Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy
Author: Gajanan V. Sherbet
Publsiher: Elsevier
Total Pages: 347
Release: 2011
ISBN 10: 0123878195
ISBN 13: 9780123878199
Language: EN, FR, DE, ES & NL

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy Book Review:

Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy
Author: G. V. Sherbet
Publsiher: Elsevier
Total Pages: 368
Release: 2011-07
ISBN 10: 9780323165310
ISBN 13: 0323165311
Language: EN, FR, DE, ES & NL

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy Book Review:

Growth Factors and their Receptors in Cancer Metastasis

Growth Factors and their Receptors in Cancer Metastasis
Author: Wen G. Jiang,K. Matsumoto,T. Nakamura
Publsiher: Springer Science & Business Media
Total Pages: 303
Release: 2006-04-11
ISBN 10: 0306483998
ISBN 13: 9780306483998
Language: EN, FR, DE, ES & NL

Growth Factors and their Receptors in Cancer Metastasis Book Review:

about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).

Signal Transduction in Cancer

Signal Transduction in Cancer
Author: David A. Frank
Publsiher: Springer Science & Business Media
Total Pages: 357
Release: 2006-04-18
ISBN 10: 0306481588
ISBN 13: 9780306481581
Language: EN, FR, DE, ES & NL

Signal Transduction in Cancer Book Review:

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Molecular Approach to Cancer Management

Molecular Approach to Cancer Management
Author: Gajanan V. Sherbet
Publsiher: Academic Press
Total Pages: 352
Release: 2017-06-15
ISBN 10: 0128128976
ISBN 13: 9780128128978
Language: EN, FR, DE, ES & NL

Molecular Approach to Cancer Management Book Review:

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. Covers all relevant topics with a defined aim of targeted therapy Encompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cells Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

Therapeutic Strategies in Cancer Biology and Pathology

Therapeutic Strategies in Cancer Biology and Pathology
Author: Gajanan V. Sherbet
Publsiher: Elsevier
Total Pages: 310
Release: 2013-07-26
ISBN 10: 0124165907
ISBN 13: 9780124165908
Language: EN, FR, DE, ES & NL

Therapeutic Strategies in Cancer Biology and Pathology Book Review:

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

The Genetics of Cancer

The Genetics of Cancer
Author: Gajanan V. Sherbet,M. S. Lakshmi
Publsiher: Academic Press
Total Pages: 338
Release: 1997-06-22
ISBN 10: 9780080542485
ISBN 13: 0080542484
Language: EN, FR, DE, ES & NL

The Genetics of Cancer Book Review:

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes

Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

Fibroblast Growth Factors  Biology And Clinical Application   Fgf Biology And Therapeutics
Author: Simons Michael
Publsiher: World Scientific
Total Pages: 284
Release: 2016-12-27
ISBN 10: 981314338X
ISBN 13: 9789813143388
Language: EN, FR, DE, ES & NL

Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics Book Review:

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states. Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches. With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer. It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

Genetic Recombination in Cancer

Genetic Recombination in Cancer
Author: Gajanan V. Sherbet
Publsiher: Elsevier
Total Pages: 264
Release: 2003-07-24
ISBN 10: 9780080521909
ISBN 13: 0080521908
Language: EN, FR, DE, ES & NL

Genetic Recombination in Cancer Book Review:

Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers

Insulin Like Growth Factors

Insulin Like Growth Factors
Author: Douglas Yee
Publsiher: IOS Press
Total Pages: 124
Release: 2003
ISBN 10: 9781586034092
ISBN 13: 158603409X
Language: EN, FR, DE, ES & NL

Insulin Like Growth Factors Book Review:

Over the past five years there has been an explosion of "targeted therapies" for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an important role in regulating the malignant phenotype. In breast cancer, there is compelling rationale that such targeted strategies should be successful. Targeting of estrogen receptor ? (ER?) has proven to be a successful way to reduce breast cancer risk, decrease the risk of death and recurrence in an adjuvant setting, and remains the first choice of treatment for advanced disease. With this success, it is hoped that other molecular pathways could also be successfully exploited. This publication reviews the role of the insulin-like growth factors (IGFs) in breast cancer. Over 100 years ago George Beatson made an intuitive leap connecting breast cancer therapy with ovarian function He removed the ovaries from a premenopausal woman with breast cancer; he reasoned that ovarian function regulated normal mammary gland function, therefore the ovaries may influence the malignant phenotype. Other discussion included cover the function of IGF action in the normal mammary gland using mouse model systems where expression and function can be manipulated and the patterns of expression of the IGFs, their binding proteins, and their receptors in the normal gland.

Blood Cell Biochemistry

Blood Cell Biochemistry
Author: Anthony D. Whetton,John Gordon
Publsiher: Springer
Total Pages: 420
Release: 1996-08-31
ISBN 10:
ISBN 13: UOM:39015041066294
Language: EN, FR, DE, ES & NL

Blood Cell Biochemistry Book Review:

Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog ical situations (see below).

Cancer Medicine

Cancer Medicine
Author: James F. Holland
Publsiher: Unknown
Total Pages: 3467
Release: 1997
ISBN 10: 9780683040951
ISBN 13: 0683040952
Language: EN, FR, DE, ES & NL

Cancer Medicine Book Review:

Transforming Growth Factor Beta in Cancer Therapy Volume II

Transforming Growth Factor Beta in Cancer Therapy  Volume II
Author: Sonia B. Jakowlew
Publsiher: Springer Science & Business Media
Total Pages: 786
Release: 2010-01-01
ISBN 10: 1597452939
ISBN 13: 9781597452939
Language: EN, FR, DE, ES & NL

Transforming Growth Factor Beta in Cancer Therapy Volume II Book Review:

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Protooncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation

Protooncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation
Author: Sohaib A. Khan,George M. Stancel
Publsiher: CRC Press
Total Pages: 288
Release: 1993-12-17
ISBN 10: 9780849386725
ISBN 13: 0849386721
Language: EN, FR, DE, ES & NL

Protooncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation Book Review:

Protooncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation reviews current information regarding the complex nature of hormone-induced cell growth and differentiation. The contributors examine the emerging consensus that protooncogenes and growth factors mediate perhaps the most crucial steps leading to cell growth and differentiation. The primary objective of this book is to unite the status of current research related to protooncogenes and growth factors from diverse physiological systems to help readers gain a comprehensive understanding of the subject. Leading researchers have contributed outstanding chapters pertaining to steroid hormone-regulated cell growth and differentiation in normal and/or neoplastic tissues. This book will appeal to basic science researchers, clinicians, industrial researchers, and graduate students.

Growth Factors and Oncogenes

Growth Factors and Oncogenes
Author: M. Bolla,E. M. Chambaz,C. Vrousos
Publsiher: Unknown
Total Pages: 222
Release: 1989
ISBN 10:
ISBN 13: UCAL:B4425349
Language: EN, FR, DE, ES & NL

Growth Factors and Oncogenes Book Review:

The major objective of this book is to bring together specialists well-known for their contribution to the basic knowledge of growth factors and oncogenes and experts engaged in clinical research and prospective in cancer therapy."

Transforming Growth Factor Beta in Cancer Therapy Volume I

Transforming Growth Factor Beta in Cancer Therapy  Volume I
Author: Sonia B. Jakowlew
Publsiher: Springer Science & Business Media
Total Pages: 735
Release: 2010-01-01
ISBN 10: 1597452920
ISBN 13: 9781597452922
Language: EN, FR, DE, ES & NL

Transforming Growth Factor Beta in Cancer Therapy Volume I Book Review:

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Hormones and Cancer

Hormones and Cancer
Author: Wayne V. Vedeckis
Publsiher: Springer Science & Business Media
Total Pages: 612
Release: 2012-12-06
ISBN 10: 1461242665
ISBN 13: 9781461242666
Language: EN, FR, DE, ES & NL

Hormones and Cancer Book Review:

The series, Hormones in Health and Disease, was launched in 1993 to provide a scientific platform for investigators engaged in research on the biological actions of hormones and to anticipate relevance for their findings in clinical applications. The first volume of the series was dedicated to the discussion and understanding of molecular mechanisms by which steroid hormones influence target cells in normal and pathological conditions. With the diversity of information and the vast amount of literature on steroid hormone physiology, a more thorough treatment of Hormones and Cancer was identified as a timely topic. In this second volume in the series, Dr. Wayne V. Vedeckis has success fully undertaken the monumental task of editing the findings of the leading investigators in hormone and cancer research. Dr. Vedeckis brings to this project two decades of research experience in hormone action; he is actively engaged in elucidating hormone and cancer interrelations. It is a pleasure to welcome him to the series as an editor and congratulate him and all contribu tors in presenting this comprehensive treatise. The 20 chapters include discussions on contemporary topics relating control of cell division and signal transduction to the basic mechanisms of carcinogenesis by cloning patient genes, and recognizing the importance of steroid receptors in treatment protocols of various endocrine abnormalities.

Transforming Growth Factor Beta in Cancer Therapy Volume II

Transforming Growth Factor Beta in Cancer Therapy  Volume II
Author: Sonia B. Jakowlew
Publsiher: Humana Press
Total Pages: 786
Release: 2010-10-28
ISBN 10: 9781617377365
ISBN 13: 1617377368
Language: EN, FR, DE, ES & NL

Transforming Growth Factor Beta in Cancer Therapy Volume II Book Review:

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Principles of Tumors

Principles of Tumors
Author: Leon P. Bignold
Publsiher: Academic Press
Total Pages: 686
Release: 2019-11-01
ISBN 10: 0128173297
ISBN 13: 9780128173299
Language: EN, FR, DE, ES & NL

Principles of Tumors Book Review:

Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine. Presents content that has been totally updated with the most recent developments of the field, including new chapters on tumor imaging exams, new surgical techniques, immunotherapy, gene therapy, and several novel therapies using natural and synthetic compounds Presents translational approaches for every topic to improve conceptual insights for new research projects Covers a broad range of subjects, making it easier for the reader to understand related fields Includes diagrams for complex topics to aid in understanding for non-specialists

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
Author: null Hasmann
Publsiher: Elsevier Inc. Chapters
Total Pages: 472
Release: 2013-05-07
ISBN 10: 0128061995
ISBN 13: 9780128061992
Language: EN, FR, DE, ES & NL

Introduction to Biological and Small Molecule Drug Research and Development Book Review:

HER2 (ErbB-2) is a member of the human epidermal growth factor receptor tyrosine kinase family which is involved in the regulation of cell proliferation, survival and differentiation. Soon after its discovery, HER2 was shown frequently to be overexpressed in breast cancer and was associated with a worse prognosis. It was identified as a target for drug development and molecular cloning of the gene and expression in cell lines provided a vehicle for the selection of HER2-specific antibodies. The monoclonal antibody trastuzumab is the first HER2-targeting drug approved for cancer treatment. By significantly extending the time to disease progression and overall survival of patients, it has become established in all treatment lines of early and metastatic HER2-positive breast cancer, as well as in HER2-positive advanced metastatic gastric or gastroesophageal junction cancer. Combination of trastuzumab with pertuzumab, a second antibody binding to a distinct epitope on HER2 which implies a different mode of action, took the treatment of HER2-positive metastatic breast cancer to the next level of success. Finally, trastuzumab emtansine is an antibodydrug conjugate that retains all pharmacodynamic activities of trastuzumab and delivers a toxic maytansinoid directly to the tumour cells. Current clinical results indicate that trastuzumab emtansine may be more efficacious and less toxic than trastuzumab plus chemotherapy, and further improvement is expected in combination with pertuzumab.