Medicine Book Review:

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

Preclinical Development Handbook

Preclinical Development Handbook
Author: Shayne Cox Gad
Publsiher: John Wiley & Sons
Total Pages: 1080
Release: 2008-03-21
ISBN 10: 9780470249048
ISBN 13: 0470249048
Language: EN, FR, DE, ES & NL

Preclinical Development Handbook Book Review:

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * In vitro mammalian cytogenetics tests * Phototoxicity * Carcinogenicity studies * The pharmacogenomics of personalized medicine * Bridging studies * Toxicogenomics and toxicoproteomics Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Pharmacogenomics and Personalized Medicine

Pharmacogenomics and Personalized Medicine
Author: Nadine Cohen
Publsiher: Humana Press
Total Pages: 509
Release: 2010-10-28
ISBN 10: 9781617379215
ISBN 13: 1617379212
Language: EN, FR, DE, ES & NL

Pharmacogenomics and Personalized Medicine Book Review:

concerns within the pharmaceutical industry about generating data that might be difficult to interpret in a regulated environment. There is also a growing apprec- tion for the challenges in translating this new information into clinical utility, including scientific, commercial, ethical, and policy challenges. Pharmacogenomics and Personalized Medicine, which is part of the Methods in Pharmacology and Toxicology series, comprises chapters on selected aspects of pharmacogenomics and personalized medicine. Our overall intent is to assist both novice and experienced investigators in understanding the current scientific ch- lenges in applying PGx to discovery and clinical development and in making app- priate decisions to engage in and interpret PGx research. Designed to share the experiences of leading experts in the field, the book is a useful guide for conducting PGx research--from discovery to the market, but we also aim to present a realistic perspective on the challenges, practicalities, and obstacles in applying pharmac- enomics. Generally, the book avoids statements such as “Pharmacogenomics is going to revolutionize the practice of medicine,” which are neither realistic nor particularly useful to anyone. The book presents an industry perspective on the implementation of PGx in research and development, in drug discovery, and in clinical trials, including rec- mendations for a systematic approach for assessing the feasibility and added value of PGx studies in clinical trials.

Routledge Handbook of Medical Law and Ethics

Routledge Handbook of Medical Law and Ethics
Author: Yann Joly,Bartha Maria Knoppers
Publsiher: Routledge
Total Pages: 480
Release: 2014-09-19
ISBN 10: 1134448724
ISBN 13: 9781134448722
Language: EN, FR, DE, ES & NL

Routledge Handbook of Medical Law and Ethics Book Review:

This book explores the scope, application and role of medical law, regulatory norms and ethics, and addresses key challenges introduced by contemporary advances in biomedical research and healthcare. While mindful of national developments, the handbook supports a global perspective in its approach to medical law. Contributors include leading scholars in both medical law and ethics, who have developed specially commissioned pieces in order to present a critical overview and analysis of the current state of medical law and ethics. Each chapter offers comprehensive coverage of longstanding and traditional topics in medical law and ethics, and provides dynamic insights into contemporary and emerging issues in this heavily debated field. Topics covered include: Bioethics, health and human rights Medical liability Law and emerging health technologies Public health law Personalized medicine The law and ethics of access to medicines in developing countries Medical research in the genome era Emerging legal and ethical issues in reproductive technologies This advanced level reference work will prove invaluable to legal practitioners, scholars, students and researchers in the disciplines of law, medicine, genetics, dentistry, theology, and medical ethics.

Medical and Health Genomics

Medical and Health Genomics
Author: Dhavendra Kumar,Stylianos Antonarakis
Publsiher: Academic Press
Total Pages: 358
Release: 2016-06-04
ISBN 10: 0127999221
ISBN 13: 9780127999227
Language: EN, FR, DE, ES & NL

Medical and Health Genomics Book Review:

Medical and Health Genomics provides concise and evidence-based technical and practical information on the applied and translational aspects of genome sciences and the technologies related to non-clinical medicine and public health. Coverage is based on evolving paradigms of genomic medicine—in particular, the relation to public and population health genomics now being rapidly incorporated in health management and administration, with further implications for clinical population and disease management. Provides extensive coverage of the emergent field of health genomics and its huge relevance to healthcare management Presents user-friendly language accompanied by explanatory diagrams, figures, and many references for further study Covers the applied, but non-clinical, sciences across disease discovery, genetic analysis, genetic screening, and prevention and management Details the impact of clinical genomics across a diverse array of public and community health issues, and within a variety of global healthcare systems

The Genetics of African Populations in Health and Disease

The Genetics of African Populations in Health and Disease
Author: Muntaser E. Ibrahim,Charles N. Rotimi
Publsiher: Cambridge University Press
Total Pages: 348
Release: 2019-12-19
ISBN 10: 1107072026
ISBN 13: 9781107072022
Language: EN, FR, DE, ES & NL

The Genetics of African Populations in Health and Disease Book Review:

A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Textbook of Personalized Medicine

Textbook of Personalized Medicine
Author: Kewal K. Jain
Publsiher: Humana Press
Total Pages: 732
Release: 2015-03-17
ISBN 10: 1493925539
ISBN 13: 9781493925537
Language: EN, FR, DE, ES & NL

Textbook of Personalized Medicine Book Review:

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Concepts in Pharmacogenomics

Concepts in Pharmacogenomics
Author: Martin M. Zdanowicz
Publsiher: ASHP
Total Pages: 414
Release: 2010
ISBN 10: 1585282340
ISBN 13: 9781585282340
Language: EN, FR, DE, ES & NL

Concepts in Pharmacogenomics Book Review:

The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time. If you are pharmacist, resident, or student curious about this new field, start with Concepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation. Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
Author: William D. Figg,Howard L. McLeod
Publsiher: Springer Science & Business Media
Total Pages: 623
Release: 2004-03-26
ISBN 10: 1592597343
ISBN 13: 9781592597345
Language: EN, FR, DE, ES & NL

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Book Review:

Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.

Genomic Medicine

Genomic Medicine
Author: Dhavendra Kumar,Charis Eng
Publsiher: Oxford University Press (UK)
Total Pages: 814
Release: 2014
ISBN 10: 019989602X
ISBN 13: 9780199896028
Language: EN, FR, DE, ES & NL

Genomic Medicine Book Review:

Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.

The Mayo Clinic Diet

The Mayo Clinic Diet
Author: By the weight-loss experts at Mayo Clinic
Publsiher: Good Books
Total Pages: 270
Release: 2013-01-01
ISBN 10: 9781561487776
ISBN 13: 1561487775
Language: EN, FR, DE, ES & NL

The Mayo Clinic Diet Book Review:

Now in paperback! The #1 New York Times bestseller with a brand-new, two-week menu guide designed to kick-start your weight loss. From Mayo Clinic, a leading authority on health and nutrition, comes The Mayo Clinic Diet, designed to be the last diet you'll ever need. In two simple phases, you'll be on the road to a healthy weight for the rest of your life. Packed with lots of extra encouragement — meal planners, recipes, tips for overcoming challenges, starting an exercise plan, and much more — The Mayo Clinic Diet gives you everything you need in one book. Toss out the scales and calculators and pick up the foods you love. This is the diet you've been waiting for!

Problem Solving through Precision Oncology

Problem Solving through Precision Oncology
Author: Peter Selby
Publsiher: EBN Health, an imprint of Evidence-based Networks Ltd
Total Pages: 256
Release: 2016-11-07
ISBN 10: 184692653X
ISBN 13: 9781846926532
Language: EN, FR, DE, ES & NL

Problem Solving through Precision Oncology Book Review:

Winner of the BMA Oncology Book of the Year Award. This practical learning and reference handbook provides an overview of the latest progress in the developing field of precision oncology, plus a ground breaking collection of case studies ("Problems") showing precision oncology in practice. The book includes a clear, readable summary of developments, alongside real-life case studies, providing a valuable update for all involved in the oncology community. The editors lead research and clinical teams at four UK centres of excellence in the field.

Molecular Diagnostics

Molecular Diagnostics
Author: George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson
Publsiher: Academic Press
Total Pages: 520
Release: 2016-10-27
ISBN 10: 0128029889
ISBN 13: 9780128029886
Language: EN, FR, DE, ES & NL

Molecular Diagnostics Book Review:

Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field