Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders
Author: Michael Aschner,Lucio G. Costa
Publsiher: Academic Press
Total Pages: 450
Release: 2015-06-18
ISBN 10: 012800407X
ISBN 13: 9780128004074
Language: EN, FR, DE, ES & NL

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders Book Review:

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders Written by an international selection of the world’s foremost experts in the field of neurotoxicology Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience

Environmental Neuroscience

Environmental Neuroscience
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Board on Environmental Studies and Toxicology,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 86
Release: 2021-01-22
ISBN 10: 0309683092
ISBN 13: 9780309683098
Language: EN, FR, DE, ES & NL

Environmental Neuroscience Book Review:

Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical. On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.

Environmental Neuroscience

Environmental Neuroscience
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Board on Environmental Studies and Toxicology,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 86
Release: 2020-12-22
ISBN 10: 0309683122
ISBN 13: 9780309683128
Language: EN, FR, DE, ES & NL

Environmental Neuroscience Book Review:

Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical. On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Shamim I. Ahmad
Publsiher: Springer Science & Business Media
Total Pages: 390
Release: 2012-03-12
ISBN 10: 1461406536
ISBN 13: 9781461406532
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Review:

The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Environmental Factors in Neurodegenerative Diseases

Environmental Factors in Neurodegenerative Diseases
Author: Anonim
Publsiher: Academic Press
Total Pages: 290
Release: 2017-09-19
ISBN 10: 0128127651
ISBN 13: 9780128127650
Language: EN, FR, DE, ES & NL

Environmental Factors in Neurodegenerative Diseases Book Review:

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Linking Environmental Exposure to Neurodevelopmental Disorders

Linking Environmental Exposure to Neurodevelopmental Disorders
Author: Anonim
Publsiher: Academic Press
Total Pages: 312
Release: 2018-05-24
ISBN 10: 0128155523
ISBN 13: 9780128155523
Language: EN, FR, DE, ES & NL

Linking Environmental Exposure to Neurodevelopmental Disorders Book Review:

Advances in Neurotoxicology, Volume Two, addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Neurodevelopmental Disorders

Neurodevelopmental Disorders
Author: Bin Chen,Kenneth Y. Kwan
Publsiher: Academic Press
Total Pages: 426
Release: 2020-05-24
ISBN 10: 0128144106
ISBN 13: 9780128144107
Language: EN, FR, DE, ES & NL

Neurodevelopmental Disorders Book Review:

Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Features leading experts in various subfields as section editors and article authors Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship Covers disorders of the nervous system that arise through defects in neural development

Child Neuropsychology

Child Neuropsychology
Author: Margaret Semrud-Clikeman,Phyllis Anne Teeter Ellison
Publsiher: Springer Science & Business Media
Total Pages: 487
Release: 2009-06-15
ISBN 10: 9780387889634
ISBN 13: 0387889639
Language: EN, FR, DE, ES & NL

Child Neuropsychology Book Review:

During the past decade, significant advances have been made in the field of neurodevelopmental disorders, resulting in a considerable impact on conceptualization, diagnostics, and practice. The second edition of Child Neuropsychology: Assessment and Interventions for Neurodevelopmental Disorders brings readers up to speed clearly and authoritatively, offering the latest information on neuroimaging technologies, individual disorders, and effective treatment of children and adolescents. Starting with the basics of clinical child neuropsychology and functional anatomy, the authors present a transactional framework for assessment, diagnosis, and intervention. The book carefully links structure and function—and behavioral and biological science—for a more nuanced understanding of brain development and of pathologies as varied as pervasive developmental disorders, learning disabilities, neuromotor dysfunction, seizure disorders, and childhood cancers. This volume features a range of salient features valuable to students as well as novice and seasoned practitioners alike, including: Overview chapters that discuss the effects of biogenic and environmental factors on neurological functioning. New emphasis on multicultural/cross-cultural aspects of neuropsychology and assessment. Brand new chapters on interpretation, neuropsychological assessment process, and report writing. An integrative model of neurological, neuroradiological, and psychological assessment and diagnosis. Balanced coverage of behavioral, pharmacological, and educational approaches to treatment. Case studies illustrating typical and distinctive presentations and successful diagnosis, treatment planning, and intervention. Important practice updates, including the new HIPAA regulations. Child Neuropsychology, 2nd Edition, is vital reading for school, clinical child, and counseling psychologists as well as neuropsychologists. The book also provides rich background and practical material for graduate students entering these fields.

Neurological Psychiatric and Developmental Disorders

Neurological  Psychiatric  and Developmental Disorders
Author: Institute of Medicine,Board on Global Health,Committee on Nervous System Disorders in Developing Countries
Publsiher: National Academies Press
Total Pages: 458
Release: 2001-01-01
ISBN 10: 9780309170932
ISBN 13: 0309170931
Language: EN, FR, DE, ES & NL

Neurological Psychiatric and Developmental Disorders Book Review:

Brain disordersâ€"neurological, psychiatric, and developmentalâ€"now affect at least 250 million people in the developing world, and this number is expected to rise as life expectancy increases. Yet public and private health systems in developing countries have paid relatively little attention to brain disorders. The negative attitudes, prejudice, and stigma that often surround many of these disorders have contributed to this neglect. Lacking proper diagnosis and treatment, millions of individual lives are lost to disability and death. Such conditions exact both personal and economic costs on families, communities, and nations. The report describes the causes and risk factors associated with brain disorders. It focuses on six representative brain disorders that are prevalent in developing countries: developmental disabilities, epilepsy, schizophrenia, bipolar disorder, depression, and stroke. The report makes detailed recommendations of ways to reduce the toll exacted by these six disorders. In broader strokes, the report also proposes six major strategies toward reducing the overall burden of brain disorders in the developing world.

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease
Author: Randy L Jirtle,Frederick L. Tyson
Publsiher: Springer Science & Business Media
Total Pages: 302
Release: 2013-05-16
ISBN 10: 3642233805
ISBN 13: 9783642233807
Language: EN, FR, DE, ES & NL

Environmental Epigenomics in Health and Disease Book Review:

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Environmental Factors and Their Role in Developmental Disorders

Environmental Factors and Their Role in Developmental Disorders
Author: Claire Marie Koenig
Publsiher: Unknown
Total Pages: 329
Release: 2012
ISBN 10: 9781267657633
ISBN 13: 1267657634
Language: EN, FR, DE, ES & NL

Environmental Factors and Their Role in Developmental Disorders Book Review:

From conception to death exposure to environmental agents with potential toxicity is unavoidable. Advancement of the chemical industry in the 20th century has led to an estimated 70,000 to 100,000 chemicals registered for commercial use, the majority of which have had little to no toxicological testing. Further 90% of approved pharmacological drug treatments in the U.S. have no evaluation of teratogenicity or neurodevelopmental toxicity in humans. This gap in our knowledge of exposure to these chemicals and their toxicological potential is significant reason for concern. In the present study, two potential neurodevelopmental toxicants, brominated diphenyl ether-47 (BDE-47), an environmental pollutant, and misoprostol, a pharmacological agent, were evaluated for effects on brain development and behavior in mice after early developmental exposure. BDE-47 is one of 209 congeners in a class of widely used flame retardant chemicals known as polybrominated diphenyl ethers (PBDEs). BDE-47 makes up almost 50% of the congener profile in human tissues including breast milk, placenta and umbilical cord serum. To evaluate the neurotoxic potential of BDE-47, mice were chronically exposed low levels of BDE-47 (i.e., 0.03, 0.1 or 1.0 mg/kg/day) that were selected to be within the range of reported human exposure. Our research found that exposure of pregnant C567BL/6 dams to BDE-47 resulted in significant accumulation of the chemical in offspring tissue both during gestation and lactation, and levels in dam tissues were similar to those reported for humans. Behavioral testing showed that spatial learning and memory were altered in mouse pups following perinatal exposure. These results highlight the potential health risk that presented by perinatal exposure to BDE-47 and potentially other similar flame retardants. Misoprostol is commonly used in gynecological and obstetric practices at the time of birth to induce labor. However, high doses of misoprostol given early in pregnancy to induce abortion can result in Möbius Syndrome in surviving offspring as well as behaviors that show similarities with autism spectrum disorders. This raised the possibility that misoprostol treatment might show neurodevelopmental toxicity when given at the time of birth. Therefore mouse pups were exposed to one of three doses of misoprostol (0.4, 4or 40 mg/kg) at the approximate time in development equivalent to human birth. The results showed that when misoprostol is given at this developmental age it did not appear to significantly affect neurological development in mice. This failure to find evidence of neurodevelopmental toxicity from neonatal exposure to misoprostol is important because it can help future research to focus on those environmental agents that may be more likely to be involved in the etiology of neurodevelopmental disorders such as autism.

Autism Spectrum Disorder

Autism Spectrum Disorder
Author: Michael Fitzgerald
Publsiher: BoD – Books on Demand
Total Pages: 378
Release: 2015-04-02
ISBN 10: 9535120379
ISBN 13: 9789535120377
Language: EN, FR, DE, ES & NL

Autism Spectrum Disorder Book Review:

This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.

Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases
Author: Marie-Francoise Chesselet
Publsiher: Springer Science & Business Media
Total Pages: 410
Release: 2000-10-19
ISBN 10: 1592590063
ISBN 13: 9781592590063
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Neurodegenerative Diseases Book Review:

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

The SAGE Encyclopedia of Intellectual and Developmental Disorders

The SAGE Encyclopedia of Intellectual and Developmental Disorders
Author: Ellen Braaten
Publsiher: SAGE Publications
Total Pages: 1944
Release: 2018-01-29
ISBN 10: 1506353304
ISBN 13: 9781506353302
Language: EN, FR, DE, ES & NL

The SAGE Encyclopedia of Intellectual and Developmental Disorders Book Review:

According to the CDC "about one in six, or about 15%, of children aged 3 through 17 years have one or more developmental disabilities," such as ADHD, autism spectrum disorders, cerebral palsy, intellectual disability, and learning disability. Intellectual disorders are characterized by significant limitations in both intellectual functioning and in adaptive behavior, which covers many everyday social and practical skills, impacting learning, reasoning, problem solving, and other cognitive processes. These disabilities originate before the age of 18 and continue across the life span. Developmental disorders are chronic disabilities that can be cognitive or physical or both. The disabilities appear before the age of 22 and are likely to progress across the lifespan. Some developmental disorders are largely physical issues, such as cerebral palsy or epilepsy. Some individuals may have a disorder that includes a physical and intellectual disability; for example, Down syndrome or fetal alcohol syndrome. Intellectual and developmental disorders are significant and growing issues that are studied across a number of disciplines. The SAGE Encyclopedia of Intellectual and Developmental Disorders is aimed at students interested in psychology, counseling, education, social work, psychiatry, health sciences, and more. This encyclopedia will provide an in-depth look at a wide range of disorders, alongside interventions, the latest research translated for an undergraduate audience, historical context, and assessment tools for higher-level students. We will take a truly interdisciplinary approach by also covering sociocultural viewpoints, policy implications, educational applications, ethical issues, and more.

The Synaptic Organization of the Brain

The Synaptic Organization of the Brain
Author: Gordon M. Shepherd
Publsiher: Oxford University Press
Total Pages: 719
Release: 2004
ISBN 10: 019515956X
ISBN 13: 9780195159561
Language: EN, FR, DE, ES & NL

The Synaptic Organization of the Brain Book Review:

This is a thorough revision of the standard text on local circuits in the different regions of the brain. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods.

Pathophysiology E Book

Pathophysiology   E Book
Author: Kathryn L. McCance,Sue E. Huether
Publsiher: Elsevier Health Sciences
Total Pages: 1720
Release: 2018-01-10
ISBN 10: 032341320X
ISBN 13: 9780323413206
Language: EN, FR, DE, ES & NL

Pathophysiology E Book Book Review:

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 8th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW chapter on obesity and nutritional disorders, along with expanded coverage of rare diseases and epigenetics. It’s the most comprehensive and authoritative pathophysiology text available! The most comprehensive and authoritative pathophysiology text on the market provides unparalleled coverage of Pathophysiology content. Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes — more than in any other pathophysiology text. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition. Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes. Additional What’s New boxes highlight the most current research and clinical development. Nutrition and Disease boxes explain the link between concepts of health promotion and disease. Chapter summary reviews provide concise synopses of the main points of each chapter. NEW! Chapter on obesity and nutritional disorders thoroughly covers these growing global concerns. NEW! Added coverage of rare diseases and epigenetics further explore genetic disease traits. NEW! Over 50 new or heavily revised illustrations visually highlight pathophysiology concepts. NEW! More than 30 new 3D animations on Evolve bring difficult concepts to life for a new perspective on disease processes.

Clinical Handbook of Air Pollution Related Diseases

Clinical Handbook of Air Pollution Related Diseases
Author: Fabio Capello,Antonio Vittorino Gaddi
Publsiher: Springer
Total Pages: 679
Release: 2018-02-21
ISBN 10: 3319627317
ISBN 13: 9783319627311
Language: EN, FR, DE, ES & NL

Clinical Handbook of Air Pollution Related Diseases Book Review:

This book examines in detail the clinical implications of those diseases that either are primarily triggered by air pollution or represent direct consequences of air pollutants. The aim is to provide medical practitioners with practical solutions to issues in diagnosis and treatment while simultaneously furnishing other interested parties with crucial information on the field. The book introduces the concept that air pollution-related diseases constitute a new class of pathologies. A wide range of conditions mainly attributable to air pollution are discussed, covering different body systems and pollution impacts in subsets of the population. In addition to presenting state of the art overviews of clinical aspects, the book carefully examines the implications of current knowledge for social and public health strategies aimed at disease prevention and prophylaxis. The Clinical Handbook of Air Pollution-Related Diseases will greatly assist doctors and healthcare workers when dealing with the consequences of air pollution in their everyday practice and will provide researchers, industry, and policymakers with valuable facts and insights.

Molecular Genetic Investigation of Autosomal Recessive Neurodevelopmental Disorders

Molecular Genetic Investigation of Autosomal Recessive Neurodevelopmental Disorders
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2021
ISBN 10:
ISBN 13: OCLC:690666266
Language: EN, FR, DE, ES & NL

Molecular Genetic Investigation of Autosomal Recessive Neurodevelopmental Disorders Book Review:

Development of the human brain occurs in a number of complex pre- and postnatal stages which are governed by both genetic and environmental factors. Aberrant brain development due to inherited defects may result in a wide spectrum of neurological disorders which are commonly encountered in the clinical field of paediatric neurology. In the work for this thesis, I have investigated the molecular basis and defined the clinical features of three autosomal recessive neurological syndromes. I studied a cohort of children with early onset epileptic encephalopathy and, in one family, identified a novel homozygous pathogenic mutation of PLCB1. I have also utilised autozygosity mapping techniques to study consanguineous families with a complex motor disorder, infantile parkinsonism-dystonia, and identified loss-of function mutations in the gene encoding the dopamine transporter (SLC6A3). Subsequent acquisition of a cohort of similarly affected children allowed detailed clinical and molecular characterisation of this novel disorder, dopamine transporter deficiency syndrome. Finally I have delineated the clinical and genetic features of PLA2G6-associated neurodegeneration. The identification of disease-causing genes contributes greatly to understanding the disease mechanisms underlying such early-onset disorders, and also provides novel insights into normal human neurodevelopment.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science
Author: Dr. Inamuddin,Rajender Boddula,Abdullah M. Asiri
Publsiher: Elsevier
Total Pages: 312
Release: 2020-12-01
ISBN 10: 0128218983
ISBN 13: 9780128218983
Language: EN, FR, DE, ES & NL

Green Sustainable Process for Chemical and Environmental Engineering and Science Book Review:

Green Solvents for Environmental Remediation provides an in-depth overview of environmental remediation by using eutectic solvents, ionic liquids, biosolvents, and switchable solvents, of ionic-liquids, biosolvents, Gas-expanded solvents Liquid polymers, supercritical fluids, Polymer-based green solvents, Switchable solvents, etc. This book offers all-types of green solvents for the removal of contaminations from the soil, air, and water. It summarizes in-depth literature on the application of various green solvents in the areas such as municipal water, extraction, bioremediation, phytoremediation, soil and sediment remediation, toxic gases removal, and various industrial effluents. A brief introduction, limitations, and advantages to the practical use of green solvents are also discussed. This book is authored by experts in a broad range of fields. It is an invaluable reference guide for the sustainable and environmentally friendly development of synthetic methodologies for environmental, analytical, engineering, and industrial technology. Provides an up-to-date research record on green solvents for environmental protection Includes latest advances in environmental remediation Outlines eco-friendly green solvents for toxic contaminants degradation and purification Covers all-types of green solvent-driven environmental remediation technologies Key references to obtain great results in environmental remediation using green solvents

Gene Environment Interactions

Gene Environment Interactions
Author: Moyra Smith
Publsiher: Academic Press
Total Pages: 438
Release: 2020-01-24
ISBN 10: 0128196130
ISBN 13: 9780128196137
Language: EN, FR, DE, ES & NL

Gene Environment Interactions Book Review:

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine