Electrophysiology Measurements for Studying Neural Interfaces

Electrophysiology Measurements for Studying Neural Interfaces
Author: Mohammad M. Aria
Publsiher: Academic Press
Total Pages: 178
Release: 2020-05-15
ISBN 10: 0128170719
ISBN 13: 9780128170717
Language: EN, FR, DE, ES & NL

Electrophysiology Measurements for Studying Neural Interfaces Book Review:

Electrophysiology Measurements for Studying Neural Interfaces helps readers to choose a proper cell line and set-up for studying different bio-electronic interfaces before delving into the electrophysiology techniques available. Therefore, this book details the materials and devices needed for different types of neural stimulation such as photoelectrical and photothermal stimulations. Also, modern techniques like optical electrophysiology and calcium imaging in this book provides readers with more available approaches to monitor neural activities in addition to whole-cell patch-clamp technology. Details steps of an electrophysiology project from start to finish for graduate students employing the technique in their research Includes sample electrophysiological studies with multiple cell lines (PC12, N2a, NG108, SHSY, and embryonic stem cell lines) to facilitate research Features data analysis of electrophysiology results from various relevant experiments and cell culture tips

Guide to Research Techniques in Neuroscience

Guide to Research Techniques in Neuroscience
Author: Matt Carter,Jennifer C. Shieh
Publsiher: Academic Press
Total Pages: 418
Release: 2015-02-27
ISBN 10: 0128005971
ISBN 13: 9780128005972
Language: EN, FR, DE, ES & NL

Guide to Research Techniques in Neuroscience Book Review:

Neuroscience is, by definition, a multidisciplinary field: some scientists study genes and proteins at the molecular level while others study neural circuitry using electrophysiology and high-resolution optics. A single topic can be studied using techniques from genetics, imaging, biochemistry, or electrophysiology. Therefore, it can be daunting for young scientists or anyone new to neuroscience to learn how to read the primary literature and develop their own experiments. This volume addresses that gap, gathering multidisciplinary knowledge and providing tools for understanding the neuroscience techniques that are essential to the field, and allowing the reader to design experiments in a variety of neuroscience disciplines. Written to provide a "hands-on" approach for graduate students, postdocs, or anyone new to the neurosciences Techniques within one field are compared, allowing readers to select the best techniques for their own work Includes key articles, books, and protocols for additional detailed study Data analysis boxes in each chapter help with data interpretation and offer guidelines on how best to represent results Walk-through boxes guide readers step-by-step through experiments

Neural Interface Engineering for Electrophysiology Application

Neural Interface Engineering for Electrophysiology Application
Author: Hyungsoo Kim
Publsiher: Unknown
Total Pages: 69
Release: 2018
ISBN 10:
ISBN 13: OCLC:1077771842
Language: EN, FR, DE, ES & NL

Neural Interface Engineering for Electrophysiology Application Book Review:

The brain is a wondrous and complex organ, a biological machine forged by the evolutionary forces of nature. The human brain contains 100 billion neurons and each neuron is connected by synapses to several thousand other neurons. Connected neurons work together to produce perceptions and sensations, memories and emotions, physical movements and abstract constructs. The neurons communicate by means of electricity that passes along and across their cellular membrane. Much of what is known about brain physiology is through the measurement of this electrical activity, either with relatively large electrodes placed on the scalp or tiny microelectrodes inserted into the brain tissue itself. At the finer end of this scale, scientists have discovered much about the way individual neurons extract sensory information, adapt their behavior to form a memory, and convey signals to other regions of the brain. However, it has long been recognized that the brain operates on a global scale, through the collective behavior and interaction of its neural units1. Information is processed in several regions of the brain simultaneously, and the activity of neighboring neurons can be quite different from one another. By one analogy, the attempt to assess brain function by observing a single neuron is like looking at the output of one transistor to learn how a computer works. Thus, the recording of many neurons simultaneously is necessary to truly reveal the mechanisms of the brain2. In recent decades, a variety of recording techniques have been developed for a neural interface such as electroencephalography (EEG), magneto-encephalography (MEG), electrocorticography (ECOG), local field potential (LFP) recordings, micro-electrode array (MEA) and peripheral nerve interfaces (PNIs) to the micron-level precision required for multi-neuron recording. Their small size allows many recording channels to be placed onto one device. One of the goals of neural interface research is to create a seamless connection between the nervous system and the neuroprostheses either by stimulating or by recording from neural tissue to restore or substitute function for individuals with neurological deficits or disabilities. Hence, significant amount of scientific and technological efforts have been devoted to develop neural interfaces that link the nervous system with robotic prosthetic devices. The creation of a novel neural interface is essential for developing the full potential of advanced prosthesis technology required to replace lost limbs. Additionally, meticulous studies of a single neuron and between neurons utilizing the neural interface technology should be made to elucidate fundamental biological phenomena such as cellular processes and heterogeneities. Particularly, an electrophysiological study of neural networks can provide knowledge to unravel the functions of brain. When fundamental research about molecular and cellular mechanisms of a single neuron and electrophysiological studies using neural interfaces on both the central and peripheral nervous systems are done together, it has a synergistic effect on neural interface technology. The research and methodologies described in this dissertation stem from our research group's efforts to optimize the design and expand the applications of neural interfaces. The dissertation is organized into four chapters. Chapter 1 is a review of neural interface technology and study of neural signal detection. This chapter provides a foundation for Chapter 2 and 3. Chapter 2 is a study of a neural interface as cellular level research. We present an advanced single-neuronal cell culture and monitoring platform using a fully transparent microfluidic dielectrophoresis (DEP) device for unabated monitoring of neuronal cell development and function. The device is mounted inside a sealed incubation chamber to ensure improved homeostatic conditions and reduced contamination risk. Consequently, we successfully trap and culture single neurons on a desired location and monitor their growth process over a week. Chapter 3 deals with the specific application of PNIs to the sciatic nerve of a rat as a nervous system-level research. We developed novel devices, "cuff and sieve electrodes" (CASE), that integrate microfabricated cuff and sieve electrodes capable of broad (via cuff) and precise (via sieve) selectivity to increase the strengths and simultaneously decrease the weaknesses of traditional electrode designs. We performed terminal device implantations in a rat sciatic transection and repair model to test the capacity of the CASE interface. The sciatic nerve was stimulated by the sieve portion of the CASE electrode and somatosensory evoked potentials were recorded from the somatosensory cortex via micro-eletrocorticography. The ability to elicit cortical responses from sciatic nerve stimulation demonstrates the proof of concept for both the implantation and chronic monitoring of CASE interfaces for innovative prosthetic control. Lastly, in Chapter 4, I will identify areas in which further investigation is needed and propose future directions of both cellular and system-level neural interface.

Optical Neural Interfaces

Optical Neural Interfaces
Author: Massimo De Vittorio,Ferruccio Pisanello,John A. Assad
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-11-01
ISBN 10: 2889630803
ISBN 13: 9782889630806
Language: EN, FR, DE, ES & NL

Optical Neural Interfaces Book Review:

Acta oto rhino laryngologica Belgica

Acta oto rhino laryngologica Belgica
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1998
ISBN 10:
ISBN 13: UCLA:L0078662673
Language: EN, FR, DE, ES & NL

Acta oto rhino laryngologica Belgica Book Review:

Closing the Loop Around Neural Systems

Closing the Loop Around Neural Systems
Author: Steve M Potter,Eberhard E Fetz,Ahmed El Hady
Publsiher: Frontiers Media SA
Total Pages: 423
Release: 2014-12-03
ISBN 10: 288919356X
ISBN 13: 9782889193561
Language: EN, FR, DE, ES & NL

Closing the Loop Around Neural Systems Book Review:

Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1986
ISBN 10:
ISBN 13: STANFORD:36105113763689
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry

Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry
Author: Matthew Douglas Johnson
Publsiher: Unknown
Total Pages: 329
Release: 2006
ISBN 10:
ISBN 13: UOM:39015069227943
Language: EN, FR, DE, ES & NL

Spatiotemporal Neural Interface Dynamics Elucidated with Multi Channel Electrochemistry Book Review:

Optogenetics

Optogenetics
Author: Krishnarao Appasani
Publsiher: Cambridge University Press
Total Pages: 544
Release: 2017-04-27
ISBN 10: 1107053013
ISBN 13: 9781107053014
Language: EN, FR, DE, ES & NL

Optogenetics Book Review:

Discovered little more than a decade ago, optogenetics - a revolutionary technique combining genetic and optical methods to observe and control the function of neurons - is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson's disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.

Platform Development for In vitro Study of Magnetically Induced Excitation of Neural Tissue

Platform Development for In vitro Study of Magnetically Induced Excitation of Neural Tissue
Author: Eric J. Basham
Publsiher: Unknown
Total Pages: 442
Release: 2010
ISBN 10:
ISBN 13: UCAL:X84374
Language: EN, FR, DE, ES & NL

Platform Development for In vitro Study of Magnetically Induced Excitation of Neural Tissue Book Review:

The Synaptic Organization of the Brain

The Synaptic Organization of the Brain
Author: Gordon M. Shepherd
Publsiher: Oxford University Press
Total Pages: 719
Release: 2004
ISBN 10: 019515956X
ISBN 13: 9780195159561
Language: EN, FR, DE, ES & NL

The Synaptic Organization of the Brain Book Review:

This is a thorough revision of the standard text on local circuits in the different regions of the brain. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods.

Electrophysiological Analysis of Synaptic Transmission

Electrophysiological Analysis of Synaptic Transmission
Author: Nicholas Graziane,Yan Dong
Publsiher: Unknown
Total Pages: 263
Release: 2016
ISBN 10: 9781493932740
ISBN 13: 1493932748
Language: EN, FR, DE, ES & NL

Electrophysiological Analysis of Synaptic Transmission Book Review:

Electrophysiology is one of the finest approaches capable of detecting and analyzing electrical events in the brain. However, like all other experimental approaches, it has its limitations. This book was created to serve as a guide for those endeavoring to understand the function of electrophysiology and its underlying components: neurons, neural systems, and the brain. It introduces and highlights important topics in the field of electrophysiology, while also extending these topics to practical electrophysiological approaches through the perspective of the two authors. This book is ideal for graduate students or junior postdoctoral fellows interested in starting a journey in synaptic neuroscience.

A Report for the Year on the Research and Other Activities of the Division of Biology

A Report for the Year     on the Research and Other Activities of the Division of Biology
Author: California Institute of Technology. Division of Biology
Publsiher: Unknown
Total Pages: 329
Release: 1991
ISBN 10:
ISBN 13: STANFORD:36105016177938
Language: EN, FR, DE, ES & NL

A Report for the Year on the Research and Other Activities of the Division of Biology Book Review:

Electrophysiological Recording Techniques

Electrophysiological Recording Techniques
Author: Robert P. Vertes,Robert W. Stackman, Jr.
Publsiher: Humana Press
Total Pages: 284
Release: 2010-11-22
ISBN 10: 9781603272018
ISBN 13: 1603272011
Language: EN, FR, DE, ES & NL

Electrophysiological Recording Techniques Book Review:

Applying neurophysiological methods to the study of brain-behavior relationships proved to be a major advance in the early days of neuroscience research. Considerable technological progress has been made very recently, and the impact on modern neuroscience will be invaluable. In Electrophysiological Recording Techniques, experts in the field present a current view of the widespread application of electrophysiological methods to the study of the brain and to the problem of brain-behavior relationships. The book has been organized to display the range of modern neurophysiological methods ranging from the recordings of single neurons and neuronal ensembles to recordings of field potentials within discrete brain regions and across multiple brain areas. Many of the chapters also address the major challenge of applying the appropriate methods to analyze and interpret neurophysiological recording data. As a volume in the popular Neuromethods series, the chapters provide authoritative reviews of many commonly used approaches in the field today in both the basic research level and in clinical settings. Practical and up-to-date, Electrophysiological Recording Techniques serves as a key reference volume for researchers working in this ever-changing and vital field.

Scientific and Technical Aerospace Reports

Scientific and Technical Aerospace Reports
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1975
ISBN 10:
ISBN 13: UVA:X004872598
Language: EN, FR, DE, ES & NL

Scientific and Technical Aerospace Reports Book Review:

Single Channel Recording

Single Channel Recording
Author: Bert Sakmann,Erwin Neher
Publsiher: Springer Science & Business Media
Total Pages: 700
Release: 2009-10-03
ISBN 10: 1441912290
ISBN 13: 9781441912299
Language: EN, FR, DE, ES & NL

Single Channel Recording Book Review:

Edited by the 1991 winners of the Nobel Prize in Physiology or Medicine, this Second Edition includes new chapters covering such applications as capacitance measurements; single-cell PCR measurements; whole-cell recording from brain slices in combination with imaging techniques; atomic force microscopy of cells and membranes attached to glass pipettes; and patch clamping.

Handbook of Neural Activity Measurement

Handbook of Neural Activity Measurement
Author: Romain Brette,Alain Destexhe
Publsiher: Cambridge University Press
Total Pages: 479
Release: 2012-09-06
ISBN 10: 0521516226
ISBN 13: 9780521516228
Language: EN, FR, DE, ES & NL

Handbook of Neural Activity Measurement Book Review:

Underlying principles of the various techniques are explained, enabling neuroscientists to extract meaningful information from their measurements.

Network Neuroscience

Network Neuroscience
Author: Flavio Fröhlich
Publsiher: Academic Press
Total Pages: 482
Release: 2016-09-20
ISBN 10: 0128015861
ISBN 13: 9780128015865
Language: EN, FR, DE, ES & NL

Network Neuroscience Book Review:

Studying brain networks has become a truly interdisciplinary endeavor, attracting students and seasoned researchers alike from a wide variety of academic backgrounds. What has been lacking is an introductory textbook that brings together the different fields and provides a gentle introduction to the major concepts and findings in the emerging field of network neuroscience. Network Neuroscience is a one-stop-shop that is of equal use to the neurobiologist, who is interested in understanding the quantitative methods employed in network neuroscience, and to the physicist or engineer, who is interested in neuroscience applications of mathematical and engineering tools. The book spans 27 chapters that cover everything from individual cells all the way to complex network disorders such as depression and autism spectrum disorders. An additional 12 toolboxes provide the necessary background for making network neuroscience accessible independent of the reader’s background. Dr. Flavio Frohlich (www.networkneuroscientist.org) wrote this book based on his experience of mentoring dozens of trainees in the Frohlich Lab, from undergraduate students to senior researchers. The Frohlich lab (www.frohlichlab.org) pursues a unique and integrated vision that combines computer simulations, animal model studies, human studies, and clinical trials with the goal of developing novel brain stimulation treatments for psychiatric disorders. The book is based on a course he teaches at UNC that has attracted trainees from many different departments, including neuroscience, biomedical engineering, psychology, cell biology, physiology, neurology, and psychiatry. Dr. Frohlich has consistently received rave reviews for his teaching. With this book he hopes to make his integrated view of neuroscience available to trainees and researchers on a global scale. His goal is to make the book the training manual for the next generation of (network) neuroscientists, who will be fusing biology, engineering, and medicine to unravel the big questions about the brain and to revolutionize psychiatry and neurology. Easy-to-read, comprehensive introduction to the emerging field of network neuroscience Includes 27 chapters packed with information on topics from single neurons to complex network disorders such as depression and autism Features 12 toolboxes serve as primers to provide essential background knowledge in the fields of biology, mathematics, engineering, and physics

Neurobiology of Motor Control

Neurobiology of Motor Control
Author: Scott L. Hooper,Ansgar Büschges
Publsiher: John Wiley & Sons
Total Pages: 512
Release: 2017-06-12
ISBN 10: 1118873343
ISBN 13: 9781118873342
Language: EN, FR, DE, ES & NL

Neurobiology of Motor Control Book Review:

A multi-disciplinary look at the current state of knowledge regarding motor control and movement—from molecular biology to robotics The last two decades have seen a dramatic increase in the number of sophisticated tools and methodologies for exploring motor control and movement. Multi-unit recordings, molecular neurogenetics, computer simulation, and new scientific approaches for studying how muscles and body anatomy transform motor neuron activity into movement have helped revolutionize the field. Neurobiology of Motor Control brings together contributions from an interdisciplinary group of experts to provide a review of the current state of knowledge about the initiation and execution of movement, as well as the latest methods and tools for investigating them. The book ranges from the findings of basic scientists studying model organisms such as mollusks and Drosophila, to biomedical researchers investigating vertebrate motor production to neuroengineers working to develop robotic and smart prostheses technologies. Following foundational chapters on current molecular biological techniques, neuronal ensemble recording, and computer simulation, it explores a broad range of related topics, including the evolution of motor systems, directed targeted movements, plasticity and learning, and robotics. Explores motor control and movement in a wide variety of organisms, from simple invertebrates to human beings Offers concise summaries of motor control systems across a variety of animals and movement types Explores an array of tools and methodologies, including electrophysiological techniques, neurogenic and molecular techniques, large ensemble recordings, and computational methods Considers unresolved questions and how current scientific advances may be used to solve them going forward Written specifically to encourage interdisciplinary understanding and collaboration, and offering the most wide-ranging, timely, and comprehensive look at the science of motor control and movement currently available, Neurobiology of Motor Control is a must-read for all who study movement production and the neurobiological basis of movement—from molecular biologists to roboticists.

Indwelling Neural Implants

Indwelling Neural Implants
Author: William M. Reichert
Publsiher: CRC Press
Total Pages: 296
Release: 2007-12-17
ISBN 10: 9781420009309
ISBN 13: 1420009303
Language: EN, FR, DE, ES & NL

Indwelling Neural Implants Book Review:

Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. This seminal work provides researchers with an up-to-date account of the progress in the field that they can build upon to bring us closer to realizing the full value of neural implants in combating otherwise intractable human health problems.