Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
Author: Kenneth K.W. To,William C.S. Cho
Publsiher: Academic Press
Total Pages: 458
Release: 2020-07-29
ISBN 10: 0128199032
ISBN 13: 9780128199039
Language: EN, FR, DE, ES & NL

Drug Repurposing in Cancer Therapy Book Review:

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
Author: Kenneth K.W. To,William C.S. Cho
Publsiher: Academic Press
Total Pages: 458
Release: 2020-08-17
ISBN 10: 0128196688
ISBN 13: 9780128196687
Language: EN, FR, DE, ES & NL

Drug Repurposing in Cancer Therapy Book Review:

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Repurposed Drugs Targeting Cancer Signaling Pathways Clinical Insights to Improve Oncologic Therapies

Repurposed Drugs Targeting Cancer Signaling Pathways  Clinical Insights to Improve Oncologic Therapies
Author: Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-08-26
ISBN 10: 2889712397
ISBN 13: 9782889712397
Language: EN, FR, DE, ES & NL

Repurposed Drugs Targeting Cancer Signaling Pathways Clinical Insights to Improve Oncologic Therapies Book Review:

Drug Repurposing

Drug Repurposing
Author: Farid A. Badria
Publsiher: BoD – Books on Demand
Total Pages: 234
Release: 2020-12-02
ISBN 10: 1839685204
ISBN 13: 9781839685200
Language: EN, FR, DE, ES & NL

Drug Repurposing Book Review:

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Conference on Drug Design and Discovery Technologies

Conference on Drug Design and Discovery Technologies
Author: Manikanta Murahari,Lakshmi Sundar,Soma Chaki,Vasanthanathan Poongavanam,Pritesh Bhat,Usha Y Nayak
Publsiher: Royal Society of Chemistry
Total Pages: 350
Release: 2019-11-20
ISBN 10: 1788018621
ISBN 13: 9781788018623
Language: EN, FR, DE, ES & NL

Conference on Drug Design and Discovery Technologies Book Review:

This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.

Metronomic Chemotherapy

Metronomic Chemotherapy
Author: Guido Bocci,Giulio Francia
Publsiher: Springer
Total Pages: 295
Release: 2014-09-04
ISBN 10: 3662436043
ISBN 13: 9783662436042
Language: EN, FR, DE, ES & NL

Metronomic Chemotherapy Book Review:

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Artificial Intelligence in Oncology Drug Discovery and Development

Artificial Intelligence in Oncology Drug Discovery and Development
Author: John Cassidy,Belle Taylor
Publsiher: BoD – Books on Demand
Total Pages: 192
Release: 2020-09-09
ISBN 10: 1789846897
ISBN 13: 9781789846898
Language: EN, FR, DE, ES & NL

Artificial Intelligence in Oncology Drug Discovery and Development Book Review:

There exists a profound conflict at the heart of oncology drug development. The efficiency of the drug development process is falling, leading to higher costs per approved drug, at the same time personalised medicine is limiting the target market of each new medicine. Even as the global economic burden of cancer increases, the current paradigm in drug development is unsustainable. In this book, we discuss the development of techniques in machine learning for improving the efficiency of oncology drug development and delivering cost-effective precision treatment. We consider how to structure data for drug repurposing and target identification, how to improve clinical trials and how patients may view artificial intelligence.

pH Interfering Agents as Chemosensitizers in Cancer Therapy

pH Interfering Agents as Chemosensitizers in Cancer Therapy
Author: Claudiu Supuran,Simone Carradori
Publsiher: Academic Press
Total Pages: 228
Release: 2020-09-15
ISBN 10: 0128209283
ISBN 13: 9780128209288
Language: EN, FR, DE, ES & NL

pH Interfering Agents as Chemosensitizers in Cancer Therapy Book Review:

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

Drug Repositioning Current Advances and Future Perspectives

Drug Repositioning  Current Advances and Future Perspectives
Author: Yuhei Nishimura,Hideaki Hara
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-01-11
ISBN 10: 288945696X
ISBN 13: 9782889456963
Language: EN, FR, DE, ES & NL

Drug Repositioning Current Advances and Future Perspectives Book Review:

Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

Metallo Drugs Development and Action of Anticancer Agents

Metallo Drugs  Development and Action of Anticancer Agents
Author: Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 588
Release: 2018-02-05
ISBN 10: 311047073X
ISBN 13: 9783110470734
Language: EN, FR, DE, ES & NL

Metallo Drugs Development and Action of Anticancer Agents Book Review:

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Natural Products and Cancer Drug Discovery

Natural Products and Cancer Drug Discovery
Author: Farid A. Badria
Publsiher: BoD – Books on Demand
Total Pages: 316
Release: 2017-07-05
ISBN 10: 9535133136
ISBN 13: 9789535133131
Language: EN, FR, DE, ES & NL

Natural Products and Cancer Drug Discovery Book Review:

This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.

Oxidative Stress

Oxidative Stress
Author: Canhua Huang,Yuanyuan Zhang
Publsiher: Springer Nature
Total Pages: 323
Release: 2021-05-27
ISBN 10: 981160522X
ISBN 13: 9789811605222
Language: EN, FR, DE, ES & NL

Oxidative Stress Book Review:

This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.

Phenotypic Drug Discovery

Phenotypic Drug Discovery
Author: Beverley Isherwood,Angelique Augustin
Publsiher: Royal Society of Chemistry
Total Pages: 272
Release: 2020-12-10
ISBN 10: 1839160799
ISBN 13: 9781839160790
Language: EN, FR, DE, ES & NL

Phenotypic Drug Discovery Book Review:

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.

Drug Repositioning

Drug Repositioning
Author: Michael J. Barratt,Donald E. Frail
Publsiher: John Wiley & Sons
Total Pages: 477
Release: 2012-05-29
ISBN 10: 0470878274
ISBN 13: 9780470878279
Language: EN, FR, DE, ES & NL

Drug Repositioning Book Review:

With Viagra the most famous example, drug repositioning has been growing in importance for pharmaceutical companies seeking to reinvigorate development pipelines. This book provides a broad overview of drug repositioning including the business reasons and unique opportunities and challenges. Its coverage also presents a number of current and emerging technologies that are being applied, along with relevant case studies, as well as neglected diseases to consider. Pharmaceutical researchers will learn how to use drug repositioning techniques to increase the lifespan and applications of their drugs, and also decrease both costs and development time.

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery
Author: Jens-Uwe Peters
Publsiher: John Wiley & Sons
Total Pages: 510
Release: 2012-03-13
ISBN 10: 0470590904
ISBN 13: 9780470590904
Language: EN, FR, DE, ES & NL

Polypharmacology in Drug Discovery Book Review:

"Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology"--Provided by publisher.

Colorectal Cancer

Colorectal Cancer
Author: Jindong Chen
Publsiher: BoD – Books on Demand
Total Pages: 128
Release: 2018-05-16
ISBN 10: 1789231000
ISBN 13: 9781789231007
Language: EN, FR, DE, ES & NL

Colorectal Cancer Book Review:

With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.

An Investigation Into Mechanisms of Action of Colchicine Zinc Acetate and Paracetemol Potential Candidates for Drug Repurposing in Head and Neck Cancer Therapy

An Investigation Into Mechanisms of Action of Colchicine  Zinc Acetate and Paracetemol   Potential Candidates for Drug Repurposing in Head and Neck Cancer Therapy
Author: Nadia Shakir
Publsiher: Unknown
Total Pages: 54
Release: 2014
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1181747583
Language: EN, FR, DE, ES & NL

An Investigation Into Mechanisms of Action of Colchicine Zinc Acetate and Paracetemol Potential Candidates for Drug Repurposing in Head and Neck Cancer Therapy Book Review:

Tyrosine Kinases as Druggable Targets in Cancer

Tyrosine Kinases as Druggable Targets in Cancer
Author: Huan Ren
Publsiher: BoD – Books on Demand
Total Pages: 134
Release: 2019-09-25
ISBN 10: 1789848083
ISBN 13: 9781789848083
Language: EN, FR, DE, ES & NL

Tyrosine Kinases as Druggable Targets in Cancer Book Review:

Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment.

The Evolution of Drug Discovery

The Evolution of Drug Discovery
Author: Enrique Ravina
Publsiher: John Wiley & Sons
Total Pages: 504
Release: 2011-01-11
ISBN 10: 3527326693
ISBN 13: 9783527326693
Language: EN, FR, DE, ES & NL

The Evolution of Drug Discovery Book Review:

Based on his profound knowledge of past and present paradigms in the development of medicines, the author takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people who discovered them, he brings abstract science to life in anecdotal form. The book is beautifully illustrated, containing historical photographs of drugs and their discoverers, and abounds with references to the primary literature, listing seminal publications alongside more modern reviews for readers seeking further details. For anyone with a more than superficial interest in the science of drugs: instructive and enjoyable for a broad audience of students, instructors and professionals in pharmacy, the pharmaceutical chemistry and related fields.

Drug Repurposing and Repositioning

Drug Repurposing and Repositioning
Author: Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
Publsiher: National Academies Press
Total Pages: 118
Release: 2014-08-08
ISBN 10: 0309302072
ISBN 13: 9780309302074
Language: EN, FR, DE, ES & NL

Drug Repurposing and Repositioning Book Review:

Drug development can be time-consuming and expensive. Recent estimates suggest that, on average, it takes 10 years and at least $1 billion to bring a drug to market. Given the time and expense of developing drugs de novo, pharmaceutical companies have become increasingly interested in finding new uses for existing drugs - a process referred to as drug repurposing or repositioning. Historically, drug repurposing has been largely an unintentional, serendipitous process that took place when a drug was found to have an offtarget effect or a previously unrecognized on-target effect that could be used for identifying a new indication. Perhaps the most recognizable example of such a successful repositioning effort is sildenafil. Originally developed as an anti-hypertensive, sildenafil, marketed as Viagra and under other trade names, has been repurposed for the treatment of erectile dysfunction and pulmonary arterial hypertension. Viagra generated more than $2 billion worldwide in 2012 and has recently been studied for the treatment of heart failure. Given the widespread interest in drug repurposing, the Roundtable on Translating Genomic-Based Research for Health of the Institute of Medicine hosted a workshop on June 24, 2013, in Washington, DC, to assess the current landscape of drug repurposing activities in industry, academia, and government. Stakeholders, including government officials, pharmaceutical company representatives, academic researchers, regulators, funders, and patients, were invited to present their perspectives and to participate in workshop discussions. Drug Repurposing and Repositioning is the summary of that workshop. This report examines enabling tools and technology for drug repurposing; evaluates the business models and economic incentives for pursuing a repurposing approach; and discusses how genomic and genetic research could be positioned to better enable a drug repurposing paradigm.