Gene Environment Interactions

Gene Environment Interactions
Author: Moyra Smith
Publsiher: Academic Press
Total Pages: 438
Release: 2020-01-24
ISBN 10: 0128196130
ISBN 13: 9780128196137
Language: EN, FR, DE, ES & NL

Gene Environment Interactions Book Review:

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine

Gene Environment Interactions in Psychiatry

Gene Environment Interactions in Psychiatry
Author: Bart Ellenbroek,Ji Un Youn
Publsiher: Academic Press
Total Pages: 366
Release: 2016-07-26
ISBN 10: 012801783X
ISBN 13: 9780128017838
Language: EN, FR, DE, ES & NL

Gene Environment Interactions in Psychiatry Book Review:

Gene-Environment Interactions in Psychiatry: Nature, Nurture, Neuroscience begins with the basic aspects of gene–environment studies, such as basic genetics, principles of animals modeling, and the basic processes of how environmental factors affect brain and behavior, with part two describing the most important psychiatric disorders in detail. Each chapter has a similar structure that includes a general description of the disorder that is followed by an analysis of the role of genes and how they are affected by environmental factors. Each chapter ends with a description of the most relevant animal models, again focusing on gene–environment interactions. The book concludes with a critical evaluation of the current research and an outlook for the (possible) future, offering a vignette into the fascinating world of nature, nurture, and neuroscience. Written to provide in-depth basic knowledge on gene–environment interactions for graduate students, postgraduate students, clinicians, and scientists Includes descriptions of the major psychiatric disorders Provides detailed descriptions of animal models and basic genetic information Presents well-illustrated color figures to explain complex features in a simple manner

Gene Environment Interaction Analysis

Gene Environment Interaction Analysis
Author: Sumiko Anno
Publsiher: CRC Press
Total Pages: 212
Release: 2016-03-30
ISBN 10: 9814669644
ISBN 13: 9789814669641
Language: EN, FR, DE, ES & NL

Gene Environment Interaction Analysis Book Review:

Gene–environment (G × E) interaction analysis is a statistical method for clarifying G × E interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of G × E interaction analysis. It compiles and details cutting-edge research in bioinformatics and computational biology and will appeal to anyone involved in bioinformatics and computational biology.

Gene Environment Interactions

Gene Environment Interactions
Author: Lucio G. Costa,David L. Eaton
Publsiher: John Wiley & Sons
Total Pages: 576
Release: 2005-12-16
ISBN 10: 0471758035
ISBN 13: 9780471758037
Language: EN, FR, DE, ES & NL

Gene Environment Interactions Book Review:

Understanding the play between heredity and environment, andrelating it to disease causation, is the task of ecogenetics.Gene-Environment Interactions: Fundamentals of Ecogenetics presentsthe first comprehensive survey of this discipline, reflecting itsrelationship with toxicology, epidemiology, pharmacology, publichealth, and other medical and biological fields. Divided into four sections, the text elucidates key basic andadvanced topics: * Section 1 covers fundamentals, including the history of thediscipline, a discussion of the molecular laboratory toolscurrently available to assess genotypes, using such measurements inmolecular epidemiology studies, and the statistical issues involvedin their analysis. * Section 2 focuses on a number of key genetic polymorphismsrelevant for ecogenetics, including enzymes of phase I and phase IImetabolism, enzymes involved in DNA repair, as well as receptorsand ion channels. This highlights characteristics of selected,widely studied genotypic/phenotypic differences, and allowsdiscussion of how given genetic variations can influence responsesto exogenous chemicals. * Section 3 examines gene-environment interactions through adisease-based approach, addressing how genetic polymorphisms caninfluence susceptibility to various diseases. Chapters coverimportant disease conditions such as various types of cancer,neurodegenerative diseases, cardiovascular disease, chronicpulmonary diseases, infectious diseases, diabetes, andobesity. * The final section discusses the ethical, legal, and social issuesthat arise when investigating and evaluating genetic polymorphismsin human populations, as well as the impact of ecogenetics on riskassessment, regulatory policies, and medicine and publichealth. Packed with clear examples illustrating concepts, as well asnumerous tables and figures, Gene-Environment Interactions:Fundamentals of Ecogenetics is a unique resource for a wide rangeof physicians, students, and other specialists.

Schizophrenia A Consequence of Gene Environment Interactions

Schizophrenia  A Consequence of Gene Environment Interactions
Author: Tim Karl, Jonathon C. Arnold
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2015-06-06
ISBN 10: 2889195317
ISBN 13: 9782889195312
Language: EN, FR, DE, ES & NL

Schizophrenia A Consequence of Gene Environment Interactions Book Review:

Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the development of the disorder. This work is starting to produce valuable new animal models and reveal novel insights into the pathophysiology of schizophrenia. Eventually, it might help advance studies of the molecular pathways involved in this mental disorder and propose more specific molecular medicine. However, the complexity of this multi-factorial line of research has also caused difficulties in data interpretation and comparison. Our research topic is intended to cover past and current directions in research dedicated to the understanding and measurement of gene-environment interactions (GxE) in schizophrenia, the neurobiological and behavioural consequences of such interactions as well as the challenges and limitations one encounters when working on complex aetiological systems.

Gene Environment Interactions

Gene Environment Interactions
Author: Moyra Smith
Publsiher: Academic Press
Total Pages: 438
Release: 2020-01-14
ISBN 10: 0128197978
ISBN 13: 9780128197974
Language: EN, FR, DE, ES & NL

Gene Environment Interactions Book Review:

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome’s intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine

Gene Environment Transactions in Developmental Psychopathology

Gene Environment Transactions in Developmental Psychopathology
Author: Patrick H. Tolan,Bennett L. Leventhal
Publsiher: Springer
Total Pages: 301
Release: 2017-04-29
ISBN 10: 3319492276
ISBN 13: 9783319492278
Language: EN, FR, DE, ES & NL

Gene Environment Transactions in Developmental Psychopathology Book Review:

This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.

Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes

Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes
Author: Michael Windle
Publsiher: MIT Press
Total Pages: 304
Release: 2016-07-08
ISBN 10: 0262034689
ISBN 13: 9780262034685
Language: EN, FR, DE, ES & NL

Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes Book Review:

Diverse methodological and statistical approaches for investigating the role of gene-environment interactions in a range of complex diseases and traits.

Beyond Our Genes

Beyond Our Genes
Author: Raffaele Teperino
Publsiher: Springer Nature
Total Pages: 266
Release: 2020-01-24
ISBN 10: 3030352137
ISBN 13: 9783030352134
Language: EN, FR, DE, ES & NL

Beyond Our Genes Book Review:

The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.

Genotype by Environment Interaction

Genotype by Environment Interaction
Author: Manjit S. Kang,Hugh G. Gauch
Publsiher: CRC-Press
Total Pages: 416
Release: 1996-02-06
ISBN 10: 9780849340031
ISBN 13: 0849340039
Language: EN, FR, DE, ES & NL

Genotype by Environment Interaction Book Review:

Genotype-by-Environment Interaction (GEI) is a prevalent issue among crop farmers, plant breeders, geneticists, and production agronomists. This book brings together contributions from expert plant breeders and quantitative geneticists to better understand the relationship between crop performance and environment. This information can reduce the cost of extensive genotype evaluation by eliminating unnecessary testing sites and by fine-tuning breeding programs. Molecular aspects of GEI are discussed for the first time and key bibliographical references on GEI are included in an appendix.

Fundamentals of Genetic Epidemiology

Fundamentals of Genetic Epidemiology
Author: Muin J. Khoury,Director Office of Genetics and Disease Prevention Muin J Khoury, M.D.,Terri H. Beaty,Terri H.. Beaty,Bernice H. Cohen,Professor of Epidemiology Bernice H Cohen
Publsiher: Monographs in Epidemiology and
Total Pages: 383
Release: 1993
ISBN 10: 0195052889
ISBN 13: 9780195052886
Language: EN, FR, DE, ES & NL

Fundamentals of Genetic Epidemiology Book Review:

With continued progress in mapping and sequencing of the human genome, and increasing recognition of the role of genes in disease etiology, there is a need for a more sophisticated approach to the investigation of the causes of complex chronic diseases. This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease etiology. After a brief historical overview of genetics and epidemiology and their gradual rapprochement, the authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations. They describe fundamental research strategies of genetic epidemiology including population and family studies. Among the former are the study of the distribution of genetic traits and the role of nonspecific genetic indicators (such as inbreeding and admixture) in the occurrence of diseases. Among the latter are the analysis of familial aggregation of disease and its causes by epidemiologic methods as well as techniques of formal genetic analysis (variance components, segregation and linkage analysis). Finally, the authors discuss the increasing applications of genetic epidemiology in preventive medicine, public health surveillance, and the emerging ethical issues regarding use of genetic information in society.

Handbook of Statistical Methods for Case Control Studies

Handbook of Statistical Methods for Case Control Studies
Author: Ørnulf Borgan,Norman Breslow,Nilanjan Chatterjee,Mitchell H. Gail,Alastair Scott,Chris J. Wild
Publsiher: CRC Press
Total Pages: 536
Release: 2018-06-27
ISBN 10: 1351650122
ISBN 13: 9781351650120
Language: EN, FR, DE, ES & NL

Handbook of Statistical Methods for Case Control Studies Book Review:

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses. Book Sections Classical designs and causal inference, measurement error, power, and small-sample inference Designs that use full-cohort information Time-to-event data Genetic epidemiology About the Editors Ørnulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic. Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology. Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies. Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology. Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data. Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.

Cancer and the Environment

Cancer and the Environment
Author: Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine
Publsiher: National Academies Press
Total Pages: 160
Release: 2002-09-01
ISBN 10: 030908475X
ISBN 13: 9780309084758
Language: EN, FR, DE, ES & NL

Cancer and the Environment Book Review:

The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

A Comparison of Approaches to the Investigation of Gene environment Interactions when Using Out of Study Controls

A Comparison of Approaches to the Investigation of Gene environment Interactions when Using Out of Study Controls
Author: Elisabeth Miya Orth
Publsiher: Unknown
Total Pages: 78
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:955343627
Language: EN, FR, DE, ES & NL

A Comparison of Approaches to the Investigation of Gene environment Interactions when Using Out of Study Controls Book Review:

Most diseases are not based solely on genetic factors, but are instead a mix of genetic and environmental factors. Genetic association studies have become a standard approach to identifying genetic risk factors for disease and examining how those genetic risk factors interact with environmental factors to influence risk of disease. In some genetic association studies, the cases are collected with detailed clinical and demographic information, but due to costs of genotyping, the controls are drawn from an existing data base. There are multiple ways to potentially test for a gene-environment interaction when not much is known about the controls, including case-only analysis, stratified analysis, case-parental control study, and affected relative pair study. This thesis examined the best alternative analysis approach, in terms of power, for gene-environment interactions in a case-control study when there are many more controls than cases, and when there is no information on the environmental factors among controls. For a case-control study with unrelated cases and controls, three alternative potential solutions to the problem of having no environmental information on the controls were compared: the case-only to two modified stratified analyses. Simulation studies were carried out in addition to a real data analysis. The case-only analysis was the most powerful approach for testing for a gene-environment interaction when the information on the environment is missing for the controls, however the power for the stratified analyses was not greatly reduced compared to the case-only approach for most of the simulation conditions we considered. For a genome-wide analysis, one recommended approach based on this work is to use both the case-only and stratified approaches with cautious interpretation of strong interaction results that exist only for the case-only approach.

No Two Alike Human Nature and Human Individuality

No Two Alike  Human Nature and Human Individuality
Author: Judith Rich Harris
Publsiher: W. W. Norton & Company
Total Pages: 352
Release: 2010-02-15
ISBN 10: 0393079511
ISBN 13: 9780393079517
Language: EN, FR, DE, ES & NL

No Two Alike Human Nature and Human Individuality Book Review:

A groundbreaking theory of personality. The author of the controversial book The Nurture Assumption tackles the biggest mystery in all of psychology: What makes people differ so much in personality and behavior? It can't just be "nature and nurture," because even identical twins who grow up together—same genes, same parents—have different personalities. And if psychologists can't explain why identical twins are different, they also can't explain why each of us differs from everyone else. Why no two people are alike. Harris turns out to be well suited for the role of detective—it isn't easy to pull the wool over her eyes. She rounds up the usual suspects and shows why none of the currently popular explanations for human differences—birth order effects, for example, or interactions between genes and environment—can be the perpetrator she is looking for. None of these theories can solve the mystery of human individuality. The search for clues carries Harris into some fascinating byways of science. The evidence she examines ranges from classic experiments in social psychology to cutting-edge research in neuroscience. She looks at studies of twins, research on autistic children, observations of chimpanzees, birds, and even ants. Her solution is a startlingly original one: the first completely new theory of personality since Freud's. Based on a principle of evolutionary psychology—the idea that the human mind is a toolbox of special-purpose devices—Harris's theory explains how attributes we all have in common can make us different. This is the story of a scientific quest, but it is also the personal story of a courageous and innovative woman who refused to be satisfied with "what everyone knows is true."

Environmental Epigenetics

Environmental Epigenetics
Author: L. Joseph Su,Tung-chin Chiang
Publsiher: Springer
Total Pages: 321
Release: 2015-05-18
ISBN 10: 1447166787
ISBN 13: 9781447166788
Language: EN, FR, DE, ES & NL

Environmental Epigenetics Book Review:

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Genes Behavior and the Social Environment

Genes  Behavior  and the Social Environment
Author: Institute of Medicine,Board on Health Sciences Policy,Committee on Assessing Interactions Among Social, Behavioral, and Genetic Factors in Health
Publsiher: National Academies Press
Total Pages: 384
Release: 2006-12-07
ISBN 10: 0309101964
ISBN 13: 9780309101967
Language: EN, FR, DE, ES & NL

Genes Behavior and the Social Environment Book Review:

Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.

Gene environment Interactions Indisruptive Behaviors

Gene environment Interactions Indisruptive Behaviors
Author: Anonim
Publsiher: Unknown
Total Pages: 200
Release: 2020
ISBN 10: 9789403427690
ISBN 13: 9403427698
Language: EN, FR, DE, ES & NL

Gene environment Interactions Indisruptive Behaviors Book Review:

The Wiley Encyclopedia of Personality and Individual Differences Personality Processes and Individuals Differences

The Wiley Encyclopedia of Personality and Individual Differences  Personality Processes and Individuals Differences
Author: Annamaria Di Fabio,Donald H. Saklofske,Con Stough
Publsiher: John Wiley & Sons
Total Pages: 592
Release: 2020-11-03
ISBN 10: 1119793939
ISBN 13: 9781119793939
Language: EN, FR, DE, ES & NL

The Wiley Encyclopedia of Personality and Individual Differences Personality Processes and Individuals Differences Book Review:

Volume 3, Personality Processes and Individuals Differences of The Wiley Encyclopedia of Personality and Individual Differences The Encyclopedia of Personality and Individual Differences (EPID) is organized into four volumes that look at the many likenesses and differences between individuals. Each of these four volumes focuses on a major content area in the study of personality psychology and individuals' differences. The first volume, Models and Theories, surveys the significant classic and contemporary viewpoints, perspectives, models, and theoretical approaches to the study of personality and individuals' differences (PID). The second volume on Measurement and Assessment examines key classic and modern methods and techniques of assessment in the study of PID. Volume III, titled Personality Processes and Individuals Differences, covers the important traditional and current dimensions, constructs, and traits in the study of PID. The final volume discusses three major categories: clinical contributions, applied research, and cross-cultural considerations, and touches on topics such as culture and identity, multicultural identities, cross-cultural examinations of trait structures and personality processes, and more. Each volume contains approximately 100 entries on personality and individual differences written by a diverse international panel of leading psychologists Covers significant classic and contemporary personality psychology models and theories, measurement and assessment techniques, personality processes and individuals differences, and research Provides a comprehensive and in-depth overview of the field of personality psychology The Encyclopedia of Personality and Individual Differences is an important resource for all psychology students and professionals engaging in the study and research of personality.

Bipolar Disorder Vulnerability

Bipolar Disorder Vulnerability
Author: Jair Soares,Consuelo Walss-Bass,Paolo Brambilla
Publsiher: Academic Press
Total Pages: 288
Release: 2018-06-09
ISBN 10: 0128125608
ISBN 13: 9780128125601
Language: EN, FR, DE, ES & NL

Bipolar Disorder Vulnerability Book Review:

Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness. Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomics Examines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorder Explores the interaction between genomic and environmental influences that shape behavior