Gluten Related Disorders: Diagnostic approaches, Treatment Pathways and Future Perspectives

Gluten-related disorders are prevalent among human societies, specifically in developing countries. These diseases have similar clinical manifestations and although they are characterized by a specific pathophysiological response to ingestion of gluten, differential diagnosis of these disorders is very challenging and failure to diagnosis and treat these disorders at an early stage, can lead to irreparable health and cost damages. Gluten Related Disorders: Diagnostic Approaches, Treatment Pathways and Future Perspectives reports up-to-date scientific findings within a historical perspective to identify the main differences and distinctive features of each of these diseases leading to better diagnosis and treatment options as well as pathogenesis of gluten disorders for use in future research endeavors. This reference is perfect for researchers, scientists and medical practitioners currently addressing gluten-related diseases. Delivers a wide perspective of gluten-related disorders highlighting the differences and overlaps in clinical presentations of these disorders, aiding in the process of differential diagnosis Offers the pathogenesis of gluten disorders for use in future research endeavors Provides a comprehensive overview on all aspects of gluten-related disorders incorporating several up-to-date scientific findings bringing recognition to the main differences and distinctive features between the diseases

Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.

Few other fields in human biology have experienced such a tremendous progress as celiac disease has during the past few years. The contributors to 'Frontiers in Celiac Disease' are world-renowned opinion leaders who made these advances possible. Their expertise has been assembled here to provide a comprehensive overview of the current knowledge of the epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of celiac disease. In addition, the stage is set for innovative strategies for preventive interventions and treatment alternatives to a gluten-free diet. A valuable reference for basic and translational scientists, this book also serves as a practical resource to healthcare professionals, including general practitioners, subspecialists, dieticians, nutritionists, and nurses and nurse practitioners. Students from different disciplines will find this book a helpful guide to expand and deepen their knowledge of celiac disease.

Coeliac Disease and Gluten-Related Disorders provides an updated and comprehensive overview on the crucial aspects and clinical management of gluten-related disorders. It provides an overview of the scientific background, mechanisms involved, and emphasizes the translational effect of research on clinical practice. Highlighted throughout are insights into future research areas likely to have a crucial impact in the clinical management of these common conditions. The book is perfect for researchers and gastroenterologists involved in Coeliac Disease and other gluten-related disorders. Presents both research and clinically based perspectives on the most relevant issues of gluten-related disorders Provides a wide-ranging discussion and the most updated opinions by international experts in the field of coeliac disease and gluten-related disorders Translates the latest research insights into practical suggestions for specialists

This groundbreaking core textbook offers a comprehensive overview of different approaches to the assessment and treatment of psychological disorders. The book retains important diagnostic perspectives, including the DSM-5, ICD-10, ICD-11 and PDM, but also widens the scope of coverage beyond mainstream psychiatric models to include psychological, biological, historical, sociocultural and therapeutic approaches. Contemporary and well-balanced, this book provides an even-handed and holistic foundation, allowing students to develop a strong critical mindset while retaining a robust research-driven orientation. This book is ideal for undergraduate and postgraduates students on abnormal psychology, psychopathology, mental health or clinical psychology modules.

Remarkable progress has been made in our knowledge of celiac disease, yet the diagnosis is often overlooked. The practical challenge for healthcare professionals is to identify the disease and offer patients a gluten-free diet that will restore most to full health and help to prevent further complications. This comprehensively revised second edition of 'Fast Facts: Celiac Disease', written by three international experts, considers: • Celiac disease in all its forms - typical, atypical, silent, potential and latent • Gluten sensitivity, genetic risk and predisposing physiological abnormalities • The variable presentation of disease in both adults and children • Associated immune disorders • The puzzle of diagnosis, solved by clinical, serological, histological and genetic investigation • Troublesome, and sometimes life-threatening, non-malignant complications • The close links between celiac disease and dermatitis herpetiformis • The risk of malignancy, its treatment and prognosis • Management with a gluten-free diet, and the emotional and social implications of the diet • Potential new therapies Highly readable with informative illustrations, 'Fast Facts: Celiac Disease' provides an up-to-date account of this common yet easily missed condition. It is an excellent clinical resource for the primary care team, gastroenterologists in training and anyone who wants to know more about this challenging disease. Contents: • Definition • Epidemiology • Pathophysiology • Clinical manifestations • Diagnosis • Non-malignant complications • Dermatitis herpetiformis • Malignant complications • Management • Future trends • Useful resources

The Autoimmune Diseases is composed of 25 chapters dealing with different aspects of some specific autoimmune diseases. The book begins with the elucidation of the genetic predisposition to autoimmune diseases. Subsequent chapters explore numerous kinds of autoimmune diseases. Other chapters describe the antireceptor antibodies and the sensitivity and specificity of autoantibody testing. This book is designed to provide a deeper understanding of this increasingly important field of medical science for physicians and investigators involved in the diagnosis, treatment, or research of autoimmune ...

Practical, delicious ways to manage a gluten-free diet. If you have a wheat allergy, gluten intolerance, celiac disease, or just want to enjoy the benefits of a diet free of wheat, barley, and rye, then this handy pocket guide gets you on the gluten-free path. You’ll get a handle on the whos, whats, whys, and hows of going gluten-free as well as trusted advice on how to manage gluten sensitivity. Packed with practical advice ranging from what to eat and what to avoid to how to shop and cook, this book gets you started living — and loving — a gluten-free lifestyle.

The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

Wheat provides over 20% of the calories for the world population of 5. 3 billion persons. It is widely grown in five of the six continents. It is a highly versatile food product in that it can be stored safely for long periods of time and transported in bulk over long distances. In relative terms, it is reasonably priced; over the past quarter century, the inflation-adjusted price of wheat has been declining. Modern milling and baking technology required for the transformation of wheat grain into consumable baked products is available or accessible in all countries of the world. For these reasons, and because Canada is one of world's leading wheat producing countries, it seemed appropriate to include a major symposium on wheat in the scientific and technical program of the 8th World Congress of Food Science and Technology held in Toronto, Canada during September 29-0ctober 4, 1992. In selecting the topics for the symposium on wheat, we attempted to cover a full range of subjects including economics and marketing, nutrition, grading, processing, constituent chemistry and functionality, biote- nology, and safety of genetically modified wheat varieties. The major focus was on common hard (bread) wheats; separate papers were devoted to the unique characteristics and technological properties of common soft (biscuit) and durum (pasta) wheats. Each paper was presented by an acknowledged international expert. This book provides a more permanent record of the papers presented at the symposium.

Written by Jerome Sarris and Jon Wardle, Clinical Naturopathy: An evidence-based guide to practice articulates evidence-based clinical practice. It details the principles, treatment protocols and interventions at the forefront of naturopathic practice in the 21st century. Clinical Naturopathy equips you to critically evaluate your patients, analyse treatment protocols, and provide evidence-based prescriptions. A rigorously researched update of common clinical conditions and their naturopathic treatment according to evidence-based guidelines Treatment decision trees Outline of core principles of naturopathic practice Herb–drug interactions table Laboratory reference values Food sources of nutrients Cancer medication interactions Includes an Enhanced eBook version with purchase. The enhanced eBook allows the end user to access all of the text, figures, and references from the book on a variety of devices.

This pocketbook presents, at a glance, selected key indicators on agriculture and food security, and is meant to serve as an easy-to- access and quick reference for all stakeholders and partners involved in policy formulation or decision making processes. The indicators are presented in two sections, one thematic and one country-specific; they are organized along four main themes: 1) The setting, which measures the state of the agricultural resource base by assessing the supply of land, labour, capital and inputs; 2) Hunger dimensions, to gauge the state of food insecurity and malnutrition, and highlight the four dimensions - availability, access, stability and utilization - that determine the scale of hunger and the shape of undernourishment; 3) Food supply, which evaluates the past and present productive capacity of world agriculture, together with the role of trade, in meeting the world's demand for food, feed and other products; 4) Environment, which examines the sustainability of agriculture in the context of the pressure it exerts on its ecological surroundings. The pocketbook is part of FAO's efforts to support national, regional and international partners in improving the availability of high quality and timely data, in view of sustainable agricultural development and zero hunger.

The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research. Explains how to modify the gut microbiota and how the current strategies used to do this produce their effects Explores the gut microbiota as a therapeutic target Provides the synthesis of existing data from both mainstream and non-mainstream sources through experienced researchers in the field Serves as a ‘one-stop’ shop for a topic that’s currently spread across a number of various journals

Mucosal immunology is so important since most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes. Mucosal Immunology, now in its third edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective and excellent organization. * The most comprehensive text on mucosal immunology from internationally recognized experts in the field * Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases * Contains nine new chapters and an expanded appendix

This book is an up-to-date, comprehensive review of the neuropsychiatry of different types of cognitive impairment by active authorities in the field. There is an emphasis on diagnostic and management issues. Cognitive impairment both with and without criteria for dementia is covered. A critical appraisal of the methodological aspects and limitations of the current research on the neuropsychiatry of cognitive impairment and dementia is included. Unanswered questions and controversies are addressed. Non-pharmacological and pharmacological aspects of management are discussed, to provide robust information on drug dosages, side effects and interaction, in order to enable the reader to manage these patients more safely. Illustrative cases provide real life scenarios that are clinically relevant and engaging to read. Neuropsychiatric Symptoms of Cognitive Impairment and Dementia is aimed at neurologists, psychiatrists, gerontologists, and general physicians. It will also be of interest to intensive care doctors, psychologists and neuropsychologists, research and specialist nurses, clinical researchers and methodologists.

Celiac disease (CD) occurs in about 1% of people worldwide. Diagnosis rates are increasing due to a true rise in incidence, rather than increased awareness and detection. CD affects genetically susceptible individuals who are triggered by the ingestion of gluten. The disease has many clinical manifestations, ranging from severe to minimally symptomatic or non-symptomatic presentations. Diagnosis requires the presence of duodenal chronic inflammation, and most patients have circulating antibodies against tissue transglutaminase. Our understanding of the basic and clinical aspects of CD increases, which is as a major health problem of almost global occurrence. Case finding, distinguishing CD from other gluten-sensitive conditions, better care, and balanced use of resources are the current challenges.

Celiac Disease is an authoritative text intended to educate healthcare practitioners, gastroenterologists, physicians and nutritionists about the diverse manifestations, complications and management of gluten-sensitive enteropathy. The seventeen-chapter text provides the latest research on pathophysiology, including animal models, immunopathogenesis, genetics and the intestinal microflora. The book also features chapters on diagnosis, monitoring, complications and nutritional management, including therapies on the horizon. The text concludes with appendices that provide educational tools for symptom monitoring and dietary guidance. Written by specialists in their respective fields, Celiac Disease is a comprehensive resource that provides the healthcare practitioner an evidence-based practical guide to pathogenesis and therapy of celiac disease.

The intestinal epithelium has to perform two opposing tasks: it must facilitate absorption and secretion of solutes and water; but still provide a defense against unwanted uptake or loss of solutes, water and noxious agents. The papers in this volume discuss both functions as they interact in health and in disease. They focus on new regulative pathways and properties of solute transporters; and the molecular basis of the barrier-forming paracellular structures and models for studying disturbed transport and barrier properties. Special attention is given to mechanisms of diarrhoea caused by enterotoxins or by inflammatory bowel diseases.