Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
Author: Suming Huang,Michael D Litt,C. Ann Blakey
Publsiher: Academic Press
Total Pages: 482
Release: 2015-10-19
ISBN 10: 0128004711
ISBN 13: 9780128004715
Language: EN, FR, DE, ES & NL

Epigenetic Gene Expression and Regulation Book Review:

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation
Author: Suming Huang
Publsiher: Academic Press
Total Pages: 400
Release: 2015-08-01
ISBN 10: 9780127999586
ISBN 13: 0127999582
Language: EN, FR, DE, ES & NL

Epigenetic Gene Expression and Regulation Book Review:

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Gene Regulation Epigenetics and Hormone Signaling

Gene Regulation  Epigenetics and Hormone Signaling
Author: Subhrangsu S. Mandal
Publsiher: John Wiley & Sons
Total Pages: 668
Release: 2017-10-23
ISBN 10: 3527322817
ISBN 13: 9783527322817
Language: EN, FR, DE, ES & NL

Gene Regulation Epigenetics and Hormone Signaling Book Review:

The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Epigenetics for Drug Discovery

Epigenetics for Drug Discovery
Author: Nessa Carey
Publsiher: Royal Society of Chemistry
Total Pages: 321
Release: 2015-11-20
ISBN 10: 1782628487
ISBN 13: 9781782628484
Language: EN, FR, DE, ES & NL

Epigenetics for Drug Discovery Book Review:

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia. The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section highlights the ongoing challenges in creating safe and efficacious epigenetic drugs. Written and edited by experts within the field from both industry and academia, this book provides an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.

Non coding RNAs and Epigenetic Regulation of Gene Expression

Non coding RNAs and Epigenetic Regulation of Gene Expression
Author: Kevin V. Morris
Publsiher: Unknown
Total Pages: 329
Release: 2012
ISBN 10: 9781912530571
ISBN 13: 1912530570
Language: EN, FR, DE, ES & NL

Non coding RNAs and Epigenetic Regulation of Gene Expression Book Review:

Gene Expression and Regulation in Mammalian Cells

Gene Expression and Regulation in Mammalian Cells
Author: Fumiaki Uchiumi
Publsiher: BoD – Books on Demand
Total Pages: 334
Release: 2018-02-21
ISBN 10: 9535138553
ISBN 13: 9789535138556
Language: EN, FR, DE, ES & NL

Gene Expression and Regulation in Mammalian Cells Book Review:

"Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.

Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation
Author: Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publsiher: Unknown
Total Pages: 692
Release: 1996
ISBN 10:
ISBN 13: UOM:39015047449171
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms of Gene Regulation Book Review:

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Chromatin and Gene Regulation

Chromatin and Gene Regulation
Author: Bryan M. Turner
Publsiher: John Wiley & Sons
Total Pages: 288
Release: 2008-04-15
ISBN 10: 0470751673
ISBN 13: 9780470751671
Language: EN, FR, DE, ES & NL

Chromatin and Gene Regulation Book Review:

Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.

Prognostic Epigenetics

Prognostic Epigenetics
Author: Anonim
Publsiher: Academic Press
Total Pages: 442
Release: 2019-11-01
ISBN 10: 012814260X
ISBN 13: 9780128142608
Language: EN, FR, DE, ES & NL

Prognostic Epigenetics Book Review:

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers

Non coding RNAs and Epigenetic Regulation of Gene Expression

Non coding RNAs and Epigenetic Regulation of Gene Expression
Author: Kevin V. Morris
Publsiher: Horizon Scientific Press
Total Pages: 216
Release: 2012
ISBN 10: 9781904455943
ISBN 13: 1904455948
Language: EN, FR, DE, ES & NL

Non coding RNAs and Epigenetic Regulation of Gene Expression Book Review:

Non-coding RNAs potentially play an active role in modulating gene transcription and epigenetic states. Several genes in differentiated cells may be under some form of RNA-based transcriptional and epigenetic regulatory control. This form of regulation may be controlled by selective pressures and influence the adaptability of the cell. The concept that RNA can control epigenetic states impacts our understanding of the basic fabric of the cell and may have therapeutic potential. Many studies have been carried out on the modulation of gene transcription by non-coding RNAs. This book, written by a group of distinguished scientists, represents an important overview and summary of the field to date. The 13 chapters are organized into three sections: a) Non-coding RNAs: Form, Function and Diversity; b) Non-coding RNAs: Gene Regulation and Epigenetics; and c) Non-coding RNAs: Disease and Therapeutics. This up-to-date volume is an essential book for those working in the area and represents a major information resource on current research in the fast-moving fields of epigenetics, the regulation of gene expression, and RNA research.

Epigenetics in Human Disease

Epigenetics in Human Disease
Author: Trygve O. Tollefsbol
Publsiher: Academic Press
Total Pages: 577
Release: 2012
ISBN 10: 0123884152
ISBN 13: 9780123884152
Language: EN, FR, DE, ES & NL

Epigenetics in Human Disease Book Review:

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Regulation of Gene Expression in the Nervous System

Regulation of Gene Expression in the Nervous System
Author: Anna Maria Giuffrida Stella,Jean de Vellis,J. Regino Perez-Polo
Publsiher: Wiley-Liss
Total Pages: 465
Release: 1990-07-19
ISBN 10:
ISBN 13: UOM:39015018477763
Language: EN, FR, DE, ES & NL

Regulation of Gene Expression in the Nervous System Book Review:

Offers an up-to-date account of the latest research findings concerned with the regulatory mechanisms of gene expression in neuronal and glial cells under different conditions. The book explores the cellular and neurobiological aspects of important phenomena of the nervous system and its role in health, disease and injury. Contributions from prominent scientists in the field address a variety of specific topics concerned with gene expression in the nervous system--from growth, hormonal and trophic factors to neural tissue reactions in injury or aging.

DNA Modifications in the Brain

DNA Modifications in the Brain
Author: Timothy W Bredy
Publsiher: Academic Press
Total Pages: 180
Release: 2016-12-23
ISBN 10: 0128017813
ISBN 13: 9780128017814
Language: EN, FR, DE, ES & NL

DNA Modifications in the Brain Book Review:

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Provides a comprehensive overview of the many facets of DNA modifications Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels Contains contributions by influential leaders in the field Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

Deciphering the Gene Expression Control in Epigenetic Post transcriptional and Translational Regulation

Deciphering the Gene Expression Control in Epigenetic  Post transcriptional and Translational Regulation
Author: Jianan Lin
Publsiher: Unknown
Total Pages: 329
Release: 2019
ISBN 10:
ISBN 13: OCLC:1196359731
Language: EN, FR, DE, ES & NL

Deciphering the Gene Expression Control in Epigenetic Post transcriptional and Translational Regulation Book Review:

Regulation of gene expression, through which cells increase or decrease the gene products, is an essential part of development, which not only determines the cellular differentiation but also responds to the environmental changes. A wide range of gene regulation mechanisms are involved in two major processes, from Deoxyribonucleic acid (DNA) to Ribonucleic acid (RNA), and from RNA to protein, also known as transcription and translation, respectively. Though the regulation of gene expression is not fully understood, this complex process has been characterized to several major steps, which includes epigenetic regulation, transcriptional regulation, post-transcriptional regulation and translational regulation. The present study covers three main projects related to three of the aforementioned steps of gene regulation. First, we study the DNA methylation dynamics in the bovine early embryos. To understand the epigenetic reprogramming and regulation in the embryonic development, we characterize the methylation process at the single-base level in early embryos. Second, we develop a novel method, called Protein-RNA Association Strength (PRAS), to predict the functional targets of RNA-Binding Proteins (RBPs) that play important roles in the regulation of gene expression in the post-transcriptional process. The development of various Cross-linking and immunoprecipitation with high-throughput sequencing (CLIP-seq) data makes it possible to investigate the transcriptomic binding sites of RBPs. We aim to fill the gap between the peak-calling methods and the interpretation of RBPs' biological functions based on CLIP-seq data. Third, we study the regulation of c-MYC on the mRNA translation. The oncogenic c-MYC (MYC) transcription factor has broad effects on gene expression and cell behavior. We study how MYC affects the global translation of mRNAs and the translation start-site usage in the human lymphoma cell line. In sum, we perform data analysis and methodology development in these three specific projects related to the regulation of gene expression, which will help us better understand the central dogma of biology.

Epigenetics Nuclear Organization Gene Function

Epigenetics  Nuclear Organization   Gene Function
Author: John C. Lucchesi
Publsiher: Oxford University Press
Total Pages: 240
Release: 2018-12-19
ISBN 10: 0192567160
ISBN 13: 9780192567161
Language: EN, FR, DE, ES & NL

Epigenetics Nuclear Organization Gene Function Book Review:

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

Epigenetics in Psychiatry

Epigenetics in Psychiatry
Author: Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publsiher: Elsevier
Total Pages: 664
Release: 2014-06-23
ISBN 10: 0124171346
ISBN 13: 9780124171343
Language: EN, FR, DE, ES & NL

Epigenetics in Psychiatry Book Review:

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

Specific Gene Expression and Epigenetics

Specific Gene Expression and Epigenetics
Author: Taylor & Francis Group
Publsiher: Apple Academic Press
Total Pages: 328
Release: 2021-03-31
ISBN 10: 9781774633526
ISBN 13: 1774633523
Language: EN, FR, DE, ES & NL

Specific Gene Expression and Epigenetics Book Review:

This title includes a number of Open Access chapters. This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: - Gene expression in colon cancer tissue - Epigenetics in human acute kidney injury - Embryologically relevant candidate genes in MRKH patients - DNA methylation in common skeletal disorders - Causal relationships in genomics - Predicting severe asthma exacerbations in children - Epigenetic understanding of gene-environment interactions in psychiatric disorders

Autophagy Biology and Diseases

Autophagy  Biology and Diseases
Author: Zhiping Xie
Publsiher: Springer Nature
Total Pages: 329
Release: 2021
ISBN 10: 9811628300
ISBN 13: 9789811628306
Language: EN, FR, DE, ES & NL

Autophagy Biology and Diseases Book Review:

Epigenetic Inheritance and Evolution

Epigenetic Inheritance and Evolution
Author: Eva Jablonka,Marion J. Lamb
Publsiher: Oxford University Press on Demand
Total Pages: 346
Release: 1999
ISBN 10: 9780198540632
ISBN 13: 0198540639
Language: EN, FR, DE, ES & NL

Epigenetic Inheritance and Evolution Book Review:

This book discusses the evidence for and against the heritability of acquired characters. Since it presents original and controversial arguments about the importance of epigenetic inheritance, this work provides a basis for discussion, modelling, and experimental investigation of the role of environmentally induced variation in evolution. Of interest to a broad range of biologists and other scientists. With a new Preface describing the impact of the hardback editionon subsequent research and a new Appendix of selected publications influenced by the book.

Epigenetics in Plants of Agronomic Importance Fundamentals and Applications

Epigenetics in Plants of Agronomic Importance  Fundamentals and Applications
Author: Raúl Alvarez-Venegas,Clelia De-la-Peña,Juan Armando Casas-Mollano
Publsiher: Springer
Total Pages: 415
Release: 2019-04-26
ISBN 10: 3030147606
ISBN 13: 9783030147600
Language: EN, FR, DE, ES & NL

Epigenetics in Plants of Agronomic Importance Fundamentals and Applications Book Review:

Over the past few decades, chromatin modulation has emerged as an important regulator of gene expression. This second edition provides detailed information on the epigenetic mechanisms in plants, illustrating the value of this research in plants of agronomic importance. It examines recent advances regarding plants’ epigenetic regulation in response to abiotic and biotic types of stress; the epigenetic basis of plant immunity; evolution and functions of plant histones; epigenetic variation and plant breeding; and epigenome editing and crop improvement. The content is intended to promote the development of future biotechnologies to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases, and to increase crop productivity. The development of new fields, like epigenome editing and RNA epigenetics, will certainly improve our understanding of currently known epigenetic modifications and their roles in e.g. host-pathogen interactions, crop productivity, and in response to environmental stimuli. This volume contains twelve new/revised chapters, written by an international team of experts on plant epigenetics, and addresses the needs of researchers and professionals in the fields of agronomics, crop breeding, epigenetics, plant biochemistry, plant developmental biology, and related disciplines.