Gene Therapy of Cancer

Gene Therapy of Cancer
Author: Stanton L. Gerson,Edmund C. Lattime
Publsiher: Elsevier
Total Pages: 534
Release: 2002-04-04
ISBN 10: 9780080491363
ISBN 13: 0080491367
Language: EN, FR, DE, ES & NL

Gene Therapy of Cancer Book Review:

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy
Author: Roland W. Herzog,Sergei Zolotukhin
Publsiher: World Scientific
Total Pages: 388
Release: 2010
ISBN 10: 9814280917
ISBN 13: 9789814280914
Language: EN, FR, DE, ES & NL

A Guide to Human Gene Therapy Book Review:

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Gene Therapy

Gene Therapy
Author: Mauro Giacca
Publsiher: Springer Science & Business Media
Total Pages: 303
Release: 2010-11-01
ISBN 10: 9788847016439
ISBN 13: 8847016436
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic lessons, and have often noticed that the field is very attractive to scientists of all disciplines. However, as yet no comprehensive book on the subject has been published. Indeed, most books in the field are either a collection of gene transfer laboratory protocols or deal with the subject in a rather superficial manner. Hence the idea to write a gene therapy textbook that is broad and comprehensive, but at the same time provides sufficient molecular and clinical detail to be of interest to students, professors, and specialists in the various disciplines that contribute to gene therapy. I have tried to keep the language plain and, whenever possible, non-technical. Since the book is intended to be a textbook in the field of gene therapy in both the basic science and clinical areas, whenever technical descriptions are required, they are provided.

Gene Therapy

Gene Therapy
Author: David Cooper,Prof Nick Lemoine
Publsiher: Garland Science
Total Pages: 360
Release: 2020-09-11
ISBN 10: 1000144682
ISBN 13: 9781000144680
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

Gene Therapy describes the delivery systems now available to target a given tissue with specific gene or oligonucleotide sequences, and explores the utility of animal modules as test systems. In the context of selected disease states, it summarises in vitro and in vivo studies and clinical trials performed to date.

Gene Therapy

Gene Therapy
Author: United States. Congress. Senate. Committee on Health, Education, Labor, and Pensions. Subcommittee on Public Health
Publsiher: Unknown
Total Pages: 126
Release: 2000
ISBN 10:
ISBN 13: PSU:000046314529
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

Gene Therapy

Gene Therapy
Author: United States,United States. Congress. House. Committee on Science, Space, and Technology
Publsiher: Unknown
Total Pages: 160
Release: 1995
ISBN 10:
ISBN 13: UCR:31210014030975
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

Gene Therapy

Gene Therapy
Author: Rex A. Hudson,United States. Congress. Senate. Committee on Health, Education, Labor, and Pensions. Subcommittee on Public Health
Publsiher: Unknown
Total Pages: 75
Release: 2000
ISBN 10:
ISBN 13: PSU:000047030688
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

Human Gene Therapy

Human Gene Therapy
Author: United States. Congress. Office of Technology Assessment
Publsiher: Unknown
Total Pages: 105
Release: 1984
ISBN 10:
ISBN 13: UCR:31210024829408
Language: EN, FR, DE, ES & NL

Human Gene Therapy Book Review:

Human Gene Therapy

Human Gene Therapy
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1987
ISBN 10:
ISBN 13: UCR:31210010557104
Language: EN, FR, DE, ES & NL

Human Gene Therapy Book Review:

Gene Therapy for Viral Infections

Gene Therapy for Viral Infections
Author: Patrick Arbuthnot
Publsiher: Academic Press
Total Pages: 392
Release: 2015-06-01
ISBN 10: 0124114520
ISBN 13: 9780124114524
Language: EN, FR, DE, ES & NL

Gene Therapy for Viral Infections Book Review:

Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field

Muscle Gene Therapy

Muscle Gene Therapy
Author: Dongsheng Duan
Publsiher: Springer Science & Business Media
Total Pages: 275
Release: 2009-11-26
ISBN 10: 9781441912077
ISBN 13: 144191207X
Language: EN, FR, DE, ES & NL

Muscle Gene Therapy Book Review:

Muscle disease represents an important health threat to the general population. There is essentially no cure. Gene therapy holds great promise to correct the genetic defects and eventually achieve full recovery in these diseases. Significant progresses have been made in the field of muscle gene therapy over the last few years. The development of novel gene delivery vectors has substantially enhanced specificity and efficiency of muscle gene delivery. The new knowledge on the immune response to viral vectors has added new insight in overcoming the immune obstacles. Most importantly, the field has finally moved from small experimental animal models to human patients. This book will bring together the leaders in the field of muscle gene transfer to provide an updated overview on the progress of muscle gene therapy. It will also highlight important clinical applications of muscle gene therapy.

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
Author: David T. Curiel
Publsiher: Academic Press
Total Pages: 868
Release: 2016-03-10
ISBN 10: 0128005106
ISBN 13: 9780128005101
Language: EN, FR, DE, ES & NL

Adenoviral Vectors for Gene Therapy Book Review:

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Cell and Gene Therapies

Cell and Gene Therapies
Author: Miguel-Angel Perales,Syed A. Abutalib,Catherine Bollard
Publsiher: Springer
Total Pages: 288
Release: 2018-11-27
ISBN 10: 3319543687
ISBN 13: 9783319543680
Language: EN, FR, DE, ES & NL

Cell and Gene Therapies Book Review:

In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee.

Gene Therapy in Neurological Disorders

Gene Therapy in Neurological Disorders
Author: Mingjie Li,B. Joy Snider
Publsiher: Academic Press
Total Pages: 450
Release: 2018-05-25
ISBN 10: 012809821X
ISBN 13: 9780128098219
Language: EN, FR, DE, ES & NL

Gene Therapy in Neurological Disorders Book Review:

Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system. Provides background information and experimental details of gene therapy tools applied for neuroscience research and neurological disorders Covers a broad range of gene delivery and regulation tools, therapeutic agents, and target cells, including emerging new technologies such as CRISPR/Cas9 genome editing Discusses applications of gene therapy tools to neurological disorders including neurodegeneration, muscular dystrophy, trauma and chronic pain, and neoplastic diseases

Choosing Targets for Gene Therapy

Choosing Targets for Gene Therapy
Author: Karina J. Matissek
Publsiher: Unknown
Total Pages: 329
Release: 2011
ISBN 10:
ISBN 13: OCLC:1154219883
Language: EN, FR, DE, ES & NL

Choosing Targets for Gene Therapy Book Review:

Choosing Targets for Gene Therapy.

Gene Therapy Prospective Technology assessment in its societal context

Gene Therapy  Prospective Technology assessment in its societal context
Author: Jörg Niewöhner,Christof Tannert
Publsiher: Elsevier
Total Pages: 274
Release: 2011-08-19
ISBN 10: 9780080470931
ISBN 13: 0080470939
Language: EN, FR, DE, ES & NL

Gene Therapy Prospective Technology assessment in its societal context Book Review:

This book presents work that has been conducted as part of the research project "Discourse on ethical questions of biomedicine" of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany. This book offers ground-breaking ideas on how the daily interworking of cutting-edge biomedical research assess the broader social context and its communication to stakeholders and the public. Editors cover three aspects: Scientific, Ethical and Legal, and Perception and Communication. This work establishes an international and interdisciplinary network of excellent researchers at the beginning of their careers, who brilliantly integrate their work into the different perspectives on gene therapy from the natural and social sciences, as well as the humanities and law. * Discusses biological and cellular barriers limiting the clinical application of nonviral gene delivery systems * Addresses such questions as: Does patent granting hinder the development of Gene Therapy products? * Offers insight in the future of public perception of gene therapy in Europe * Provides details on how to communicate risks in gene therapy

Second Generation Cell and Gene Based Therapies

Second Generation Cell and Gene Based Therapies
Author: Alain Vertes,Nathan J. Dowden,Devyn Smith,Nasib Qureshi
Publsiher: Academic Press
Total Pages: 846
Release: 2020-02-07
ISBN 10: 0128120339
ISBN 13: 9780128120330
Language: EN, FR, DE, ES & NL

Second Generation Cell and Gene Based Therapies Book Review:

Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products. The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies

Fast Facts Gene Therapy

Fast Facts  Gene Therapy
Author: R. Herzog,L. Popplewell
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 104
Release: 2020-04-24
ISBN 10: 3318066672
ISBN 13: 9783318066678
Language: EN, FR, DE, ES & NL

Fast Facts Gene Therapy Book Review:

Gene therapy has emerged as a discipline in medicine that can provide treatments for diseases that have no other therapies available, save lives of patients for whom there is no other hope and replace suboptimal treatments with lasting cures. 'Fast Facts: Gene Therapy' provides an overview of the field, looking at the main vector systems used to transfer the therapeutic gene constructs, the molecular mechanisms and the history of gene therapy, as well as the safety and ethical considerations of this important advance. Multiple examples of diseases that are already successfully treated with gene therapy are given, with discussion of treatments that hold promise for the future. This book will be informative and of value to health professionals, researchers, students and anyone with an interest in this exciting and fast-moving area. Contents: • Principles of gene therapy • Gene therapy techniques • Ethical and safety considerations • Gene therapies with proven clinical efficacy • Genome editing • Research directions – the next wave of treatments

Gene Therapy of the Central Nervous System From Bench to Bedside

Gene Therapy of the Central Nervous System  From Bench to Bedside
Author: Michael G. Kaplitt,Matthew During
Publsiher: Gulf Professional Publishing
Total Pages: 355
Release: 2006
ISBN 10: 9780123976321
ISBN 13: 0123976324
Language: EN, FR, DE, ES & NL

Gene Therapy of the Central Nervous System From Bench to Bedside Book Review:

Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. * Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells * Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis * Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use

Gene and Cell Therapy

Gene and Cell Therapy
Author: Nancy Smyth Templeton
Publsiher: CRC Press
Total Pages: 1120
Release: 2008-10-06
ISBN 10: 9780849387999
ISBN 13: 084938799X
Language: EN, FR, DE, ES & NL

Gene and Cell Therapy Book Review:

Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression. New Topics Covered in this Edition: Gene and Cell Therapies for Diabetes and Cardiovascular Diseases Clinical Trials Human Embryonic Stem Cells Tissue Engineering Combined with Cell Therapies Novel Polymers Relevant Nanotechnologies SiRNA Therapeutic Strategies Dendrimer Technologies Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies. The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness. The final section discusses recent clinical trials and regulatory issues surrounding the new technology. This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.