Journal of the National Cancer Institute

Journal of the National Cancer Institute
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: NYPL:33433078243049
Language: EN, FR, DE, ES & NL

Journal of the National Cancer Institute Book Review:

JAMA

JAMA
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: NWU:35558004989311
Language: EN, FR, DE, ES & NL

JAMA Book Review:

Journal of the National Cancer Institute

Journal of the National Cancer Institute
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: NWU:35558004949935
Language: EN, FR, DE, ES & NL

Journal of the National Cancer Institute Book Review:

"Summaries of papers" contained in the journal accompany each issue, 19--

The New England Journal of Medicine

The New England Journal of Medicine
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: UCSD:31822034143735
Language: EN, FR, DE, ES & NL

The New England Journal of Medicine Book Review:

The Vanishing Physician Scientist

The Vanishing Physician Scientist
Author: Andrew I. Schafer
Publsiher: Cornell University Press
Total Pages: 304
Release: 2011-06-15
ISBN 10: 0801462428
ISBN 13: 9780801462429
Language: EN, FR, DE, ES & NL

The Vanishing Physician Scientist Book Review:

Throughout history, physicians have played a vital role in medical discovery. These physician-scientists devote the majority of their professional effort to seeking new knowledge about health and disease through research and represent the entire continuum of biomedical investigation. They bring a unique perspective to their work and often base their scientific questions on the experience of caring for patients. Physician-scientists also effectively communicate between researchers in the "pure sciences" and practicing health care providers. Yet there has been growing concern in recent decades that, due to complex changes, physician-scientists are vanishing from the scene. In this book, leading physician-scientists and academic physicians examine the problem from a variety of perspectives: historical, demographic, scientific, cultural, sociological, and economic. They make valuable recommendations that—if heeded—should preserve and revitalize the community of physician-scientists as the profession continues to evolve and boundaries between doctors and researchers shift.

Designing Clinical Research

Designing Clinical Research
Author: Stephen B. Hulley,Steven R. Cummings,Warren S. Browner,Deborah G. Grady,Thomas B. Newman
Publsiher: Lippincott Williams & Wilkins
Total Pages: 384
Release: 2011-11-30
ISBN 10: 1451165854
ISBN 13: 9781451165852
Language: EN, FR, DE, ES & NL

Designing Clinical Research Book Review:

Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop. Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.

Translational Neuroscience

Translational Neuroscience
Author: Edgar Garcia-Rill
Publsiher: John Wiley & Sons
Total Pages: 168
Release: 2012-02-07
ISBN 10: 047096071X
ISBN 13: 9780470960714
Language: EN, FR, DE, ES & NL

Translational Neuroscience Book Review:

Translational research looks to take the latest innovations made in the laboratory setting to translate findings into effective and sustainable medical interventions and improved preventative measures. Funding support is increasingly tied to practical healthcare outcomes, with this trend likely only to increase in coming years, Translational Neuroscience: A Guide to a Successful Program, is a timely guide to developing research programs that bring translational advances to the forefront. Translational Neuroscience provides practical information from scientists with first-hand experience in developing a cutting-edge translational facility. The book opens with chapters that provide guidance to organizing a center for translational science. Chapters look at topics ranging from mentoring and career planning for clinician scientists to improving the design of core facilities and addressing infrastructure needs. The second half of the book provides valuable case studies of translational neuroscience in action, with examples ranging from using to transcranial magnetic stimulation to studies on drug abuse and telemedicine applications. The final chapter looks to the future of basic science research, how academic health centers can be reorganized, and how future generations of translational neuroscientists can be trained. Translational Neuroscience provides a blueprint to developing an innovative and successful translational research program. Deans, department chairs, academic health center administrators, and researchers will find this guide useful for drafting programs in translational research and avoiding costly pitfalls. While grounded in examples from basic neuroscience research, this book will be a useful tool to all scientists looking to develop centers of translational science across research disciplines.

Envisioning a Transformed Clinical Trials Enterprise in the United States

Envisioning a Transformed Clinical Trials Enterprise in the United States
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publsiher: National Academies Press
Total Pages: 248
Release: 2012-09-13
ISBN 10: 0309253187
ISBN 13: 9780309253185
Language: EN, FR, DE, ES & NL

Envisioning a Transformed Clinical Trials Enterprise in the United States Book Review:

There is growing recognition that the United States' clinical trials enterprise (CTE) faces great challenges. There is a gap between what is desired - where medical care is provided solely based on high quality evidence - and the reality - where there is limited capacity to generate timely and practical evidence for drug development and to support medical treatment decisions. With the need for transforming the CTE in the U.S. becoming more pressing, the IOM Forum on Drug Discovery, Development, and Translation held a two-day workshop in November 2011, bringing together leaders in research and health care. The workshop focused on how to transform the CTE and discussed a vision to make the enterprise more efficient, effective, and fully integrated into the health care system. Key issue areas addressed at the workshop included: the development of a robust clinical trials workforce, the alignment of cultural and financial incentives for clinical trials, and the creation of a sustainable infrastructure to support a transformed CTE. This document summarizes the workshop.

Clinical and Translational Science

Clinical and Translational Science
Author: David Robertson,Gordon H. Williams
Publsiher: Academic Press
Total Pages: 808
Release: 2016-11-25
ISBN 10: 012802111X
ISBN 13: 9780128021118
Language: EN, FR, DE, ES & NL

Clinical and Translational Science Book Review:

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Peptide Drug Discovery and Development

Peptide Drug Discovery and Development
Author: Miguel Castanho,Nuno Santos
Publsiher: John Wiley & Sons
Total Pages: 390
Release: 2011-10-24
ISBN 10: 3527636749
ISBN 13: 9783527636747
Language: EN, FR, DE, ES & NL

Peptide Drug Discovery and Development Book Review:

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Immunotherapy in Translational Cancer Research

Immunotherapy in Translational Cancer Research
Author: Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Publsiher: John Wiley & Sons
Total Pages: 312
Release: 2018-05-01
ISBN 10: 1118123220
ISBN 13: 9781118123225
Language: EN, FR, DE, ES & NL

Immunotherapy in Translational Cancer Research Book Review:

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Developing a Program of Research

Developing a Program of Research
Author: Nancy Edwards,Susan Roelofs
Publsiher: Unknown
Total Pages: 390
Release: 2019
ISBN 10: 9780889274990
ISBN 13: 0889274991
Language: EN, FR, DE, ES & NL

Developing a Program of Research Book Review:

Developing a Program of Research offers the first practical guide on creating, evolving and sustaining a successful program of research in applied health, social sciences, and education fields. Discover how accomplished researchers from a variety of disciplines developed their programs built interdisciplinary networks, and worked with decision-makers to maximize their research impact. Learn how to navigate the key roles and structures of research institutes, and develop an understanding of the role and context of funding agencies. Enriched with practical exercises, international case studies and thought-provoking questions, this is the essential guide for anyone who's exploring--or revisiting--the challenging and rewarding process of developing a research program. An indispensable resource for early- and mid-career researchers, Developing a Program of Research also holds invaluable information for established researchers seeking to shifting their focus--as well as for mentors and educators of early-career researchers, and leaders of organizational research units, centres, and institutes. Filled with insights from established and experienced researchers, this book serves as both a practical handbook and a behind-the-scenes look at how to develop a program of research.

Research Report

Research Report
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1999
ISBN 10:
ISBN 13: CHI:58625848
Language: EN, FR, DE, ES & NL

Research Report Book Review:

A National Cancer Clinical Trials System for the 21st Century

A National Cancer Clinical Trials System for the 21st Century
Author: Institute of Medicine,Board on Health Care Services,Committee on Cancer Clinical Trials and the NCI Cooperative Group Program
Publsiher: National Academies Press
Total Pages: 316
Release: 2010-07-08
ISBN 10: 9780309157872
ISBN 13: 0309157870
Language: EN, FR, DE, ES & NL

A National Cancer Clinical Trials System for the 21st Century Book Review:

The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research.

Pediatric Formulations

Pediatric Formulations
Author: Daniel Bar-Shalom,Klaus Rose
Publsiher: Springer Science & Business Media
Total Pages: 439
Release: 2014-01-30
ISBN 10: 1489980113
ISBN 13: 9781489980113
Language: EN, FR, DE, ES & NL

Pediatric Formulations Book Review:

Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.

Clinical Trials

Clinical Trials
Author: Steven Piantadosi
Publsiher: John Wiley & Sons
Total Pages: 720
Release: 2013-05-29
ISBN 10: 1118625854
ISBN 13: 9781118625859
Language: EN, FR, DE, ES & NL

Clinical Trials Book Review:

Learn rigorous statistical methods to ensure valid clinicaltrials This Second Edition of the critically hailed Clinical Trials buildson the text's reputation as a straightforward and authoritativepresentation of statistical methods for clinical trials. Readersare introduced to the fundamentals of design for various types ofclinical trials and then skillfully guided through the completeprocess of planning the experiment, assembling a study cohort,assessing data, and reporting results. Throughout the process, theauthor alerts readers to problems that may arise during the courseof the trial and provides commonsense solutions. The author bases the revisions and updates on his own classroomexperience, as well as feedback from students, instructors, andmedical and statistical professionals involved in clinical trials.The Second Edition greatly expands its coverage, ranging fromstatistical principles to controversial topics, includingalternative medicine and ethics. At the same time, it offers morepragmatic advice for issues such as selecting outcomes, samplesize, analysis, reporting, and handling allegations of misconduct.Readers familiar with the First Edition will discover completelynew chapters, including: * Contexts for clinical trials * Statistical perspectives * Translational clinical trials * Dose-finding and dose-ranging designs Each chapter is accompanied by a summary to reinforce the keypoints. Revised discussion questions stimulate critical thinkingand help readers understand how they can apply their newfoundknowledge, and updated references are provided to direct readers tothe most recent literature. This text distinguishes itself with its accessible and broadcoverage of statistical design methods--the crucial building blocksof clinical trials and medical research. Readers learn to conductclinical trials that produce valid qualitative results backed byrigorous statistical methods.

Mixed Methods in Health Sciences Research

Mixed Methods in Health Sciences Research
Author: Leslie Curry,Marcella Nunez-Smith
Publsiher: SAGE Publications
Total Pages: 432
Release: 2014-09-30
ISBN 10: 1483347141
ISBN 13: 9781483347141
Language: EN, FR, DE, ES & NL

Mixed Methods in Health Sciences Research Book Review:

Mixed Methods in Health Sciences Research: A Practical Primer, by Leslie Curry and Marcella Nunez-Smith, presents key theories, concepts, and approaches in an accessible way. Packed with illustrations from the health sciences literature, this ready-to-use guidebook shows readers how to design, conduct, review, and use mixed methods research findings. Helpful checklists, figures, tables, templates, and much more give readers examples that will elevate the quality of their research, facilitate communication about their methods, and improve efficiency over the course of their projects. Real-world examples and insights from mixed methods researchers provide unique perspectives on every aspect of mixed methods research. This book successfully pulls together foundational mixed methods principles, synthesizes the knowledge base in the field, and translates it for a health science researcher audience. “The content is highly applicable to real life research teams in the areas of clinical research, health services research, and implementation science, providing sound content and practical advice. The authors have synthesized and pull key concepts from a variety of sources to provide a concise resource.” —Linda M. Herrick, South Dakota State University “Everything from the references, to the topics, checklists, conceptual graphic representations, and organizers, interviews, and resources, all contribute to the content and aid with understanding and/or application. … It addresses specific MM research as it pertains to health sciences in a way that other texts just do not even attempt.” —Denise L. Winsor, University of Memphis “[This text is] a very pragmatic approach to mixed methods research; excellent resources, tables, and figures [are] provided, along with cases and examples of value to researchers and grant reviewers. Its relevance to practice, education, and research, as well as to potential policy implications, is a strong focus that would make this a valued textbook for any researcher!” ? —Karen Devereaux Melillo, University of Massachusetts Lowell “The text is cutting edge. It leads the way with its focus on team dynamics. [The authors] succeed in making the book relevant and practical. They also articulate a number of key insights in the area of mixed methods that rarely get addressed, such as teams and conflict. Great read with a lot of good, practical information for mixed methods researchers at all levels. The practical approach of this text makes it an innovative and valuable resource.” —John G. Schumacher, University of Maryland

Translational Medicine Tools And Techniques

Translational Medicine  Tools And Techniques
Author: Aamir Shahzad
Publsiher: Academic Press
Total Pages: 196
Release: 2015-11-24
ISBN 10: 0128034947
ISBN 13: 9780128034941
Language: EN, FR, DE, ES & NL

Translational Medicine Tools And Techniques Book Review:

Translational Medicine: Tools and Techniques provides a standardized path from basic research to the clinic and brings together various policy and practice issues to simplify the broad interdisciplinary field. With discussions from academic and industry leaders at international institutions who have successfully implemented translational medicine techniques and tools in various settings, readers will be guided through implementation strategies relevant to their own needs and institutions. The book also addresses regulatory processes in USA, EU, Japan and China. By providing details on omics sciences techniques, biomarkers, data mining and management approaches, case reports from industry, and tools to assess the value of different technologies and techniques, this book is the first to provide a user-friendly go-to guide for key opinion leaders (KOLs), industry administrators, faculty members, clinicians, researchers, and students interested in translational medicine. Includes detailed and standardized information about the techniques and tools used in translational medicine Provides specific industry case scenarios Explains how to use translational medicine tools and techniques to plan and improve infrastructures and capabilities while reducing cost and optimizing resources

Examining the Impact of Real World Evidence on Medical Product Development

Examining the Impact of Real World Evidence on Medical Product Development
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publsiher: National Academies Press
Total Pages: 230
Release: 2019-04-05
ISBN 10: 030948832X
ISBN 13: 9780309488327
Language: EN, FR, DE, ES & NL

Examining the Impact of Real World Evidence on Medical Product Development Book Review:

Randomized controlled trials (RCTs) have traditionally served as the gold standard for generating evidence about medical interventions. However, RCTs have inherent limitations and may not reflect the use of medical products in the real world. Additionally, RCTs are expensive, time consuming, and cannot answer all questions about a product or intervention. Evidence generated from real-world use, such as real-world evidence (RWE) may provide valuable information, alongside RCTs, to inform medical product decision making. To explore the potential for using RWE in medical product decision making, the National Academies of Sciences, Engineering, and Medicine planned a three-part workshop series. The series was designed to examine the current system of evidence generation and its limitations, to identify when and why RWE may be an appropriate type of evidence on which to base decisions, to learn from successful initiatives that have incorporated RWE, and to describe barriers that prevent RWE from being used to its full potential. This publication summarizes the discussions from the entire workshop series.

Intervention Research

Intervention Research
Author: Bernadette Mazurek Melnyk, PhD, RN, CPNP/ PMHNP, FNAP, FAAN,Dianne Morrison-Beedy, PhD, RN, WHNP, FNAP, FAANP, FAAN
Publsiher: Springer Publishing Company
Total Pages: 496
Release: 2012-04-23
ISBN 10: 0826109586
ISBN 13: 9780826109583
Language: EN, FR, DE, ES & NL

Intervention Research Book Review:

2012 First Place AJN Book of the Year Award Winner in Nursing Research! "This is a resource for success and should be a part of any researcher's library."--Doody's Medical Reviews This book is a practical, user-friendly guide for health care researchers across multiple disciplines who are involved in intervention research. It provides all of the essential elements needed for understanding how to design, conduct, analyze, and fund intervention studies that are replicable and can withstand the scrutiny of the Institutional Review Board and peer review. Developed from an annual continuing education workshop on intervention studies conducted by Dr. Melnyk, this text is the most comprehensive body of information available on this topic. Contributors address the design of interventions that are ethically considerate and sensitive to culture, race/ethnicity, and gender, minimizing threats to external and internal validity, measurement, and budgeting. The guide explores such implementation issues as subject recruitment and retention, data management, and specialized settings, cost analysis, and explaining intervention effects. The text also guides readers in writing grant applications that fund , and addresses how to move intervention study findings into the real world. A unique addition to the book is the availability of digital examples of progress reports, final reports, and research grant applications that have received funding from the National Institutes of Health and other relevant organizations. This text is a valuable resource for all health care professionals conducting research and for doctoral students in health care studies. Key Features: Presents the essential tools for designing, conducting, analyzing, and funding intervention studies Designed for use by health care professionals conducting intervention research Provides comprehensive, accessible guidelines for doctoral students across all health care disciplines Instructs readers on writing grant applications that fund Includes digital examples of funded research grants, progress reports, and final reports