Genomics Proteomics and Metabolomics in Nutraceuticals and Functional Foods

Genomics  Proteomics and Metabolomics in Nutraceuticals and Functional Foods
Author: Debasis Bagchi,Anand Swaroop,Manashi Bagchi
Publsiher: John Wiley & Sons
Total Pages: 688
Release: 2015-08-18
ISBN 10: 1118930436
ISBN 13: 9781118930434
Language: EN, FR, DE, ES & NL

Genomics Proteomics and Metabolomics in Nutraceuticals and Functional Foods Book Review:

Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.

Metabolomics and Microbiomics

Metabolomics and Microbiomics
Author: Vassilios Fanos
Publsiher: Academic Press
Total Pages: 144
Release: 2016-08-30
ISBN 10: 0128054506
ISBN 13: 9780128054505
Language: EN, FR, DE, ES & NL

Metabolomics and Microbiomics Book Review:

Metabolomics and Microbiomics: Personalized Medicine from the Fetus to the Adult encompasses the most recent advances on the usage of metabolomics and microbiome research to improve disease diagnosis and healthcare. Medicine is changing from epidemiologic, descriptive, reductionist, and reactive approaches to individualized, predictive, and holistic ones by applying microbiomics to understand the functionality of the human body. The book discusses topics such as systems biology approaches, omics technologies, perinatal programming, and personalized medicine. It also discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing. The book is a valuable resource for medical professionals and researchers in metabolomics, nutrition, microbiology, and personalized-predictive medicine. The book also will appeal to non-specialized professionals who may take advantage of its captivating and simple language. Covers the latest scientific discoveries in order to improve health and early diagnosis of diseases Brings a holistic and perinatal programming approach—from fetus to adulthood—to early and long-term prevention of diseases Provides illustrations and diagrams to facilitate understanding for readers Discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing

Epigenetics and Human Health

Epigenetics and Human Health
Author: Alexander Haslberger,Sabine Greßler
Publsiher: John Wiley & Sons
Total Pages: 316
Release: 2011-08-24
ISBN 10: 352764475X
ISBN 13: 9783527644759
Language: EN, FR, DE, ES & NL

Epigenetics and Human Health Book Review:

After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Preclinical Rheumatic Disease An Issue of Rheumatic Disease Clinics

Preclinical Rheumatic Disease  An Issue of Rheumatic Disease Clinics
Author: Vivian P. Bykerk
Publsiher: Elsevier Health Sciences
Total Pages: 281
Release: 2016-12-13
ISBN 10: 0323320430
ISBN 13: 9780323320436
Language: EN, FR, DE, ES & NL

Preclinical Rheumatic Disease An Issue of Rheumatic Disease Clinics Book Review:

The ability to intervene at the earliest phases in the pathogenesis of a chronic rheumatic disease caused by auto-inflammatory, autoimmune, or tissue injury mechanisms has th epotential to prevent disease manifestations and consequences, limited loss of quality of life, comorbidity, and costs to society. This issue is dedicated to exploring the stages of rheumatic disease, biologic mechanisms contributing to the pathogenesis along with possible ways to study and screen for persons at risk with the ultimate goal of finding ways to prevent these devastating diseases.

Male Infertility An Issue of Urologic Clinics E Book

Male Infertility An Issue of Urologic Clinics E Book
Author: James M. Hotaling
Publsiher: Elsevier Health Sciences
Total Pages: 240
Release: 2020-05-11
ISBN 10: 0323712088
ISBN 13: 9780323712088
Language: EN, FR, DE, ES & NL

Male Infertility An Issue of Urologic Clinics E Book Book Review:

Together with Consulting Editor Dr. Samir Taneja, Dr. Badrinath Konety has put together a comprehensive issue that addresses the latest clinical updates in Male Infertility. Expert authors have contributed clinical review articles on the following topics: Cutting edge evaluation in male infertility; Optimal endocrine evaluation and treatment; Sperm extraction in obstructive azoospermia: What’s next; FNA vs. microTESE; ROSI (round spermatid injection); Reproductive Urology in the context of an IVF practice; Care delivery in male infertility; Qualitative research in male infertility; Male Infertility & Somatic Health; DNA fragmentation: Does testicular sperm make sense; CRISPR & Genetics of Male Infertility after whole genome sequencing; Transgenerational epigenetics: A window into paternal health influences on offspring; Spermatogonial Stem Cell Culture in oncofertility; Personalized medicine for the infertile male; and Male Infertility & The future of IVF. Readers will come away with the clinical information they need to improve outcomes in patients with infertility.

Genetics Meets Metabolomics

Genetics Meets Metabolomics
Author: Karsten Suhre
Publsiher: Springer Science & Business Media
Total Pages: 318
Release: 2012-06-15
ISBN 10: 1461416892
ISBN 13: 9781461416890
Language: EN, FR, DE, ES & NL

Genetics Meets Metabolomics Book Review:

This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.

Fundamentals of Advanced Omics Technologies From Genes to Metabolites

Fundamentals of Advanced Omics Technologies  From Genes to Metabolites
Author: Anonim
Publsiher: Newnes
Total Pages: 490
Release: 2014-02-14
ISBN 10: 0444626700
ISBN 13: 9780444626707
Language: EN, FR, DE, ES & NL

Fundamentals of Advanced Omics Technologies From Genes to Metabolites Book Review:

Fundamentals of Advanced Omics Technologies: From Genes to Metabolites covers the fundamental aspects of the new instrumental and methodological developments in omics technologies, including those related to genomics, transcriptomics, epigenetics, proteomics and metabolomics, as well as other omics approaches such as glycomics, peptidomics and foodomics. The principal applications are presented in the following complementary volume. The chapters discuss in detail omics technologies, DNA microarray analysis, next-generation sequencing technologies, genome-wide analysis of methylation and histone modifications, emerging nanotechniques in proteomics, imaging mass spectrometry in proteomics, recent quantitative proteomics approaches, and advances in high-resolution NMR-based metabolomics, as well as MS-based non-targeted metabolomics and metabolome analysis by CE-MS, global glycomics analyses, foodomics, and high resolution analytical tools for quantitative peptidomics. Key aspects related to chemometrics, bioinformatics, data treatment, data integration and systems biology, deep-sequencing data analysis, statistical approaches for the analysis of microarray data, the integration of transcriptome and metabolome data and computational approaches for visualization and integration of omics data are also covered. Covers the latest advances in instrumentation, experimental design, sample preparation, and data analysis Provides thorough explanations and descriptions of specific omics technologies Describes advanced tools and methodologies for data pretreatment, storage, curation and analysis, as well as data integration

Metabolism in Cancer

Metabolism in Cancer
Author: Thorsten Cramer,Clemens A. Schmitt
Publsiher: Springer
Total Pages: 266
Release: 2016-08-24
ISBN 10: 3319421182
ISBN 13: 9783319421186
Language: EN, FR, DE, ES & NL

Metabolism in Cancer Book Review:

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Epigenetic Markers

Epigenetic Markers
Author: M. Widschwendter,S. Srivastava
Publsiher: IOS Press
Total Pages: 137
Release: 2007
ISBN 10: 9781586037222
ISBN 13: 1586037226
Language: EN, FR, DE, ES & NL

Epigenetic Markers Book Review:

DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA's four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off. This book contains ten articles that explore the details and challenges of cancer epigenetics.

Toxicology and Epigenetics

Toxicology and Epigenetics
Author: Saura C. Sahu
Publsiher: John Wiley & Sons
Total Pages: 688
Release: 2012-08-23
ISBN 10: 1118349032
ISBN 13: 9781118349038
Language: EN, FR, DE, ES & NL

Toxicology and Epigenetics Book Review:

Epigenetics is the study of both heritable and non-heritablechanges in the regulation of gene activity and expression thatoccur without an alteration in the DNA sequence. Thisdynamic and rapidly developing discipline is making its impactacross the biomedical sciences, in particular in toxicology whereepigenetic differences can mean that different individuals responddifferently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensionalcharacter of this emerging area of toxicology, describingcutting-edge molecular technologies to unravel epigenetic changes,the use of in vivo and in vitro models, as well asthe potential use of toxicological epigenetics in regulatoryenvironments. An international team of experts consider theinterplay between epigenetics and toxicology in a number of areas,including environmental, nutritional, pharmacological, andcomputational toxicology, nanomaterials, proteomics andmetabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact indevelopment and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight intothe current trends and future directions of research in thisrapidly expanding field for investigators, toxicologists, riskassessors and regulators in academia, industry and government.

Epigenetic Methods in Neuroscience Research

Epigenetic Methods in Neuroscience Research
Author: Nina N. Karpova
Publsiher: Humana Press
Total Pages: 258
Release: 2015-10-13
ISBN 10: 9781493927531
ISBN 13: 1493927531
Language: EN, FR, DE, ES & NL

Epigenetic Methods in Neuroscience Research Book Review:

This volume presents state-of-the-art methods for reliable detection of epigenetic changes in the nervous system. Epigenetic Methods in Neuroscience Research guides readers through methods for the analyses of chromatin remodeling, transposable elements, non-coding RNAs, such as miRNAs, and circadian oscillations, including: analysis of DNA methylation in neuronal and glial cells or small tissue samples; sensitive method for quantification of alternative methylated forms of cytosines by liquid chromatography/mass spectrometry; affinity-based detection of modified cytosines by immunohistochemistry or methylated DNA immunoprecipitation; chromatin immunoprecipitation, or ChIP; miRNA high-throughput profiling and the in situ detection of miRNA subtle expression in the brain; analysis of genes with alternative 3’UTRs; and the cite-specific delivery of chromatin-modifying drugs. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Epigenetic Methods in Neuroscience Research provides multidisciplinary epigenetic approach to study genome, and neural, plasticity that will help the reader to successfully address the challenges associated with neurodevelopmental, psychiatric, and neurodegenerative disorders.

Sports Exercise and Nutritional Genomics

Sports  Exercise  and Nutritional Genomics
Author: Debmalya Barh,Ildus I. Ahmetov
Publsiher: Academic Press
Total Pages: 606
Release: 2019-08-25
ISBN 10: 0128163402
ISBN 13: 9780128163405
Language: EN, FR, DE, ES & NL

Sports Exercise and Nutritional Genomics Book Review:

Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions is the first reference volume to offer a holistic examination of omics-driven advances across different aspects of exercise and sports physiology, biochemistry, sports medicine, psychology, anthropology, and sports nutrition; and highlighting the opportunities towards advance personalized training and athlete health management. More than 70 international experts from 14 countries have discussed key exercise and sport-related themes through the prism of genomics, epigenomics, transcriptomics, proteomics, metabolomics, telomere biology, talent in sport, individual differences in response to regular physical activity, that in the future may empower coaches, sports physicians, fitness experts, genetic counselors, and translational scientists to employ various omics data and approaches in improving health and physical performance of people participating in sports and exercise activities. Contributors address current knowledge of genetic influence on athletic performance, individual responses to exercise training, as well as the genetics of musculoskeletal phenotypes, exercise-related injuries, flexibility, and neurodegenerative disorders in athletes. Finally, performance-related and psychological traits associated with epigenetic, transcriptomic and metagenomic biomarkers are also considered, along with nutritional and pharmacogenomic aids in sports medicine and personalized nutrition. Effectively synthesizes key themes across molecular aspects of exercise and sports sciences Provides a knowledge base for future translation of omics solutions to talent identification, individualized training, and nutrition Features contributions from international experts (researchers and clinicians) in the subject area

Toxicology and Epigenetics

Toxicology and Epigenetics
Author: Saura C. Sahu
Publsiher: John Wiley & Sons
Total Pages: 688
Release: 2012-08-23
ISBN 10: 1118349067
ISBN 13: 9781118349069
Language: EN, FR, DE, ES & NL

Toxicology and Epigenetics Book Review:

Epigenetics is the study of both heritable and non-heritablechanges in the regulation of gene activity and expression thatoccur without an alteration in the DNA sequence. Thisdynamic and rapidly developing discipline is making its impactacross the biomedical sciences, in particular in toxicology whereepigenetic differences can mean that different individuals responddifferently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensionalcharacter of this emerging area of toxicology, describingcutting-edge molecular technologies to unravel epigenetic changes,the use of in vivo and in vitro models, as well asthe potential use of toxicological epigenetics in regulatoryenvironments. An international team of experts consider theinterplay between epigenetics and toxicology in a number of areas,including environmental, nutritional, pharmacological, andcomputational toxicology, nanomaterials, proteomics andmetabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact indevelopment and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight intothe current trends and future directions of research in thisrapidly expanding field for investigators, toxicologists, riskassessors and regulators in academia, industry and government.

Environmental Metabolomics

Environmental Metabolomics
Author: Diana Alvarez-Munoz,Marinella Farre
Publsiher: Elsevier
Total Pages: 368
Release: 2020-05-19
ISBN 10: 0128181974
ISBN 13: 9780128181973
Language: EN, FR, DE, ES & NL

Environmental Metabolomics Book Review:

Environmental Metabolomics Applications in Field and Laboratory Studies: From the Exposome to the Metabolome presents an overview of the current state of aquatic environments and problems caused by human pressure and daily life. The presence of contaminants in nature and their effects are evaluated, along with recommendations for preservation. This book not only shows readers how to implement techniques, it also guides them through the process. As metabolomics becomes a more routine technique for environmental studies and future perspectives, a guide for validation and globalization of current approaches is needed. Presents relevant and reliable information on the use of different analytical techniques for establishing the environmental metabolomics of polluted systems Includes a critical review of each central topic in every chapter, together with a bibliography and future trends Provides, for the first time, a global opinion and guide for achieving standardized results

Reproductive Toxicology Third Edition

Reproductive Toxicology  Third Edition
Author: Robert W. Kapp,Rochelle W. Tyl
Publsiher: CRC Press
Total Pages: 512
Release: 2016-04-19
ISBN 10: 1420073443
ISBN 13: 9781420073447
Language: EN, FR, DE, ES & NL

Reproductive Toxicology Third Edition Book Review:

Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology’s contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research. This ground-breaking resource includes: New and important critical mechanistic topics such as epigenetics and omics The first significant compilation of epigenetic mechanisms An in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction New guidelines with respect to the latest research applications in the field

Cancer Epigenetics

Cancer Epigenetics
Author: Ramona G. Dumitrescu,Mukesh Verma
Publsiher: Humana Press
Total Pages: 492
Release: 2012-02-24
ISBN 10: 9781617796111
ISBN 13: 1617796115
Language: EN, FR, DE, ES & NL

Cancer Epigenetics Book Review:

The epigenetic regulation plays an important role in normal development and maintenance of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation. More recently, epigenetic changes have been observed in early stages of tumor development and together with the genetic alterations have been defined as abnormalities, necessary for cancer initiation and progression. In, Cancer Epigenetics: Methods and Protocols, expert researchers reviewed these epigenetics changes in different tumor types and described several technologies that are currently available to detect epigenetic changes. These technologies have lead to a better understanding of the processes in normal and cancerous cells. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosis.

Pleased to Meet Me

Pleased to Meet Me
Author: Bill Sullivan
Publsiher: National Geographic Books
Total Pages: 336
Release: 2019-08-06
ISBN 10: 1426220561
ISBN 13: 9781426220562
Language: EN, FR, DE, ES & NL

Pleased to Meet Me Book Review:

Why are you attracted to a certain "type?" Why are you a morning person? Why do you vote the way you do? From a witty new voice in popular science comes a clever, life-changing look at what makes you you. "I can't believe I just said that." "What possessed me to do that?" "What's wrong with me?" We're constantly seeking answers to these fundamental human questions, and now, science has the answers. The foods we enjoy, the people we love, the emotions we feel, and the beliefs we hold can all be traced back to our DNA, germs, and environment. This witty, colloquial book is popular science at its best, describing in everyday language how genetics, epigenetics, microbiology, and psychology work together to influence our personality and actions. Mixing cutting-edge research and relatable humor, Pleased to Meet Me is filled with fascinating insights that shine a light on who we really are--and how we might become our best selves.

Neuroepigenomics in Aging and Disease

Neuroepigenomics in Aging and Disease
Author: Raul Delgado-Morales
Publsiher: Springer
Total Pages: 525
Release: 2017-05-18
ISBN 10: 3319538896
ISBN 13: 9783319538891
Language: EN, FR, DE, ES & NL

Neuroepigenomics in Aging and Disease Book Review:

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Metabolic Phenotyping in Personalized and Public Healthcare

Metabolic Phenotyping in Personalized and Public Healthcare
Author: Jeremy Nicholson,Ara Darzi,Elaine Holmes,John C. Lindon
Publsiher: Academic Press
Total Pages: 428
Release: 2016-02-11
ISBN 10: 0128004142
ISBN 13: 9780128004142
Language: EN, FR, DE, ES & NL

Metabolic Phenotyping in Personalized and Public Healthcare Book Review:

Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream. Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making Discusses longitudinal sampling from individual patients for stratified medicine Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England

A Life Course Approach to Healthy Ageing

A Life Course Approach to Healthy Ageing
Author: Diana Kuh,Rachel Cooper,Rebecca Hardy,Marcus Richards,Yoav Ben-Shlomo
Publsiher: OUP Oxford
Total Pages: 288
Release: 2013-12-19
ISBN 10: 0191008184
ISBN 13: 9780191008184
Language: EN, FR, DE, ES & NL

A Life Course Approach to Healthy Ageing Book Review:

Healthy ageing has long been a neglected area of epidemiological research as the traditional focus has been on specific chronic diseases of older life. There is a growing consensus from scientists, research funders and policy makers that ageing itself needs to be studied from an interdisciplinary and life course perspective, to inform strategies for reducing the societal and individual costs of an ageing population. A Life Course Approach to Healthy Ageing is a synthesis of life course perspectives in epidemiology and interdisciplinary perspectives in ageing research. It brings together expert investigators of maturing birth cohort and ageing studies, cross-cutting methodologists, and authorities in ageing research and knowledge transfer from across the world in one wide-ranging volume. Contributors discuss how aspects of healthy ageing are conceptualised, defined and measured; relate to each other; change across life; and are influenced by biological, psychological and social factors operating from early life onwards. They identify research gaps, and suggest how evidence from observational studies can be strengthened through improved study design and longitudinal analysis, thereby increasing the research contribution to practice or policy change. The book considers how we might delay or slow down the progressive, generalised impairment of function that occurs at the individual, body system and cellular levels, as people grow older. It also considers the determinants of wellbeing in older people, including personal fulfilment, positive emotions and social relationships. Broad in scope, discussing topics from genetics to psychological and social wellbeing, A Life Course Approach to Healthy Ageing is a key resource for epidemiologists, social scientists, clinicians, public health physicians, policy makers and practitioners with a research interest in healthy ageing.