CRISPR Genome Surgery in Stem Cells and Disease Tissues

CRISPR Genome Surgery in Stem Cells and Disease Tissues
Author: Stephen H. Tsang
Publsiher: Academic Press
Total Pages: 225
Release: 2021-05-01
ISBN 10: 0128178779
ISBN 13: 9780128178775
Language: EN, FR, DE, ES & NL

CRISPR Genome Surgery in Stem Cells and Disease Tissues Book Review:

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy

Human Genome Editing

Human Genome Editing
Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publsiher: National Academies Press
Total Pages: 328
Release: 2017-08-13
ISBN 10: 0309452880
ISBN 13: 9780309452885
Language: EN, FR, DE, ES & NL

Human Genome Editing Book Review:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Advances in Genome Editing

Advances in Genome Editing
Author: Jennifer A. Doudna
Publsiher: Anonim
Total Pages: 329
Release: 2016
ISBN 10: 9781618962331
ISBN 13: 1618962337
Language: EN, FR, DE, ES & NL

Advances in Genome Editing Book Review:

Genome Editing and Engineering

Genome Editing and Engineering
Author: Krishnarao Appasani
Publsiher: Cambridge University Press
Total Pages: 586
Release: 2018-07-31
ISBN 10: 1107170370
ISBN 13: 9781107170377
Language: EN, FR, DE, ES & NL

Genome Editing and Engineering Book Review:

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Stem Cells for Cancer and Genetic Disease Treatment

Stem Cells for Cancer and Genetic Disease Treatment
Author: Phuc Van Pham,Ahmed El-Hashash
Publsiher: Springer
Total Pages: 190
Release: 2018-11-07
ISBN 10: 3319980653
ISBN 13: 9783319980652
Language: EN, FR, DE, ES & NL

Stem Cells for Cancer and Genetic Disease Treatment Book Review:

This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or disorders. Stem Cells for Cancer and Genetic Disease Treatment and the other books in the Stem Cells in Clinical Applicationsseries will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering as well as cancer or genetics research.

Osteoarthritis, Inflammation and Degradation

Osteoarthritis, Inflammation and Degradation
Author: Joseph A. Buckwalter,Martin K. Lotz,J. F. Stoltz
Publsiher: IOS Press
Total Pages: 299
Release: 2007-01-01
ISBN 10: 1586037730
ISBN 13: 9781586037734
Language: EN, FR, DE, ES & NL

Osteoarthritis, Inflammation and Degradation Book Review:

Osteoarthritis is a public health issue due to its impact in term of handicap. Regarded as a multi-factorial disease, mechanistic and inflammatory theories are no more opposed but, on the contrary, are framed within the same continuum: osteoarthritis, inflammation and degeneration. This book helps readers understand the secrets of this disease.

Corneal Regeneration

Corneal Regeneration
Author: Jorge L. Alió,Jorge L. Alió del Barrio,Francisco Arnalich-Montiel
Publsiher: Springer
Total Pages: 507
Release: 2019-02-20
ISBN 10: 3030013049
ISBN 13: 9783030013042
Language: EN, FR, DE, ES & NL

Corneal Regeneration Book Review:

This text provides expert instruction on the varying surgical techniques currently employed for the regeneration of the ocular surface. Corneal Regeneration: Therapy and Surgery begins with a thorough discussion of current research based on data obtained in clinical human studies, and discusses the potential clinical implications for this promising new stage of eye surgery. Sections devoted to the stem cell, regenerative surgery and therapy of the ocular surface epithelium, corneal stroma, and corneal endothelium follow, each section comprehensively covering applied anatomy, current therapy and regenerative techniques, with a look to future directions of the field including eventual cell therapy. Corneal Regeneration: Therapy and Surgery is the first book of its kind, systematically covering the developments the medical community has achieved in corneal regeneration from all angles. Written and edited by leading experts in the field, researchers and ophthalmologists alike will find this to be a unique source of information on corneal regeneration, as well as a thoughtful reflection on potential applications of regenerative surgery in ophthalmology as a whole.

Encyclopedia of Tissue Engineering and Regenerative Medicine

Encyclopedia of Tissue Engineering and Regenerative Medicine
Author: Anonim
Publsiher: Academic Press
Total Pages: 1418
Release: 2019-06-04
ISBN 10: 0128137002
ISBN 13: 9780128137000
Language: EN, FR, DE, ES & NL

Encyclopedia of Tissue Engineering and Regenerative Medicine Book Review:

Encyclopedia of Tissue Engineering and Regenerative Medicine provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. By providing concise expositions on a broad range of topics, this encyclopedia is an excellent resource. Tissue engineering and regenerative medicine are relatively new fields still in their early stages of development, yet they already show great promise. This encyclopedia brings together foundational content and hot topics in both disciplines into a comprehensive resource, allowing deeper interdisciplinary research and conclusions to be drawn from two increasingly connected areas of biomedicine. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the fields of tissue engineering and regenerative medicine Contains multimedia features, including hyperlinked references and further readings, cross-references and diagrams/images Represents the most comprehensive and exhaustive product on the market on the topic

The Columbia Guide to Basic Elements of Eye Care

The Columbia Guide to Basic Elements of Eye Care
Author: Daniel S. Casper,George A. Cioffi
Publsiher: Springer
Total Pages: 531
Release: 2019-07-01
ISBN 10: 3030108864
ISBN 13: 9783030108861
Language: EN, FR, DE, ES & NL

The Columbia Guide to Basic Elements of Eye Care Book Review:

This unique resource is a practical, easy-to-use guide for the non-ophthalmologist healthcare provider as they encounter patients with eye complaints and other concerning ophthalmic conditions. The Columbia Guide to Basic Elements of Eye Care is specifically designed with the non-ophthalmologist in mind, and provides a foundation of basic eye anatomy and physiology, functional analysis, pathology, and concepts in eye care. Each chapter delivers an accessible summary of various ophthalmic diseases and conditions, all of which are frequently encountered in everyday practice. These chapters provide in-depth discussions on a wide range of topics, from testing and examination procedures to management protocols, referral guidelines and expected frequency of follow-up for each disorder. Complete with hundreds of high-quality, descriptive illustrations and clinical photographs, The Columbia Guide to Basic Elements of Eye Care presents clear, understandable explanations of basic eye anatomy, physiology, disease and treatment for non-ophthalmic practitioners and students. In doing so, this guide provides a framework for determining the normal versus the abnormal, helping the reader recognize which patients require referral, and identify which conditions are developing, require urgent treatment, or can be routinely followed. Non-ophthalmologist healthcare providers and students alike will find this book, written by leaders in the field, a practical resource to consult as they encounter patients with treatable but potentially sight-threatening conditions.

Cellular Therapies for Retinal Disease

Cellular Therapies for Retinal Disease
Author: Steven D. Schwartz,Aaron Nagiel,Robert Lanza
Publsiher: Springer
Total Pages: 143
Release: 2017-06-20
ISBN 10: 3319494791
ISBN 13: 9783319494791
Language: EN, FR, DE, ES & NL

Cellular Therapies for Retinal Disease Book Review:

This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by two world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.

Human Germline Modification and the Right to Science

Human Germline Modification and the Right to Science
Author: Andrea Boggio,Cesare P. R. Romano,Jessica Almqvist
Publsiher: Cambridge University Press
Total Pages: 324
Release: 2020-01-09
ISBN 10: 1108499872
ISBN 13: 9781108499873
Language: EN, FR, DE, ES & NL

Human Germline Modification and the Right to Science Book Review:

A survey of the regulation of human germline genome modification in eighteen countries and the emerging international standards.

Andreoli and Carpenter's Cecil Essentials of Medicine E-Book

Andreoli and Carpenter's Cecil Essentials of Medicine E-Book
Author: Ivor Benjamin,Robert C. Griggs,Thomas E. Andreoli,J. Gregory Fitz
Publsiher: Elsevier Health Sciences
Total Pages: 1312
Release: 2010-04-06
ISBN 10: 1437726739
ISBN 13: 9781437726732
Language: EN, FR, DE, ES & NL

Andreoli and Carpenter's Cecil Essentials of Medicine E-Book Book Review:

Students, residents, and instructors swear by Andreoli and Carpenter’s Cecil Essentials of Medicine because it presents just the right amount of information, just the right way. Edited by the late Thomas E. Andreoli, MD as well as Ivor Benjamin, MD, Robert C. Griggs, MD, and Edward J. Wing, MD, it focuses on core principles and how they apply to patient care, covering everything you need to know to succeed on a medical rotation or residency. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible. New chapters on "Pre- and Post-Operative Care" and "Palliative Care," plus the integration of molecular biology and other new horizons in medicine, familiarize you with the most current clinical concepts. An expanded International Editorial Board provides increased input from respected practitioners worldwide. Excellent images and clinical photographs vividly illustrate the appearance and clinical features of disease. Masterful editing and a user-friendly full-color design make absorbing and retaining information as effortless as possible.

Second Generation Cell and Gene-Based Therapies

Second Generation Cell and Gene-Based Therapies
Author: Alain Vertes,Nathan J. Dowden,Devyn Smith,Nasib Qureshi
Publsiher: Academic Press
Total Pages: 846
Release: 2020-02-07
ISBN 10: 0128120339
ISBN 13: 9780128120330
Language: EN, FR, DE, ES & NL

Second Generation Cell and Gene-Based Therapies Book Review:

Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products. The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies

CRISPR-Cas Systems

CRISPR-Cas Systems
Author: Rodolphe Barrangou,John van der Oost
Publsiher: Springer Science & Business Media
Total Pages: 302
Release: 2012-12-13
ISBN 10: 364234657X
ISBN 13: 9783642346576
Language: EN, FR, DE, ES & NL

CRISPR-Cas Systems Book Review:

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Precision Medicine, CRISPR, and Genome Engineering

Precision Medicine, CRISPR, and Genome Engineering
Author: Stephen H. Tsang
Publsiher: Springer
Total Pages: 178
Release: 2017-11-11
ISBN 10: 3319639048
ISBN 13: 9783319639048
Language: EN, FR, DE, ES & NL

Precision Medicine, CRISPR, and Genome Engineering Book Review:

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.

Progress in Stem Cell Transplantation

Progress in Stem Cell Transplantation
Author: Taner Demirer
Publsiher: BoD – Books on Demand
Total Pages: 208
Release: 2015-12-02
ISBN 10: 9535122274
ISBN 13: 9789535122272
Language: EN, FR, DE, ES & NL

Progress in Stem Cell Transplantation Book Review:

This book documents the increased amount of stem cell-related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies discussed in basic and clinical chapters from authors around the world involved in stem cell studies and research. It thereby complements and extends the basic coverage of stem cells, such as mesenchymal stem cells, effect of stem cells on aging, cover hematopoietic stem cells, storage and cryopreservation, issues related to clinical applications such as haploidentical transplants and use of stem cells for the treatment of Huntingtons disease. Clearly, the treatment of various malignant and nonmalignant diseases depends heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.

SCHWARTZ'S PRINCIPLES OF SURGERY 2-volume set 11th edition

SCHWARTZ'S PRINCIPLES OF SURGERY 2-volume set 11th edition
Author: F. Charles Brunicardi,Dana K. Andersen,Timothy R. Billiar,David L. Dunn,John G. Hunter,Lillian Kao,Jeffrey B. Matthews,Raphael E. Pollock
Publsiher: McGraw Hill Professional
Total Pages: 2448
Release: 2019-05-29
ISBN 10: 1259835375
ISBN 13: 9781259835377
Language: EN, FR, DE, ES & NL

SCHWARTZ'S PRINCIPLES OF SURGERY 2-volume set 11th edition Book Review:

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The BEST EDITION yet of the #1 text for surgical practice and education For half-a-century, no other text has provided such a solid grounding in basic science, anatomy, operative techniques, and more recently, professional development and leadership training, as Schwartz’s Principles of Surgery. Written by the world’s foremost surgeons, this landmark reference offers distinctly modern and all-encompassing coverage of every important topic in general surgery. Enhanced by a new two volume presentation, the Eleventh Edition has been completely updated and refreshed with an emphasis on state-of-the-art, evidence-based surgical care. You will find an exciting array of new contributors from around the world, new chapters on cutting-edge topics, plus the acclaimed learning aids that make the material easier to understand and memorize. This outstanding content is bolstered by more than 800 photographs and 1,300 line drawings, most in full color, as well as online videos demonstrating key operations. Here’s why the Eleventh Edition is the best edition yet: Six timely new chapters on important topics such as enhanced recovery after surgery (ERAS), ambulatory/outpatient surgery, evidence for surgery practice, skills and simulation, and web-based education and social media High-quality full-color design showcases an unsurpassed illustration program Emphasis on high-yield discussion of diagnosis and treatment of surgical disease, arranged by organ system and surgical specialty Acclaimed learning aids (many new to this edition), including an abundance of completely up-to-date tables that summarize the most current evidence, boxed key points, detailed anatomical figures, diagnostic and management algorithms, and an abundance of completely up-to-date tables, and key references More than the field’s cornerstone textbook, Schwartz’s Principles of Surgery is an international compendium of the knowledge and technique of the world’s leading surgeons.

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease
Author: Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publsiher: Academic Press
Total Pages: 878
Release: 2017-10-31
ISBN 10: 0128041986
ISBN 13: 9780128041987
Language: EN, FR, DE, ES & NL

Genetics of Bone Biology and Skeletal Disease Book Review:

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

The Science of Stem Cells

The Science of Stem Cells
Author: Jonathan M. W. Slack
Publsiher: John Wiley & Sons
Total Pages: 264
Release: 2018-01-16
ISBN 10: 1119235154
ISBN 13: 9781119235156
Language: EN, FR, DE, ES & NL

The Science of Stem Cells Book Review:

Introduces all of the essential cell biology and developmental biology background for the study of stem cells This book gives you all the important information you need to become a stem cell scientist. It covers the characterization of cells, genetic techniques for modifying cells and organisms, tissue culture technology, transplantation immunology, properties of pluripotent and tissue specific stem cells and, in particular, the relevant aspects of mammalian developmental biology. It dispels many misconceptions about stem cells—especially that they can be miracle cells that can cure all ills. The book puts emphasis on stem cell behavior in its biological context and on how to study it. Throughout, the approach is simple, direct, and logical, and evidence is given to support conclusions. Stem cell biology has huge potential for advancing therapies for many distressing and recalcitrant diseases, and its potential will be realized most quickly when as many people as possible have a good grounding in the science of stem cells. Content focused on the basic science underpinning stem cell biology Covers techniques of studying cell properties and cell lineage in vivo and in vitro Explains the basics of embryonic development and cell differentiation, as well as the essential cell biology processes of signaling, gene expression, and cell division Includes instructor resources such as further reading and figures for downloading Offers an online supplement summarizing current clinical applications of stem cells Written by a prominent leader in the field, The Science of Stem Cells is an ideal course book for advanced undergraduates or graduate students studying stem cell biology, regenerative medicine, tissue engineering, and other topics of science and biology.

The Immunological Barriers to Regenerative Medicine

The Immunological Barriers to Regenerative Medicine
Author: Paul J. Fairchild
Publsiher: Springer Science & Business Media
Total Pages: 334
Release: 2012-10-17
ISBN 10: 1461454808
ISBN 13: 9781461454809
Language: EN, FR, DE, ES & NL

The Immunological Barriers to Regenerative Medicine Book Review:

This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.