Fed Batch Fermentation

Fed Batch Fermentation
Author: G G Moulton
Publsiher: Elsevier
Total Pages: 188
Release: 2014-10-16
ISBN 10: 1908818336
ISBN 13: 9781908818331
Language: EN, FR, DE, ES & NL

Fed Batch Fermentation Book Review:

Fed-batch Fermentation is primarily a practical guide for recombinant protein production in E. coli using a Fed-batch Fermentation process. Ideal users of this guide are teaching labs and R&D labs that need a quick and reproducible process for recombinant protein production. It may also be used as a template for the production of recombinant protein product for use in clinical trials. The guide highlights a method whereby a medium cell density - final Ods = 30-40 (A600) - Fed-batch Fermentation process can be accomplished within a single day with minimal supervision. This process can also be done on a small (2L) scale that is scalable to 30L or more. All reagents (media, carbon source, plasmid vector and host cell) used are widely available and are relatively inexpensive. This method has been used to produce three different protein products following cGMP guidelines for Phase I clinical studies. This process can be used as a teaching tool for the inexperienced fermentation student or researcher in the fields of bioprocessing and bioreactors. It is an important segue from E. coli shake flask cultures to bioreactor The fed-batch fermentation is designed to be accomplished in a single day with the preparation work being done on the day prior The fed-batch fermentation described in this book is a robust process and can be easily scaled for CMO production of protein product

Fed Batch Cultures

Fed Batch Cultures
Author: Henry C. Lim,Hwa Sung Shin
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2013-04-22
ISBN 10: 1107328128
ISBN 13: 9781107328129
Language: EN, FR, DE, ES & NL

Fed Batch Cultures Book Review:

Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.

Cell Culture Engineering

Cell Culture Engineering
Author: Gyun Min Lee,Helene Faustrup Kildegaard
Publsiher: John Wiley & Sons
Total Pages: 440
Release: 2020-01-13
ISBN 10: 3527343342
ISBN 13: 9783527343348
Language: EN, FR, DE, ES & NL

Cell Culture Engineering Book Review:

Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to present expert coverage of topics such as: cell line development for therapeutic protein production; development of a transient gene expression upstream platform; and CHO synthetic biology. They provide readers with everything they need to know about enhancing product and bioprocess attributes using genome-scale models of CHO metabolism; omics data and mammalian systems biotechnology; perfusion culture; and much more. This all-new, up-to-date reference covers all of the important aspects of cell culture engineering, including cell engineering, system biology approaches, and processing technology. It describes the challenges in cell line development and cell engineering, e.g. via gene editing tools like CRISPR/Cas9 and with the aim to engineer glycosylation patterns. Furthermore, it gives an overview about synthetic biology approaches applied to cell culture engineering and elaborates the use of CHO cells as common cell line for protein production. In addition, the book discusses the most important aspects of production processes, including cell culture media, batch, fed-batch, and perfusion processes as well as process analytical technology, quality by design, and scale down models. -Covers key elements of cell culture engineering applied to the production of recombinant proteins for therapeutic use -Focuses on mammalian and animal cells to help highlight synthetic and systems biology approaches to cell culture engineering, exemplified by the widely used CHO cell line -Part of the renowned "Advanced Biotechnology" book series Cell Culture Engineering: Recombinant Protein Production will appeal to biotechnologists, bioengineers, life scientists, chemical engineers, and PhD students in the life sciences.

Batch Fermentation

Batch Fermentation
Author: Ali Cinar,Satish J. Parulekar,Cenk Undey,Gulnur Birol
Publsiher: CRC Press
Total Pages: 648
Release: 2003-04-01
ISBN 10: 9780203911358
ISBN 13: 0203911350
Language: EN, FR, DE, ES & NL

Batch Fermentation Book Review:

Illustrating techniques in model development, signal processing, data reconciliation, process monitoring, quality assurance, intelligent real-time process supervision, and fault detection and diagnosis, Batch Fermentation offers valuable simulation and control strategies for batch fermentation applications in the food, pharmaceutical, and chemical industries. The book provides approaches for determining optimal reference trajectories and operating conditions; estimating final product quality; modifying, adjusting, and enhancing batch process operations; and designing integrated real-time intelligent knowledge-based systems for process monitoring and fault diagnosis.

Fed Batch Fermentation A Practical Guide to Scalable Recombinant Protein Production in Escherichia Coli

Fed Batch Fermentation  A Practical Guide to Scalable Recombinant Protein Production in Escherichia Coli
Author: G. G. Moulton
Publsiher: Woodhead Publishing
Total Pages: 270
Release: 2017-11-13
ISBN 10: 9780081013670
ISBN 13: 0081013671
Language: EN, FR, DE, ES & NL

Fed Batch Fermentation A Practical Guide to Scalable Recombinant Protein Production in Escherichia Coli Book Review:

Fed-batch Fermentation is primarily a practical guide for recombinant protein production in E. coli using a Fed-batch Fermentation process. Ideal users of this guide are teaching labs and R&D labs that need a quick and reproducible process for recombinant protein production. It may also be used as a template for the production of recombinant protein product for use in clinical trials. The guide highlights a method whereby a medium cell density - final Ods = 30-40 (A600) - Fed-batch Fermentation process can be accomplished within a single day with minimal supervision. This process can also be done on a small (2L) scale that is scalable to 30L or more. All reagents (media, carbon source, plasmid vector and host cell) used are widely available and are relatively inexpensive. This method has been used to produce three different protein products following cGMP guidelines for Phase I clinical studies. This process can be used as a teaching tool for the inexperienced fermentation student or researcher in the fields of bioprocessing and bioreactors. It is an important segue from E. coli shake flask cultures to bioreactorThe fed-batch fermentation is designed to be accomplished in a single day with the preparation work being done on the day priorThe fed-batch fermentation described in this book is a robust process and can be easily scaled for CMO production of protein product

Modelling of a Fed batch Fermentation Process

Modelling of a Fed batch Fermentation Process
Author: Ulla Saarela,Kauko Leiviskä,Esko Juuso
Publsiher: Unknown
Total Pages: 23
Release: 2003
ISBN 10: 9789514270833
ISBN 13: 9514270835
Language: EN, FR, DE, ES & NL

Modelling of a Fed batch Fermentation Process Book Review:

Batch to batch Iterative Learning Control of a Fed batch Fermentation Process

Batch to batch Iterative Learning Control of a Fed batch Fermentation Process
Author: Jegalakshimi Jewaratnam,University of Newcastle upon Tyne. School of Chemical Engineering and Advanced Materials
Publsiher: Unknown
Total Pages: 164
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:842218296
Language: EN, FR, DE, ES & NL

Batch to batch Iterative Learning Control of a Fed batch Fermentation Process Book Review:

Comprehensive Biotechnology

Comprehensive Biotechnology
Author: Anonim
Publsiher: Newnes
Total Pages: 5320
Release: 2011-08-26
ISBN 10: 0080885047
ISBN 13: 9780080885049
Language: EN, FR, DE, ES & NL

Comprehensive Biotechnology Book Review:

The second edition of Comprehensive Biotechnology continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence. All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas. Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field

Fed batch Fermentation Control Survey

Fed batch Fermentation Control Survey
Author: Steve Bistline
Publsiher: Unknown
Total Pages: 98
Release: 2016
ISBN 10: 1928374650XXX
ISBN 13: OCLC:980922461
Language: EN, FR, DE, ES & NL

Fed batch Fermentation Control Survey Book Review:

Bioprocess Engineering Principles

Bioprocess Engineering Principles
Author: Pauline M. Doran
Publsiher: Elsevier
Total Pages: 439
Release: 1995-04-03
ISBN 10: 9780080528120
ISBN 13: 0080528120
Language: EN, FR, DE, ES & NL

Bioprocess Engineering Principles Book Review:

The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture and environmental management. Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in co-operation with chemical engineers to achieve pragmatic commercial goals. For many years aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists. This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant cells, plant and animal cell cultures, immobilised catalysts as well as traditional fermentation systems. * * First book to present the principles of bioprocess engineering in a way that is accessible to biological scientists * Explains process analysis from an engineering point of view, but uses worked examples relating to biological systems * Comprehensive, single-authored * 170 problems and worked examples encompass a wide range of applications, involving recombinant plant and animal cell cultures, immobilized catalysts, and traditional fermentation systems * 13 chapters, organized according to engineering sub-disciplines, are groupled in four sections - Introduction, Material and Energy Balances, Physical Processes, and Reactions and Reactors * Each chapter includes a set of problems and exercises for the student, key references, and a list of suggestions for further reading * Includes useful appendices, detailing conversion factors, physical and chemical property data, steam tables, mathematical rules, and a list of symbols used * Suitable for course adoption - follows closely curricula used on most bioprocessing and process biotechnology courses at senior undergraduate and graduate levels.

Modelling and Optimal Control of Fed batch Fermentation Process for the Production of Yeast

Modelling and Optimal Control of Fed batch Fermentation Process for the Production of Yeast
Author: Ncedo S. Mkondweni
Publsiher: Unknown
Total Pages: 310
Release: 2002
ISBN 10: 1928374650XXX
ISBN 13: OCLC:52564859
Language: EN, FR, DE, ES & NL

Modelling and Optimal Control of Fed batch Fermentation Process for the Production of Yeast Book Review:

Development of Streptavidin Fed batch Fermentation in a 20 L Bioreactor

Development of Streptavidin Fed batch Fermentation in a 20 L Bioreactor
Author: Livia Knörr
Publsiher: Unknown
Total Pages: 53
Release: 2010
ISBN 10: 1928374650XXX
ISBN 13: OCLC:818367427
Language: EN, FR, DE, ES & NL

Development of Streptavidin Fed batch Fermentation in a 20 L Bioreactor Book Review:

Theoretical and Numerical Optimization of Fed batch Fermentation

Theoretical and Numerical Optimization of Fed batch Fermentation
Author: Hwa Sung Shin
Publsiher: Unknown
Total Pages: 464
Release: 2006
ISBN 10: 9780542874871
ISBN 13: 0542874873
Language: EN, FR, DE, ES & NL

Theoretical and Numerical Optimization of Fed batch Fermentation Book Review:

The theme of this research is to find the general rule of optimal feed rate strategy to optimize the fed-batch fermentation through the investigation of the effect of biological properties; specific kinetic rates, process time, inlet substrate concentration, feed rate limits and initial inoculum states, on the optimal feed rate strategy. Cell mass and metabolite maximization at the final time are target problems.

On line Optimisation of a Multivariable Fed batch Fermentation Process

On line Optimisation of a Multivariable Fed batch Fermentation Process
Author: Paul Anthony Montgomery
Publsiher: Unknown
Total Pages: 135
Release: 1989
ISBN 10: 1928374650XXX
ISBN 13: OCLC:53548205
Language: EN, FR, DE, ES & NL

On line Optimisation of a Multivariable Fed batch Fermentation Process Book Review:

Current Developments in Biotechnology and Bioengineering

Current Developments in Biotechnology and Bioengineering
Author: Ashok Pandey,Christian Larroche,Carlos Ricardo Soccol
Publsiher: Elsevier
Total Pages: 478
Release: 2017-09-12
ISBN 10: 0444639918
ISBN 13: 9780444639912
Language: EN, FR, DE, ES & NL

Current Developments in Biotechnology and Bioengineering Book Review:

Current Developments in Biotechnology and Bioengineering: Current Advances in Solid-State Fermentation provides knowledge and information on solid-state fermentation involving the basics of microbiology, biochemistry, molecular biology, genetics and principles of genetic engineering, metabolic engineering and biochemical engineering. This volume of the series is on Solid-State fermentation (SSF), which would cover the basic and applied aspects of SSF processes, including engineering aspects such as design of bioreactors in SSF. The book offers a pool of knowledge on biochemical and microbiological aspects as well as chemical and biological engineering aspects of SSF to provide an integrated knowledge and version to the readers. Provides state-of-the-art information on basic and fundamental principles of solid-state fermentation Includes key features for the education and understanding of biotechnology education and R&D, in particular on SSF Lists fermentation methods for the production of a wide variety of enzymes and metabolites Provides examples of the various industrial applications of enzymes in solid state fermentation

Modelling of batch and fed batch fermentation

Modelling of batch and fed batch fermentation
Author: Julian Ernest Hugh Glyn
Publsiher: Unknown
Total Pages: 135
Release: 1989
ISBN 10: 1928374650XXX
ISBN 13: OCLC:871298932
Language: EN, FR, DE, ES & NL

Modelling of batch and fed batch fermentation Book Review:

Control of the Quasi steady State in Fed batch Fermentation

Control of the Quasi steady State in Fed batch Fermentation
Author: Nicolas Kalogerakis
Publsiher: Unknown
Total Pages: 282
Release: 1979
ISBN 10: 1928374650XXX
ISBN 13: OCLC:61534786
Language: EN, FR, DE, ES & NL

Control of the Quasi steady State in Fed batch Fermentation Book Review:

A Mathematical Model of a Fed Batch Fermentation Process

A Mathematical Model of a Fed Batch Fermentation Process
Author: Thomas H. Magee,David Russell
Publsiher: Unknown
Total Pages: 162
Release: 1996
ISBN 10: 1928374650XXX
ISBN 13: OCLC:299230202
Language: EN, FR, DE, ES & NL

A Mathematical Model of a Fed Batch Fermentation Process Book Review:

Optimal Control of Fed batch Fermentation Processes

Optimal Control of Fed batch Fermentation Processes
Author: Wirat Vanichsriratana
Publsiher: Unknown
Total Pages: 135
Release: 1996
ISBN 10: 1928374650XXX
ISBN 13: OCLC:59620991
Language: EN, FR, DE, ES & NL

Optimal Control of Fed batch Fermentation Processes Book Review:

Pichia Protocols

Pichia Protocols
Author: James M Cregg
Publsiher: Springer Science & Business Media
Total Pages: 268
Release: 2007-08-08
ISBN 10: 1588294293
ISBN 13: 9781588294296
Language: EN, FR, DE, ES & NL

Pichia Protocols Book Review:

This book focuses on recent developments of Pichia pastoris as a recombinant protein production system. Highlighted topics include a discussion on the use of fermentors to grow Pichia pastoris, information on the O- and N-linked glycosylation, methods for labeling Pichia pastoris expressed proteins for structural studies, and the introduction of mutations in Pichia pastoris genes by the methods of restriction enzyme-mediated integration (REMI). Each chapter presents cutting-edge and cornerstone protocols for utilizing P. pastoris as a model recomibinant protein production system. This volume fully updates and expands upon the first edition.