Drug Discovery Targeting Drug Resistant Bacteria

Drug Discovery Targeting Drug Resistant Bacteria
Author: Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publsiher: Academic Press
Total Pages: 432
Release: 2020-05-15
ISBN 10: 0128184817
ISBN 13: 9780128184813
Language: EN, FR, DE, ES & NL

Drug Discovery Targeting Drug Resistant Bacteria Book Review:

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Antibacterial Drug Discovery to Combat MDR

Antibacterial Drug Discovery to Combat MDR
Author: Iqbal Ahmad,Shamim Ahmad,Kendra P. Rumbaugh
Publsiher: Springer Nature
Total Pages: 680
Release: 2019-11-09
ISBN 10: 9811398712
ISBN 13: 9789811398711
Language: EN, FR, DE, ES & NL

Antibacterial Drug Discovery to Combat MDR Book Review:

This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Antibiotic Drug Discovery

Antibiotic Drug Discovery
Author: Steven M Firestine,Troy Lister
Publsiher: Royal Society of Chemistry
Total Pages: 271
Release: 2017-05-19
ISBN 10: 1782629874
ISBN 13: 9781782629870
Language: EN, FR, DE, ES & NL

Antibiotic Drug Discovery Book Review:

Recent years have seen a resurgence of antibiotic drug discovery. This book brings together the relevant information to assess the state-of-the-art. It identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities. Addressing the need for continued investment in antibiotic drug development, the book provides a point of reference for the rapidly expanding infectious disease research community. In addition to its attention on new targets, the book focusses on the medicinal chemistry and chemistry of the targets. Within this framework, chapters from leading researchers in academia and industry address findings in important areas such as biofilm production, narrow spectrum antibiotics and novel antibacterials from previously uncultured soil bacteria. This book will be a useful resource for postgraduate students and researchers in medicinal chemistry wishing to understand the latest approaches to antibiotic drug discovery.

Sustainable Agriculture Reviews 46

Sustainable Agriculture Reviews 46
Author: Harsh Panwar
Publsiher: Springer Nature
Total Pages: 329
Release:
ISBN 10: 3030530248
ISBN 13: 9783030530242
Language: EN, FR, DE, ES & NL

Sustainable Agriculture Reviews 46 Book Review:

Antibiotic Discovery and Development

Antibiotic Discovery and Development
Author: Thomas J. Dougherty,Michael J. Pucci
Publsiher: Springer Science & Business Media
Total Pages: 1127
Release: 2011-12-18
ISBN 10: 1461414008
ISBN 13: 9781461414001
Language: EN, FR, DE, ES & NL

Antibiotic Discovery and Development Book Review:

This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Model Organisms for Microbial Pathogenesis Biofilm Formation and Antimicrobial Drug Discovery

Model Organisms for Microbial Pathogenesis  Biofilm Formation and Antimicrobial Drug Discovery
Author: Busi Siddhardha,Madhu Dyavaiah,Asad Syed
Publsiher: Springer Nature
Total Pages: 684
Release: 2020-03-28
ISBN 10: 9811516952
ISBN 13: 9789811516955
Language: EN, FR, DE, ES & NL

Model Organisms for Microbial Pathogenesis Biofilm Formation and Antimicrobial Drug Discovery Book Review:

This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.

Drug Discovery and Development

Drug Discovery and Development
Author: Omboon Vallisuta,Suleiman Olimat
Publsiher: BoD – Books on Demand
Total Pages: 330
Release: 2015-06-03
ISBN 10: 9535121286
ISBN 13: 9789535121282
Language: EN, FR, DE, ES & NL

Drug Discovery and Development Book Review:

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Antimicrobials Advances in Research and Application 2012 Edition

Antimicrobials   Advances in Research and Application  2012 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 464
Release: 2012-12-26
ISBN 10: 146499305X
ISBN 13: 9781464993053
Language: EN, FR, DE, ES & NL

Antimicrobials Advances in Research and Application 2012 Edition Book Review:

Antimicrobials—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Antimicrobials. The editors have built Antimicrobials—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antimicrobials in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antimicrobials—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Frontiers in Anti Cancer Drug Discovery

Frontiers in Anti Cancer Drug Discovery
Author: Atta-ur-Rahman,M. Iqbal Choudhary
Publsiher: Bentham Science Publishers
Total Pages: 340
Release: 2018-12-06
ISBN 10: 1681087014
ISBN 13: 9781681087016
Language: EN, FR, DE, ES & NL

Frontiers in Anti Cancer Drug Discovery Book Review:

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The ninth volume of the series features chapters covering the following topics: - New research on the therapeutic intervention of cancer and cancer drug delivery - Dabrafenib usage in melanoma therapy - Targeting autophagy in cancer therapy - Pro-apoptotic and anti-telomerase activity of naturally occurring compounds - CDK inhibitors - Oral nanostructure drug delivery for anti-cancer treatment

Antimicrobial Drug Discovery

Antimicrobial Drug Discovery
Author: G. Tegos,George Tegos and Eleftherios Mylonakis
Publsiher: CABI
Total Pages: 369
Release: 2012
ISBN 10: 9781780640310
ISBN 13: 1780640315
Language: EN, FR, DE, ES & NL

Antimicrobial Drug Discovery Book Review:

Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.

Antiparasitic and Antibacterial Drug Discovery

Antiparasitic and Antibacterial Drug Discovery
Author: Paul M. Selzer
Publsiher: John Wiley & Sons
Total Pages: 489
Release: 2009-06-08
ISBN 10: 3527323279
ISBN 13: 9783527323272
Language: EN, FR, DE, ES & NL

Antiparasitic and Antibacterial Drug Discovery Book Review:

Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

Beyond Antimicrobials Non Traditional Approaches to Combating Multidrug Resistant Bacteria

Beyond Antimicrobials  Non Traditional Approaches to Combating Multidrug Resistant Bacteria
Author: Natalia V. Kirienko,Laurence Rahme,You-Hee Cho
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-12-24
ISBN 10: 2889632563
ISBN 13: 9782889632565
Language: EN, FR, DE, ES & NL

Beyond Antimicrobials Non Traditional Approaches to Combating Multidrug Resistant Bacteria Book Review:

Antimicrobial Drug Discovery

Antimicrobial Drug Discovery
Author: George Tegos,Eleftherios Mylonakis
Publsiher: CABI
Total Pages: 357
Release: 2012
ISBN 10: 1845939433
ISBN 13: 9781845939434
Language: EN, FR, DE, ES & NL

Antimicrobial Drug Discovery Book Review:

Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Drug Resistance in Bacteria Fungi Malaria and Cancer

Drug Resistance in Bacteria  Fungi  Malaria  and Cancer
Author: Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
Publsiher: Springer
Total Pages: 630
Release: 2017-03-21
ISBN 10: 3319486837
ISBN 13: 9783319486833
Language: EN, FR, DE, ES & NL

Drug Resistance in Bacteria Fungi Malaria and Cancer Book Review:

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Microbial Genomics and Drug Discovery

Microbial Genomics and Drug Discovery
Author: Thomas J. Dougherty,Steven J. Projan
Publsiher: CRC Press
Total Pages: 264
Release: 2003-05-14
ISBN 10: 9780203911464
ISBN 13: 0203911466
Language: EN, FR, DE, ES & NL

Microbial Genomics and Drug Discovery Book Review:

Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition

Antibiotic Drug Resistance

Antibiotic Drug Resistance
Author: José-Luis Capelo-Martínez,Gilberto Igrejas
Publsiher: John Wiley & Sons
Total Pages: 720
Release: 2019-09-24
ISBN 10: 1119282527
ISBN 13: 9781119282525
Language: EN, FR, DE, ES & NL

Antibiotic Drug Resistance Book Review:

This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance
Author: Mohmmad Younus Wani,Aijaz Ahmad
Publsiher: Academic Press
Total Pages: 268
Release: 2020-04-30
ISBN 10: 0128205784
ISBN 13: 9780128205785
Language: EN, FR, DE, ES & NL

Combination Therapy Against Multidrug Resistance Book Review:

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

How to Overcome the Antibiotic Crisis

How to Overcome the Antibiotic Crisis
Author: Marc Stadler,Petra Dersch
Publsiher: Springer
Total Pages: 496
Release: 2016-12-21
ISBN 10: 3319492845
ISBN 13: 9783319492841
Language: EN, FR, DE, ES & NL

How to Overcome the Antibiotic Crisis Book Review:

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.

Antibiotics and Bacterial Resistance

Antibiotics and Bacterial Resistance
Author: Wiley
Publsiher: John Wiley & Sons
Total Pages: 146
Release: 2013-01-14
ISBN 10: 1118580915
ISBN 13: 9781118580912
Language: EN, FR, DE, ES & NL

Antibiotics and Bacterial Resistance Book Review:

The need for novel antibiotics is greater now than perhaps anytime since the pre-antibiotic era. Indeed, the recent collapse ofmany pharmaceutical antibacterial groups, combined with theemergence of hypervirulent and pan-antibiotic-resistant bacteriahas severely compromised infection treatment options and led todramatic increases in the incidence and severity of bacterialinfections. This collection of reviews and laboratory protocols gives thereader an introduction to the causes of antibiotic resistance, thebacterial strains that pose the largest danger to humans (i.e.,streptococci, pneumococci and enterococci) and the antimicrobialagents used to combat infections with these organisms. Some newavenues that are being investigated for antibiotic development arealso discussed. Such developments include the discovery of agentsthat inhibit bacterial RNA degradation, the bacterial ribosome, andstructure-based approaches to antibiotic drug discovery. Two laboratory protocols are provided to illustrate differentstrategies for discovering new antibiotics. One is a bacterialgrowth inhibition assay to identify inhibitors of bacterial growththat specifically target conditionally essential enzymes in thepathway of interest. The other protocol is used to identifyinhibitors of bacterial cell-to-cell signaling. This e-book — a curated collection from eLS, WIREs, andCurrent Protocols — offers a fantastic introduction to thefield of antibiotics and antibiotic resistance for students orinterdisciplinary collaborators. Table of Contents: Introduction Antibiotics and the Evolution of Antibiotic Resistance eLS Jose L Martinez, Fernando Baquero Antimicrobials Against Streptococci, Pneumococci andEnterococci eLS Susan Donabedian, Adenike Shoyinka Techniques & Applications RNA decay: a novel therapeutic target in bacteria WIREs RNA Tess M. Eidem, Christelle M. Roux, Paul M. Dunman Antibiotics that target protein synthesis WIREs RNA Lisa S. McCoy, Yun Xie, Yitzhak Tor Methods High-Throughput Assessment of Bacterial Growth Inhibition byOptical Density Measurements Current Protocols Chemical Biology Jennifer Campbell Structure-Based Approaches to Antibiotic Drug Discovery Current Protocols Microbiology George Nicola, Ruben Abagyan Novel Approaches to Bacterial Infection Therapy by Interferingwith Cell-to-Cell Signaling Current Protocols Microbiology David A. Rasko, Vanessa Sperandio

New edge of antibiotic development antimicrobial peptides and corresponding resistance

New edge of antibiotic development  antimicrobial peptides and corresponding resistance
Author: Octavio L. Franco,Nádia S. Parachin
Publsiher: Frontiers E-books
Total Pages: 329
Release: 2014-09-26
ISBN 10: 2889193012
ISBN 13: 9782889193011
Language: EN, FR, DE, ES & NL

New edge of antibiotic development antimicrobial peptides and corresponding resistance Book Review:

Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects.