Handbook of Microdialysis

Handbook of Microdialysis
Author: Anonim
Publsiher: Elsevier
Total Pages: 712
Release: 2007-02-02
ISBN 10: 0080469663
ISBN 13: 9780080469669
Language: EN, FR, DE, ES & NL

Handbook of Microdialysis Book Review:

Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis. Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience. * Presents microdialysis methods and interpretation including the technical aspects of microdialysis as a sampling technique followed by the analytical chemical methods * Discusses the role of microdialysis in pharmacology, drug development and models of CNS pathology * Includes clinical applications of microdialysis

Handbook of Non Invasive Methods and the Skin Second Edition

Handbook of Non Invasive Methods and the Skin  Second Edition
Author: Jorgen Serup,Gregor B. E. Jemec,Gary L. Grove
Publsiher: CRC Press
Total Pages: 1056
Release: 2006-02-23
ISBN 10: 1420003305
ISBN 13: 9781420003307
Language: EN, FR, DE, ES & NL

Handbook of Non Invasive Methods and the Skin Second Edition Book Review:

Firmly established as the leading international reference in this field, Non-Invasive Methods and the Skin broke new ground with its comprehensive coverage of methods used in both clinical and experimental dermatology. Completely revised and updated, containing more than twice as much information, the Second Edition continues the tradition. The authors' thorough research and clear organization make this book a baseline reference for those using noninvasive biophysical methods to study the skin. Arranged by physical modality and structured to provide educational and practical information, the second edition, like its predecessor, will prove to be of value to young researchers and senior scientists alike. The coverage of major evaluation and measurement methods share a consistent format, including scope, sources of error, application, and validity. This edition incorporates 69 revised chapters with more than 90 new chapters covering topics such as computer technique, imaging techniques, skin friction, barrier functions, and more. New chapters provide coverage of: computers, computer techniques, and image analysis imaging techniques, including clinical photography legal situations and guidelines behind instrumental use skin friction barrier functions important new techniques such as in vitro confocal microscopy, OCT, and Raman spectroscopy veterinary/animal research use of methods The truly interdisciplinary, international panel of contributors includes experts from the specialties of dermatology, bioengineering, pathology, manufacturing engineering, medical physics, pharmacology, microbiology, neurology, surgery, obstetrics and gynecology, cardiovascular research, and pharmacy from academic institutions and hospitals in countries such as Denmark, Germany, the United Kingdom, the United States, Japan, Israel, Taiwan, and Singapore. The revision is extensive and covers a broad spectrum of methods while providing the same caliber of authoritative information that made the previous edition so popular. Application oriented, practical, and instructive, this Second Edition will meet the needs of the researchers today, and in years to come.

Microdialysis in the Neurosciences

Microdialysis in the Neurosciences
Author: Terry E. Robinson,J. B. Justice
Publsiher: Elsevier Science Limited
Total Pages: 450
Release: 1991
ISBN 10: 9780444893758
ISBN 13: 044489375X
Language: EN, FR, DE, ES & NL

Microdialysis in the Neurosciences Book Review:

Until very recently most experimental studies on brain chemistry were conducted with postmortem tissue. However, because of shortcomings with postmortem methods and also the desire to directly relate neurochemistry to behavior, there has been a rapid growth of interest towards in vivo neurochemical methods. The recent availability of small diameter hollow dialysis fibres and very sensitive analytical techniques has made microdialysis practical for the routine measurement of many endogenous neurochemicals in vivo. With its adoption in the neurosciences as the preferred technique for in vivo sampling, microdialysis techniques provide the focus for this present volume. This book provides a single reference source for detailed methodological information on the conduct of microdialysis experiments for studying neurotransmitter dynamics in vivo. The emphasis is on practical considerations, and contributors have been encouraged to share their "tricks of the trade" to help other researchers quickly and easily adopt these methodologies in their own laboratories. A comprehensive overview of developments in microdialysis technology and allied analytical techniques is provided, both thought-provoking to experienced researchers, as well as a valuable aid to novices establishing these techniques for themselves.

Coupling in Vivo Microdialysis Sampling to Mass Spectrometry to Detect Neuropeptides in a Decapod Crustacean

Coupling in Vivo Microdialysis Sampling to Mass Spectrometry to Detect Neuropeptides in a Decapod Crustacean
Author: Heidi Leigh Behrens
Publsiher: Unknown
Total Pages: 116
Release: 2008
ISBN 10:
ISBN 13: WISC:89100582519
Language: EN, FR, DE, ES & NL

Coupling in Vivo Microdialysis Sampling to Mass Spectrometry to Detect Neuropeptides in a Decapod Crustacean Book Review:

The Protein Protocols Handbook

The Protein Protocols Handbook
Author: John M. Walker
Publsiher: Springer Protocols Handbooks
Total Pages: 1991
Release: 2009-10-07
ISBN 10:
ISBN 13: STANFORD:36105215315776
Language: EN, FR, DE, ES & NL

The Protein Protocols Handbook Book Review:

The third edition of The Protein Protocols Handbook introduces 57 critically important new chapters, and significantly updates the previous edition's tried-and-trusted methods. The book offers over 200 key, readily reproducible protocols that ensure results.

Neurotransmitters and Neuromodulators

Neurotransmitters and Neuromodulators
Author: Oliver von Bohlen und Halbach,Rolf Dermietzel
Publsiher: John Wiley & Sons
Total Pages: 402
Release: 2006-12-13
ISBN 10: 3527609075
ISBN 13: 9783527609079
Language: EN, FR, DE, ES & NL

Neurotransmitters and Neuromodulators Book Review:

A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.

Handbook of Pharmaceutical Biotechnology

Handbook of Pharmaceutical Biotechnology
Author: Shayne C. Gad
Publsiher: Wiley-Interscience
Total Pages: 1659
Release: 2007-06-11
ISBN 10:
ISBN 13: UOM:39015064951935
Language: EN, FR, DE, ES & NL

Handbook of Pharmaceutical Biotechnology Book Review:

Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods.

Comprehensive Handbook of Alcohol Related Pathology

Comprehensive Handbook of Alcohol Related Pathology
Author: Victor R. Preedy,Ronald Ross Watson
Publsiher: Academic Press
Total Pages: 1670
Release: 2005
ISBN 10: 9780125643726
ISBN 13: 0125643721
Language: EN, FR, DE, ES & NL

Comprehensive Handbook of Alcohol Related Pathology Book Review:

This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.*Over 100 chapters conveniently divided into 3 sections*Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes*Each chapter is highly illustrated with tables as well as figures

Microdialysis in the Neurosciences

Microdialysis in the Neurosciences
Author: T.E. Robinson,J.B. Justice
Publsiher: Elsevier
Total Pages: 476
Release: 2013-10-22
ISBN 10: 1483164659
ISBN 13: 9781483164656
Language: EN, FR, DE, ES & NL

Microdialysis in the Neurosciences Book Review:

Techniques in the Behavioral and Neural Sciences, Volume 7: Microdialysis in the Neurosciences focuses on the neurochemical methods employed in behavioral and neural sciences. The selection first elaborates on the introduction to intracerebral microdialysis, quantitative microdialysis, and microdialysis compared with other in vivo release models. Discussions focus on computational methods, post-mortem tissue analysis, perfusion methods, and features, development, and future applications of microdialysis. The text then takes a look at the practical aspects of using microdialysis for determination of brain interstitial concentrations and microdialysis and liquid chromatography. The publication examines the procedures for microdialysis with smallbore HPLC, use of microdialysis in pharmacokinetics and pharmacodynamics, and brain dialysis of monoamines. Topics include significance of monoamine concentrations in dialysates; criteria for brain dialysis of monoamines; distribution of drugs to the interstitium of various tissues; methods to measure the extracellular concentration by microdialysis; and application to studies on drug abuse. The manuscript then elaborates on the feasibility of repeated microdialysis for within-subjects design experiments and microdialysis and automated on-line analysis approach to study central cholinergic transmission in vivo. The text is a dependable reference for readers interested in the use of microdialysis in neurosciences.

Danish Medical Bulletin

Danish Medical Bulletin
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: NWU:35558005146416
Language: EN, FR, DE, ES & NL

Danish Medical Bulletin Book Review:

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology
Author: Glen Baker,Susan Dunn,Abel Lajtha,Andrew Holt
Publsiher: Springer Science & Business Media
Total Pages: 485
Release: 2007
ISBN 10: 0387303596
ISBN 13: 9780387303598
Language: EN, FR, DE, ES & NL

Handbook of Neurochemistry and Molecular Neurobiology Book Review:

The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition

Handbook of Sample Preparation

Handbook of Sample Preparation
Author: Janusz Pawliszyn,Heather L. Lord
Publsiher: Wiley-Blackwell
Total Pages: 480
Release: 2011-03-17
ISBN 10: 9780813823621
ISBN 13: 0813823625
Language: EN, FR, DE, ES & NL

Handbook of Sample Preparation Book Review:

Discover new keys to solving analytical problems using the Latest sample preparation methods Commonly viewed of as a routine task rather than as an integral component in the analytical process, sample preparation has long been undervalued as a science and underdeveloped as a technology. In an effort to reverse this trend, Handbook of Sample Preparation shows why sample preparation deserves closer scientific scrutiny, and makes a compelling case for colleges and professional laboratories to devote more resources to promote the benefits of its correct application. Handbook of Sample Preparation includes: A solid overview of standard sampling methodologies and their analytical capabilities An introduction of non-traditional sampling technologies, which address the need for solvent-free alternatives, automation, and miniaturization A discussion of the analytical shift toward performing sampling on-site, rather than in the laboratory An examination of various extraction technologies and their applications for different types of matrices A look at how to take advantage of new sampling strategies to streamline laboratory procedures, reduce research costs, and increase overall productivity An excellent primer on the fundamentals of extraction as well as a sound guide on the latest technological upgrades influencing current sampling techniques, this versatile text serves as an important and accessible tool for both students and seasoned practitioners as they seek new avenues for improving the accuracy of their analyses.

Neuropharmacology Methods in Epilepsy Research

Neuropharmacology Methods in Epilepsy Research
Author: Steven L. Peterson,Timothy E. Albertson
Publsiher: CRC Press
Total Pages: 272
Release: 2019-05-07
ISBN 10: 0429525354
ISBN 13: 9780429525353
Language: EN, FR, DE, ES & NL

Neuropharmacology Methods in Epilepsy Research Book Review:

There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now. Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied. Each chapter features: Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsy Topics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations. Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizures This unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.

Handbook of Neurosurgery

Handbook of Neurosurgery
Author: Mark S. Greenberg
Publsiher: Thieme
Total Pages: 1352
Release: 2010-02-01
ISBN 10: 1604063270
ISBN 13: 9781604063271
Language: EN, FR, DE, ES & NL

Handbook of Neurosurgery Book Review:

A must-have...[a] low-cost, highly portable, and extremely useful reference volume, which will undoubtedly enjoy continued longevity into the foreseeable future.--Journal of NeurosurgeryA vital resource...For rapid access to the diagnosis and management of all neurosurgical things, there is no substitute.--The Journal of TRAUMA Injury, Infection, and Critical CareFor two decades, Handbook of Neurosurgery -- now in a fully updated seventh edition -- has been an invaluable companion for every neurosurgery resident and nurse, as well as neurologists and others involved in the care of patients with brain and spine disorders. Dr. Greenberg's classic text covers the breadth of neurosurgery and its allied specialties and provides the latest information on anatomy and physiology, differential diagnosis, and currently accepted principles of clinical management. Renowned for its scope and accessibility, this portable, single-volume guide is packed with more than 1,300 pages of practical information, including thousands of literature citations, handy cross-references, and a thorough index.Features: New to the seventh edition: detailed coverage of blunt cervical arterial injuries; awake craniotomies; brain mapping; new grading systems for cervical and thoracolumbar fractures; radiation safety for neurosurgeons; organ donation after cardiac death; and expanded discussion of endovascular techniques Numerous updates, including information on dural arteriovenous malformations; tumors and molecular biology; and new neuromonitoring modalities such as brain oxygen tension, cerebral microdialysis, and regional cerebral blood flow The return of basic surgical material to acquaint readers with the operating room A practical new feature called Booking the Case supplies helpful information about scheduling surgery and obtaining informed consent Highly valuable section on hot topics in neurocritical care Color highlights and full-color inserts to enhance readability Comprehensive and conveniently compact, this book is a must-have reference for neurosurgery residents and a useful tool for anyone working in the clinical neurosciences.

Acta Dermato venereologica

Acta Dermato venereologica
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1996
ISBN 10:
ISBN 13: NWU:35558004311904
Language: EN, FR, DE, ES & NL

Acta Dermato venereologica Book Review:

Neurobiology of DOPA as a Neurotransmitter

Neurobiology of DOPA as a Neurotransmitter
Author: Yoshimi Misu,Yoshio Goshima
Publsiher: CRC Press
Total Pages: 408
Release: 2005-11-01
ISBN 10: 9781420023329
ISBN 13: 1420023322
Language: EN, FR, DE, ES & NL

Neurobiology of DOPA as a Neurotransmitter Book Review:

New research suggests it is highly probable that DOPA, in addition to being a precursor to dopamine, functions by itself as a neurotramsmitter and/or neuromodulator. Neurobiology of DOPA as a Neurotransmitter integrates background information about DOPA as an inert amino acid precursor of dopamine with the evidence showing that DOPA fulfills several criteria of neurotransmitters. Providing easy access to, and complete understanding of, the latest research on the subject, the book makes the case that DOPA meets many of the criteria of neurotransmitters and includes anti-evidence in some instances. The book begins with a historical review of current knowledge of DOPA. It characterizes DOPA as a prominent example showing transmutation from an inert substance to a gold drug in Parkinson's disease and further to a neurotransmitter in its own right. The next chapters cover the essential criteria of a neurotransmitter such as synthesis, existence, and competitive antagonism. The book describes metabolism composed of catecholamine synthesis and degradation products related to neuron death, physiological release of DOPA in the lower brainstem, striatum, and nucleus accumbens, and physiological or pharmacological responses involved in baroreflex neurotransmission and related to behavioral science including interactions with catecholamines, acetylcholine, glutamate, and GABA. The book explores recognition sites, transport sites, and therapeutic role and mechanisms for neuron death related to adverse influence in the treatment of Parkinson's Disease. Edited by experts in the field, the breadth and depth of information contained in this book is confirmed by a quick scan of the chapter authors. They summarize the issues surrounding DOPA neurotoxicity and explore the link between experimental studies and clinical relevance.

Handbook of HPLC

Handbook of HPLC
Author: Danilo Corradini
Publsiher: CRC Press
Total Pages: 715
Release: 2016-04-19
ISBN 10: 1420016946
ISBN 13: 9781420016949
Language: EN, FR, DE, ES & NL

Handbook of HPLC Book Review:

High performance liquid chromatography (HPLC) is one of the most widespread analytical and preparative scale separation techniques used for both scientific investigations and industrial and biomedical analysis. Now in its second edition, this revised and updated version of the Handbook of HPLC examines the new advances made in this field since the

Applications of Microdialysis in Pharmaceutical Science

Applications of Microdialysis in Pharmaceutical Science
Author: Tung-Hu Tsai
Publsiher: John Wiley & Sons
Total Pages: 584
Release: 2011-07-13
ISBN 10: 9781118011287
ISBN 13: 1118011287
Language: EN, FR, DE, ES & NL

Applications of Microdialysis in Pharmaceutical Science Book Review:

Discover new and emerging applications for microdialysis in drug evaluation Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces. This book explores the full range of clinical applications for microdialysis, focusing on its use in different organ and tissue systems for pharmacokinetic and pharmacodynamic studies. Readers gain a full understanding of the underlying science of microdialysis, current techniques and practices, as well as its many applications in pharmaceutical research. Applications of Microdialysis in Pharmaceutical Science starts with an introduction to basic principles and then covers analytical considerations, pharmacodynamic and pharmacokinetic studies, clinical aspects, and special applications. Topics include: Role of microdialysis in drug development, including crucial sampling considerations and applications for nervous system diseases Continuous measurement of glucose concentrations in diabetics Applications for clinical evaluation and basic research on organ systems, including monitoring exogenous and endogenous compounds in the lungs Pharmacokinetic and pharmacodynamic evaluation of anticancer drugs Comparison of microdialysis with imaging approaches to evaluate in vivo drug distribution Special applications of microdialysis in studies of cell culture assays, drug-drug interactions, and environmental monitoring Throughout the book, readers will find simple models that clarify complex concepts and easy-to-follow examples that guide them through key applications in pharmaceutical research. In short, this book enables pharmaceutical researchers to take full advantage of microdialysis techniques for the preclinical and clinical evaluation of drugs and much more.

Chemical Analysis

Chemical Analysis
Author: David D. Cunningham,Julie A. Stenken
Publsiher: Unknown
Total Pages: 450
Release: 1941
ISBN 10:
ISBN 13: CHI:092101800
Language: EN, FR, DE, ES & NL

Chemical Analysis Book Review:

Handbook of the Behavioral Neurobiology of Serotonin

Handbook of the Behavioral Neurobiology of Serotonin
Author: Christian P. Muller,Barry Jacobs
Publsiher: Academic Press
Total Pages: 836
Release: 2009-12-30
ISBN 10: 9780080878171
ISBN 13: 0080878172
Language: EN, FR, DE, ES & NL

Handbook of the Behavioral Neurobiology of Serotonin Book Review:

Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders. The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community Of great value not only for researchers and experts, but also for students and clinicians as a background reference