From Molecules to Networks

From Molecules to Networks
Author: John H. Byrne,James Lewis Roberts
Publsiher: Academic Press
Total Pages: 583
Release: 2004
ISBN 10: 9780121486600
ISBN 13: 0121486605
Language: EN, FR, DE, ES & NL

From Molecules to Networks Book Review:

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference. * Highly referenced for readers to pursue topics of interest in greater detail * Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks * Richly illustrated, four color presentation throughout * Includes CD-ROM of all of the illustrations

From Molecules to Networks

From Molecules to Networks
Author: Ruth Heidelberger,M. Neal Waxham,John H. Byrne,James L. Roberts
Publsiher: Academic Press
Total Pages: 656
Release: 2009-01-27
ISBN 10: 9780080920832
ISBN 13: 0080920837
Language: EN, FR, DE, ES & NL

From Molecules to Networks Book Review:

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. • Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook • Discusses emerging new understanding of non-classical molecules that affect neuronal signaling • Full colour, professional graphics throughout • Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease.

From Molecules to Networks

From Molecules to Networks
Author: Ruth Heidelberger,M. Neal Waxham,John H. Byrne,James L. Roberts
Publsiher: Elsevier
Total Pages: 583
Release: 2003-11-10
ISBN 10: 9780080491356
ISBN 13: 0080491359
Language: EN, FR, DE, ES & NL

From Molecules to Networks Book Review:

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference. * Highly referenced for readers to pursue topics of interest in greater detail * Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks * Richly illustrated, four color presentation throughout * Includes CD-ROM of all of the illustrations

From Molecules to Networks

From Molecules to Networks
Author: John H. Byrne,Ruth Heidelberger,M. Neal Waxham
Publsiher: Academic Press
Total Pages: 694
Release: 2014-05-23
ISBN 10: 0123982677
ISBN 13: 9780123982674
Language: EN, FR, DE, ES & NL

From Molecules to Networks Book Review:

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches 80% updated and new content New Chapter on "Biophysics of Voltage-Gated Ion Channels" New Chapter on "Synaptic Plasticity" Includes a chapter on the Neurobiology of Disease Highly referenced, comprehensive and quantitative Full color, professional graphics throughout All graphics are available in electronic version for teaching purposes

Cellular and Molecular Neurophysiology

Cellular and Molecular Neurophysiology
Author: Constance Hammond
Publsiher: Academic Press
Total Pages: 444
Release: 2014-12-30
ISBN 10: 0123973228
ISBN 13: 9780123973221
Language: EN, FR, DE, ES & NL

Cellular and Molecular Neurophysiology Book Review:

Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations Fifteen appendices describing neurobiological techniques are interspersed in the text

Fundamentals Of Network Biology

Fundamentals Of Network Biology
Author: Zhang Wenjun
Publsiher: World Scientific
Total Pages: 568
Release: 2018-05-16
ISBN 10: 1786345102
ISBN 13: 9781786345103
Language: EN, FR, DE, ES & NL

Fundamentals Of Network Biology Book Review:

As the first comprehensive title on network biology, this book covers a wide range of subjects including scientific fundamentals (graphs, networks, etc) of network biology, construction and analysis of biological networks, methods for identifying crucial nodes in biological networks, link prediction, flow analysis, network dynamics, evolution, simulation and control, ecological networks, social networks, molecular and cellular networks, network pharmacology and network toxicology, big data analytics, and more. Across 12 parts and 26 chapters, with Matlab codes provided for most models and algorithms, this self-contained title provides an in-depth and complete insight on network biology. It is a valuable read for high-level undergraduates and postgraduates in the areas of biology, ecology, environmental sciences, medical science, computational science, applied mathematics, and social science. Contents: Mathematical Fundamentals: Fundamentals of Graph TheoryGraph AlgorithmsFundamentals of Network TheoryOther FundamentalsCrucial Nodes/Subnetworks/Modules, Network Types, and Structural Comparison: Identification of Crucial Nodes and Subnetworks/ModulesDetection of Network TypesComparison of Network StructureNetwork Dynamics, Evolution, Simulation and Control: Network DynamicsNetwork Robustness and Sensitivity AnalysisNetwork ControlNetwork EvolutionCellular AutomataSelf-OrganizationAgent-based ModelingFlow Analysis: Flow/Flux AnalysisLink and Node Prediction: Link Prediction: Sampling-based MethodsLink Prediction: Structure- and Perturbation-based MethodsLink Prediction: Node-Similarity-based MethodsNode PredictionNetwork Construction: Construction of Biological NetworksPharmacological and Toxicological Networks: Network Pharmacology and ToxicologyEcological Networks: Food WebsMicroscopic Networks: Molecular and Cellular NetworksSocial Networks: Social Network AnalysisSoftware: Software for Network AnalysisBig Data Analytics: Big Data Analytics for Network Biology Readership: Advanced undergraduates and graduate students and researchers in biology, ecology, pharmacology, applied mathematics, computational science, etc. Keywords: Network Biology;Network Analysis;Food Webs;Molecular Networks;Social Networks;Network Pharmacology;Link Prediction;Network Dynamics;Big Data Analytics;Software;Models;Algorithms;Nodes;LinksReview:0

Cellular and Molecular Neurobiology

Cellular and Molecular Neurobiology
Author: Constance Hammond
Publsiher: Elsevier
Total Pages: 493
Release: 2012-12-02
ISBN 10: 0080983928
ISBN 13: 9780080983929
Language: EN, FR, DE, ES & NL

Cellular and Molecular Neurobiology Book Review:

This Second Edition, is the new, thoroughly revised edition of the established and well-respected authoritative text in the field. Cellular and Molecular Neurobiology is hypothesis driven and firmly based on numerous experiments performed by experts in the field. Seven new chapters (five new and two totally rewritten) complement and expand on the first edition and are written in a way that encourages students to ask questions. Additionally, new, groundbreaking research data on dendritic processing is presented in a very easy-to-understand format. * A presentation that is hypothesis driven and firmly based on experiment * A concise but in depth explanation of molecular properties and functions of excitable cells * Over 400 two-colour illustrations * Appendices describing neurobiological techniques

Neuronal Networks in Brain Function CNS Disorders and Therapeutics

Neuronal Networks in Brain Function  CNS Disorders  and Therapeutics
Author: Carl Faingold,Hal Blumenfeld
Publsiher: Academic Press
Total Pages: 512
Release: 2013-12-26
ISBN 10: 0124158641
ISBN 13: 9780124158641
Language: EN, FR, DE, ES & NL

Neuronal Networks in Brain Function CNS Disorders and Therapeutics Book Review:

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Fundamentals of Brain Network Analysis

Fundamentals of Brain Network Analysis
Author: Alex Fornito,Andrew Zalesky,Edward Bullmore
Publsiher: Academic Press
Total Pages: 494
Release: 2016-03-04
ISBN 10: 0124081185
ISBN 13: 9780124081185
Language: EN, FR, DE, ES & NL

Fundamentals of Brain Network Analysis Book Review:

Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain

From Molecules to Minds

From Molecules to Minds
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 90
Release: 2008-11-07
ISBN 10: 9780309178457
ISBN 13: 0309178452
Language: EN, FR, DE, ES & NL

From Molecules to Minds Book Review:

Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?

Molecular Neurology

Molecular Neurology
Author: Stephen Waxman
Publsiher: Elsevier
Total Pages: 600
Release: 2010-07-26
ISBN 10: 9780080546186
ISBN 13: 0080546188
Language: EN, FR, DE, ES & NL

Molecular Neurology Book Review:

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments

The Making of Memory

The Making of Memory
Author: Steven Peter Russell Rose
Publsiher: Anchor
Total Pages: 355
Release: 1993
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015029964692
Language: EN, FR, DE, ES & NL

The Making of Memory Book Review:

Combining a richly detailed account of scientists at work with a highly readable explanation of cutting-edge neuroscience, this book offers fascinating new insights on the cellular mechanisms of memory and learning.

Computational Modeling of Genetic and Biochemical Networks

Computational Modeling of Genetic and Biochemical Networks
Author: James M. Bower,Hamid Bolouri
Publsiher: MIT Press
Total Pages: 336
Release: 2001
ISBN 10: 9780262524230
ISBN 13: 0262524236
Language: EN, FR, DE, ES & NL

Computational Modeling of Genetic and Biochemical Networks Book Review:

How new modeling techniques can be used to explore functionally relevant molecular and cellular relationships.

Discovering the Brain

Discovering the Brain
Author: National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publsiher: National Academies Press
Total Pages: 194
Release: 1992-01-01
ISBN 10: 0309045290
ISBN 13: 9780309045292
Language: EN, FR, DE, ES & NL

Discovering the Brain Book Review:

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brain--an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attention--and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniques--what various technologies can and cannot tell us--and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakers--and many scientists as well--with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

From Single Molecules to Networks

From Single Molecules to Networks
Author: Jun Lin
Publsiher: Unknown
Total Pages: 112
Release: 2012
ISBN 10: 9781267294630
ISBN 13: 1267294639
Language: EN, FR, DE, ES & NL

From Single Molecules to Networks Book Review:

To understand polymers, the fundamental building blocks of our lives, both social and biological, will not only fulfill the intellectual curiosity of scientists, but more importantly help us to have a better 'life'. So it is not surprising that to understand the physical properties of polymers and polymer networks has long been a major goal of most basic and applied science and engineering disciplines. However, it has been difficult to associate polymer theories directly to experimental data. While many polymer theories only describe the motion of individual polymer chains or small polymer networks, traditional polymer experiments measure the behavior of polymers that averaged over a huge number of molecules (109-1023). This thesis focuses on the development of techniques to visualize and to manipulate single DNA molecules and biopolymer networks. These techniques allow us to directly test single polymer dynamics measurements against polymer theories and to understand the structure-mechanics relationships in polymer networks.

Biological Network Analysis

Biological Network Analysis
Author: Pietro Hiram Guzzi,Swarup Roy
Publsiher: Elsevier
Total Pages: 210
Release: 2020-05-11
ISBN 10: 0128193514
ISBN 13: 9780128193518
Language: EN, FR, DE, ES & NL

Biological Network Analysis Book Review:

Biological Network Analysis: Trends, Approaches, Graph Theory, and Algorithms considers three major biological networks, including Gene Regulatory Networks (GRN), Protein-Protein Interaction Networks (PPIN), and Human Brain Connectomes. The book's authors discuss various graph theoretic and data analytics approaches used to analyze these networks with respect to available tools, technologies, standards, algorithms and databases for generating, representing and analyzing graphical data. As a wide variety of algorithms have been developed to analyze and compare networks, this book is a timely resource. Presents recent advances in biological network analysis, combining Graph Theory, Graph Analysis, and various network models Discusses three major biological networks, including Gene Regulatory Networks (GRN), Protein-Protein Interaction Networks (PPIN) and Human Brain Connectomes Includes a discussion of various graph theoretic and data analytics approaches

MATLAB for Neuroscientists

MATLAB for Neuroscientists
Author: Pascal Wallisch,Michael E. Lusignan,Marc D. Benayoun,Tanya I. Baker,Adam Seth Dickey,Nicholas G. Hatsopoulos
Publsiher: Academic Press
Total Pages: 570
Release: 2014-01-09
ISBN 10: 0123838371
ISBN 13: 9780123838377
Language: EN, FR, DE, ES & NL

MATLAB for Neuroscientists Book Review:

MATLAB for Neuroscientists serves as the only complete study manual and teaching resource for MATLAB, the globally accepted standard for scientific computing, in the neurosciences and psychology. This unique introduction can be used to learn the entire empirical and experimental process (including stimulus generation, experimental control, data collection, data analysis, modeling, and more), and the 2nd Edition continues to ensure that a wide variety of computational problems can be addressed in a single programming environment. This updated edition features additional material on the creation of visual stimuli, advanced psychophysics, analysis of LFP data, choice probabilities, synchrony, and advanced spectral analysis. Users at a variety of levels—advanced undergraduates, beginning graduate students, and researchers looking to modernize their skills—will learn to design and implement their own analytical tools, and gain the fluency required to meet the computational needs of neuroscience practitioners. The first complete volume on MATLAB focusing on neuroscience and psychology applications Problem-based approach with many examples from neuroscience and cognitive psychology using real data Illustrated in full color throughout Careful tutorial approach, by authors who are award-winning educators with strong teaching experience

Fundamental Neuroscience

Fundamental Neuroscience
Author: Larry Squire,Darwin Berg,Floyd E. Bloom,Sascha du Lac,Anirvan Ghosh,Larry R. Squire,Nicholas C. Spitzer,Susan K. McConnell,James L. Roberts,Michael J. Zigmond
Publsiher: Elsevier
Total Pages: 1426
Release: 2002-11-19
ISBN 10: 0080521800
ISBN 13: 9780080521800
Language: EN, FR, DE, ES & NL

Fundamental Neuroscience Book Review:

With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates. The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities. Key Features * Logically organized into 7 sections, with uniform editing of the content for a "one-voice" feel throughout all 54 chapters * Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts * Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM

Models of the Ecological Hierarchy

Models of the Ecological Hierarchy
Author: Ferenc Jordán,Sven Erik Jorgensen
Publsiher: Newnes
Total Pages: 562
Release: 2012
ISBN 10: 0444593969
ISBN 13: 9780444593962
Language: EN, FR, DE, ES & NL

Models of the Ecological Hierarchy Book Review:

"Based on selected papers covering the presentations at the 7th European Conference on Ecological Modelling, organized by ISEM and hosted by The Microsoft Research--University of Trento Center for Computational and Systems Biology from 30 May to 2 June, 2011 in Riva del Garde, Italy"--P. xi.

Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery
Author: Juan Bueno
Publsiher: Academic Press
Total Pages: 192
Release: 2020-01-22
ISBN 10: 0128189290
ISBN 13: 9780128189290
Language: EN, FR, DE, ES & NL

Molecular Evolutionary Models in Drug Discovery Book Review:

Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies