Drug Discovery Targeting Drug Resistant Bacteria

Drug Discovery Targeting Drug Resistant Bacteria
Author: Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publsiher: Academic Press
Total Pages: 432
Release: 2020-05-15
ISBN 10: 0128184817
ISBN 13: 9780128184813
Language: EN, FR, DE, ES & NL

Drug Discovery Targeting Drug Resistant Bacteria Book Review:

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Antibiotics and Bacterial Resistance

Antibiotics and Bacterial Resistance
Author: Wiley
Publsiher: John Wiley & Sons
Total Pages: 146
Release: 2013-01-14
ISBN 10: 1118580915
ISBN 13: 9781118580912
Language: EN, FR, DE, ES & NL

Antibiotics and Bacterial Resistance Book Review:

The need for novel antibiotics is greater now than perhaps anytime since the pre-antibiotic era. Indeed, the recent collapse ofmany pharmaceutical antibacterial groups, combined with theemergence of hypervirulent and pan-antibiotic-resistant bacteriahas severely compromised infection treatment options and led todramatic increases in the incidence and severity of bacterialinfections. This collection of reviews and laboratory protocols gives thereader an introduction to the causes of antibiotic resistance, thebacterial strains that pose the largest danger to humans (i.e.,streptococci, pneumococci and enterococci) and the antimicrobialagents used to combat infections with these organisms. Some newavenues that are being investigated for antibiotic development arealso discussed. Such developments include the discovery of agentsthat inhibit bacterial RNA degradation, the bacterial ribosome, andstructure-based approaches to antibiotic drug discovery. Two laboratory protocols are provided to illustrate differentstrategies for discovering new antibiotics. One is a bacterialgrowth inhibition assay to identify inhibitors of bacterial growththat specifically target conditionally essential enzymes in thepathway of interest. The other protocol is used to identifyinhibitors of bacterial cell-to-cell signaling. This e-book — a curated collection from eLS, WIREs, andCurrent Protocols — offers a fantastic introduction to thefield of antibiotics and antibiotic resistance for students orinterdisciplinary collaborators. Table of Contents: Introduction Antibiotics and the Evolution of Antibiotic Resistance eLS Jose L Martinez, Fernando Baquero Antimicrobials Against Streptococci, Pneumococci andEnterococci eLS Susan Donabedian, Adenike Shoyinka Techniques & Applications RNA decay: a novel therapeutic target in bacteria WIREs RNA Tess M. Eidem, Christelle M. Roux, Paul M. Dunman Antibiotics that target protein synthesis WIREs RNA Lisa S. McCoy, Yun Xie, Yitzhak Tor Methods High-Throughput Assessment of Bacterial Growth Inhibition byOptical Density Measurements Current Protocols Chemical Biology Jennifer Campbell Structure-Based Approaches to Antibiotic Drug Discovery Current Protocols Microbiology George Nicola, Ruben Abagyan Novel Approaches to Bacterial Infection Therapy by Interferingwith Cell-to-Cell Signaling Current Protocols Microbiology David A. Rasko, Vanessa Sperandio

Antibiotic Drug Discovery

Antibiotic Drug Discovery
Author: Steven M. Firestine,Troy Lister
Publsiher: Royal Society of Chemistry
Total Pages: 271
Release: 2017-05-30
ISBN 10: 1782624244
ISBN 13: 9781782624240
Language: EN, FR, DE, ES & NL

Antibiotic Drug Discovery Book Review:

This book identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities.

Beyond Antimicrobials Non Traditional Approaches to Combating Multidrug Resistant Bacteria

Beyond Antimicrobials  Non Traditional Approaches to Combating Multidrug Resistant Bacteria
Author: Natalia V. Kirienko,Laurence Rahme,You-Hee Cho
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-12-24
ISBN 10: 2889632563
ISBN 13: 9782889632565
Language: EN, FR, DE, ES & NL

Beyond Antimicrobials Non Traditional Approaches to Combating Multidrug Resistant Bacteria Book Review:

Discovering Antibacterial and Anti resistance Agents Targeting Multi drug Resistant ESKAPE Pathogens

Discovering Antibacterial and Anti resistance Agents Targeting Multi drug Resistant ESKAPE Pathogens
Author: Renee Marie Fleeman
Publsiher: Unknown
Total Pages: 138
Release: 2017
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1102390057
Language: EN, FR, DE, ES & NL

Discovering Antibacterial and Anti resistance Agents Targeting Multi drug Resistant ESKAPE Pathogens Book Review:

Antibiotic resistance has been a developing problem for mankind in recent decades and multi-drug resistant bacteria are now encountered that are resistant to all treatment options available. In 2014, the World Health Organization announced that this problem is driving us towards a “post-antibiotic era” that will change the face of modern medicine as we know it. If lack of novel antibiotic development and FDA approval continues, by the year 2050, 10 million people will die each year to an antimicrobial resistant bacterial infection. With lack of pharmaceutical industry involvement in developing novel antibiotics, the responsibility now lies within the academic institutions to identify potential novel therapeutics to fuel the antibiotic drug discovery pipeline. Combinatorial chemistry is one technique used to expedite the discovery process by assessing a large chemical space in a relatively short time when compared to traditional screening approaches. Combinatorial libraries can be screened using multiple approaches and has shown successful application towards many disease states. We initially discovered broad spectrum antibacterial bis-cyclic guanidines using combinatorial libraries and expanded on the knowledge of the physiochemical attributes necessary to inhibit Gram negative bacterial pathogens. Following this success, we continued to assess the combinatorial libraries for adjunctive therapeutics that potentiate the activity of obsolete clinical antibiotics. The polyamine efflux pump inhibitors discovered in this subsequent study prove the benefits of using the large chemical space provided in the combinatorial libraries to identify a variety of therapeutics. Our studies always begin with identifying an active compound and active compounds undergo hit-to-lead optimization. This optimization studies are of utmost importance in developing a novel antibacterial agent for therapeutic applications. Our medicinal chemistry work described here is proof of the success of careful structure activity analyses to optimize a hit scaffold to create a more effective antibacterial agent. Overall, our work described here reveals the potential role of academic institutions in fending off the impending “post-antibiotic era”.

How to Overcome the Antibiotic Crisis

How to Overcome the Antibiotic Crisis
Author: Marc Stadler,Petra Dersch
Publsiher: Springer
Total Pages: 496
Release: 2016-12-21
ISBN 10: 3319492845
ISBN 13: 9783319492841
Language: EN, FR, DE, ES & NL

How to Overcome the Antibiotic Crisis Book Review:

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.

Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance
Author: Mohmmad Younus Wani,Aijaz Ahmad
Publsiher: Academic Press
Total Pages: 268
Release: 2020-04-30
ISBN 10: 0128205784
ISBN 13: 9780128205785
Language: EN, FR, DE, ES & NL

Combination Therapy Against Multidrug Resistance Book Review:

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Make Antibiotics Great Again Combating Drug Resistance by Targeting LexA a Regulator of Bacterial Evolution

Make Antibiotics Great Again  Combating Drug Resistance by Targeting LexA  a Regulator of Bacterial Evolution
Author: Charlie Y. Mo
Publsiher: Unknown
Total Pages: 274
Release: 2016
ISBN 10: 1928374650XXX
ISBN 13: OCLC:982010069
Language: EN, FR, DE, ES & NL

Make Antibiotics Great Again Combating Drug Resistance by Targeting LexA a Regulator of Bacterial Evolution Book Review:

The ability of bacterial pathogens to evolve and adapt to our antimicrobial agents has precipitated a global health crisis where treatment options for bacterial infections are running low. Recently, studies have shown that the ability to acquire resistance is linked to the SOS response, which is a widely conserved network of genes involved in both high fidelity and error-prone DNA damage repair. The SOS response is regulated by the DNA-binding protein, RecA, and a repressor-protease, LexA. When the cell experiences stress, which can be caused by antibiotics, RecA polymerizes along single-stranded DNA and thereby stimulates LexA to undergo a conformational change and self-cleavage reaction (autoproteolysis). LexA self-cleavage de-represses downstream SOS genes, which are involved in both stress tolerance and mutagenesis. Various studies have shown that inactivating LexA autoproteolysis can both reduce the viability of bacteria under antibiotic stress and impede their ability to acquire resistance. These results therefore suggest that targeting LexA therapeutically could offer a novel way to combat the rise of resistance in pathogens, although to date no LexA inhibitors have been found. To facilitate the development of such therapeutics, we focused our efforts on examining LexA from 1) biochemical, 2) microbiological, and 3) drug discovery perspectives. On the biochemical front, we elucidated the substrate preference of LexA’s serine protease active site to form a better understanding of the target enzyme’s active site architecture. Performing saturation mutagenesis on the LexA’s internal cleavage loop, we showed that LexA possesses a unique active site, revealing residues involved in specific molecular recognition and conformational change. On the microbiological front, we examined how different LexA activities can impact bacterial drug susceptibility and stress-induced mutagenesis. Employing engineered E. coli strains with a spectrum of SOS activities, we showed that modulating LexA activity can increase bacterial susceptibility to antibiotics, while also tuning stress-induced mutagenesis. Finally, on the drug discovery front, we designed a high-throughput screen that enabled us to discover small molecule inhibitors of the LexA/RecA axis in collaboration with GlaxoSmithKline. Together, this work provides a multi-pronged foray into developing therapeutics that target the SOS pathway and combat the rise of antibiotic resistance.

Microbial Evolution and Co Adaptation

Microbial Evolution and Co Adaptation
Author: Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publsiher: National Academies Press
Total Pages: 330
Release: 2009-05-10
ISBN 10: 0309131219
ISBN 13: 9780309131216
Language: EN, FR, DE, ES & NL

Microbial Evolution and Co Adaptation Book Review:

Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses
Author: OECD,World Health Organization
Publsiher: OECD Publishing
Total Pages: 250
Release: 2020-04-01
ISBN 10: 1108864120
ISBN 13: 9781108864121
Language: EN, FR, DE, ES & NL

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses Book Review:

Antimicrobial resistance (AMR) is a biological mechanism whereby a microorganism evolves over time to develop the ability to become resistant to antimicrobial therapies such as antibiotics. The drivers of and potential solutions to AMR are complex, often spanning multiple sectors. The internationally recognized response to AMR advocates for a ‘One Health’ approach, which requires policies to be developed and implemented across human, animal, and environmental health.

Antimicrobial Drug Resistance

Antimicrobial Drug Resistance
Author: Douglas L. Mayers,Jack D. Sobel,Marc Ouellette,Keith S. Kaye,Dror Marchaim
Publsiher: Springer
Total Pages: 773
Release: 2017-06-19
ISBN 10: 3319467182
ISBN 13: 9783319467184
Language: EN, FR, DE, ES & NL

Antimicrobial Drug Resistance Book Review:

The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.

Discovery and Development of Antimicrobial Agents Targeting Multi drug Resistant Bacterial Fungal and Parasitic Pathogens

Discovery and Development of Antimicrobial Agents Targeting Multi drug Resistant Bacterial  Fungal  and Parasitic Pathogens
Author: Danielle N. Turner
Publsiher: Unknown
Total Pages: 382
Release: 2019
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1255633714
Language: EN, FR, DE, ES & NL

Discovery and Development of Antimicrobial Agents Targeting Multi drug Resistant Bacterial Fungal and Parasitic Pathogens Book Review:

The Resistance Phenomenon in Microbes and Infectious Disease Vectors

The Resistance Phenomenon in Microbes and Infectious Disease Vectors
Author: Institute of Medicine,Board on Global Health,Forum on Emerging Infections
Publsiher: National Academies Press
Total Pages: 333
Release: 2003-03-26
ISBN 10: 9780309168304
ISBN 13: 0309168309
Language: EN, FR, DE, ES & NL

The Resistance Phenomenon in Microbes and Infectious Disease Vectors Book Review:

The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.

Drug Repurposing

Drug Repurposing
Author: Farid A. Badria
Publsiher: BoD – Books on Demand
Total Pages: 234
Release: 2020-12-02
ISBN 10: 1839685204
ISBN 13: 9781839685200
Language: EN, FR, DE, ES & NL

Drug Repurposing Book Review:

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

New Approaches Against Drug Resistant M tuberculosis

New Approaches Against Drug Resistant M  tuberculosis
Author: Maria Rosalia Pasca,Yossef Av-Gay,Giorgia Mori
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-06-09
ISBN 10: 288966869X
ISBN 13: 9782889668694
Language: EN, FR, DE, ES & NL

New Approaches Against Drug Resistant M tuberculosis Book Review:

Antibacterial Drug Discovery to Combat MDR

Antibacterial Drug Discovery to Combat MDR
Author: Iqbal Ahmad,Shamim Ahmad,Kendra P. Rumbaugh
Publsiher: Springer Nature
Total Pages: 680
Release: 2019-11-09
ISBN 10: 9811398712
ISBN 13: 9789811398711
Language: EN, FR, DE, ES & NL

Antibacterial Drug Discovery to Combat MDR Book Review:

This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Antimicrobial Resistance

Antimicrobial Resistance
Author: Yashwant Kumar
Publsiher: BoD – Books on Demand
Total Pages: 142
Release: 2019-05-02
ISBN 10: 178985783X
ISBN 13: 9781789857832
Language: EN, FR, DE, ES & NL

Antimicrobial Resistance Book Review:

The discovery of antibiotics was considered a milestone in health sciences and became the mainstay of antimicrobial therapy to treat and control bacterial infections. However, its utility has subsequently become limited, due to the emergence and spread of antimicrobial resistance among different bacterial species, which has emerged as a global threat. The development and spread of antimicrobial resistance have been attributed to many factors, including indiscriminate use of antibiotics in the healthcare and livestock industries. The present scenario of antibiotic resistance urgently requires interventions in terms of development of newer antimicrobials, evaluation of alternative therapies, and formulation of stringent policies to curb indiscriminate use of antimicrobials. This book highlights the importance and development of antimicrobial resistance in zoonotic, environmental and food bacteria, including the significance of candidate alternative therapies.

Ethics and Drug Resistance Collective Responsibility for Global Public Health

Ethics and Drug Resistance  Collective Responsibility for Global Public Health
Author: Euzebiusz Jamrozik,Michael Selgelid
Publsiher: Springer Nature
Total Pages: 448
Release: 2020-10-26
ISBN 10: 3030278743
ISBN 13: 9783030278748
Language: EN, FR, DE, ES & NL

Ethics and Drug Resistance Collective Responsibility for Global Public Health Book Review:

This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.

Antibiotic Drug Resistance

Antibiotic Drug Resistance
Author: José-Luis Capelo-Martínez,Gilberto Igrejas
Publsiher: John Wiley & Sons
Total Pages: 720
Release: 2019-09-24
ISBN 10: 1119282527
ISBN 13: 9781119282525
Language: EN, FR, DE, ES & NL

Antibiotic Drug Resistance Book Review:

This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Preclinical Antimicrobial Drug Discovery

Preclinical Antimicrobial Drug Discovery
Author: Bill Lee
Publsiher: Unknown
Total Pages: 254
Release: 2006
ISBN 10: 1928374650XXX
ISBN 13: OCLC:253842059
Language: EN, FR, DE, ES & NL

Preclinical Antimicrobial Drug Discovery Book Review:

"The incidence of infections caused by antibiotic-resistant bacteria and fungi is rising rapidly. Once considered as little more than a nuisance, antibiotic resistance has become a serious threat. The mortality rate for some infections is approaching that of the pre-antibiotic era. New antimicrobials are needed urgently. Prior to the introduction of any new antimicrobial, comprehensive toxicity and efficacy profiles are assessed in preclinical studies. This thesis focuses on two key stages of preclinical antimicrobial drug development, specifically compound screening in vitro and animal efficacy testing in vivo. We developed a sensitive colorimetric platform with high-throughput capacity for the rapid screening of candidate antimicrobials. This platform could be adapted to assess compounds targeting a range of bacteria, fungi (such as Candida albicans), and protozoan parasites (such as Leishmania major). When this assay was modified to measure minimum inhibitory concentrations (MICs) for bacteria, 100% agreement within one dilution was achieved compared to the gold-standard method. A novel antifungal compound was taken forward to animal testing in an immunocompromised mouse model. We demonstrated herein that a histone deacetylase inhibitor in combination with an imidazole can synergise to produce a potent antifungal effect. A dose-dependent response, defined as a lower fungal burden and a higher survival rate, was achieved with increasing concentrations of the novel inhibitor." --