Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease
Author: Gary D. Lopaschuk,Naranjan S. Dhalla
Publsiher: Springer
Total Pages: 295
Release: 2014-08-22
ISBN 10: 1493912275
ISBN 13: 9781493912278
Language: EN, FR, DE, ES & NL

Cardiac Energy Metabolism in Health and Disease Book Review:

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Novel Concepts in Cardiac Energy Metabolism From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism  From Biology to Disease
Author: Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran
Publsiher: Frontiers Media SA
Total Pages: 89
Release: 2019-08-08
ISBN 10: 2889459381
ISBN 13: 9782889459384
Language: EN, FR, DE, ES & NL

Novel Concepts in Cardiac Energy Metabolism From Biology to Disease Book Review:

The Scientist s Guide to Cardiac Metabolism

The Scientist s Guide to Cardiac Metabolism
Author: Michael Schwarzer,Torsten Doenst
Publsiher: Academic Press
Total Pages: 240
Release: 2015-11-04
ISBN 10: 0128026146
ISBN 13: 9780128026144
Language: EN, FR, DE, ES & NL

The Scientist s Guide to Cardiac Metabolism Book Review:

The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field

ATP and the Heart

ATP and the Heart
Author: Joanne S. Ingwall
Publsiher: Springer Science & Business Media
Total Pages: 244
Release: 2012-12-06
ISBN 10: 1461510937
ISBN 13: 9781461510932
Language: EN, FR, DE, ES & NL

ATP and the Heart Book Review:

ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations. This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.

Myocardial Energy Metabolism

Myocardial Energy Metabolism
Author: J.W. de Jong
Publsiher: Springer Science & Business Media
Total Pages: 310
Release: 2012-12-06
ISBN 10: 9400913192
ISBN 13: 9789400913196
Language: EN, FR, DE, ES & NL

Myocardial Energy Metabolism Book Review:

Mitochondrial Diseases

Mitochondrial Diseases
Author: Eylem Taskin,Celal Guven,Yusuf Sevgiler
Publsiher: BoD – Books on Demand
Total Pages: 496
Release: 2018-08-29
ISBN 10: 1789236746
ISBN 13: 9781789236743
Language: EN, FR, DE, ES & NL

Mitochondrial Diseases Book Review:

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Cardiac Energetics

Cardiac Energetics
Author: R. Jacob,Hanjoerg Just,C. Holubarsch
Publsiher: Springer Science & Business Media
Total Pages: 425
Release: 2013-04-17
ISBN 10: 3662112892
ISBN 13: 9783662112892
Language: EN, FR, DE, ES & NL

Cardiac Energetics Book Review:

Assessment of cardiac energetics at the level of ATP-synthesis, chemomechanical energy transformation and whole organ dynamics as a function of haemodynamic load, ventricular configuration and oxygen- and substrates supply is basic to understanding cardiac function under physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and heart failure) conditions. Moreover, cardiac energetics should be an important consideration in the choice and application of drugs especially in the case of vasodilators, inotropic agents and in cardioprotective measures. Only by considering energetics at the subcellular, cellular, and whole-heart level we can arrive at a better understanding of cardiac performance and ultimately better clinical judgement and drug therapy. Quantification of myocardial energetics will also help to determine the optimal time for surgical interventions such as valvular replacement or aneurysm resection. The present volume is the outcome of an international symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will certainly help bridge the existing gap between basic research involving isolated structures and that involving the whole organ, on the one hand, and render the results derived from basic research applicable to clinical problems, on the other hand.

The Sinatra Solution

The Sinatra Solution
Author: Stephen T. Sinatra
Publsiher: Basic Health Publications, Inc.
Total Pages: 253
Release: 2007-10
ISBN 10: 9781591202165
ISBN 13: 1591202167
Language: EN, FR, DE, ES & NL

The Sinatra Solution Book Review:

A board-certified cardiologist discusses the importance of energy metabolism on cardiovascular health and the positive impact three energy-supplying nutrients--CoQ10, Carnitine, and Ribose--have on the cardiovascular system.

Inflammation in Heart Failure

Inflammation in Heart Failure
Author: Matthijs Blankesteijn,Raffaele Altara
Publsiher: Academic Press
Total Pages: 220
Release: 2014-12-05
ISBN 10: 0128004851
ISBN 13: 9780128004852
Language: EN, FR, DE, ES & NL

Inflammation in Heart Failure Book Review:

Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases

Oxford Textbook of Heart Failure

Oxford Textbook of Heart Failure
Author: Theresa A. McDonagh,Roy S. Gardner,Andrew L. Clark,Henry Dargie
Publsiher: Oxford University Press
Total Pages: 641
Release: 2011-07-14
ISBN 10: 0199577722
ISBN 13: 9780199577729
Language: EN, FR, DE, ES & NL

Oxford Textbook of Heart Failure Book Review:

The Oxford Textbook of Heart Failure takes the reader from an understanding of the basic mechanisms of heart failure, through to an appreciation of the complexities of heart failure management and the improvements possible with good treatment. Written by internationally renowned leaders in the field, this definitive textbook comprehensively covers all aspects necessary to manage a patient with heart failure, and is essential reading for consultant cardiologists, those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses. The online version of the Oxford Textbook of Heart Failure contains the full text of the print edition (which can be browsed by the contents list or searched), links from references in the text to external sources (via PubMed, ISI, and CrossRef), and over 300 figures and illustrations from the print edition, downloadable into PowerPoint.

Clinical Bioenergetics

Clinical Bioenergetics
Author: Sergej M. Ostojic
Publsiher: Academic Press
Total Pages: 716
Release: 2020-11-12
ISBN 10: 0128227729
ISBN 13: 9780128227725
Language: EN, FR, DE, ES & NL

Clinical Bioenergetics Book Review:

Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders Features chapter contributions from international leaders in translational bioenergetics research and clinical practice

Biophysics of the Failing Heart

Biophysics of the Failing Heart
Author: R. John Solaro,Jil C. Tardiff
Publsiher: Springer Science & Business Media
Total Pages: 253
Release: 2013-08-13
ISBN 10: 146147678X
ISBN 13: 9781461476788
Language: EN, FR, DE, ES & NL

Biophysics of the Failing Heart Book Review:

Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.

Acute Heart Failure

Acute Heart Failure
Author: Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo
Publsiher: Springer Science & Business Media
Total Pages: 931
Release: 2009-12-24
ISBN 10: 9781846287824
ISBN 13: 1846287820
Language: EN, FR, DE, ES & NL

Acute Heart Failure Book Review:

For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.

Cellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease
Author: Monte Willis,Jonathon W. Homeister,James R. Stone
Publsiher: Academic Press
Total Pages: 338
Release: 2013-12-23
ISBN 10: 0124055257
ISBN 13: 9780124055254
Language: EN, FR, DE, ES & NL

Cellular and Molecular Pathobiology of Cardiovascular Disease Book Review:

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Heart Failure A Companion to Braunwald s Heart Disease E Book

Heart Failure  A Companion to Braunwald s Heart Disease E Book
Author: G. Michael Felker,Douglas L. Mann
Publsiher: Elsevier Health Sciences
Total Pages: 784
Release: 2019-02-06
ISBN 10: 0323609880
ISBN 13: 9780323609883
Language: EN, FR, DE, ES & NL

Heart Failure A Companion to Braunwald s Heart Disease E Book Book Review:

Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).

Metabolic Syndrome and Psychiatric Illness Interactions Pathophysiology Assessment and Treatment

Metabolic Syndrome and Psychiatric Illness  Interactions  Pathophysiology  Assessment and Treatment
Author: Scott D Mendelson
Publsiher: Academic Press
Total Pages: 224
Release: 2007-12-19
ISBN 10: 9780080556529
ISBN 13: 0080556523
Language: EN, FR, DE, ES & NL

Metabolic Syndrome and Psychiatric Illness Interactions Pathophysiology Assessment and Treatment Book Review:

Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome). This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome. The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise. The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications. Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.

Cardiomyopathies

Cardiomyopathies
Author: Kaan Kırali
Publsiher: BoD – Books on Demand
Total Pages: 470
Release: 2017-04-12
ISBN 10: 9535130390
ISBN 13: 9789535130390
Language: EN, FR, DE, ES & NL

Cardiomyopathies Book Review:

Cardiomyopathies are the most featured cardiac pathologies in the twenty-first century, that threaten public health and burden healthcare budgets. This book is composed of the main topics on pathophysiology, general forms and specific types of cardiomyopathies and it also introduces new research in the field. Specific forms with or without genetic inheritance are discussed separately to attract the readers' attention on these topics. Well-known medical follow-up strategies occur ineffective at the end-stage heart failure, however, new surgical approaches can be an alternative for these patients to get a chance at the last crossroad and to improve their life quality and survival and also to gain or prolong time until possible heart transplantation.

Handbook of Cardiac Anatomy Physiology and Devices

Handbook of Cardiac Anatomy  Physiology  and Devices
Author: Paul A. Iaizzo
Publsiher: Springer
Total Pages: 817
Release: 2015-11-13
ISBN 10: 331919464X
ISBN 13: 9783319194646
Language: EN, FR, DE, ES & NL

Handbook of Cardiac Anatomy Physiology and Devices Book Review:

This book covers the latest information on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Key chapters address animal models for cardiac research, cardiac mapping systems, heart-valve disease and genomics-based tools and technology. Once again, a companion of supplementary videos offer unique insights into the working heart that enhance the understanding of key points within the text. Comprehensive and state-of-the art, the Handbook of Cardiac Anatomy, Physiology and Devices, Third Edition provides clinicians and biomedical engineers alike with the authoritative information and background they need to work on and implement tomorrow’s generation of life-saving cardiac devices.

Cardiotoxicity

Cardiotoxicity
Author: Wenyong Tan
Publsiher: BoD – Books on Demand
Total Pages: 162
Release: 2018-11-14
ISBN 10: 1789842379
ISBN 13: 9781789842371
Language: EN, FR, DE, ES & NL

Cardiotoxicity Book Review:

Cardiotoxicity may be caused by radiotherapy and/or anticancer agents for many malignancies, adverse effects of some drugs in the context of medical intervention or heavy metal intake, especially during the anticancer therapy. This book intends to bring forward the recent development in toxicities from cancer treatment. It updates the possible mechanisms of cardiotoxicities of some anticancer agents and the suggested prevention and treatment strategies. This book contains many valuable contributions from the researchers in oncology and cardiology as well as the clinicians who are experts in this field.

Post Genomic Cardiology

Post Genomic Cardiology
Author: José Marín-García
Publsiher: Academic Press
Total Pages: 688
Release: 2011-04-28
ISBN 10: 9780080554549
ISBN 13: 0080554547
Language: EN, FR, DE, ES & NL

Post Genomic Cardiology Book Review:

Recent advances in molecular and cellular biology have markedly changed our understanding of the heart, and this is having tremendous ramifications for the clinician. This unique reference offers a comprehensive and critical evaluation of this contribution in the field of cardiovascular molecular medicine providing the reader with a sense of new directions in which molecular medicine might be applied. It begins with a detailed primer that makes readily accessible recent molecular, genetic and cellular techniques. Rounding out the coverage of this exciting field are critical and comprenhesive discussions on the use of molecular, genetic and cellular techniques used to identify the etiology and pathophysiology of specific cardiac diseases. * Discusses diagnostic and therapeutic options available not only in the adult and aging individuals but also in infants/children * Numerous illustrations and flow-charts * Explans cutting-edge molecular techniques, including analysis of mitochondria, their role in cardiac dysfunction and updated analysis of Cardioprotection and Metabolic Syndrome * Presentation of recent translational studies for the treatment of cardiovascular diseases is included (e.g., gene therapy, pharmacological treatments and stem cell transplantation)