CRISPR and RNAi Systems

CRISPR and RNAi Systems
Author: Kamel A. Abd-Elsalam,Ki-Taek Lim
Publsiher: Elsevier
Total Pages: 840
Release: 2021-03-10
ISBN 10: 0128219114
ISBN 13: 9780128219119
Language: EN, FR, DE, ES & NL

CRISPR and RNAi Systems Book Review:

CRISPR and RNAi Systems: Nanobiotechnology Approaches to Plant Breeding and Protection presents a complete understanding of the RNAi and CRISPR/Cas9 techniques for controlling mycotoxins, fighting plant nematodes, and detecting plant pathogens. CRISPR/Cas genome editing enables efficient targeted modification in most crops, thus promising to accelerate crop improvement. CRISPR/Cas9 can be used for management of plant insects and various plant pathogens. This book is an important reference source for both plant scientists and environmental scientists who want to understand how nanobiotechnologically-based approaches are being used to create more efficient plant protection and plant breeding systems. Plants are vulnerable to pathogens including fungi, bacteria and viruses which can cause critical problems and deficits. Crop protection by plant breeding delivers a promising solution with no obvious effect on human health or the local ecosystem. Crop improvement has been the most powerful approach for producing unique crop cultivars since domestication occurred, making possible the main innovations in feeding the globe and community development. Genome editing is one of the genetic devices that can be implemented, and disease resistance is frequently cited as the most encouraging application of CRISPR/Cas9 technology in agriculture. Shows how nanotechnology is being used as the basis for new solutions for more efficient plant breeding and plant protection Outlines the major techniques and applications of both CRISPR and RNAi technologies Assesses the major challenges of escalating these technologies on a mass scale

Genome Engineering via CRISPR Cas9 System

Genome Engineering via CRISPR Cas9 System
Author: Vijai Singh,Pawan K. Dhar
Publsiher: Academic Press
Total Pages: 384
Release: 2020-02-18
ISBN 10: 0128181419
ISBN 13: 9780128181416
Language: EN, FR, DE, ES & NL

Genome Engineering via CRISPR Cas9 System Book Review:

Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields. Provides basic understanding and a clear picture on how to design, use and implement the CRISPR-Cas9 system in different organisms Explains how to create an animal model for disease research and screening purposes using CRISPR Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, neurology, cancer, industry, and many more

RNA Interference and CRISPR Technologies

RNA Interference and CRISPR Technologies
Author: Mouldy Sioud
Publsiher: Humana
Total Pages: 486
Release: 2021-02-15
ISBN 10: 9781071602928
ISBN 13: 1071602926
Language: EN, FR, DE, ES & NL

RNA Interference and CRISPR Technologies Book Review:

This volume explores the uses of RNAi and CRISPR interferences as a general method for inhibiting gene expression, with focus on their biological functions, design, chemical modifications, delivery, and preclinical/clinical applications. In addition to relevant backgrounds, the chapters in this book discuss simple and accurate protocols dealing with the latest advances in RNAi and CRISPR applications and look at how these methods differ from one another. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, RNA Interference and CRISPR Technologies: Technical Advances and New Therapeutic Opportunities is a valuable resource for any scientist, teachers, graduate student, postdoc, and clinician interested in this field. This book also benefits anyone in research and development in biotech and pharmaceutical companies who want to understand more about these technologies, and their applications in biology and medicine.

Gene Function

Gene Function
Author: S. Rosenthal,H. Bielka,Ch. Coutelle
Publsiher: Elsevier
Total Pages: 564
Release: 2014-05-09
ISBN 10: 1483188515
ISBN 13: 9781483188515
Language: EN, FR, DE, ES & NL

Gene Function Book Review:

Gene Function, contains the proceedings of the 12th Meeting of the Federation of European Biochemical Societies held in Dresden, Germany in 1978. The meeting provided a forum for discussing progress in the understanding of gene function and covered topics ranging from the functional organization of chromatin to principles of interactions and recognition models. The role of DNA sequence in the recognition of restriction endonucleases and modification enzymes is also examined, along with gene expression, RNA processing and modification, and isolation and synthesis of genes. Comprised of 49 chapters, this volume begins with an overview of what can be learned from the genetic analysis of the lac repressor, followed by a discussion on the topography of the interaction the lac repressor, RNA polymerase, and histones with DNA. The reader is then introduced to complementarity and recognition code between regulatory proteins and DNA; chromatin replication in vitro; and the cytoplasmic "petite" mutation in Saccharomyces cerevisiae. Subsequent chapters explore arc-like and helical arrangements of nucleosome cores; changes in gene expression during cellular differentiation; polyadenylation and processing of pre-messenger RNA; and the molecular biology of bacteriophages T3 and T7. This book will be of interest to geneticists, biochemists, and molecular biologists.

CRISPR Cas Systems

CRISPR Cas Systems
Author: Rodolphe Barrangou,John van der Oost
Publsiher: Springer Science & Business Media
Total Pages: 302
Release: 2012-12-13
ISBN 10: 364234657X
ISBN 13: 9783642346576
Language: EN, FR, DE, ES & NL

CRISPR Cas Systems Book Review:

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Human Genome Editing

Human Genome Editing
Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publsiher: National Academies Press
Total Pages: 328
Release: 2017-08-13
ISBN 10: 0309452880
ISBN 13: 9780309452885
Language: EN, FR, DE, ES & NL

Human Genome Editing Book Review:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Gene Editing in Plants

Gene Editing in Plants
Author: Anonim
Publsiher: Academic Press
Total Pages: 264
Release: 2017-08-31
ISBN 10: 0128117443
ISBN 13: 9780128117446
Language: EN, FR, DE, ES & NL

Gene Editing in Plants Book Review:

Gene Editing in Plants, Volume 149 aims to provide the reader with an up-to-date survey of cutting-edge research with gene editing tools and an overview of the implications of this research on the nutritional quality of fruits, vegetables and grains. New chapters in the updated volume include topics relating to Genome Engineering and Agriculture: Opportunities and Challenges, the Use of CRISPR/Cas9 for Crop Improvement in Maize and Soybean, the Use of Zinc-Finger Nucleases for Crop Improvement, Gene Editing in Polyploid Crops: Wheat, Camelina, Canola, Potato, Cotton, Peanut, Sugar Cane, and Citrus, and Gene Editing With TALEN and CRISPR/Cas in Rice. This ongoing serial contain contributions from leading scientists and researchers in the field of gene editing in plants who describe the results of their own research in this rapidly expanding area of science. Shows the importance of revolutionary gene editing technology on plant biology research and its application to agricultural production Provides insight into what may lie ahead in this rapidly expanding area of plant research and development Contains contributions from major leaders in the field of plant gene editing

Gene Editing

Gene Editing
Author: Yuan-Chuan Chen,Shiu-Jau Chen
Publsiher: BoD – Books on Demand
Total Pages: 108
Release: 2019-05-29
ISBN 10: 1789845084
ISBN 13: 9781789845082
Language: EN, FR, DE, ES & NL

Gene Editing Book Review:

Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.

Modulating Gene Expression

Modulating Gene Expression
Author: Aditi Singh,Mohammad W. Khan
Publsiher: BoD – Books on Demand
Total Pages: 134
Release: 2019-05-29
ISBN 10: 1838806962
ISBN 13: 9781838806965
Language: EN, FR, DE, ES & NL

Modulating Gene Expression Book Review:

RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.

Genome Editing and Engineering

Genome Editing and Engineering
Author: Krishnarao Appasani
Publsiher: Cambridge University Press
Total Pages: 586
Release: 2018-07-31
ISBN 10: 1107170370
ISBN 13: 9781107170377
Language: EN, FR, DE, ES & NL

Genome Editing and Engineering Book Review:

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Genome Editing in Neurosciences

Genome Editing in Neurosciences
Author: Rudolf Jaenisch,Feng Zhang,Fred Gage
Publsiher: Springer
Total Pages: 123
Release: 2017-09-14
ISBN 10: 331960192X
ISBN 13: 9783319601922
Language: EN, FR, DE, ES & NL

Genome Editing in Neurosciences Book Review:

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Diversity and Evolution of Butterfly Wing Patterns

Diversity and Evolution of Butterfly Wing Patterns
Author: Toshio Sekimura,H. Frederik Nijhout
Publsiher: Springer
Total Pages: 321
Release: 2017-08-29
ISBN 10: 9811049564
ISBN 13: 9789811049569
Language: EN, FR, DE, ES & NL

Diversity and Evolution of Butterfly Wing Patterns Book Review:

This book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as “evo-devo,” “eco-devo,” ”developmental genetics,” “ecology and adaptation,” “food plants,” and “theoretical modeling.” The past decade-and-a-half has seen a veritable revolution in our understanding of the development, genetics and evolution of butterfly wing patterns. In addition, studies of how environmental and climatic factors affect the expression of color patterns has led to increasingly deeper understanding of the pervasiveness and underlying mechanisms of phenotypic plasticity. In recognition of the great progress in research on the biology, an international meeting titled “Integrative Approach to Understanding the Diversity of Butterfly Wing Patterns (IABP-2016)” was held at Chubu University, Japan in August 2016. This book consists of selected contributions from the meeting. Authors include main active researchers of new findings of corresponding genes as well as world leaders in both experimental and theoretical approaches to wing color patterns. The book provides excellent case studies for graduate and undergraduate classes in evolution, genetics/genomics, developmental biology, ecology, biochemistry, and also theoretical biology, opening the door to a new era in the integrative approach to the analysis of biological problems. This book is open access under a CC BY 4.0 license.

Plant Genomes

Plant Genomes
Author: Jean-Nicolas Volff
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 145
Release: 2008-01-01
ISBN 10: 3805584911
ISBN 13: 9783805584913
Language: EN, FR, DE, ES & NL

Plant Genomes Book Review:

Recent major advances in the field of comparative genomics and cytogenomics of plants, particularly associated with the completion of ambitious genome projects, have uncovered astonishing facets of the architecture and evolutionary history of plant genomes. The aim of this book was to review these recent developments as well as their implications in our understanding of the mechanisms which drive plant diversity. New insights into the evolution of gene functions, gene families and genome size are presented, with particular emphasis on the evolutionary impact of polyploidization and transposable elements. Knowledge on the structure and evolution of plant sex chromosomes, centromeres and microRNAs is reviewed and updated. Taken together, the contributions by internationally recognized experts present a panoramic overview of the structural features and evolutionary dynamics of plant genomes.This volume of Genome Dynamics will provide researchers, teachers and students in the fields of biology and agronomy with a valuable source of current knowledge on plant genomes.

Modern Prometheus

Modern Prometheus
Author: Jim Kozubek
Publsiher: Cambridge University Press
Total Pages: 478
Release: 2018-04-26
ISBN 10: 1108454623
ISBN 13: 9781108454629
Language: EN, FR, DE, ES & NL

Modern Prometheus Book Review:

This book tells the dramatic story of Crispr and the potential impact of this gene-editing technology.

Plant Gene Silencing

Plant Gene Silencing
Author: Kirankumar S. Mysore,Muthappa Senthil-Kumar
Publsiher: Humana Press
Total Pages: 307
Release: 2015-03-05
ISBN 10: 9781493924523
ISBN 13: 1493924524
Language: EN, FR, DE, ES & NL

Plant Gene Silencing Book Review:

This volume provides readers with a comprehensive review of various gene silencing methodologies and its applications. It provides a historical overview of gene silencing mechanisms in plants, vectors, and strategies available for plant gene silencing, practical applications of gene silencing, bioinformatics tools, and other resources. In addition to these review chapters, this book includes methodology for virus-induced gene silencing (VIGS) in various different plant species, understanding plant stress responses using VIGS, miRNA identification, DNA interference, host-induced gene silencing, use of artificial miRNAs for gene silencing, high throughput RNAi, and more. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Plant Gene Silencing: Methods and Protocols seeks to aid scientists to further understand functional relevance of target genes using gene silencing methods and use these technologies in commercial plant varieties.

Regulatory RNAs in Prokaryotes

Regulatory RNAs in Prokaryotes
Author: Anita Marchfelder,Wolfgang Hess
Publsiher: Springer Science & Business Media
Total Pages: 258
Release: 2012-12-23
ISBN 10: 3709102189
ISBN 13: 9783709102183
Language: EN, FR, DE, ES & NL

Regulatory RNAs in Prokaryotes Book Review:

This book provides a comprehensive and up-to-date collection of review articles focusing on RNA-mediated regulation in prokaryotes. The various modes of action include the direct interaction with proteins, direct sensing of metabolites or of physical parameters, and the interaction with RNAs to stimulate or prevent binding of ribosomes or to stimulate degradation. Written by leading experts in the field, the book covers small RNA functions, RNA thermometers, riboswitches, the diversity of small RNA-guided CRISPR-Cas defense systems and selected RNA chaperons in both prokaryotic domains, bacteria and archaea. Recent advances towards the computational identification of regulatory RNAs and their targets are included and particular attention is paid to small RNA in pathogenic bacteria. This volume is the only one exclusively covering regulatory RNAs in the prokaryotic domains to date, making it essential literature for anyone interested in RNA function and gene regulation and a valuable resource for teaching these concepts.

Plant Breeding from Laboratories to Fields

Plant Breeding from Laboratories to Fields
Author: Sven Bode Andersen
Publsiher: BoD – Books on Demand
Total Pages: 300
Release: 2013-05-22
ISBN 10: 953511090X
ISBN 13: 9789535110903
Language: EN, FR, DE, ES & NL

Plant Breeding from Laboratories to Fields Book Review:

Breeding of crop plants to make them more adapted to human agricultural systems has been on-going during domestication the last 10 000 years. However, only recently with the invention of the Mendelian principles of genetics and the subsequent development of quantitative genetics during the twentieth century has such genetic crop improvement become based on a general theory. During the last 50 years plant breeding has entered a molecular era based on molecular tools to analyse DNA, RNA and proteins and associate such molecular results with plant phenotype. These marker trait associations develop fast to enable more efficient breeding. However, they still leave a major part of breeding to be performed through selection of phenotypes using quantitative genetic tools. The ten chapters of this book illustrate this development.

Advances in Genome Editing

Advances in Genome Editing
Author: Jennifer A. Doudna
Publsiher: Unknown
Total Pages: 329
Release: 2016
ISBN 10: 9781618962331
ISBN 13: 1618962337
Language: EN, FR, DE, ES & NL

Advances in Genome Editing Book Review:

Molecular Medicines for Cancer

Molecular Medicines for Cancer
Author: Deepak Chitkara,Anupama Mittal,Ram I. Mahato
Publsiher: CRC Press
Total Pages: 610
Release: 2018-09-03
ISBN 10: 1351978373
ISBN 13: 9781351978378
Language: EN, FR, DE, ES & NL

Molecular Medicines for Cancer Book Review:

The field of molecular medicine covers the medical interventions targeting molecular structures and mechanisms that are involved in disease progression. In cancer, several molecular mechanisms have been shown to impact its progression, aggressiveness and chemoresistance. Increasing evidence demonstrates the role of nanotechnology and outcome of molecular therapy. Several books have discussed molecular biology and mechanisms involved in cancer, but this text gives an account of molecular therapeutics in cancer relating to advancements of nanotechnology. It provides a description of the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology. Key Features: Provides current information in the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology Presents important aspects of nanotechnology in the site-specific delivery of anticancer agents Includes up to date information on oligonucleotide and gene based therapies in cancer Describes small targeted molecules, antibodies and oligonucleotides which have shown to selectively target the molecular structures thereby influencing signal transduction Facilitates discussion between researchers involved in cancer therapy and nanoscientists

The Black Box of Biology

The Black Box of Biology
Author: Michel Morange
Publsiher: Unknown
Total Pages: 528
Release: 2020
ISBN 10: 0674281365
ISBN 13: 9780674281363
Language: EN, FR, DE, ES & NL

The Black Box of Biology Book Review:

Michel Morange updates the history of molecular biology at a moment when scientists are making big strides in genetic engineering and exploring new avenues, from epigenetics to systems biology. Morange places the latest findings and ideas in historical context, describing in accessible terms how transformative the molecular revolution has been.