Emerging Concepts in Ribosome Structure Biogenesis and Function

Emerging Concepts in Ribosome Structure  Biogenesis  and Function
Author: Vijay Kumar
Publsiher: Academic Press
Total Pages: 296
Release: 2021-09-25
ISBN 10: 0128167343
ISBN 13: 9780128167342
Language: EN, FR, DE, ES & NL

Emerging Concepts in Ribosome Structure Biogenesis and Function Book Review:

Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research. Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth. Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases. Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations.

Translational Control

Translational Control
Author: John W. B. Hershey,Michael Mathews,Nahum Sonenberg,Cold Spring Harbor Laboratory
Publsiher: Unknown
Total Pages: 794
Release: 1996
ISBN 10: 9780879694586
ISBN 13: 0879694580
Language: EN, FR, DE, ES & NL

Translational Control Book Review:

A comprehensive account of recent research in translational control and the molecular mechanisms involved, focusing on the numerous control mechanisms observed in eukaryotes. Subjects include basic mechanisms; the role of phosphorylation; regulation by trans-acting proteins; effects of viral infection; and mRNA stability. Other topics include translational control mediated by upstream AUG codons; a comparative view of initiation site selection mechanisms; and genetics of mitochondrial translation. For researchers with interests in gene expression, RNA biology, and protein synthesis. Annotation copyright by Book News, Inc., Portland, OR

The Eukaryotic Ribosome

The Eukaryotic Ribosome
Author: H. Bielka
Publsiher: Springer
Total Pages: 338
Release: 2011-11-23
ISBN 10: 9783642682742
ISBN 13: 364268274X
Language: EN, FR, DE, ES & NL

The Eukaryotic Ribosome Book Review:

Contents References 11 II. A short historical survey 13 References 16 III. Ribosomes within the cell 20 1. Proportion of ribosomes in tissues 21 2. Free and membrane-bound ribo- mes 22 3. Ribosomes in nucleoli 26 4. Structure of polysomes in the cell 26 5. Ribosomal crystals 33 6. References 33 IV. Some general properties of ribosomes 41 1. Physical characteristics 41 2. Chemical characteristics 43 3. References 44 V. Morphology of ribosomes and poly somes 47 1. Electron microscopy 47 a) The small ribosomal subunit 48 b) The large ribosomal subunit 48 c) The monomeric ribosome 52 d) Three-dimensional models 54 e) Polysomes 55 2. Small-angle X-ray scattering 55 a) The monomeric ribosome 56 b) Polysomes 57 3. References 57 VI. Chemical components 61 1. Ribosomal proteins 61 a) Electrophoretic separation and num ber 61 b) Preparation of single ribosomal pro teins 67 c) Molecular weights 68 d) Amino acid composition and amino acid sequences 71 e) Stoichiometry 71 f) Posttranslational modifications 72 g) Comparison of ribosomal proteins of different tissues 73 h) Species specificities and evolution 74 i) Ribosomal proteins of mitochondria and chloroplasts 75 k) Ribosomal mutants with altered pro teins 75 5 3. Formation of preribosomal 2. Phosphorylation of ribosomal prote particles 139 ins 76 4. References 141 a) In vitro phosphorylation and de phosphorylation 76 VIII. Dissociation - reassociation processes b) In vivo phosphorylation 77 of ribosomal particles 151 c) Phosphorylation of ribosomal pro tein S 6 78 1.

RNA Helicases

RNA Helicases
Author: Anonim
Publsiher: Academic Press
Total Pages: 584
Release: 2012-11-13
ISBN 10: 0123972299
ISBN 13: 9780123972293
Language: EN, FR, DE, ES & NL

RNA Helicases Book Review:

This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

The Ribosome

The Ribosome
Author: Anonim
Publsiher: CSHL Press
Total Pages: 634
Release: 2001
ISBN 10: 9780879696207
ISBN 13: 0879696206
Language: EN, FR, DE, ES & NL

The Ribosome Book Review:

Archaeal Ribosomes Biogenesis Structure and Function

Archaeal Ribosomes  Biogenesis  Structure and Function
Author: Paola Londei,Anna La Teana,Sébastien Ferreira-Cerca
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-01-24
ISBN 10: 2889741419
ISBN 13: 9782889741410
Language: EN, FR, DE, ES & NL

Archaeal Ribosomes Biogenesis Structure and Function Book Review:

The Nucleolus

The Nucleolus
Author: Mark O. J. Olson
Publsiher: Springer Science & Business Media
Total Pages: 414
Release: 2011-09-15
ISBN 10: 1461405149
ISBN 13: 9781461405146
Language: EN, FR, DE, ES & NL

The Nucleolus Book Review:

Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Neural Crest Induction and Differentiation

Neural Crest Induction and Differentiation
Author: Jean-Pierre Saint-Jeannet
Publsiher: Springer Science & Business Media
Total Pages: 248
Release: 2007-08-10
ISBN 10: 0387469540
ISBN 13: 9780387469546
Language: EN, FR, DE, ES & NL

Neural Crest Induction and Differentiation Book Review:

Written by an international panel of recognized leaders in the field, Neural Crest Induction and Differentiation discusses all aspects of modern neural crest biology from its evolutionary significance to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function. Abundant color figures enhance the text providing clear and attractive illustrations of central issues and concepts.

Proteins of the Nucleolus

Proteins of the Nucleolus
Author: Danton H O'Day,Andrew Catalano
Publsiher: Springer Science & Business Media
Total Pages: 371
Release: 2013-02-26
ISBN 10: 9400758189
ISBN 13: 9789400758186
Language: EN, FR, DE, ES & NL

Proteins of the Nucleolus Book Review:

This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells. The goal of this work is to provide special insight into the nucleolus of the past, present and future, as well its regulation, translocation, and biomedical function. A multitude of topics are introduced and discussed in detail, including nucleologenesis, nucleolar architecture, nucleolar targeting, retention, anchoring, translocation, and the relationship between the nucleolus and cancer. This book also brings together work from several different species, from human to Drosophila to Dictyostelium and other eukaryotic microbes. The final chapter summarizes some of the issues brought up in the various chapters with a view to future research. This book supports the continued emergence of the nucleolus as a dynamic intranuclear region that oversees a vast diversity of events.

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 135
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology
Author: Kwang W. Jeon
Publsiher: Academic Press
Total Pages: 192
Release: 2010-11-19
ISBN 10: 9780123812537
ISBN 13: 0123812534
Language: EN, FR, DE, ES & NL

International Review of Cell and Molecular Biology Book Review:

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2008: 4.935. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists

New Concepts of Antiviral Therapy

New Concepts of Antiviral Therapy
Author: Elke Bogner,Andreas Holzenburg
Publsiher: Springer Science & Business Media
Total Pages: 538
Release: 2007-01-31
ISBN 10: 0387310479
ISBN 13: 9780387310473
Language: EN, FR, DE, ES & NL

New Concepts of Antiviral Therapy Book Review:

Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.

Emerging Cellular Stress Sensors in Neurological Disorders Closing in on the Nucleolus and the Primary Cilium

Emerging Cellular Stress Sensors in Neurological Disorders  Closing in on the Nucleolus and the Primary Cilium
Author: Rosanna Parlato,Kerry Lee Tucker
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-05-21
ISBN 10: 2889637115
ISBN 13: 9782889637119
Language: EN, FR, DE, ES & NL

Emerging Cellular Stress Sensors in Neurological Disorders Closing in on the Nucleolus and the Primary Cilium Book Review:

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1978
ISBN 10: 1928374650XXX
ISBN 13: MINN:30000008789962
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Ribosomes Structure Function and Dynamics

Ribosomes Structure  Function  and Dynamics
Author: Marina V. Rodnina,Wolfgang Wintermeyer,Rachel Green
Publsiher: Springer Science & Business Media
Total Pages: 442
Release: 2011-12-10
ISBN 10: 3709102154
ISBN 13: 9783709102152
Language: EN, FR, DE, ES & NL

Ribosomes Structure Function and Dynamics Book Review:

The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

Protein Synthesis and Ribosome Structure

Protein Synthesis and Ribosome Structure
Author: Knud H. Nierhaus,Daniel Wilson
Publsiher: John Wiley & Sons
Total Pages: 597
Release: 2009-07-10
ISBN 10: 3527616381
ISBN 13: 9783527616381
Language: EN, FR, DE, ES & NL

Protein Synthesis and Ribosome Structure Book Review:

Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.

The Ribosome

The Ribosome
Author: Aleksandr S. Spirin,Lidija P. Gavrilova
Publsiher: Springer Science & Business Media
Total Pages: 164
Release: 2012-12-06
ISBN 10: 3642884466
ISBN 13: 9783642884467
Language: EN, FR, DE, ES & NL

The Ribosome Book Review:

This monograph is neither a historical outline of the development of the concepts of protein biosynthesis and the structure and functions of the ribosomes, nor an exhaustive survey of the literature on these questions. The monograph is based upon an analysis of the modern trends in this field. The purpose of the monograph was to formulate more or less generalized representations of the structure and" function of the ribosome, as we envision it at the present day. It may be that this attempt is premature for a number of reasons, and the concepts outlined here will very soon be revised. Nonetheless, despite this risk, we believe it to be advisable to undertake this attempt for the following reasons: firstly, the undertaken analysis could aid in the comprehension of the substantial mass of extremely scattered experimental data on the ribosomes presently available; secondly, in any event, even if most of the concepts outlined rapidly become obselete, they can still serve as a stimulus for a whole series of experiments; and thirdly, we hope that some of the concepts outlined will still remain essentially correct and relatively stable. In view of the aforementioned, we should make the following reservations. First of all, we made no attempt to cite all the literature on the problems discussed, but considered it sufficient to illustrate the various premises with one or several sample references.

BIOS Instant Notes in Molecular Biology

BIOS Instant Notes in Molecular Biology
Author: Alexander McLennan,Andy Bates,Phil Turner,Michael White
Publsiher: Taylor & Francis
Total Pages: 392
Release: 2012-11-27
ISBN 10: 1136160418
ISBN 13: 9781136160417
Language: EN, FR, DE, ES & NL

BIOS Instant Notes in Molecular Biology Book Review:

Instant Notes in Molecular Biology, Fourth Edition is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts−an ideal revision checklist−followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams.

The Biogenesis of Cellular Organelles

The Biogenesis of Cellular Organelles
Author: Chris Mullins
Publsiher: Springer Science & Business Media
Total Pages: 181
Release: 2007-03-06
ISBN 10: 0387268677
ISBN 13: 9780387268675
Language: EN, FR, DE, ES & NL

The Biogenesis of Cellular Organelles Book Review:

The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.

Electron Microscopy

Electron Microscopy
Author: John J. Bozzola,Lonnie Dee Russell
Publsiher: Jones & Bartlett Learning
Total Pages: 670
Release: 1999
ISBN 10: 9780763701925
ISBN 13: 0763701920
Language: EN, FR, DE, ES & NL

Electron Microscopy Book Review:

Electron Microscopy covers all of the important aspects of electron microscopy for biologists, including theory of scanning and transmission, specimen preparation, digital imaging and image analysis, laboratory safety and interpretation of images. The text also contains a complete atlas of ultrastructure.