Drug Biomembrane Interaction Studies

Drug Biomembrane Interaction Studies
Author: Rosario Pignatello
Publsiher: Elsevier
Total Pages: 440
Release: 2013-10-31
ISBN 10: 1908818344
ISBN 13: 9781908818348
Language: EN, FR, DE, ES & NL

Drug Biomembrane Interaction Studies Book Review:

The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
Author: M.H. Chiu,N.S. Berezowski,E.J. Prenner
Publsiher: Elsevier Inc. Chapters
Total Pages: 440
Release: 2013-10-31
ISBN 10: 0128091827
ISBN 13: 9780128091821
Language: EN, FR, DE, ES & NL

Drug biomembrane interaction studies Book Review:

DSC is a straightforward, non-perturbing thermodynamic technique first developed in the early 1960s. The large number of parameters and the high sensitivity has made DSC one of the key calorimetric tools used for investigating thermodynamic properties of biopolymers, proteins, peptides and nucleic acids. There are numerous reviews covering the different macromolecular applications of DSC: this chapter will primarily focus on proteins and nucleic acids.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
Author: A. Fortunato
Publsiher: Elsevier Inc. Chapters
Total Pages: 440
Release: 2013-10-31
ISBN 10: 0128091800
ISBN 13: 9780128091807
Language: EN, FR, DE, ES & NL

Drug biomembrane interaction studies Book Review:

In DSC, the heat flow in and out of a sample and a reference material is measured as a function of temperature as the sample is heated, cooled, or held isothermally at constant temperature. The measurement signal is the energy absorbed or released by the sample in milliwatts. DSC can detect endothermic and exothermic effects, determine peak areas (transition and reaction enthalpies), determine temperatures that characterize a peak or other effects, and measure specific heat capacity. Since the end of the nineteenth century, DSC has been improved and optimized. With the numerous technological innovations, in both hardware and software, it can explore new and demanding applications. Different measurement principles, sensors, signal processing, accessories, and evaluation capabilities make differential scanning calorimetry one of the most common and versatile techniques in material characterization. Today DSC benefits from technological solutions used previously for other applications (MEMS technology, optical devices, and parameter estimation methods).

Drug Membrane Interactions

Drug Membrane Interactions
Author: Joachim K. Seydel,Michael Wiese
Publsiher: John Wiley & Sons
Total Pages: 367
Release: 2009-07-10
ISBN 10: 3527616497
ISBN 13: 9783527616497
Language: EN, FR, DE, ES & NL

Drug Membrane Interactions Book Review:

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
Author: C. Carbone,R. Pignatello
Publsiher: Elsevier Inc. Chapters
Total Pages: 440
Release: 2013-10-31
ISBN 10: 0128091819
ISBN 13: 9780128091814
Language: EN, FR, DE, ES & NL

Drug biomembrane interaction studies Book Review:

Interest in using DSC to study the interaction between different compounds and biomembrane models has increased in the last 20years. This is confirmed by the number of published research studies concerning the feasibility of investigating the behavior of different molecules, such as local anesthetics, anticancer drugs, anti-inflammatory drugs, antioxidants, antibiotics, peptides, proteins, polymers, surfactants, genetic materials, macromolecules, and also drug delivery systems (DDSs). This chapter provides a general consideration of the current applications of DSC in evaluating the interaction of different biomolecules and biomembrane models, which will be presented more thoroughly in the succeeding chapters. In particular, a detailed description of the DSC technique for studying the interaction of surfactants, genetic materials, polymers, and DDSs with biomembrane models and biomolecule toxicity studies will be provided, taking into consideration the most recent literature.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
Author: R. Pignatello
Publsiher: Elsevier Inc. Chapters
Total Pages: 440
Release: 2013-10-31
ISBN 10: 0128091789
ISBN 13: 9780128091784
Language: EN, FR, DE, ES & NL

Drug biomembrane interaction studies Book Review:

DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.

Drug biomembrane interaction studies

Drug   biomembrane interaction studies
Author: T. Musumeci,G. Puglisi
Publsiher: Elsevier Inc. Chapters
Total Pages: 440
Release: 2013-10-31
ISBN 10: 0128091851
ISBN 13: 9780128091852
Language: EN, FR, DE, ES & NL

Drug biomembrane interaction studies Book Review:

Antimicrobial agents are from different classes of molecules that suppress multiplication and growth of or kill microorganisms such as bacteria, fungi, or viruses. The precise mechanism of action of some antimicrobial agents is unknown but they must interact with or cross the cell membrane to have an effect. Identification of the damage induced by these compounds is difficult due to the complexity of cell membranes. Studying interactions using membrane models is a first step in obtaining elementary information about the effects of such drugs. We discuss interaction studies in the recent literature that use calorimetric techniques, regarding the mechanism of action or side effects of antimicrobial agents. For interaction studies with mimetic membrane models using DSC analysis, we will try to answer some key questions: (a) Does lipid composition affect the interaction? (b) Does the composition of bilayers influence the secondary structure of a peptide antimicrobial? (c) Does lipid polymorphism influence the activity and toxicity of the molecules? We underline the importance of phospholipids (neutral or anionic) chosen to produce biomembrane vesicles as models for the different studies.

Methods in Membrane Lipids

Methods in Membrane Lipids
Author: Alex Dopico
Publsiher: Springer Science & Business Media
Total Pages: 621
Release: 2007-08-30
ISBN 10: 1588296628
ISBN 13: 9781588296627
Language: EN, FR, DE, ES & NL

Methods in Membrane Lipids Book Review:

This book presents a compendium of methodologies for the study of membrane lipids, varying from traditional lab bench experimentation to computer simulation and theoretical models. The volume provides a comprehensive set of techniques for studying membrane lipids with a strong biophysical emphasis. It compares the various available techniques including the pros and cons as seen by the experts.

Indian Journal of Pure Applied Physics

Indian Journal of Pure   Applied Physics
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1994-07
ISBN 10:
ISBN 13: NYPL:33433060166166
Language: EN, FR, DE, ES & NL

Indian Journal of Pure Applied Physics Book Review:

Thermodynamics and Biophysics of Biomedical Nanosystems

Thermodynamics and Biophysics of Biomedical Nanosystems
Author: Costas Demetzos,Natassa Pippa
Publsiher: Springer
Total Pages: 475
Release: 2019-03-04
ISBN 10: 9811309892
ISBN 13: 9789811309892
Language: EN, FR, DE, ES & NL

Thermodynamics and Biophysics of Biomedical Nanosystems Book Review:

This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism. In 2018, Prof. Demetzos was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology.

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 329
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

Peptide Lipid Interactions

Peptide Lipid Interactions
Author: Sidney A. Simon,Thomas J. McIntosh
Publsiher: Academic Press
Total Pages: 601
Release: 2002-11-13
ISBN 10: 9780080925851
ISBN 13: 0080925855
Language: EN, FR, DE, ES & NL

Peptide Lipid Interactions Book Review:

This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion. Key Features * world-renowned experts * state-of-the-art experimental methods * monolayers, bilayers, biological membranes * theoretical aspects and computer simulations * rafts * synaptic transmission * membrane fusion * signal transduction

Liposomes Lipid Bilayers and Model Membranes

Liposomes  Lipid Bilayers and Model Membranes
Author: Georg Pabst,Norbert Kučerka,Mu-Ping Nieh,John Katsaras
Publsiher: CRC Press
Total Pages: 478
Release: 2014-03-04
ISBN 10: 1466507098
ISBN 13: 9781466507098
Language: EN, FR, DE, ES & NL

Liposomes Lipid Bilayers and Model Membranes Book Review:

As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine. Written by leading researchers in their fields, this book describes basic and applied research, and serves as a useful reference for both the novice and the expert. Part one covers a range of basic research topics, from theory and computational simulations to some of the most up-to-date experimental research. Topics discussed include soft matter physics of membranes, nonlamellar phases, extraction of molecules by amphiphiles, lipid models for membrane rafts, membrane dynamics, nanodiscs, microemulsions, active membranes, as well as interactions of bilayers with drugs or DNA to treat disease or for gene transfer, respectively. Part two of the book focuses on technological applications of amphiphiles, such as liposome-based nanoparticles for drug delivery, formulation of liposomes for prolonged in vivo circulation and functionalization for medical purposes, novel drug delivery systems for increased drug loading, and the use of tethered membranes for bio-sensing applications. Chapters also describe the use of liposomes in textile dyeing and how lipidic nanoparticles are used by the food industry.

Structure and Dynamics of Membranes

Structure and Dynamics of Membranes
Author: R. Lipowsky,E. Sackmann
Publsiher: Elsevier
Total Pages: 1052
Release: 1995-06-15
ISBN 10: 9780080541914
ISBN 13: 0080541917
Language: EN, FR, DE, ES & NL

Structure and Dynamics of Membranes Book Review:

The first volume of the Handbook deals with the amazing world of biomembranes and lipid bilayers. Part A describes all aspects related to the morphology of these membranes, beginning with the complex architecture of biomembranes, continues with a description of the bizarre morphology of lipid bilayers and concludes with technological applications of these membranes. The first two chapters deal with biomembranes, providing an introduction to the membranes of eucaryotes and a description of the evolution of membranes. The following chapters are concerned with different aspects of lipids including the physical properties of model membranes composed of lipid-protein mixtures, lateral phase separation of lipids and proteins and measurement of lipid-protein bilayer diffusion. Other chapters deal with the flexibility of fluid bilayers, the closure of bilayers into vesicles which attain a large variety of different shapes, and applications of lipid vesicles and liposomes. Part B covers membrane adhesion, membrane fusion and the interaction of biomembranes with polymer networks such as the cytoskeleton. The first two chapters of this part discuss the generic interactions of membranes from the conceptual point of view. The following two chapters summarize the experimental work on two different bilayer systems. The next chapter deals with the process of contact formation, focal bounding and macroscopic contacts between cells. The cytoskeleton within eucaryotic cells consists of a network of relatively stiff filaments of which three different types of filaments have been identified. As explained in the next chapter much has been recently learned about the interaction of these filaments with the cell membrane. The final two chapters deal with membrane fusion.

Indian Science Abstracts

Indian Science Abstracts
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1994
ISBN 10:
ISBN 13: UCBK:C047332394
Language: EN, FR, DE, ES & NL

Indian Science Abstracts Book Review:

Drug Membrane Interactions

Drug Membrane Interactions
Author: Joachim K. Seydel,Michael Wiese
Publsiher: John Wiley & Sons
Total Pages: 367
Release: 2009-07-10
ISBN 10: 3527616497
ISBN 13: 9783527616497
Language: EN, FR, DE, ES & NL

Drug Membrane Interactions Book Review:

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Biomimetic Lipid Membranes Fundamentals Applications and Commercialization

Biomimetic Lipid Membranes  Fundamentals  Applications  and Commercialization
Author: Fatma N. Kök,Ahu Arslan Yildiz,Fatih Inci
Publsiher: Springer
Total Pages: 306
Release: 2019-04-16
ISBN 10: 3030115968
ISBN 13: 9783030115968
Language: EN, FR, DE, ES & NL

Biomimetic Lipid Membranes Fundamentals Applications and Commercialization Book Review:

This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development. Provides fundamental knowledge on biomimetic lipid membranes; Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques; Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques; Describes the integration of biomimetic membranes with current top-notch tools and platforms; Examines applications in medicine, pharmaceutical industry, and environmental monitoring.

Drug Transporters

Drug Transporters
Author: Glynis Nicholls,Kuresh Youdim
Publsiher: Royal Society of Chemistry
Total Pages: 239
Release: 2016-08-17
ISBN 10: 1782628703
ISBN 13: 9781782628705
Language: EN, FR, DE, ES & NL

Drug Transporters Book Review:

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

Cell Physiology Source Book

Cell Physiology Source Book
Author: Nicholas Sperelakis
Publsiher: Elsevier
Total Pages: 1235
Release: 2012-12-02
ISBN 10: 0080574556
ISBN 13: 9780080574554
Language: EN, FR, DE, ES & NL

Cell Physiology Source Book Book Review:

This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics

Viral Membrane Proteins Structure Function and Drug Design

Viral Membrane Proteins  Structure  Function  and Drug Design
Author: Wolfgang B. Fischer
Publsiher: Springer Science & Business Media
Total Pages: 292
Release: 2007-08-02
ISBN 10: 9780387281469
ISBN 13: 0387281460
Language: EN, FR, DE, ES & NL

Viral Membrane Proteins Structure Function and Drug Design Book Review:

In Viral Membrane Proteins: Structure, Function, and Drug Design, Wolfgang Fischer summarizes the current structural and functional knowledge of membrane proteins encoded by viruses. In addition, contributors to the book address questions about proteins as potential drug targets. The range of information covered includes signal proteins, ion channels, and fusion proteins. This book has a place in the libraries of researchers and scientists in a wide array of fields, including protein chemistry, molecular biophysics, pharmaceutical science and research, bioanotechnology, molecular biology, and biochemistry.