Enzyme Active Sites and their Reaction Mechanisms

Enzyme Active Sites and their Reaction Mechanisms
Author: Harry Morrison
Publsiher: Academic Press
Total Pages: 264
Release: 2021-03-01
ISBN 10: 0128231947
ISBN 13: 9780128231944
Language: EN, FR, DE, ES & NL

Enzyme Active Sites and their Reaction Mechanisms Book Review:

Enzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue University, provides a detailed overview of the origin and function of forty enzymes, the chemical details of their active sites, their mechanisms of action, and associated cofactors. The enzymes featured highlight a step forward, along with possible areas of application, thus supporting new research in academic and industrial labs. Each chapter is written in a clear format, including a brief summary of enzyme function and structure, a detailed description of their mechanisms of action and associated co-factors. Additionally, an introductory chapter describes the relationship between new and evolving experimental approaches (e.g. X-ray crystallography) and recent advances in our knowledge of enzyme active sites and their reaction mechanisms. Offers a comprehensive, biochemical understanding of enzyme mechanisms and their reaction sites Supports new research in academic, medical and industrial labs, connecting discoveries powered by recent advances in technology and experimental approaches to areas of application Features short, carefully structured, actionable chapters on various enzyme classes, thus allowing for easy-use and searchability

Enzyme Inhibitors and Activators

Enzyme Inhibitors and Activators
Author: Murat Şentürk
Publsiher: BoD – Books on Demand
Total Pages: 268
Release: 2017-03-29
ISBN 10: 9535130579
ISBN 13: 9789535130574
Language: EN, FR, DE, ES & NL

Enzyme Inhibitors and Activators Book Review:

Over the recent years, medicinal chemistry has become responsible for explaining interactions of chemical molecule processes such that many scientists in the life sciences from agronomy to medicine are engaged in medicinal research. This book contains an overview focusing on the research area of enzyme inhibitor and activator, enzyme-catalyzed biotransformation, usage of microbial enzymes, enzymes associated with programmed cell death, natural products as potential enzyme inhibitors, protease inhibitors from plants in insect pest management, peptidases, and renin-angiotensin system. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Especially, emphasis is devoted to both experimental and theoretical aspect of modern medicine. The primary target audience for the book includes students, researchers, chemists, molecular biologists, medical doctors, pharmacologists, and professionals who are interested in associated areas. The textbook is written by international scientists with expertise in biochemistry, enzymology, molecular biology, and genetics, many of which are active in biochemical and pharmacological research. I would like to acknowledge the authors for their contribution to the book. We hope that the textbook will enhance the knowledge of scientists in the complexities of some medical approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of pharmacology.

Enzyme Kinetics: Catalysis and Control

Enzyme Kinetics: Catalysis and Control
Author: Daniel L. Purich
Publsiher: Elsevier
Total Pages: 920
Release: 2010-06-16
ISBN 10: 0123809258
ISBN 13: 9780123809254
Language: EN, FR, DE, ES & NL

Enzyme Kinetics: Catalysis and Control Book Review:

Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions

Enzymatic Reaction Mechanisms

Enzymatic Reaction Mechanisms
Author: Perry A. Frey,Adrian D. Hegeman
Publsiher: Oxford University Press
Total Pages: 848
Release: 2007-01-27
ISBN 10: 9780195352740
ISBN 13: 0195352742
Language: EN, FR, DE, ES & NL

Enzymatic Reaction Mechanisms Book Review:

Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.

Enzyme Inhibition and Bioapplications

Enzyme Inhibition and Bioapplications
Author: Rakesh Sharma
Publsiher: BoD – Books on Demand
Total Pages: 332
Release: 2012-05-09
ISBN 10: 953510585X
ISBN 13: 9789535105855
Language: EN, FR, DE, ES & NL

Enzyme Inhibition and Bioapplications Book Review:

Enzyme Inhibition and Bioapplications is a concise book on applied methods of enzymes used in drug testing. The present volume will serve the purpose of applied drug evaluation methods in research projects, as well as relatively experienced enzyme scientists who might wish to develop their experiments further. Chapters are arranged in the order of basic concepts of enzyme inhibition and physiological basis of cytochromes followed by new concepts of applied drug therapy; reliability analysis; and new enzyme applications from mechanistic point of view.

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition
Author: Richard B. Silverman
Publsiher: Elsevier
Total Pages: 800
Release: 2002-03-07
ISBN 10: 0080513360
ISBN 13: 9780080513362
Language: EN, FR, DE, ES & NL

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition Book Review:

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

The Enzymes

The Enzymes
Author: Paul D. Boyer
Publsiher: Academic Press
Total Pages: 886
Release: 1974
ISBN 10: 0121227103
ISBN 13: 9780121227104
Language: EN, FR, DE, ES & NL

The Enzymes Book Review:

Enzyme Kinetics and Mechanism, Part F: Detection and Characterization of Enzyme Reaction Intermediates

Enzyme Kinetics and Mechanism, Part F: Detection and Characterization of Enzyme Reaction Intermediates
Author: Daniel L. Purich
Publsiher: Elsevier
Total Pages: 650
Release: 2002-11-04
ISBN 10: 9780080489384
ISBN 13: 0080489389
Language: EN, FR, DE, ES & NL

Enzyme Kinetics and Mechanism, Part F: Detection and Characterization of Enzyme Reaction Intermediates Book Review:

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Spectroscopic Detection of Reaction Intermediates Isotopic and Kenetic Detection of Reaction Intermediates Chemical Trapping and Inhibitor Methods for Detecting Reaction Intermediates

Chemical Modelling

Chemical Modelling
Author: Alan Hinchliffe
Publsiher: Royal Society of Chemistry
Total Pages: 542
Release: 2006
ISBN 10: 0854042431
ISBN 13: 9780854042432
Language: EN, FR, DE, ES & NL

Chemical Modelling Book Review:

Chemical Modelling; Applications and Theory comprises critical literature reviews of all aspects of molecular modelling. Molecular modelling in this context refers to modelling the structure properties and reactions of atoms molecules and materials. Each chapter provides a selective review of recent literature, incorporating sufficient historical perspective for the non-specialist to gain an understanding. With chemical modelling covering such a wide range of subjects this Specialist Periodical Report serves as the first port of call to any chemist, biochemist, materials scientist or molecular physicist needing to acquaint themselves with major developments in the area. Volume 4 provides a review of the literature published from June 2003 to May 2005.

Modelling Molecular Structure and Reactivity in Biological Systems

Modelling Molecular Structure and Reactivity in Biological Systems
Author: Kevin J. Naidoo
Publsiher: Royal Society of Chemistry
Total Pages: 293
Release: 2006-01-01
ISBN 10: 0854046682
ISBN 13: 9780854046683
Language: EN, FR, DE, ES & NL

Modelling Molecular Structure and Reactivity in Biological Systems Book Review:

This book provides a complete reference on state of the art computational chemistry practised on biological systems.

Enzyme Technology

Enzyme Technology
Author: Ashok Pandey,Colin Webb,Carlos Ricardo Soccol,Christian Larroche
Publsiher: Springer Science & Business Media
Total Pages: 742
Release: 2006
ISBN 10: 9780387292946
ISBN 13: 0387292942
Language: EN, FR, DE, ES & NL

Enzyme Technology Book Review:

Publisher Description

Metal-Containing Enzymes

Metal-Containing Enzymes
Author: Anonim
Publsiher: Academic Press
Total Pages: 174
Release: 2014-11-24
ISBN 10: 0128007885
ISBN 13: 9780128007884
Language: EN, FR, DE, ES & NL

Metal-Containing Enzymes Book Review:

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in metal-containing enzymes Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables

High Resolution EPR

High Resolution EPR
Author: Graeme Hanson,Lawrence Berliner
Publsiher: Springer Science & Business Media
Total Pages: 666
Release: 2009-06-19
ISBN 10: 0387848568
ISBN 13: 9780387848563
Language: EN, FR, DE, ES & NL

High Resolution EPR Book Review:

Metalloproteins comprise approximately 30% of all known proteins, and are involved in a variety of biologically important processes, including oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis, and hydrolysis of amides and esters, environmental sulfur and nitrogen cycles, and disease mechanisms. EPR spectroscopy has an important role in not only the geometric structural characterization of the redox cofactors in metalloproteins but also their electronic structure, as this is crucial for their reactivity. The advent of x-ray crystallographic snapshots of the active site redox cofactors in metalloenzymes in conjunction with high-resolution EPR spectroscopy has provided detailed structural insights into their catalytic mechanisms. This volume was conceived in 2005 at the Rocky Mountain Conference on Analytical Chemistry (EPR Symposium) to highlight the importance of high-resolution EPR spectroscopy to the structural (geometric and electronic) characterization of redox active cofactors in metalloproteins. We have been fortunate to have enlisted internationally recognized experts in this joint venture to provide the scientific community with an overview of high-resolution EPR and its application to metals in biology. This volume, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine, covers high-resolution EPR methods, iron proteins, nickel and copper enzymes, and metals in medicine. An eloquent synopsis of each chapter is provided by John Pilbrow in the Introduction. A second volume, Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes, will appear later this year covering the complement of other metalloproteins. One of the pioneers in the development of pulsed EPR and its application to metalloproteins was Arthur Schweiger, whose contribution we include in this volume. Unfortunately, he passed away suddenly during the preparation of this volume. The editors and coauthors are extremely honored to dedicate this volume to the memory of Arthur Schweiger in recognition of his technical advances and insights into pulsed EPR and its application to metalloproteins. Arthur was extremely humble and treated everyone with equal respect. He was a gifted educator with an ability to explain complex phenomena in terms of simple intuitive pictures, had a delightful personality, and continues to be sadly missed by the community. It is an honor for the editors to facilitate the dissemination of these excellent contributions to the scientific community. Suggestions for future volumes are always appreciated.

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Author: Nilashis Nandi
Publsiher: CRC Press
Total Pages: 209
Release: 2011-07-27
ISBN 10: 1439840024
ISBN 13: 9781439840023
Language: EN, FR, DE, ES & NL

Chirality in Biological Nanospaces Book Review:

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Introduction to Enzyme and Coenzyme Chemistry

Introduction to Enzyme and Coenzyme Chemistry
Author: T. D. H. Bugg
Publsiher: John Wiley & Sons
Total Pages: 280
Release: 2012-05-29
ISBN 10: 1118348990
ISBN 13: 9781118348994
Language: EN, FR, DE, ES & NL

Introduction to Enzyme and Coenzyme Chemistry Book Review:

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Inorganic Reaction Mechanisms

Inorganic Reaction Mechanisms
Author: A. G. Sykes
Publsiher: Royal Society of Chemistry
Total Pages: 463
Release: 1981
ISBN 10: 0851863159
ISBN 13: 9780851863153
Language: EN, FR, DE, ES & NL

Inorganic Reaction Mechanisms Book Review:

Reflecting the growing volume of published work in this field, researchers will find this book an invaluable source of information on current methods and applications.

Principles and Techniques of Practical Biochemistry

Principles and Techniques of Practical Biochemistry
Author: PH D Keith Wilson,Keith Wilson,John Walker,Professor John M Walker
Publsiher: Cambridge University Press
Total Pages: 784
Release: 2000-03-16
ISBN 10: 9780521658737
ISBN 13: 052165873X
Language: EN, FR, DE, ES & NL

Principles and Techniques of Practical Biochemistry Book Review:

New edition of biochemistry textbook which introduces principles and techniques used in undergraduate practical classes.

Enzyme-Catalyzed Electron and Radical Transfer

Enzyme-Catalyzed Electron and Radical Transfer
Author: Andreas Holzenburg,Nigel S. Scrutton
Publsiher: Springer Science & Business Media
Total Pages: 693
Release: 2006-04-18
ISBN 10: 030646828X
ISBN 13: 9780306468285
Language: EN, FR, DE, ES & NL

Enzyme-Catalyzed Electron and Radical Transfer Book Review:

Dramatic advances have been made in recent years in the field of redox enzymology which has resulted in an increase of research activities. This volume will cover the recent milestone developments in this field by leading experts, uniting theory and experiment, and selecting contributions to illustrate important aspects of the mechanisms of electron and radical transfer in proteins. Features: A demonstration of the key principles controlling biological redox reactions; Experimental studies of `simple' soluble systems in various enzyme familiies to illustrate concepts in the control of electron transfer reactions; Detail of advances made in membrane electron transfer through structural descriptions of key membrane-embedded proteins; Appeal to those interested in the design and use of redox enzymes, from academics to industrialists.

Secondary Plant Products

Secondary Plant Products
Author: E. E. Conn
Publsiher: Academic Press
Total Pages: 798
Release: 2016-01-26
ISBN 10: 1483289222
ISBN 13: 9781483289229
Language: EN, FR, DE, ES & NL

Secondary Plant Products Book Review:

The Biochemistry of Plants: A Comprehensive Treatise, Volume 7: Secondary Plant Products focuses on the biochemistry of secondary compounds, including tissue culture and differentiation, complexes, and plant systematics. The selection first elaborates on the physiological roles of secondary natural products, tissue culture and the study of secondary natural products, and turnover and degradation of secondary natural products. Discussions focus on degradative reactions of nitrogenous and phenolic compounds, concept of turnover of secondary products, and plant-vertebrate interactions. The text then elaborates on secondary plant products and cell and tissue differentiation; compartmentation in natural product biosynthesis by multienzyme complexes; and secondary metabolites and plant systematics. The manuscript examines the stereochemical aspects of natural products biosynthesis, nonprotein amino acids, and amines. Topics include tryptamines, phenethylamines, and histamine, nonprotein amino acids as analogues and antimetabolites, chemistry and biogenesis, and nonprotein amino acids as indexes for chemotaxonomy. The book also tackles glycosylation and glycosidases; transmethylation and demethylation reactions in the metabolism of secondary plant products; and oxygenases and the metabolism of plant products. The selection is a vital reference for researchers interested in the biochemistry of secondary compounds.

Biology Coloring Workbook

Biology Coloring Workbook
Author: I. Edward Alcamo
Publsiher: The Princeton Review
Total Pages: 327
Release: 1998
ISBN 10: 9780679778844
ISBN 13: 0679778845
Language: EN, FR, DE, ES & NL

Biology Coloring Workbook Book Review:

Following in the successful footsteps of the "Anatomy" and the "Physiology Coloring Workbook", The Princeton Review introduces two new coloring workbooks to the line. Each book features 125 plates of computer-generated, state-of-the-art, precise, original artwork--perfect for students enrolled in allied health and nursing courses, psychology and neuroscience, and elementary biology and anthropology courses.