Drug Discovery Targeting Drug Resistant Bacteria

Drug Discovery Targeting Drug Resistant Bacteria
Author: Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publsiher: Academic Press
Total Pages: 432
Release: 2020-05-15
ISBN 10: 0128184817
ISBN 13: 9780128184813
Language: EN, FR, DE, ES & NL

Drug Discovery Targeting Drug Resistant Bacteria Book Review:

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Antibacterial Drug Discovery to Combat MDR

Antibacterial Drug Discovery to Combat MDR
Author: Iqbal Ahmad,Shamim Ahmad,Kendra P. Rumbaugh
Publsiher: Springer Nature
Total Pages: 680
Release: 2019-11-09
ISBN 10: 9811398712
ISBN 13: 9789811398711
Language: EN, FR, DE, ES & NL

Antibacterial Drug Discovery to Combat MDR Book Review:

This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Beyond Antimicrobials Non Traditional Approaches to Combating Multidrug Resistant Bacteria

Beyond Antimicrobials  Non Traditional Approaches to Combating Multidrug Resistant Bacteria
Author: Natalia V. Kirienko,Laurence Rahme,You-Hee Cho
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-12-24
ISBN 10: 2889632563
ISBN 13: 9782889632565
Language: EN, FR, DE, ES & NL

Beyond Antimicrobials Non Traditional Approaches to Combating Multidrug Resistant Bacteria Book Review:

Drug Resistance in Bacteria Fungi Malaria and Cancer

Drug Resistance in Bacteria  Fungi  Malaria  and Cancer
Author: Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
Publsiher: Springer
Total Pages: 630
Release: 2017-03-21
ISBN 10: 3319486837
ISBN 13: 9783319486833
Language: EN, FR, DE, ES & NL

Drug Resistance in Bacteria Fungi Malaria and Cancer Book Review:

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Antibiotic Discovery and Development

Antibiotic Discovery and Development
Author: Thomas J. Dougherty,Michael J. Pucci
Publsiher: Springer Science & Business Media
Total Pages: 1127
Release: 2011-12-18
ISBN 10: 1461414008
ISBN 13: 9781461414001
Language: EN, FR, DE, ES & NL

Antibiotic Discovery and Development Book Review:

This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance
Author: Mohmmad Younus Wani,Aijaz Ahmad
Publsiher: Academic Press
Total Pages: 268
Release: 2020-04-30
ISBN 10: 0128205784
ISBN 13: 9780128205785
Language: EN, FR, DE, ES & NL

Combination Therapy Against Multidrug Resistance Book Review:

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Antibiotic Resistant Bacteria A Challenge to Modern Medicine

Antibiotic Resistant Bacteria  A Challenge to Modern Medicine
Author: Sadhana Sagar,Shilpa Kaistha,Amar Jyoti Das,Rajesh Kumar
Publsiher: Springer Nature
Total Pages: 179
Release: 2019-11-14
ISBN 10: 9811398798
ISBN 13: 9789811398797
Language: EN, FR, DE, ES & NL

Antibiotic Resistant Bacteria A Challenge to Modern Medicine Book Review:

This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.

The Resistance Phenomenon in Microbes and Infectious Disease Vectors

The Resistance Phenomenon in Microbes and Infectious Disease Vectors
Author: Institute of Medicine,Board on Global Health,Forum on Emerging Infections
Publsiher: National Academies Press
Total Pages: 333
Release: 2003-03-26
ISBN 10: 9780309168304
ISBN 13: 0309168309
Language: EN, FR, DE, ES & NL

The Resistance Phenomenon in Microbes and Infectious Disease Vectors Book Review:

The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.

Antimicrobial Drug Resistance

Antimicrobial Drug Resistance
Author: Douglas L. Mayers,Jack D. Sobel,Marc Ouellette,Keith S. Kaye,Dror Marchaim
Publsiher: Springer
Total Pages: 773
Release: 2017-06-19
ISBN 10: 3319467182
ISBN 13: 9783319467184
Language: EN, FR, DE, ES & NL

Antimicrobial Drug Resistance Book Review:

The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.

Natural Products and Cancer Drug Discovery

Natural Products and Cancer Drug Discovery
Author: Farid A. Badria
Publsiher: BoD – Books on Demand
Total Pages: 316
Release: 2017-07-05
ISBN 10: 9535133136
ISBN 13: 9789535133131
Language: EN, FR, DE, ES & NL

Natural Products and Cancer Drug Discovery Book Review:

This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses
Author: OECD,World Health Organization
Publsiher: OECD Publishing
Total Pages: 250
Release: 2020-04-01
ISBN 10: 1108864120
ISBN 13: 9781108864121
Language: EN, FR, DE, ES & NL

Challenges to Tackling Antimicrobial Resistance Economic and Policy Responses Book Review:

Antimicrobial resistance (AMR) is a biological mechanism whereby a microorganism evolves over time to develop the ability to become resistant to antimicrobial therapies such as antibiotics. The drivers of and potential solutions to AMR are complex, often spanning multiple sectors. The internationally recognized response to AMR advocates for a ‘One Health’ approach, which requires policies to be developed and implemented across human, animal, and environmental health.

Bacterial Persistence

Bacterial Persistence
Author: Jan Michiels,Maarten Fauvart
Publsiher: Humana Press
Total Pages: 244
Release: 2016-08-23
ISBN 10: 9781493949045
ISBN 13: 1493949047
Language: EN, FR, DE, ES & NL

Bacterial Persistence Book Review:

This volume presents a comprehensive collection of methods that have been instrumental to the current understanding of bacterial persisters. Chapters in the book cover topics ranging from general methods for measuring persister levels in Escherichia coli cultures, protocols for the determination of the persister subpopulation in Candida albicans, quantitative measurements of Type I and Type II persisters using ScanLag, to in vitro and in vivo models for the study of the intracellular activity of antibiotics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Persistence: Methods and Protocols brings together the most respected researchers in bacterial persistence whose studies will remain vital to understanding this field for many years to come.

Drug Discovery and Development

Drug Discovery and Development
Author: Omboon Vallisuta,Suleiman Olimat
Publsiher: BoD – Books on Demand
Total Pages: 330
Release: 2015-06-03
ISBN 10: 9535121286
ISBN 13: 9789535121282
Language: EN, FR, DE, ES & NL

Drug Discovery and Development Book Review:

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Mechanisms of antibiotic resistance

Mechanisms of antibiotic resistance
Author: Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2015-06-01
ISBN 10: 2889195260
ISBN 13: 9782889195268
Language: EN, FR, DE, ES & NL

Mechanisms of antibiotic resistance Book Review:

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Frontiers in Anti Infective Drug Discovery

Frontiers in Anti Infective Drug Discovery
Author: Atta-ur-Rahman,M. Iqbal Choudhary
Publsiher: Bentham Science Publishers
Total Pages: 360
Release: 2013-09-15
ISBN 10: 160805912X
ISBN 13: 9781608059126
Language: EN, FR, DE, ES & NL

Frontiers in Anti Infective Drug Discovery Book Review:

This ebook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The third volume of this series features 6 chapters that cover a variety of topics including: - Drug Discovery for TB - Therapeutic Limitations due to Antibiotic Drug Resistance - Applications for Virus Vaccine Vectors in Infectious Disease Research - NewCastle Disease Virus - Anti-Infective Therapy Against Leishmaniasis - Anti-Viral Activity of Proanthocyanidins.

Escherichia coli

Escherichia coli
Author: Amidou Samie
Publsiher: BoD – Books on Demand
Total Pages: 434
Release: 2017-07-12
ISBN 10: 9535133292
ISBN 13: 9789535133292
Language: EN, FR, DE, ES & NL

Escherichia coli Book Review:

Escherichia coli is a versatile organism and very diverse. Members of this species vary from very pathogenic agents causing different types of diseases including meningitis, gastroenteritis, and septicemia, just to cite a few, to harmless organisms living in the intestines of both humans and animals. E. coli has also been used as a model organism for most bacteria except a few. For this reason, its study provides a huge advantage and can help understand the mechanisms involved in different processes such as pathogenesis, environmental disinfection, nutrient utilization, antibiotic resistance, and diagnostic/detection methods, and these are indeed the topics discussed in this book. The book has been divided into four main sections representing the different facets of E. coli applications, which include disease, biotechnology, environmental engineering and innovative approaches to detection, and lastly its physiology and cell biology. Such processes can be applied to the study of other organisms as well considering the development of diversity; for example, many organisms are capable of horizontal gene transfer, which is capable of increasing the fitness of the bacterial organisms involved and has a great impact on the control of such bacterial organism.

Treating Infectious Diseases in a Microbial World

Treating Infectious Diseases in a Microbial World
Author: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publsiher: National Academies Press
Total Pages: 102
Release: 2006-01-03
ISBN 10: 9780309180689
ISBN 13: 0309180686
Language: EN, FR, DE, ES & NL

Treating Infectious Diseases in a Microbial World Book Review:

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Model Organisms for Microbial Pathogenesis Biofilm Formation and Antimicrobial Drug Discovery

Model Organisms for Microbial Pathogenesis  Biofilm Formation and Antimicrobial Drug Discovery
Author: Busi Siddhardha,Madhu Dyavaiah,Asad Syed
Publsiher: Springer Nature
Total Pages: 684
Release: 2020-03-28
ISBN 10: 9811516952
ISBN 13: 9789811516955
Language: EN, FR, DE, ES & NL

Model Organisms for Microbial Pathogenesis Biofilm Formation and Antimicrobial Drug Discovery Book Review:

This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.

Structural Bioinformatics Applications in Preclinical Drug Discovery Process

Structural Bioinformatics  Applications in Preclinical Drug Discovery Process
Author: C. Gopi Mohan
Publsiher: Springer
Total Pages: 406
Release: 2019-01-10
ISBN 10: 3030052826
ISBN 13: 9783030052829
Language: EN, FR, DE, ES & NL

Structural Bioinformatics Applications in Preclinical Drug Discovery Process Book Review:

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery. The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.

How to Overcome the Antibiotic Crisis

How to Overcome the Antibiotic Crisis
Author: Marc Stadler,Petra Dersch
Publsiher: Springer
Total Pages: 496
Release: 2016-12-21
ISBN 10: 3319492845
ISBN 13: 9783319492841
Language: EN, FR, DE, ES & NL

How to Overcome the Antibiotic Crisis Book Review:

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.