CRISPR Genome Surgery in Stem Cells and Disease Tissues

CRISPR Genome Surgery in Stem Cells and Disease Tissues
Author: Stephen H. Tsang
Publsiher: Academic Press
Total Pages: 225
Release: 2021-05-01
ISBN 10: 0128178779
ISBN 13: 9780128178775
Language: EN, FR, DE, ES & NL

CRISPR Genome Surgery in Stem Cells and Disease Tissues Book Review:

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy

Human Genome Editing

Human Genome Editing
Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publsiher: National Academies Press
Total Pages: 328
Release: 2017-08-13
ISBN 10: 0309452880
ISBN 13: 9780309452885
Language: EN, FR, DE, ES & NL

Human Genome Editing Book Review:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Osteoarthritis Inflammation and Degradation

Osteoarthritis  Inflammation and Degradation
Author: Joseph A. Buckwalter,Martin K. Lotz,J. F. Stoltz
Publsiher: IOS Press
Total Pages: 299
Release: 2007-01-01
ISBN 10: 1586037730
ISBN 13: 9781586037734
Language: EN, FR, DE, ES & NL

Osteoarthritis Inflammation and Degradation Book Review:

Osteoarthritis is a public health issue due to its impact in term of handicap. Regarded as a multi-factorial disease, mechanistic and inflammatory theories are no more opposed but, on the contrary, are framed within the same continuum: osteoarthritis, inflammation and degeneration. This book helps readers understand the secrets of this disease.

Advances in Genome Editing

Advances in Genome Editing
Author: Jennifer A. Doudna
Publsiher: Unknown
Total Pages: 329
Release: 2016
ISBN 10: 9781618962331
ISBN 13: 1618962337
Language: EN, FR, DE, ES & NL

Advances in Genome Editing Book Review:

Genome Editing and Engineering

Genome Editing and Engineering
Author: Krishnarao Appasani
Publsiher: Cambridge University Press
Total Pages: 586
Release: 2018-07-31
ISBN 10: 1107170370
ISBN 13: 9781107170377
Language: EN, FR, DE, ES & NL

Genome Editing and Engineering Book Review:

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Retinal Degenerative Diseases

Retinal Degenerative Diseases
Author: Matthew M. LaVail,John Ash,Robert E. Anderson,Joe G. Hollyfield,Christian Grimm
Publsiher: Springer Science & Business Media
Total Pages: 864
Release: 2011-12-21
ISBN 10: 1461406315
ISBN 13: 9781461406310
Language: EN, FR, DE, ES & NL

Retinal Degenerative Diseases Book Review:

This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.

CRISPR Cas Systems

CRISPR Cas Systems
Author: Rodolphe Barrangou,John van der Oost
Publsiher: Springer Science & Business Media
Total Pages: 302
Release: 2012-12-13
ISBN 10: 364234657X
ISBN 13: 9783642346576
Language: EN, FR, DE, ES & NL

CRISPR Cas Systems Book Review:

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Cardiac Regeneration

Cardiac Regeneration
Author: Masaki Ieda,Wolfram-Hubertus Zimmermann
Publsiher: Springer
Total Pages: 274
Release: 2017-10-27
ISBN 10: 3319561065
ISBN 13: 9783319561066
Language: EN, FR, DE, ES & NL

Cardiac Regeneration Book Review:

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Tissue Engineered Vascular Grafts

Tissue Engineered Vascular Grafts
Author: Beat Walpoth,Helga Bergmeister,Gary Bowlin,Deling Kong,Joris Rotmans,Peter Zilla
Publsiher: Springer
Total Pages: 575
Release: 2020-10-11
ISBN 10: 9783030053352
ISBN 13: 3030053350
Language: EN, FR, DE, ES & NL

Tissue Engineered Vascular Grafts Book Review:

Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.

Precision Medicine CRISPR and Genome Engineering

Precision Medicine  CRISPR  and Genome Engineering
Author: Stephen H. Tsang
Publsiher: Springer
Total Pages: 178
Release: 2017-11-11
ISBN 10: 3319639048
ISBN 13: 9783319639048
Language: EN, FR, DE, ES & NL

Precision Medicine CRISPR and Genome Engineering Book Review:

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.

Translating Gene Therapy to the Clinic

Translating Gene Therapy to the Clinic
Author: Jeffrey Laurence,Michael Franklin
Publsiher: Academic Press
Total Pages: 346
Release: 2014-11-14
ISBN 10: 0128005645
ISBN 13: 9780128005644
Language: EN, FR, DE, ES & NL

Translating Gene Therapy to the Clinic Book Review:

Translating Gene Therapy to the Clinic, edited by Dr. Jeffrey Laurence and Michael Franklin, follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme. Presents impactful and widely supported research across the spectrum of science, method, implementation and clinical application Offers disease-based coverage from expert clinician-scientists, covering everything from arthritis to congestive heart failure, as it details specific progress and barriers for current translational use Provides key background information from immune response through genome engineering and gene transfer, relevant information for practicing clinicians contemplating enrolling patients in gene therapy trials

The Science of Stem Cells

The Science of Stem Cells
Author: Jonathan M. W. Slack
Publsiher: John Wiley & Sons
Total Pages: 264
Release: 2018-01-16
ISBN 10: 1119235154
ISBN 13: 9781119235156
Language: EN, FR, DE, ES & NL

The Science of Stem Cells Book Review:

Introduces all of the essential cell biology and developmental biology background for the study of stem cells This book gives you all the important information you need to become a stem cell scientist. It covers the characterization of cells, genetic techniques for modifying cells and organisms, tissue culture technology, transplantation immunology, properties of pluripotent and tissue specific stem cells and, in particular, the relevant aspects of mammalian developmental biology. It dispels many misconceptions about stem cells—especially that they can be miracle cells that can cure all ills. The book puts emphasis on stem cell behavior in its biological context and on how to study it. Throughout, the approach is simple, direct, and logical, and evidence is given to support conclusions. Stem cell biology has huge potential for advancing therapies for many distressing and recalcitrant diseases, and its potential will be realized most quickly when as many people as possible have a good grounding in the science of stem cells. Content focused on the basic science underpinning stem cell biology Covers techniques of studying cell properties and cell lineage in vivo and in vitro Explains the basics of embryonic development and cell differentiation, as well as the essential cell biology processes of signaling, gene expression, and cell division Includes instructor resources such as further reading and figures for downloading Offers an online supplement summarizing current clinical applications of stem cells Written by a prominent leader in the field, The Science of Stem Cells is an ideal course book for advanced undergraduates or graduate students studying stem cell biology, regenerative medicine, tissue engineering, and other topics of science and biology.

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2016

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2016
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publsiher: Unknown
Total Pages: 329
Release: 2015
ISBN 10:
ISBN 13: STANFORD:36105050682371
Language: EN, FR, DE, ES & NL

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2016 Book Review:

Stem Cells for Cancer and Genetic Disease Treatment

Stem Cells for Cancer and Genetic Disease Treatment
Author: Phuc Van Pham,Ahmed El-Hashash
Publsiher: Springer
Total Pages: 190
Release: 2018-11-07
ISBN 10: 3319980653
ISBN 13: 9783319980652
Language: EN, FR, DE, ES & NL

Stem Cells for Cancer and Genetic Disease Treatment Book Review:

This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or disorders. Stem Cells for Cancer and Genetic Disease Treatment and the other books in the Stem Cells in Clinical Applicationsseries will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering as well as cancer or genetics research.

The Ethics of Reproductive Genetics

The Ethics of Reproductive Genetics
Author: Marta Soniewicka
Publsiher: Springer
Total Pages: 257
Release: 2018-04-24
ISBN 10: 3319606840
ISBN 13: 9783319606842
Language: EN, FR, DE, ES & NL

The Ethics of Reproductive Genetics Book Review:

This book is aimed at analyzing the foundations of medical ethics by considering different moral theories and their implications for judgments in clinical practice and policy-making. It provides a review of the major types of ethical theory that can be applied to medical and bioethical issues concerning reproductive genetics. In response to the debate on the most adequate ethical doctrine to guide biomedical decisions, this book formulates views that capture the best elements in each, bearing in mind their differences and taking into account the specific character of medicine. No historically influential position in ethics is by itself adequate to be applied to reproductive decisions. Thus, this book attempts to offer a pluralistic approach to biomedical research and medical practice. One usually claims that there are some basic principles (non-maleficence, beneficence, confidentiality, autonomy, and justice) which constitute the foundations of bioethics and medical ethics. Yet these principles conflict with each other and one needs some criteria to solve these conflicts and to specify the scope of application of these principles. Exploring miscellaneous ethical approaches as introduced to biomedicine, particularly to reproductive genetics, the book shall elucidate their different assumptions concerning human nature and the relations between healthcare providers, recipients, and other affected parties (e.g. progeny, relatives, other patients, society). The book attempts to answer the question of whether the tension between these ethical doctrines generates conflict in the field of biomedicine or if these competing approaches could in some way complement each other. In this respect, lecturers and researchers in bioethics would be interested in this reading this book.

Corneal Regeneration

Corneal Regeneration
Author: Jorge L. Alió,Jorge L. Alió del Barrio,Francisco Arnalich-Montiel
Publsiher: Springer
Total Pages: 507
Release: 2019-02-20
ISBN 10: 3030013049
ISBN 13: 9783030013042
Language: EN, FR, DE, ES & NL

Corneal Regeneration Book Review:

This text provides expert instruction on the varying surgical techniques currently employed for the regeneration of the ocular surface. Corneal Regeneration: Therapy and Surgery begins with a thorough discussion of current research based on data obtained in clinical human studies, and discusses the potential clinical implications for this promising new stage of eye surgery. Sections devoted to the stem cell, regenerative surgery and therapy of the ocular surface epithelium, corneal stroma, and corneal endothelium follow, each section comprehensively covering applied anatomy, current therapy and regenerative techniques, with a look to future directions of the field including eventual cell therapy. Corneal Regeneration: Therapy and Surgery is the first book of its kind, systematically covering the developments the medical community has achieved in corneal regeneration from all angles. Written and edited by leading experts in the field, researchers and ophthalmologists alike will find this to be a unique source of information on corneal regeneration, as well as a thoughtful reflection on potential applications of regenerative surgery in ophthalmology as a whole.

Progress in Stem Cell Transplantation

Progress in Stem Cell Transplantation
Author: Taner Demirer
Publsiher: BoD – Books on Demand
Total Pages: 208
Release: 2015-12-02
ISBN 10: 9535122274
ISBN 13: 9789535122272
Language: EN, FR, DE, ES & NL

Progress in Stem Cell Transplantation Book Review:

This book documents the increased amount of stem cell-related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies discussed in basic and clinical chapters from authors around the world involved in stem cell studies and research. It thereby complements and extends the basic coverage of stem cells, such as mesenchymal stem cells, effect of stem cells on aging, cover hematopoietic stem cells, storage and cryopreservation, issues related to clinical applications such as haploidentical transplants and use of stem cells for the treatment of Huntingtons disease. Clearly, the treatment of various malignant and nonmalignant diseases depends heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.

Tumor Organoids

Tumor Organoids
Author: Shay Soker,Aleksander Skardal
Publsiher: Humana Press
Total Pages: 213
Release: 2017-10-20
ISBN 10: 3319605119
ISBN 13: 9783319605111
Language: EN, FR, DE, ES & NL

Tumor Organoids Book Review:

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Nervous System Drug Delivery

Nervous System Drug Delivery
Author: Russell R. Lonser,Malisa Sarntinoranont,Kristof Bankiewicz
Publsiher: Academic Press
Total Pages: 556
Release: 2019-06-25
ISBN 10: 0128139986
ISBN 13: 9780128139981
Language: EN, FR, DE, ES & NL

Nervous System Drug Delivery Book Review:

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques. Offers an up-to-date, comprehensive resource on drug delivery to the nervous system Provides a bridge for understanding across nervous system delivery-related physiology, drug delivery principles. and the methodologies that underlie the various methods of drug distribution (with clinical application) Written for a broad audience of researchers, clinicians and advanced graduate students in neuroscience, neurology, neurosurgery, pharmacology, radiology and psychiatry

The Columbia Guide to Basic Elements of Eye Care

The Columbia Guide to Basic Elements of Eye Care
Author: Daniel S. Casper,George A. Cioffi
Publsiher: Springer
Total Pages: 531
Release: 2019-07-01
ISBN 10: 3030108864
ISBN 13: 9783030108861
Language: EN, FR, DE, ES & NL

The Columbia Guide to Basic Elements of Eye Care Book Review:

This unique resource is a practical, easy-to-use guide for the non-ophthalmologist healthcare provider as they encounter patients with eye complaints and other concerning ophthalmic conditions. The Columbia Guide to Basic Elements of Eye Care is specifically designed with the non-ophthalmologist in mind, and provides a foundation of basic eye anatomy and physiology, functional analysis, pathology, and concepts in eye care. Each chapter delivers an accessible summary of various ophthalmic diseases and conditions, all of which are frequently encountered in everyday practice. These chapters provide in-depth discussions on a wide range of topics, from testing and examination procedures to management protocols, referral guidelines and expected frequency of follow-up for each disorder. Complete with hundreds of high-quality, descriptive illustrations and clinical photographs, The Columbia Guide to Basic Elements of Eye Care presents clear, understandable explanations of basic eye anatomy, physiology, disease and treatment for non-ophthalmic practitioners and students. In doing so, this guide provides a framework for determining the normal versus the abnormal, helping the reader recognize which patients require referral, and identify which conditions are developing, require urgent treatment, or can be routinely followed. Non-ophthalmologist healthcare providers and students alike will find this book, written by leaders in the field, a practical resource to consult as they encounter patients with treatable but potentially sight-threatening conditions.