CRISPR and RNAi Systems

CRISPR and RNAi Systems
Author: Kamel A. Abd-Elsalam,Ki-Taek Lim
Publsiher: Elsevier
Total Pages: 702
Release: 2021-03-01
ISBN 10: 0128219114
ISBN 13: 9780128219119
Language: EN, FR, DE, ES & NL

CRISPR and RNAi Systems Book Review:

CRISPR and RNAi Systems: Nanobiotechnology Approaches to Plant Breeding and Protection presents a complete understanding of the RNAi and CRISPR/Cas9 techniques for controlling mycotoxins, fighting plant nematodes, and detecting plant pathogens. CRISPR/Cas genome editing enables efficient targeted modification in most crops, thus promising to accelerate crop improvement. CRISPR/Cas9 can be used for management of plant insects and various plant pathogens. This book is an important reference source for both plant scientists and environmental scientists who want to understand how nanobiotechnologically-based approaches are being used to create more efficient plant protection and plant breeding systems. Plants are vulnerable to pathogens including fungi, bacteria and viruses which can cause critical problems and deficits. Crop protection by plant breeding delivers a promising solution with no obvious effect on human health or the local ecosystem. Crop improvement has been the most powerful approach for producing unique crop cultivars since domestication occurred, making possible the main innovations in feeding the globe and community development. Genome editing is one of the genetic devices that can be implemented, and disease resistance is frequently cited as the most encouraging application of CRISPR/Cas9 technology in agriculture. Shows how nanotechnology is being used as the basis for new solutions for more efficient plant breeding and plant protection Outlines the major techniques and applications of both CRISPR and RNAi technologies Assesses the major challenges of escalating these technologies on a mass scale

Genome Engineering via CRISPR-Cas9 System

Genome Engineering via CRISPR-Cas9 System
Author: Vijai Singh,Pawan K. Dhar
Publsiher: Academic Press
Total Pages: 384
Release: 2020-02-18
ISBN 10: 0128181419
ISBN 13: 9780128181416
Language: EN, FR, DE, ES & NL

Genome Engineering via CRISPR-Cas9 System Book Review:

Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields. Provides basic understanding and a clear picture on how to design, use and implement the CRISPR-Cas9 system in different organisms Explains how to create an animal model for disease research and screening purposes using CRISPR Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, neurology, cancer, industry, and many more

Modulating Gene Expression

Modulating Gene Expression
Author: Aditi Singh,Mohammad W. Khan
Publsiher: BoD – Books on Demand
Total Pages: 134
Release: 2019-05-29
ISBN 10: 1838806962
ISBN 13: 9781838806965
Language: EN, FR, DE, ES & NL

Modulating Gene Expression Book Review:

RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.

RNA Interference and CRISPR Technologies

RNA Interference and CRISPR Technologies
Author: Mouldy Sioud
Publsiher: Anonim
Total Pages: 486
Release: 2020
ISBN 10: 9781071602904
ISBN 13: 107160290X
Language: EN, FR, DE, ES & NL

RNA Interference and CRISPR Technologies Book Review:

This volume explores the uses of RNAi and CRISPR interferences as a general method for inhibiting gene expression, with focus on their biological functions, design, chemical modifications, delivery, and preclinical/clinical applications. In addition to relevant backgrounds, the chapters in this book discuss simple and accurate protocols dealing with the latest advances in RNAi and CRISPR applications and look at how these methods differ from one another. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, RNA Interference and CRISPR Technologies: Technical Advances and New Therapeutic Opportunities is a valuable resource for any scientist, teachers, graduate student, postdoc, and clinician interested in this field. This book also benefits anyone in research and development in biotech and pharmaceutical companies who want to understand more about these technologies, and their applications in biology and medicine. .

Gene Function

Gene Function
Author: S. Rosenthal,H. Bielka,Ch. Coutelle
Publsiher: Elsevier
Total Pages: 564
Release: 2014-05-09
ISBN 10: 1483188515
ISBN 13: 9781483188515
Language: EN, FR, DE, ES & NL

Gene Function Book Review:

Gene Function, contains the proceedings of the 12th Meeting of the Federation of European Biochemical Societies held in Dresden, Germany in 1978. The meeting provided a forum for discussing progress in the understanding of gene function and covered topics ranging from the functional organization of chromatin to principles of interactions and recognition models. The role of DNA sequence in the recognition of restriction endonucleases and modification enzymes is also examined, along with gene expression, RNA processing and modification, and isolation and synthesis of genes. Comprised of 49 chapters, this volume begins with an overview of what can be learned from the genetic analysis of the lac repressor, followed by a discussion on the topography of the interaction the lac repressor, RNA polymerase, and histones with DNA. The reader is then introduced to complementarity and recognition code between regulatory proteins and DNA; chromatin replication in vitro; and the cytoplasmic "petite" mutation in Saccharomyces cerevisiae. Subsequent chapters explore arc-like and helical arrangements of nucleosome cores; changes in gene expression during cellular differentiation; polyadenylation and processing of pre-messenger RNA; and the molecular biology of bacteriophages T3 and T7. This book will be of interest to geneticists, biochemists, and molecular biologists.

CRISPR-Cas Systems

CRISPR-Cas Systems
Author: Rodolphe Barrangou,John van der Oost
Publsiher: Springer Science & Business Media
Total Pages: 302
Release: 2012-12-13
ISBN 10: 364234657X
ISBN 13: 9783642346576
Language: EN, FR, DE, ES & NL

CRISPR-Cas Systems Book Review:

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Genome Engineering via CRISPR-Cas9 System

Genome Engineering via CRISPR-Cas9 System
Author: Vijai Singh,Pawan K. Dhar
Publsiher: Academic Press
Total Pages: 384
Release: 2020-02-18
ISBN 10: 0128181419
ISBN 13: 9780128181416
Language: EN, FR, DE, ES & NL

Genome Engineering via CRISPR-Cas9 System Book Review:

Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields. Provides basic understanding and a clear picture on how to design, use and implement the CRISPR-Cas9 system in different organisms Explains how to create an animal model for disease research and screening purposes using CRISPR Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, neurology, cancer, industry, and many more

Gene Editing in Plants

Gene Editing in Plants
Author: Anonim
Publsiher: Academic Press
Total Pages: 264
Release: 2017-08-31
ISBN 10: 0128117443
ISBN 13: 9780128117446
Language: EN, FR, DE, ES & NL

Gene Editing in Plants Book Review:

Gene Editing in Plants, Volume 149 aims to provide the reader with an up-to-date survey of cutting-edge research with gene editing tools and an overview of the implications of this research on the nutritional quality of fruits, vegetables and grains. New chapters in the updated volume include topics relating to Genome Engineering and Agriculture: Opportunities and Challenges, the Use of CRISPR/Cas9 for Crop Improvement in Maize and Soybean, the Use of Zinc-Finger Nucleases for Crop Improvement, Gene Editing in Polyploid Crops: Wheat, Camelina, Canola, Potato, Cotton, Peanut, Sugar Cane, and Citrus, and Gene Editing With TALEN and CRISPR/Cas in Rice. This ongoing serial contain contributions from leading scientists and researchers in the field of gene editing in plants who describe the results of their own research in this rapidly expanding area of science. Shows the importance of revolutionary gene editing technology on plant biology research and its application to agricultural production Provides insight into what may lie ahead in this rapidly expanding area of plant research and development Contains contributions from major leaders in the field of plant gene editing

Gene Editing

Gene Editing
Author: Yuan-Chuan Chen,Shiu-Jau Chen
Publsiher: BoD – Books on Demand
Total Pages: 108
Release: 2019-05-29
ISBN 10: 1789845084
ISBN 13: 9781789845082
Language: EN, FR, DE, ES & NL

Gene Editing Book Review:

Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.

Human Genome Editing

Human Genome Editing
Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publsiher: National Academies Press
Total Pages: 328
Release: 2017-08-13
ISBN 10: 0309452880
ISBN 13: 9780309452885
Language: EN, FR, DE, ES & NL

Human Genome Editing Book Review:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Biotechnology

Biotechnology
Author: David P. Clark,Nanette J. Pazdernik
Publsiher: Newnes
Total Pages: 850
Release: 2015-05-16
ISBN 10: 0123850169
ISBN 13: 9780123850164
Language: EN, FR, DE, ES & NL

Biotechnology Book Review:

Biotechnology, Second Edition approaches modern biotechnology from a molecular basis, which has grown out of increasing biochemical understanding of genetics and physiology. Using straightforward, less-technical jargon, Clark and Pazdernik introduce each chapter with basic concepts that develop into more specific and detailed applications. This up-to-date text covers a wide realm of topics including forensics, bioethics, and nanobiotechnology using colorful illustrations and concise applications. In addition, the book integrates recent, relevant primary research articles for each chapter, which are presented on an accompanying website. The articles demonstrate key concepts or applications of the concepts presented in the chapter, which allows the reader to see how the foundational knowledge in this textbook bridges into primary research. This book helps readers understand what molecular biotechnology actually is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future. Up-to-date text focuses on modern biotechnology with a molecular foundation Includes clear, color illustrations of key topics and concept Features clearly written without overly technical jargon or complicated examples Provides a comprehensive supplements package with an easy-to-use study guide, full primary research articles that demonstrate how research is conducted, and instructor-only resources

Molecular Biology

Molecular Biology
Author: David P. Clark,Nanette J. Pazdernik
Publsiher: Elsevier
Total Pages: 928
Release: 2012-03-20
ISBN 10: 0123785952
ISBN 13: 9780123785954
Language: EN, FR, DE, ES & NL

Molecular Biology Book Review:

Molecular Biology, Second Edition, examines the basic concepts of molecular biology while incorporating primary literature from today’s leading researchers. This updated edition includes Focuses on Relevant Research sections that integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world. The new Academic Cell Study Guide features all the articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. The text also includes updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA. An updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images. This text is designed for undergraduate students taking a course in Molecular Biology and upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry, and Agriculture. NEW: "Focus On Relevant Research" sections integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world. NEW: Academic Cell Study Guide features all articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. NEW: Animations provided include topics in protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE Updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA Updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images. Fully revised art program

The Logic of Chance

The Logic of Chance
Author: Eugene V. Koonin
Publsiher: FT Press
Total Pages: 528
Release: 2011-06-23
ISBN 10: 9780132623179
ISBN 13: 013262317X
Language: EN, FR, DE, ES & NL

The Logic of Chance Book Review:

The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and hypotheses on the key aspects of the evolution of life on earth in light of comparative genomics and systems biology. The author presents many specific examples from systems and comparative genomic analysis to begin to build a new, much more detailed, complex, and realistic picture of evolution. The book examines a broad range of topics in evolutionary biology including the inadequacy of natural selection and adaptation as the only or even the main mode of evolution; the key role of horizontal gene transfer in evolution and the consequent overhaul of the Tree of Life concept; the central, underappreciated evolutionary importance of viruses; the origin of eukaryotes as a result of endosymbiosis; the concomitant origin of cells and viruses on the primordial earth; universal dependences between genomic and molecular-phenomic variables; and the evolving landscape of constraints that shape the evolution of genomes and molecular phenomes. "Koonin's account of viral and pre-eukaryotic evolution is undoubtedly up-to-date. His "mega views" of evolution (given what was said above) and his cosmological musings, on the other hand, are interesting reading." Summing Up: Recommended Reprinted with permission from CHOICE, copyright by the American Library Association.

Genome Editing and Engineering

Genome Editing and Engineering
Author: Krishnarao Appasani
Publsiher: Cambridge University Press
Total Pages: 586
Release: 2018-07-31
ISBN 10: 1107170370
ISBN 13: 9781107170377
Language: EN, FR, DE, ES & NL

Genome Editing and Engineering Book Review:

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Bacteriophages

Bacteriophages
Author: Anonim
Publsiher: Academic Press
Total Pages: 416
Release: 2012-05-09
ISBN 10: 0123948371
ISBN 13: 9780123948373
Language: EN, FR, DE, ES & NL

Bacteriophages Book Review:

This volume, the first of a two-part series, covers topics including historical, ecological and evolutionary considerations, genomics and molecular biology, and interaction of phages with their hosts. Contributions from leading authorities Informs and updates on all the latest developments in the field

Diversity and Evolution of Butterfly Wing Patterns

Diversity and Evolution of Butterfly Wing Patterns
Author: Toshio Sekimura,H. Frederik Nijhout
Publsiher: Springer
Total Pages: 321
Release: 2017-08-29
ISBN 10: 9811049564
ISBN 13: 9789811049569
Language: EN, FR, DE, ES & NL

Diversity and Evolution of Butterfly Wing Patterns Book Review:

This book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as “evo-devo,” “eco-devo,” ”developmental genetics,” “ecology and adaptation,” “food plants,” and “theoretical modeling.” The past decade-and-a-half has seen a veritable revolution in our understanding of the development, genetics and evolution of butterfly wing patterns. In addition, studies of how environmental and climatic factors affect the expression of color patterns has led to increasingly deeper understanding of the pervasiveness and underlying mechanisms of phenotypic plasticity. In recognition of the great progress in research on the biology, an international meeting titled “Integrative Approach to Understanding the Diversity of Butterfly Wing Patterns (IABP-2016)” was held at Chubu University, Japan in August 2016. This book consists of selected contributions from the meeting. Authors include main active researchers of new findings of corresponding genes as well as world leaders in both experimental and theoretical approaches to wing color patterns. The book provides excellent case studies for graduate and undergraduate classes in evolution, genetics/genomics, developmental biology, ecology, biochemistry, and also theoretical biology, opening the door to a new era in the integrative approach to the analysis of biological problems. This book is open access under a CC BY 4.0 license.

Genome Editing in Neurosciences

Genome Editing in Neurosciences
Author: Rudolf Jaenisch,Feng Zhang,Fred Gage
Publsiher: Springer
Total Pages: 123
Release: 2017-09-14
ISBN 10: 331960192X
ISBN 13: 9783319601922
Language: EN, FR, DE, ES & NL

Genome Editing in Neurosciences Book Review:

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

A Crack in Creation

A Crack in Creation
Author: Jennifer A. Doudna,Samuel H. Sternberg
Publsiher: Houghton Mifflin Harcourt
Total Pages: 320
Release: 2017-06-13
ISBN 10: 0544716965
ISBN 13: 9780544716964
Language: EN, FR, DE, ES & NL

A Crack in Creation Book Review:

BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY Finalist for the Los Angeles Times Book Prize “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “Required reading for every concerned citizen.” — New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “An invaluable account . . . We owe Doudna several times over.” — Guardian

Advances in Genome Editing

Advances in Genome Editing
Author: Jennifer A. Doudna
Publsiher: Anonim
Total Pages: 329
Release: 2016
ISBN 10: 9781618962331
ISBN 13: 1618962337
Language: EN, FR, DE, ES & NL

Advances in Genome Editing Book Review:

Plant Genomes

Plant Genomes
Author: Jean-Nicolas Volff
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 145
Release: 2008-01-01
ISBN 10: 3805584911
ISBN 13: 9783805584913
Language: EN, FR, DE, ES & NL

Plant Genomes Book Review:

Recent major advances in the field of comparative genomics and cytogenomics of plants, particularly associated with the completion of ambitious genome projects, have uncovered astonishing facets of the architecture and evolutionary history of plant genomes. The aim of this book was to review these recent developments as well as their implications in our understanding of the mechanisms which drive plant diversity. New insights into the evolution of gene functions, gene families and genome size are presented, with particular emphasis on the evolutionary impact of polyploidization and transposable elements. Knowledge on the structure and evolution of plant sex chromosomes, centromeres and microRNAs is reviewed and updated. Taken together, the contributions by internationally recognized experts present a panoramic overview of the structural features and evolutionary dynamics of plant genomes.This volume of Genome Dynamics will provide researchers, teachers and students in the fields of biology and agronomy with a valuable source of current knowledge on plant genomes.