Gene Therapy of Cancer

Gene Therapy of Cancer
Author: Stanton L. Gerson,Edmund C. Lattime
Publsiher: Elsevier
Total Pages: 534
Release: 2002-04-04
ISBN 10: 9780080491363
ISBN 13: 0080491367
Language: EN, FR, DE, ES & NL

Gene Therapy of Cancer Book Review:

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Genetics and Gene Therapy

Genetics and Gene Therapy
Author: Sheila A.M. McLean
Publsiher: Routledge
Total Pages: 568
Release: 2017-09-08
ISBN 10: 1351934279
ISBN 13: 9781351934275
Language: EN, FR, DE, ES & NL

Genetics and Gene Therapy Book Review:

Genetics and Gene Therapy shows the wide range of the debate and the very real significance that genetics and its associated developments have for human beings, individually and collectively. Few areas of science and medicine have resulted in the volume of academic and popular literature as has genetics. The so-called revolution in understanding of the causes of disease states, and even behavioural traits, has focussed public attention on the influence of genes in making us what we are. Rapidly, however, the potential benefits of such understanding were overtaken, in the public mind at least, by the question of the possible (negative) implications of genetic knowledge and associated technologies. The chapters in this volume show just how wide-ranging concern has become, ranging from regulation to cloning, with the fear of discrimination in between. Part One begins with a range of general discussions of about the genetic enterprise itself, followed by consideration of some specific questions. Part Two then addresses cutting edge debates in genetics.

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy
Author: Roland W. Herzog,Sergei Zolotukhin
Publsiher: World Scientific
Total Pages: 388
Release: 2010
ISBN 10: 9814280917
ISBN 13: 9789814280914
Language: EN, FR, DE, ES & NL

A Guide to Human Gene Therapy Book Review:

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Gene Therapy

Gene Therapy
Author: Mauro Giacca
Publsiher: Springer Science & Business Media
Total Pages: 303
Release: 2010-11-01
ISBN 10: 9788847016439
ISBN 13: 8847016436
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic lessons, and have often noticed that the field is very attractive to scientists of all disciplines. However, as yet no comprehensive book on the subject has been published. Indeed, most books in the field are either a collection of gene transfer laboratory protocols or deal with the subject in a rather superficial manner. Hence the idea to write a gene therapy textbook that is broad and comprehensive, but at the same time provides sufficient molecular and clinical detail to be of interest to students, professors, and specialists in the various disciplines that contribute to gene therapy. I have tried to keep the language plain and, whenever possible, non-technical. Since the book is intended to be a textbook in the field of gene therapy in both the basic science and clinical areas, whenever technical descriptions are required, they are provided.

Gene Therapy for Viral Infections

Gene Therapy for Viral Infections
Author: Patrick Arbuthnot
Publsiher: Academic Press
Total Pages: 392
Release: 2015-06-01
ISBN 10: 0124114520
ISBN 13: 9780124114524
Language: EN, FR, DE, ES & NL

Gene Therapy for Viral Infections Book Review:

Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field

Somatic Gene Therapy

Somatic Gene Therapy
Author: P.L. Chang
Publsiher: CRC Press
Total Pages: 313
Release: 2018-01-17
ISBN 10: 1351085212
ISBN 13: 9781351085212
Language: EN, FR, DE, ES & NL

Somatic Gene Therapy Book Review:

As human gene therapy becomes a clinical reality, a new era in medicine dawns. Novel and innovative developments in molecular genetics now provide opportunities to treat the genetic bases of diseases often untreatable before. Somatic Gene Therapy documents these historical clinical trials, reviews current advances in the field, evaluates the use of the many different cell types and organs amenable to gene transfer, and examines the prospects of various exciting strategies for gene therapy.

Muscle Gene Therapy

Muscle Gene Therapy
Author: Dongsheng Duan
Publsiher: Springer Science & Business Media
Total Pages: 275
Release: 2009-11-26
ISBN 10: 9781441912077
ISBN 13: 144191207X
Language: EN, FR, DE, ES & NL

Muscle Gene Therapy Book Review:

Muscle disease represents an important health threat to the general population. There is essentially no cure. Gene therapy holds great promise to correct the genetic defects and eventually achieve full recovery in these diseases. Significant progresses have been made in the field of muscle gene therapy over the last few years. The development of novel gene delivery vectors has substantially enhanced specificity and efficiency of muscle gene delivery. The new knowledge on the immune response to viral vectors has added new insight in overcoming the immune obstacles. Most importantly, the field has finally moved from small experimental animal models to human patients. This book will bring together the leaders in the field of muscle gene transfer to provide an updated overview on the progress of muscle gene therapy. It will also highlight important clinical applications of muscle gene therapy.

Fast Facts Gene Therapy

Fast Facts  Gene Therapy
Author: R. Herzog,L. Popplewell
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 104
Release: 2020-04-24
ISBN 10: 3318066672
ISBN 13: 9783318066678
Language: EN, FR, DE, ES & NL

Fast Facts Gene Therapy Book Review:

Gene therapy has emerged as a discipline in medicine that can provide treatments for diseases that have no other therapies available, save lives of patients for whom there is no other hope and replace suboptimal treatments with lasting cures. 'Fast Facts: Gene Therapy' provides an overview of the field, looking at the main vector systems used to transfer the therapeutic gene constructs, the molecular mechanisms and the history of gene therapy, as well as the safety and ethical considerations of this important advance. Multiple examples of diseases that are already successfully treated with gene therapy are given, with discussion of treatments that hold promise for the future. This book will be informative and of value to health professionals, researchers, students and anyone with an interest in this exciting and fast-moving area. Contents: • Principles of gene therapy • Gene therapy techniques • Ethical and safety considerations • Gene therapies with proven clinical efficacy • Genome editing • Research directions – the next wave of treatments

Gene Therapy

Gene Therapy
Author: David Cooper,Prof Nick Lemoine
Publsiher: Garland Science
Total Pages: 360
Release: 2020-09-11
ISBN 10: 1000144682
ISBN 13: 9781000144680
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

Gene Therapy describes the delivery systems now available to target a given tissue with specific gene or oligonucleotide sequences, and explores the utility of animal modules as test systems. In the context of selected disease states, it summarises in vitro and in vivo studies and clinical trials performed to date.

Gene Therapy

Gene Therapy
Author: Surendra Nimesh
Publsiher: Woodhead Pub Limited
Total Pages: 380
Release: 2013
ISBN 10: 9781907568404
ISBN 13: 1907568409
Language: EN, FR, DE, ES & NL

Gene Therapy Book Review:

Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy. Provides an overview of nanotechnology applications in gene therapy, from preparation of nanoparticles to in vitro and in vivo studies Details the tools and techniques available for preparation, characterization and in vitro and in vivo study of nanoparticles Details the limitations of nanoparticle-mediated gene therapy and proposes ways in which they may be overcome

Gene Therapy in Neurological Disorders

Gene Therapy in Neurological Disorders
Author: Mingjie Li,B. Joy Snider
Publsiher: Academic Press
Total Pages: 450
Release: 2018-05-25
ISBN 10: 012809821X
ISBN 13: 9780128098219
Language: EN, FR, DE, ES & NL

Gene Therapy in Neurological Disorders Book Review:

Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system. Provides background information and experimental details of gene therapy tools applied for neuroscience research and neurological disorders Covers a broad range of gene delivery and regulation tools, therapeutic agents, and target cells, including emerging new technologies such as CRISPR/Cas9 genome editing Discusses applications of gene therapy tools to neurological disorders including neurodegeneration, muscular dystrophy, trauma and chronic pain, and neoplastic diseases

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
Author: David T. Curiel
Publsiher: Academic Press
Total Pages: 868
Release: 2016-03-10
ISBN 10: 0128005106
ISBN 13: 9780128005101
Language: EN, FR, DE, ES & NL

Adenoviral Vectors for Gene Therapy Book Review:

Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Human Gene Therapy

Human Gene Therapy
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1987
ISBN 10:
ISBN 13: UOM:39015045603795
Language: EN, FR, DE, ES & NL

Human Gene Therapy Book Review:

Human Gene Therapy

Human Gene Therapy
Author: Eve K. Nichols
Publsiher: Harvard University Press
Total Pages: 251
Release: 1988
ISBN 10: 9780674414808
ISBN 13: 0674414802
Language: EN, FR, DE, ES & NL

Human Gene Therapy Book Review:

Introduces the concept of gene therapy as a new medical treatment, explains how genetic diseases are now diagnosed and treated, and discusses the issues surrounding human genetic manipulation

Gene Therapy for Human Patients

Gene Therapy for Human Patients
Author: Anonim
Publsiher: Unknown
Total Pages: 13
Release: 1990
ISBN 10:
ISBN 13: UCR:31210023584277
Language: EN, FR, DE, ES & NL

Gene Therapy for Human Patients Book Review:

Gene Therapy of Cancer

Gene Therapy of Cancer
Author: Wolfgang Walther,Ulrike Stein
Publsiher: Springer Science & Business Media
Total Pages: 645
Release: 2000
ISBN 10: 1592590861
ISBN 13: 9781592590865
Language: EN, FR, DE, ES & NL

Gene Therapy of Cancer Book Review:

In Gene Therapy of Cancer: Methods and Protocols, Wolfgang Walther and Ulrike Stein survey the rapidly evolving field cancer gene therapy and provide a broad array of leading-edge protocols for the delivery of therapeutic genes into tumors. Described in step-by-step fashion and enriched with each author's own practical tips, these readily reproducible methods are currently being widely applied in cancer gene therapy investigations, including immunotherapy and tumor vaccination, suicide gene therapy, antioncogene therapy, and antisense and ribozyme gene therapy. Representative strategies are provided for gene targeting and for viral or nonviral gene delivery in cancer therapy, as well as a significant number of clinical protocols for the development of novel cancer gene therapies. Gene Therapy of Cancer: Methods and Protocols offers basic and clinical researchers a broad ranging overview and collection of the most recent advances in gene transfer techniques. Written by leading international authorities, its readily reproducible, cutting-edge methods constitute today's most valuable tools for the study of cancer gene therapy in both the laboratory and clinical trials.

Adeno associated Viral Vectors for Gene Therapy

Adeno associated Viral Vectors for Gene Therapy
Author: Kenneth I. Berns,Terence Robin Flotte
Publsiher: Unknown
Total Pages: 283
Release: 2005
ISBN 10:
ISBN 13: OCLC:1131955937
Language: EN, FR, DE, ES & NL

Adeno associated Viral Vectors for Gene Therapy Book Review:

Understanding Gene Therapy

Understanding Gene Therapy
Author: Nicholas R. Lemoine
Publsiher: Bios Scientific Pub Limited
Total Pages: 172
Release: 1999-01-01
ISBN 10: 9780387915128
ISBN 13: 0387915125
Language: EN, FR, DE, ES & NL

Understanding Gene Therapy Book Review:

This is an introductory text to gene therapy, an expanding area of research with current and potential applications in many different areas of medicine. The book explains what gene therapy is, how genes are delivered and how they are targeted.

Polymers and Nanomaterials for Gene Therapy

Polymers and Nanomaterials for Gene Therapy
Author: Ravin Narain
Publsiher: Woodhead Publishing
Total Pages: 302
Release: 2016-01-09
ISBN 10: 0081005210
ISBN 13: 9780081005217
Language: EN, FR, DE, ES & NL

Polymers and Nanomaterials for Gene Therapy Book Review:

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

Gene Therapy Prospective Technology assessment in its societal context

Gene Therapy  Prospective Technology assessment in its societal context
Author: Jörg Niewöhner,Christof Tannert
Publsiher: Elsevier
Total Pages: 274
Release: 2011-08-19
ISBN 10: 9780080470931
ISBN 13: 0080470939
Language: EN, FR, DE, ES & NL

Gene Therapy Prospective Technology assessment in its societal context Book Review:

This book presents work that has been conducted as part of the research project "Discourse on ethical questions of biomedicine" of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany. This book offers ground-breaking ideas on how the daily interworking of cutting-edge biomedical research assess the broader social context and its communication to stakeholders and the public. Editors cover three aspects: Scientific, Ethical and Legal, and Perception and Communication. This work establishes an international and interdisciplinary network of excellent researchers at the beginning of their careers, who brilliantly integrate their work into the different perspectives on gene therapy from the natural and social sciences, as well as the humanities and law. * Discusses biological and cellular barriers limiting the clinical application of nonviral gene delivery systems * Addresses such questions as: Does patent granting hinder the development of Gene Therapy products? * Offers insight in the future of public perception of gene therapy in Europe * Provides details on how to communicate risks in gene therapy