Discovery and Development of Anti Breast Cancer Agents from Natural Products

Discovery and Development of Anti Breast Cancer Agents from Natural Products
Author: Goutam Brahmachari
Publsiher: Elsevier
Total Pages: 384
Release: 2021-06-24
ISBN 10: 0128212780
ISBN 13: 9780128212783
Language: EN, FR, DE, ES & NL

Discovery and Development of Anti Breast Cancer Agents from Natural Products Book Review:

Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields. Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. Highlights active agents from natural sources for development as novel anti-cancer agents Features contributions from active researchers and leading experts working in the field Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines

Anticancer Agents from Natural Products

Anticancer Agents from Natural Products
Author: Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publsiher: CRC Press
Total Pages: 600
Release: 2005-06-13
ISBN 10: 1420039652
ISBN 13: 9781420039658
Language: EN, FR, DE, ES & NL

Anticancer Agents from Natural Products Book Review:

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Bioactive Natural Products for the Management of Cancer from Bench to Bedside

Bioactive Natural Products for the Management of Cancer  from Bench to Bedside
Author: Anil K. Sharma
Publsiher: Springer
Total Pages: 218
Release: 2019-07-17
ISBN 10: 9811376077
ISBN 13: 9789811376078
Language: EN, FR, DE, ES & NL

Bioactive Natural Products for the Management of Cancer from Bench to Bedside Book Review:

This book illustrates the importance of the Natural Biometabolites, which offer a rich reservoir of candidate compounds for drug discovery in the battle against cancer. Recent research and development efforts concerning anti-cancer drugs derived from natural products have led to the identification of numerous candidate molecules that inhibit cancer cell proliferation and metastasis using a variety of mechanisms. Given its scope, the book offers a valuable resource for cancer biologists and general oncologists alike, while also benefitting research professionals in Science, Nursing, Medicine, Biochemistry, Genetics and Bioscience who wish to understand the fundamentals of prognosis and prediction in tumorigenesis. Moreover, the book provides an essential platform for understanding drug resistance mechanisms and combatting the growing menace of multidrug resistance.

New Approaches to Natural Anticancer Drugs

New Approaches to Natural Anticancer Drugs
Author: Soodabeh Saeidnia
Publsiher: Springer
Total Pages: 106
Release: 2015-02-05
ISBN 10: 3319140272
ISBN 13: 9783319140278
Language: EN, FR, DE, ES & NL

New Approaches to Natural Anticancer Drugs Book Review:

This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.

Life Saving Drugs

Life Saving Drugs
Author: John Mann
Publsiher: Royal Society of Chemistry
Total Pages: 256
Release: 2007-10-31
ISBN 10: 184755122X
ISBN 13: 9781847551221
Language: EN, FR, DE, ES & NL

Life Saving Drugs Book Review:

In 1900 only a handful of drugs (morphine, quinine, aspirin, etc) had genuine efficacy but had little value for bacterial or viral infections or cancer. These conditions were usually untreatable. Now there are literally thousands of drugs which offer cures or greatly extended life-spans for those with life-threatening conditions. Life Saving Drugs: the Elusive Magic Bullet describes the discovery and development of antibacterial, anti-viral and anti-cancer drugs. The book highlights the colourful characters behind the inventions and the huge improvements in quality of life and life-expectancy that these drugs have produced. Emphasis is given to the new drugs that have emerged as a result of knowledge of the human genome, and the ways in which the newer drugs are being designed to tackle disease, particularly cancer, at the genetic level. Chemical structures are provided for all of the key drugs and the book is well illustrated. Life Saving Drugs: the Elusive Magic Bullet can be read as a history of drug development during the past 100 years by those with only a passing knowledge of chemistry. For anyone entering the medical profession, pharmacy, or nursing, it will provide a superb basic knowledge of all drugs they are ever likely to meet, including their modes of action. For the chemist or medicinal chemist, it will provide the fundamental knowledge of life-saving drugs that they all should know. And for the non-scientist who wants to know about 'super-bugs', SARS, Ebola, and all of the wonderful advances in treating cancer, it is illuminating and easy to read.

Anti Angiogenesis Drug Discovery and Development

Anti Angiogenesis Drug Discovery and Development
Author: M. Iqbal Choudhary
Publsiher: Bentham Science Publishers
Total Pages: 320
Release: 2014-10-29
ISBN 10: 1608058662
ISBN 13: 9781608058662
Language: EN, FR, DE, ES & NL

Anti Angiogenesis Drug Discovery and Development Book Review:

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Anti-angiogenesis Drug Discovery and Development provides is an excellent compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two recent decades. The feast of these reader-friendly reviews on topics of great scientific importance – many of which are considered significant medical breakthroughs, makes this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. The second volume of this ebook series covers topics including: -Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis -Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer -Anti-Angiogenic Therapy and Cardiovascular Diseases … and more.

Discovery and Development of Neuroprotective Agents from Natural Products

Discovery and Development of Neuroprotective Agents from Natural Products
Author: Goutam Brahmachari
Publsiher: Elsevier
Total Pages: 490
Release: 2017-05-18
ISBN 10: 0128097698
ISBN 13: 9780128097694
Language: EN, FR, DE, ES & NL

Discovery and Development of Neuroprotective Agents from Natural Products Book Review:

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Anticancer Drug Development

Anticancer Drug Development
Author: Bruce C. Baguley,David J. Kerr
Publsiher: Elsevier
Total Pages: 397
Release: 2001-11-17
ISBN 10: 0080490441
ISBN 13: 9780080490441
Language: EN, FR, DE, ES & NL

Anticancer Drug Development Book Review:

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Phytonanotechnology

Phytonanotechnology
Author: N. Thajuddin,Silvy Mathew
Publsiher: Elsevier
Total Pages: 354
Release: 2020-05-31
ISBN 10: 0128223537
ISBN 13: 9780128223536
Language: EN, FR, DE, ES & NL

Phytonanotechnology Book Review:

Phytonanotechnology: Challenges and Prospects consolidates information on the use of phytonanoparticles for biomedical, environmental and agricultural applications, covering recent advances in experimental and theoretical studies on various properties of nanoparticles derived from plant sources. The book deals with various attributes of phytonanoparticles, discussing their current and potential applications. In addition, it explores the development of phytonanoparticles, synthesis techniques, characterization techniques, environmental remediation applications, anti-microbial properties, miscellaneous applications, and multi-functional applications. Risks associated with nanoparticles are also discussed. This book is an important reference for materials scientists, engineers, environmental scientists, food scientists and biomedical scientists who want to learn more about the applications of nanoparticles derived from plant sources. Explores synthesis methods of phytonanoparticles from a variety of plant groups Discusses the major biological reactions of phytonanoparticles Outlines the major opportunities and challenges of using phytonanoparticles in biomedical, environmental and agricultural applications

Drug Discovery from Natural Products

Drug Discovery from Natural Products
Author: Olga Genilloud,Francisca Vicente,David E. Thurston,Ana Martinez,David Rotella,Salvatore Guccione,Robin Ganellin
Publsiher: Royal Society of Chemistry
Total Pages: 436
Release: 2012
ISBN 10: 1849733619
ISBN 13: 9781849733618
Language: EN, FR, DE, ES & NL

Drug Discovery from Natural Products Book Review:

An integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

Unique Aspects of Anti cancer Drug Development

Unique Aspects of Anti cancer Drug Development
Author: Jolanta Natalia Latosińska,Magdalena Latosińska
Publsiher: BoD – Books on Demand
Total Pages: 146
Release: 2017-07-12
ISBN 10: 9535133470
ISBN 13: 9789535133476
Language: EN, FR, DE, ES & NL

Unique Aspects of Anti cancer Drug Development Book Review:

The evidence of cancer in humans, animals and plant species suggests that it is as old as multicellular life on Earth. Why is it so difficult to understand and fight? Because cancer begins from the organism's own mutated single cell focused on its own survival. It would be naive to expect that cancer could be ever entirely eliminated, but there is still hope for finding effective treatments. The book is to give a view of selected aspects of cancer like its spread in nature, novel anticancer drugs based on Chinese herbs or birch bark, novel promising targets of annexins and kinases and progress in immunotherapy. It is our hope that you will find in this book interesting, inspiring and stimulating information concerning cancer research.

Frontiers in Clinical Drug Research Anti Cancer Agents

Frontiers in Clinical Drug Research   Anti Cancer Agents
Author: Atta-ur-Rahman
Publsiher: Bentham Science Publishers
Total Pages: 340
Release: 2014-09-16
ISBN 10: 1608057984
ISBN 13: 9781608057986
Language: EN, FR, DE, ES & NL

Frontiers in Clinical Drug Research Anti Cancer Agents Book Review:

Frontiers in Clinical Drug Research - Anti-Cancer Agents should prove to be a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field. The chapters in this volume have been written by leading experts from the field. The contents of this book include new approaches to cancer therapy, treatment of metastatic non-small cell lung cancer with epidermal growth factor receptor-tyrosine kinase inhibitors, targeting key signaling pathways in pediatric brain tumors, current status of cladribine in lymphoid and myeloid malignancies, natural anti-cancer products and the mechanisms of telomere and telomerase regulation in hematologic malignancies. The eBook series is essential to all scientists involved in clinical drug research who wish to keep abreast of rapid and important developments in the field. The readers will find these reviews valuable and will certainly trigger further research in the pharmaceutical development of anti-cancer agents.

Topics in Anti Cancer Research

Topics in Anti Cancer Research
Author: Atta-ur Rahman,Khurshid Zaman
Publsiher: Bentham Science Publishers
Total Pages: 650
Release: 2014-11-28
ISBN 10: 1608059081
ISBN 13: 9781608059089
Language: EN, FR, DE, ES & NL

Topics in Anti Cancer Research Book Review:

This is the third volume of the Patent eBook Series entitled Topics in Anti-Cancer Research. This eBook comprises updated reviews on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery. The comprehensive range of themes covered in this third volume will be of benefit to clinicians, scientists and R&D experts looking for new targets for the prevention of cancer and discovery of drugs for the treatment of different cancer types. Regulation of tumor cells by TRAIL receptors, development of anti- cancer drugs & immunomodulatory drugs, molecular studies of adrenocortical cancer, role of inhibitors of inosine monophosphate dehydrogenase in cancer, recent updates in glioblastoma stem cells, latest approaches for cancer gene therapy and metabolic therapy for cancer were reviewed and updated. The role of pH regulation and application of hyperthermia, thiosemicarbazone derivatives, tamoxifen-based therapies for cancer treatment andproteome-based complex therapy of tumors, calcium signaling and angiogenesis, antineoplastic role of GHRH antagonists and therapeutic applications in human tumors and clinical oncology have been extensively discussed in the light of recent innovations. The topics covered in this third volume will be valuable for those interested in scientists interests in methods for the prevention of cancer as well its management.

Naturally Occurring Small Molecules For Disease And Cancer Treatment Therapeutic Benefits In Combination Therapy

Naturally Occurring Small Molecules For Disease And Cancer Treatment  Therapeutic Benefits In Combination Therapy
Author: Ho John Wing Shing
Publsiher: World Scientific
Total Pages: 172
Release: 2019-04-23
ISBN 10: 9814525642
ISBN 13: 9789814525640
Language: EN, FR, DE, ES & NL

Naturally Occurring Small Molecules For Disease And Cancer Treatment Therapeutic Benefits In Combination Therapy Book Review:

Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.

Anticancer Agents

Anticancer Agents
Author: Qiao-Hong Chen
Publsiher: MDPI
Total Pages: 606
Release: 2021-03-02
ISBN 10: 3036501401
ISBN 13: 9783036501406
Language: EN, FR, DE, ES & NL

Anticancer Agents Book Review:

This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.

Natural Products and Cancer Drug Discovery

Natural Products and Cancer Drug Discovery
Author: Frank E. Koehn
Publsiher: Springer Science & Business Media
Total Pages: 244
Release: 2012-11-09
ISBN 10: 1461446546
ISBN 13: 9781461446545
Language: EN, FR, DE, ES & NL

Natural Products and Cancer Drug Discovery Book Review:

This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Natural Products in Clinical Trials Volume 1

Natural Products in Clinical Trials  Volume 1
Author: Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
Publsiher: Bentham Science Publishers
Total Pages: 253
Release: 2018-03-03
ISBN 10: 1681082136
ISBN 13: 9781681082134
Language: EN, FR, DE, ES & NL

Natural Products in Clinical Trials Volume 1 Book Review:

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Anti Obesity Drug Discovery and Development

Anti Obesity Drug Discovery and Development
Author: Atta-ur-Rahman,M. Iqbal Choudhary
Publsiher: Bentham Science Publishers
Total Pages: 295
Release: 2014-08-08
ISBN 10: 1608059146
ISBN 13: 9781608059140
Language: EN, FR, DE, ES & NL

Anti Obesity Drug Discovery and Development Book Review:

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. Fifteen well written reviews make this special volume an excellent compilation of recent developments in anti-obesity treatment. The reviews cover a variety of topics including the development of specific, safe and effective receptor antagonists, the role of epithelial endocrine cells and post operative treatment strategies. This book should be useful to clinicians and medicinal chemists involved in ant-obesity research and therapy.

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products
Author: Goutam Brahmachari
Publsiher: Elsevier
Total Pages: 332
Release: 2016-10-11
ISBN 10: 0128096926
ISBN 13: 9780128096925
Language: EN, FR, DE, ES & NL

Discovery and Development of Antidiabetic Agents from Natural Products Book Review:

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
Author: Carmen Avendano,J. Carlos Menendez
Publsiher: Elsevier
Total Pages: 768
Release: 2015-06-11
ISBN 10: 0444626670
ISBN 13: 9780444626677
Language: EN, FR, DE, ES & NL

Medicinal Chemistry of Anticancer Drugs Book Review:

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature