Disease Pathways

Disease Pathways
Author: Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev
Publsiher: Elsevier
Total Pages: 732
Release: 2019-10-18
ISBN 10: 0128170875
ISBN 13: 9780128170878
Language: EN, FR, DE, ES & NL

Disease Pathways Book Review:

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

The Person with Alzheimer s Disease

The Person with Alzheimer s Disease
Author: Phyllis Braudy Harris
Publsiher: JHU Press
Total Pages: 289
Release: 2002-06-06
ISBN 10: 9780801868771
ISBN 13: 0801868777
Language: EN, FR, DE, ES & NL

The Person with Alzheimer s Disease Book Review:

The first book to provide a comprehensive look at what it's like to have dementia and the subjective experience of living with progressive memory loss. Few families are untouched by Alzheimer's disease or a related dementia. Moving accounts of what it is like to care for someone with this disease have already been published, as well as how-to books that offer caregivers advice and information on coping. But this book is the first to provide a comprehensive report of what it is like to have dementia oneself—the subjective experience of living with progressive memory loss. Each chapter discusses a different aspect of having dementia, from the initial assessment and diagnosis through placement in a nursing home. The discussions are grounded in qualitative research and case studies, which convey the variable and personal nature of the experience. They seek to help clinicians, researchers, students, and caregivers (both professionals and family members) understand the experience of dementia, and thereby to promote better caregiving through a person-centered approach. Contributors: Kathleen Kahn-Denis, Judson Retirement Community; Casey Durkin, a psychotherapist in Cleveland, Ohio; Jane Gilliard, Dementia Voice, UK; Phyllis Braudy Harris, John Carroll University; John Keady, University of Wales, UK; John Killick, University of Stirling, UK; Rebecca G. Logsdon, University of Washington; Charlie Murphy, University of Stirling, UK; Alison Phinney, University of British Columbia, Canada; Steven R. Sabat, Georgetown University; Dorothy Seman, Alzheimer's Family Care Center, Chicago; Lisa Snyder, University of California, San Diego; Jane Stansell, Alzheimer's Family Care Center, Chicago; Gloria Sterin, Shaker Heights, Ohio; Jon C. Stuckey, Messiah College; Robyn Yale, Consultant to the Alzheimer's Association, San Francisco; Rosalie Young, Wayne State University School of Medicine.

Signaling Pathways in Liver Diseases

Signaling Pathways in Liver Diseases
Author: Jean-Francois Dufour,Pierre-Alain Clavien
Publsiher: Springer Science & Business Media
Total Pages: 526
Release: 2009-12-01
ISBN 10: 9783642001505
ISBN 13: 3642001505
Language: EN, FR, DE, ES & NL

Signaling Pathways in Liver Diseases Book Review:

Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.

A More Excellent Way

A More Excellent Way
Author: Henry W. Wright
Publsiher: Whitaker Distribution
Total Pages: 526
Release: 2009
ISBN 10: 9781603741026
ISBN 13: 160374102X
Language: EN, FR, DE, ES & NL

A More Excellent Way Book Review:

"Presents the case that the roots of psychological and biological diseases are spiritual, and provides advice on how to eradicate disease instead of treating symptoms"--Provided by publisher.

G Protein Signaling Pathways in Health and Disease

G Protein Signaling Pathways in Health and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 300
Release: 2019-02-15
ISBN 10: 0128167246
ISBN 13: 9780128167243
Language: EN, FR, DE, ES & NL

G Protein Signaling Pathways in Health and Disease Book Review:

G Protein Signaling Pathways in Health and Disease, Volume 161 in the Progress in Molecular Biology and Translational Science series, provides informative and exciting monographs on a wide variety of research topics related to G Protein Signaling Pathways in Health and Disease. The series gives in-depth knowledge on the important molecular biological aspects of organismal physiology and function, along with insights on how this knowledge can be applied to understand and ameliorate human disease. This updated release covers Diseases associated with mutations in CNGA3, Mutations in arrestins, Diseases caused by mutations in GPR101, Diseases caused by mutations in lutropin receptor, and much more. Comprises 15-20 chapters, providing substantial coverage on a given topic Contains ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided in each chapter Provides a comprehensive guide to the latest information available on prions, viruses, bacteria, and eukaryotes

Alzheimer s Disease Pathways to Practice Assessing Diagnosis and Outcome Measures

Alzheimer s Disease Pathways to Practice  Assessing Diagnosis and Outcome Measures
Author: Anonim
Publsiher: Unknown
Total Pages: 27
Release: 2005
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1069075291
Language: EN, FR, DE, ES & NL

Alzheimer s Disease Pathways to Practice Assessing Diagnosis and Outcome Measures Book Review:

Neural Network Analysis of Genetic Disease Pathways

Neural Network Analysis of Genetic Disease Pathways
Author: Jason Gregory Brooks
Publsiher: Unknown
Total Pages: 144
Release: 2001
ISBN 10: 1928374650XXX
ISBN 13: OCLC:49677403
Language: EN, FR, DE, ES & NL

Neural Network Analysis of Genetic Disease Pathways Book Review:

Cerebral Amyloid Angiopathy in Alzheimer s Disease Pathways for Elimination of AB from the Human Brain

Cerebral Amyloid Angiopathy in Alzheimer s Disease  Pathways for Elimination of AB from the Human Brain
Author: Stephen Preston
Publsiher: Unknown
Total Pages: 139
Release: 2000
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1116083461
Language: EN, FR, DE, ES & NL

Cerebral Amyloid Angiopathy in Alzheimer s Disease Pathways for Elimination of AB from the Human Brain Book Review:

Energy Balance and Colorectal Cancer

Energy Balance and Colorectal Cancer
Author: Universiteit Maastricht
Publsiher: Unknown
Total Pages: 135
Release: 2013
ISBN 10: 9789082130805
ISBN 13: 9082130807
Language: EN, FR, DE, ES & NL

Energy Balance and Colorectal Cancer Book Review:

Obstructive Sleep Apnea as a Patient Contested Disease

Obstructive Sleep Apnea as a Patient Contested Disease
Author: Dana Zarhin
Publsiher: Unknown
Total Pages: 269
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:892094546
Language: EN, FR, DE, ES & NL

Obstructive Sleep Apnea as a Patient Contested Disease Book Review:

The Warburg Effect Regulation Under Siege The Intertwined Pathways in Health and Disease

The Warburg Effect Regulation Under Siege  The Intertwined Pathways in Health and Disease
Author: Concetta Bubici,Salvatore Papa
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-10-17
ISBN 10: 2889630013
ISBN 13: 9782889630011
Language: EN, FR, DE, ES & NL

The Warburg Effect Regulation Under Siege The Intertwined Pathways in Health and Disease Book Review:

Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.

Neurobiology of Huntington s Disease

Neurobiology of Huntington   s Disease
Author: Donald C. Lo,Robert E. Hughes
Publsiher: CRC Press
Total Pages: 338
Release: 2010-07-02
ISBN 10: 1420008250
ISBN 13: 9781420008258
Language: EN, FR, DE, ES & NL

Neurobiology of Huntington s Disease Book Review:

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Communities in Action

Communities in Action
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on Community-Based Solutions to Promote Health Equity in the United States
Publsiher: National Academies Press
Total Pages: 582
Release: 2017-04-27
ISBN 10: 0309452961
ISBN 13: 9780309452960
Language: EN, FR, DE, ES & NL

Communities in Action Book Review:

In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

Clinical Pathways In Vitreoretinal Disease

Clinical Pathways In Vitreoretinal Disease
Author: Scott M. Steidl,Mary Elizabeth Hartnett
Publsiher: Thieme
Total Pages: 524
Release: 2011-01-01
ISBN 10: 1604064587
ISBN 13: 9781604064582
Language: EN, FR, DE, ES & NL

Clinical Pathways In Vitreoretinal Disease Book Review:

Vitreoretinal disease is the leading cause of severe vision loss in most developed countries. This all-encompassing new book is designed to enhance diagnosis and treatment of retinal pathology as you proceed from initial finding to differential diagnosis and treatment. Using evidence-based medicine to develop management strategies and featuring pathway diagrams and decision-making trees, the book links specific symptoms to the appropriate diagnosis and most effective treatment. A top team of retinal specialists have come together to create this pace-setting reference, covering everything from retinal detachment and hemorrhage, to pigmented lesions and noninfectious inflammation. Chapters are uniquely arranged by presenting symptom instead of diagnosis, allowing you to find material quickly and easily. Key features of this valuable book:Broad coverage of all important topics, including both pediatric and adult retinal diseasesClinical decision-making trees and pathway diagrams offering a yes-or-no approach to diagnosis and treatmentBeneficial question and answer format provides clarity and explanations for specific problemsHelpful table of contents organized by presenting symptomCLINICAL PATHWAY IN VITREORETINAL DISEASE is essential for all retina specialists, general ophthalmologists, and residents who treat severe vision loss. It offers the valuable information needed to reach an accurate diagnosis and provide optimal patient care. The book also serves as an excellent text for retina and general ophthalmology courses.

Reviews on New Drug Targets in Age Related Disorders

Reviews on New Drug Targets in Age Related Disorders
Author: Paul C. Guest
Publsiher: Springer Nature
Total Pages: 340
Release: 2020-04-17
ISBN 10: 303042667X
ISBN 13: 9783030426675
Language: EN, FR, DE, ES & NL

Reviews on New Drug Targets in Age Related Disorders Book Review:

Aging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.

Proteomics based Identification and Characterisation of Spinal Muscular Atrophy Disease Pathways

Proteomics based Identification and Characterisation of Spinal Muscular Atrophy Disease Pathways
Author: Darija Šoltić
Publsiher: Unknown
Total Pages: 135
Release: 2020
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1222803734
Language: EN, FR, DE, ES & NL

Proteomics based Identification and Characterisation of Spinal Muscular Atrophy Disease Pathways Book Review:

The Involvement of the Three Main Inflammatory Bowel Disease Pathways and the Secretion of Trypsin Proteolytic Activity on Intestinal Epithelial Cells

The Involvement of the Three Main Inflammatory Bowel Disease Pathways and the Secretion of Trypsin Proteolytic Activity on Intestinal Epithelial Cells
Author: Núria Solà Tapias
Publsiher: Unknown
Total Pages: 217
Release: 2018
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1137474806
Language: EN, FR, DE, ES & NL

The Involvement of the Three Main Inflammatory Bowel Disease Pathways and the Secretion of Trypsin Proteolytic Activity on Intestinal Epithelial Cells Book Review:

Crohn's disease (CD) and Ulcerative colitis (UC) are two forms of Inflammatory Bowel Disease (IBD), a chronic inflammatory pathology affecting the digestive tract. Patients suffer from relapsing flares, diarrhea, abdominal pain and bleeding. Although the molecular mechanisms of IBD are poorly understood, recent data suggest that IBD occurs in genetically predisposed individuals developing an abnormal immune response to intestinal microbes after, being exposed to specific environmental triggers. Genetic studies have reported more than 170 polymorphisms susceptible to be involved in IBD pathogenesis. The strongest associations have highlighted three main pathways altered in IBD including bacterial sensing (NOD2, CD), autophagy (ATG16L1 and IRGM, CD) and endoplasmic reticulum stress (ER-Stress) (XBP1, UC). The role of intestinal barrier function is also strongly implicated in IBD pathogenesis, and is modulated by factors present in the lumen derived from microbiota, food or at a molecular level, by factors such as proteases. In IBD pathophysiology, the inflammatory process is characterized by impaired intestinal biology including disruption of tight junctions and leaky gut, decreased amount of Paneth and Goblet cells, and translocation of luminal antigens triggering inflammation. Previous studies have demonstrated an increased level of active serine proteases in the stools and tissues of IBD patients, supposing that proteases originate from infiltrated immune cells, pancreatic secretion or microbiota. However, our team has reported that intestinal epithelial cells are a major source of serine proteases, in particular trypsin-like enzymes, are released by a stressed epithelium in pathogenic context such as irritable bowel syndrome. In this project, we aimed at better understanding whether the three main pathways involved in IBD (Nod2, autophagy, ER-stress) could be linked to an epithelial release of trypsin and reciprocally, if epithelial trypsin is able to induce or modulate these three IBD pathways. We confirmed that trypsin-like activity was significantly higher in biopsies from UC and CD patients compared to healthy controls. In Caco-2 monolayers cultured in transwells, secreted trypsin-like proteolytic activity remained stable upon NOD2 stimulation but decreased under autophagy induction. Thapsigargin (Tg) stimulation a well-known ER-stress inducer, enhanced the apical release of trypsin-like activity in Caco2 cells. [...].

The Embodiment of Social Isolation

The Embodiment of Social Isolation
Author: Gretchen L. Hermes
Publsiher: Unknown
Total Pages: 568
Release: 2003
ISBN 10: 1928374650XXX
ISBN 13: OCLC:55134354
Language: EN, FR, DE, ES & NL

The Embodiment of Social Isolation Book Review:

Improving Healthcare Quality in Europe Characteristics Effectiveness and Implementation of Different Strategies

Improving Healthcare Quality in Europe Characteristics  Effectiveness and Implementation of Different Strategies
Author: OECD,World Health Organization
Publsiher: OECD Publishing
Total Pages: 135
Release: 2019-10-17
ISBN 10: 9264805907
ISBN 13: 9789264805903
Language: EN, FR, DE, ES & NL

Improving Healthcare Quality in Europe Characteristics Effectiveness and Implementation of Different Strategies Book Review:

This volume, developed by the Observatory together with OECD, provides an overall conceptual framework for understanding and applying strategies aimed at improving quality of care. Crucially, it summarizes available evidence on different quality strategies and provides recommendations for their implementation. This book is intended to help policy-makers to understand concepts of quality and to support them to evaluate single strategies and combinations of strategies.

Defining the Role of TDP 43 in Neurodegenerative Disease Pathways

Defining the Role of TDP 43 in Neurodegenerative Disease Pathways
Author: Iga Natalia Wegorzewska
Publsiher: Unknown
Total Pages: 140
Release: 2014
ISBN 10: 1928374650XXX
ISBN 13: OCLC:891208821
Language: EN, FR, DE, ES & NL

Defining the Role of TDP 43 in Neurodegenerative Disease Pathways Book Review:

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder characterized by muscle weakness and spasticity due to selective degeneration of upper and lower motor neurons, with no effective treatment available. Interestingly, ALS and Frontotemporal lobar degeneration (FTLD) show considerable clinical and pathologic overlap. Mutations in the TAR DNA-binding protein (TDP-43) are a major component of ubiquitinated neuronal cytoplasmic inclusions in patients with familial as well as sporadic ALS, and TDP-43 aggregates are found in both ALS and FTLD-U (FTLD with ubiquitin aggregates), suggesting a common underlying mechanism. TDP-43 is a DNA/RNA binding protein that has been shown to play a role in transcription and mRNA processing, but whose physiologic function is not completely understood. We have characterized mice expressing the disease associated A315T TDP-43 mutant that develop a progressive neurodegenerative disease and recapitulate selective ubiquitin pathology and degeneration of layer V and spinal motor neurons. Surprisingly, TDP-43 is rarely present in large cytoplasmic ubiquitinated aggregates, and is not required for TDP-43 induced neurodegeneration, and instead suggested that altered DNA/RNA binding protein function is important to TDP-43-related neurodeegenration. To compare wild type (WT) and mutant TDP-43 and examine expression in various cell types at various levels, we have created new inducible transgenic mice expressing FLAG-tagged sequence following a transcriptional stop sequence flanked by loxP sites. By crossing to mice expressing universal Cre under the actin promoter, we created matched WT and mutant lines expressing the transgene at about one fold over endogenous levels. Neither WT nor mutant lines developed overt degeneration, behavioral abnormalities, or disease-associated pathology. However, the comparison of the dosage in the low expressing lines and original high expressing A315T line with corresponding phenotypes indicated that overexpression of TDP-43 produced neurodegeneration in a dose-dependent manner with expression above a threshold level. Furthermore, neurodegeneration correlated with the reduction of endogenous mouse TDP-43, which suggests that dysregulation of TDP-43 is taking place once this threshold of disease is crossed as well. In order to elucidate the mechanisms that drive TDP-43 mediated neurodegeneration, information on RNA binding targets combined with global expression and splicing changes is essential to understand the resulting misregulation that eventually leads to pathologic aggregate formation, cell loss, and axon degeneration. By immunoprecipitating and sequencing cross-linked RNAs bound to TDP-43 (known as CLIP-seq) we identified a long list of TDP-43 target RNAs in our TDP-43 based model of ALS/FTLD. Our analysis identified a TDP-43 auto-regulatory mechanism disrupted in neurodegeneration caused by altered splicing the 3' UTR of TDP-43's own transcript. Additional disease relevant targets whose splicing patterns was affected when overexpression of TDP-43 is driving neurodegeneration includes disease-related Fus/Tls, as well as others. While we are just beginning to understand the network of genes whose alternative splicing contributes to neurodegeneration, ongoing and future studies of TDP-43 mediated RNA processing will be important for the development of therapeutic interventions in patients.