Concepts and Experimental Protocols of Modelling and Informatics in Drug Design

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design
Author: Om Silakari,Pankaj Kumar Singh
Publsiher: Academic Press
Total Pages: 396
Release: 2020-11-05
ISBN 10: 0128205474
ISBN 13: 9780128205471
Language: EN, FR, DE, ES & NL

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design Book Review:

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets. Additionally, it discusses data retrieval system, molecular surfaces, and freeware and online servers. The book is a valuable source for graduate students and researchers on bioinformatics, molecular modeling, biotechnology and several members of biomedical field who need to understand more about computer-aided molecular modeling. Presents exercises with solutions to aid readers in validating their own protocol Brings a thorough interpretation of results of each exercise to help readers compare them to their own study Explains each parameter utilized in the algorithms to help readers understand and manipulate various features of molecules and target protein to design their study

Quantitative Molecular Pharmacology and Informatics in Drug Discovery

Quantitative Molecular Pharmacology and Informatics in Drug Discovery
Author: Michael Lutz,Terry Kenakin
Publsiher: John Wiley & Sons
Total Pages: 428
Release: 2000-01-10
ISBN 10: 9780471988618
ISBN 13: 0471988618
Language: EN, FR, DE, ES & NL

Quantitative Molecular Pharmacology and Informatics in Drug Discovery Book Review:

Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the modern drug discovery process. The book discusses the pharmacology of drug testing and provides a detailed description of the statistical methods used to analyze the resulting data. Application of genetic and genomic tools for identification of biological targets is reviewed in the context of drug discovery projects. Covering both the theoretical principles upon which the techniques are based and the practicalities of drug discovery, this informative guide. * outlines in step-by-step detail the advantages and disadvantages of each technology and approach and links these to the type of chemical target being sought after in the drug discovery process; and, * provides excellent demonstrations of how to use powerful pharmacological and statistical tools to optimize high-throughput screening assays. Written by two internationally known and well-regarded experts, this book is an essential reference for research and development scientists working in the pharmaceutical and biotechnology industries. It will also be useful for postgraduates studying pharmacology and applied statistics.

Chemoinformatics Approaches to Virtual Screening

Chemoinformatics Approaches to Virtual Screening
Author: Alexandre Varnek,Alex Tropsha
Publsiher: Royal Society of Chemistry
Total Pages: 338
Release: 2008
ISBN 10: 0854041443
ISBN 13: 9780854041442
Language: EN, FR, DE, ES & NL

Chemoinformatics Approaches to Virtual Screening Book Review:

Chemoinformatics is broadly a scientific discipline encompassing the design, creation, organization, management, retrieval, analysis, dissemination, visualization and use of chemical information. It is distinct from other computational molecular modeling approaches in that it uses unique representations of chemical structures in the form of multiple chemical descriptors; has its own metrics for defining similarity and diversity of chemical compound libraries; and applies a wide array of statistical, data mining and machine learning techniques to very large collections of chemical compounds in order to establish robust relationships between chemical structure and its physical or biological properties. Chemoinformatics addresses a broad range of problems in chemistry and biology; however, the most commonly known applications of chemoinformatics approaches have been arguably in the area of drug discovery where chemoinformatics tools have played a central role in the analysis and interpretation of structure-property data collected by the means of modern high throughput screening. Early stages in modern drug discovery often involved screening small molecules for their effects on a selected protein target or a model of a biological pathway. In the past fifteen years, innovative technologies that enable rapid synthesis and high throughput screening of large libraries of compounds have been adopted in almost all major pharmaceutical and biotech companies. As a result, there has been a huge increase in the number of compounds available on a routine basis to quickly screen for novel drug candidates against new targets/pathways. In contrast, such technologies have rarely become available to the academic research community, thus limiting its ability to conduct large scale chemical genetics or chemical genomics research. However, the landscape of publicly available experimental data collection methods for chemoinformatics has changed dramatically in very recent years. The term "virtual screening" is commonly associated with methodologies that rely on the explicit knowledge of three-dimensional structure of the target protein to identify potential bioactive compounds. Traditional docking protocols and scoring functions rely on explicitly defined three dimensional coordinates and standard definitions of atom types of both receptors and ligands. Albeit reasonably accurate in many cases, conventional structure based virtual screening approaches are relatively computationally inefficient, which has precluded them from screening really large compound collections. Significant progress has been achieved over many years of research in developing many structure based virtual screening approaches. This book is the first monograph that summarizes innovative applications of efficient chemoinformatics approaches towards the goal of screening large chemical libraries. The focus on virtual screening expands chemoinformatics beyond its traditional boundaries as a synthetic and data-analytical area of research towards its recognition as a predictive and decision support scientific discipline. The approaches discussed by the contributors to the monograph rely on chemoinformatics concepts such as: -representation of molecules using multiple descriptors of chemical structures -advanced chemical similarity calculations in multidimensional descriptor spaces -the use of advanced machine learning and data mining approaches for building quantitative and predictive structure activity models -the use of chemoinformatics methodologies for the analysis of drug-likeness and property prediction -the emerging trend on combining chemoinformatics and bioinformatics concepts in structure based drug discovery The chapters of the book are organized in a logical flow that a typical chemoinformatics project would follow - from structure representation and comparison to data analysis and model building to applications of structure-property relationship models for hit identification and chemical library design. It opens with the overview of modern methods of compounds library design, followed by a chapter devoted to molecular similarity analysis. Four sections describe virtual screening based on the using of molecular fragments, 2D pharmacophores and 3D pharmacophores. Application of fuzzy pharmacophores for libraries design is the subject of the next chapter followed by a chapter dealing with QSAR studies based on local molecular parameters. Probabilistic approaches based on 2D descriptors in assessment of biological activities are also described with an overview of the modern methods and software for ADME prediction. The book ends with a chapter describing the new approach of coding the receptor binding sites and their respective ligands in multidimensional chemical descriptor space that affords an interesting and efficient alternative to traditional docking and screening techniques. Ligand-based approaches, which are in the focus of this work, are more computationally efficient compared to structure-based virtual screening and there are very few books related to modern developments in this field. The focus on extending the experiences accumulated in traditional areas of chemoinformatics research such as Quantitative Structure Activity Relationships (QSAR) or chemical similarity searching towards virtual screening make the theme of this monograph essential reading for researchers in the area of computer-aided drug discovery. However, due to its generic data-analytical focus there will be a growing application of chemoinformatics approaches in multiple areas of chemical and biological research such as synthesis planning, nanotechnology, proteomics, physical and analytical chemistry and chemical genomics.

Biomarkers in Drug Development

Biomarkers in Drug Development
Author: Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
Publsiher: John Wiley & Sons
Total Pages: 784
Release: 2011-09-20
ISBN 10: 1118210425
ISBN 13: 9781118210420
Language: EN, FR, DE, ES & NL

Biomarkers in Drug Development Book Review:

Discover how biomarkers can boost the success rate of drugdevelopment efforts As pharmaceutical companies struggle to improve the success rateand cost-effectiveness of the drug development process, biomarkershave emerged as a valuable tool. This book synthesizes and reviewsthe latest efforts to identify, develop, and integrate biomarkersas a key strategy in translational medicine and the drugdevelopment process. Filled with case studies, the bookdemonstrates how biomarkers can improve drug development timelines,lower costs, facilitate better compound selection, reducelate-stage attrition, and open the door to personalizedmedicine. Biomarkers in Drug Development is divided into eightparts: Part One offers an overview of biomarkers and their role in drugdevelopment. Part Two highlights important technologies to help researchersidentify new biomarkers. Part Three examines the characterization and validation processfor both drugs and diagnostics, and provides practical advice onappropriate statistical methods to ensure that biomarkers fulfilltheir intended purpose. Parts Four through Six examine the application of biomarkers indiscovery, preclinical safety assessment, clinical trials, andtranslational medicine. Part Seven focuses on lessons learned and the practical aspectsof implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including dataintegration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or moreleading experts, including scientists from biotechnology andpharmaceutical firms, academia, and the U.S. Food and DrugAdministration. Their contributions offer pharmaceutical andclinical researchers the most up-to-date understanding of thestrategies used for and applications of biomarkers in drugdevelopment.

Chemoinformatics in Drug Discovery

Chemoinformatics in Drug Discovery
Author: Tudor I. Oprea
Publsiher: John Wiley & Sons
Total Pages: 515
Release: 2006-03-06
ISBN 10: 3527604200
ISBN 13: 9783527604203
Language: EN, FR, DE, ES & NL

Chemoinformatics in Drug Discovery Book Review:

This handbook provides the first-ever inside view of today's integrated approach to rational drug design. Chemoinformatics experts from large pharmaceutical companies, as well as from chemoinformatics service providers and from academia demonstrate what can be achieved today by harnessing the power of computational methods for the drug discovery process. With the user rather than the developer of chemoinformatics software in mind, this book describes the successful application of computational tools to real-life problems and presents solution strategies to commonly encountered problems. It shows how almost every step of the drug discovery pipeline can be optimized and accelerated by using chemoinformatics tools -- from the management of compound databases to targeted combinatorial synthesis, virtual screening and efficient hit-to-lead transition. An invaluable resource for drug developers and medicinal chemists in academia and industry.

Chemoinformatics Approaches to Structure and Ligand Based Drug Design

Chemoinformatics Approaches to Structure  and Ligand Based Drug Design
Author: Adriano D. Andricopulo,Leonardo L. G. Ferreira
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-02-05
ISBN 10: 2889457443
ISBN 13: 9782889457441
Language: EN, FR, DE, ES & NL

Chemoinformatics Approaches to Structure and Ligand Based Drug Design Book Review:

Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches. Readers are provided with outstanding contributions focusing on a wide variety of topics which will be of great value to those interested in the many different and exciting facets of drug design.

Drug Design

Drug Design
Author: Gerhard Klebe
Publsiher: Springer
Total Pages: 901
Release: 2013-07-10
ISBN 10: 9783642179068
ISBN 13: 3642179061
Language: EN, FR, DE, ES & NL

Drug Design Book Review:

Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.

Modelling Methodology for Physiology and Medicine

Modelling Methodology for Physiology and Medicine
Author: Ewart Carson,Claudio Cobelli
Publsiher: Newnes
Total Pages: 588
Release: 2013-12-05
ISBN 10: 0124095259
ISBN 13: 9780124095250
Language: EN, FR, DE, ES & NL

Modelling Methodology for Physiology and Medicine Book Review:

Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems

In Silico Drug Design

In Silico Drug Design
Author: Kunal Roy
Publsiher: Academic Press
Total Pages: 886
Release: 2019-02-12
ISBN 10: 0128163771
ISBN 13: 9780128163771
Language: EN, FR, DE, ES & NL

In Silico Drug Design Book Review:

In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing

New Drugs and Targets for Asthma and COPD

New Drugs and Targets for Asthma and COPD
Author: T.T. Hansel,P.J. Barnes
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 324
Release: 2010-08-31
ISBN 10: 3805595670
ISBN 13: 9783805595674
Language: EN, FR, DE, ES & NL

New Drugs and Targets for Asthma and COPD Book Review:

Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.

Chemoinformatics for Drug Discovery

Chemoinformatics for Drug Discovery
Author: Jürgen Bajorath
Publsiher: John Wiley & Sons
Total Pages: 432
Release: 2013-09-25
ISBN 10: 1118743091
ISBN 13: 9781118743096
Language: EN, FR, DE, ES & NL

Chemoinformatics for Drug Discovery Book Review:

Chemoinformatics strategies to improve drug discoveryresults With contributions from leading researchers in academia and thepharmaceutical industry as well as experts from the softwareindustry, this book explains how chemoinformatics enhances drugdiscovery and pharmaceutical research efforts, describing whatworks and what doesn't. Strong emphasis is put on tested and provenpractical applications, with plenty of case studies detailing thedevelopment and implementation of chemoinformatics methods tosupport successful drug discovery efforts. Many of these casestudies depict groundbreaking collaborations between academia andthe pharmaceutical industry. Chemoinformatics for Drug Discovery is logicallyorganized, offering readers a solid base in methods and models andadvancing to drug discovery applications and the design ofchemoinformatics infrastructures. The book features 15 chapters,including: What are our models really telling us? A practical tutorial onavoiding common mistakes when building predictive models Exploration of structure-activity relationships and transfer ofkey elements in lead optimization Collaborations between academia and pharma Applications of chemoinformatics in pharmaceuticalresearch—experiences at large international pharmaceuticalcompanies Lessons learned from 30 years of developing successfulintegrated chemoinformatic systems Throughout the book, the authors present chemoinformaticsstrategies and methods that have been proven to work inpharmaceutical research, offering insights culled from their owninvestigations. Each chapter is extensively referenced withcitations to original research reports and reviews. Integrating chemistry, computer science, and drug discovery,Chemoinformatics for Drug Discovery encapsulates the fieldas it stands today and opens the door to further advances.

Advances in Molecular Oncology

Advances in Molecular Oncology
Author: Fabrizio d'Adda di Fagagna,Susanna Chiocca,Fraser McBlane,Ugo Cavallaro
Publsiher: Springer Science & Business Media
Total Pages: 276
Release: 2007-07-18
ISBN 10: 0387691162
ISBN 13: 9780387691169
Language: EN, FR, DE, ES & NL

Advances in Molecular Oncology Book Review:

Proceedings of the 2nd Annual IFOM-IEO Meeting on Cancer. This is a new meeting, it has about 200 attendees from Australia, Austria, Belgium, Brazil, Canada, England, France, Germany, Greece, Ireland, Italy, Japan, Netherlands, Spain, Sweden, Switzerland, and the USA. The 2nd IFOM-IEO international meeting on cancer will provide a forum in which the world’s leading cancer researchers and young scientists will discuss the latest advances in molecular oncology. The impact of recent breakthroughs in basic research and of emerging technologies on molecular medicine in cancer will be highlighted.

A Buyer s and User s Guide to Astronomical Telescopes and Binoculars

A Buyer s and User s Guide to Astronomical Telescopes and Binoculars
Author: James Mullaney
Publsiher: Springer Science & Business Media
Total Pages: 223
Release: 2013-10-10
ISBN 10: 1461487331
ISBN 13: 9781461487333
Language: EN, FR, DE, ES & NL

A Buyer s and User s Guide to Astronomical Telescopes and Binoculars Book Review:

Amateur astronomers of all skill levels are always contemplating their next telescope, and this book points the way to the most suitable instruments. Similarly, those who are buying their first telescopes – and these days not necessarily a low-cost one – will be able to compare and contrast different types and manufacturers. This exciting and revised new guide provides an extensive overview of binoculars and telescopes. It includes detailed up-to-date information on sources, selection and use of virtually every major type, brand, and model on today’s market, a truly invaluable treasure-trove of information and helpful advice for all amateur astronomers. Originally written in 2006, much of the first edition is inevitably now out of date, as equipment advances and manufacturers come and go. This second edition not only updates all the existing sections of “A Buyer’s and User’s Guide to Astronomical Telescopes and Binoculars” but adds two new ones: Astro-imaging and Professional-Amateur collaboration. Thanks to the rapid and amazing developments that have been made in digital cameras – not those specialist cool-chip astronomical cameras, not even DSLRs, but regular general-purpose vacation cameras – it is easily possible to image all sorts of astronomical objects and fields. Technical developments, including the Internet, have also made it possible for amateur astronomers to make a real contribution to science by working with professionals. Selecting the right device for a variety of purposes can be an overwhelming task in a market crowded with observing options, but this comprehensive guide clarifies the process. Anyone planning to purchase binoculars or telescopes for astronomy – whether as a first instrument or as an upgrade to the next level – will find this book a treasure-trove of information and advice. It also supplies the reader with many useful hints and tips on using astronomical telescopes or binoculars to get the best possible results from your purchase.

Project Management for Healthcare Informatics

Project Management for Healthcare Informatics
Author: Susan Houston,Lisa Anne Bove
Publsiher: Springer Science & Business Media
Total Pages: 140
Release: 2007-11-25
ISBN 10: 0387736832
ISBN 13: 9780387736839
Language: EN, FR, DE, ES & NL

Project Management for Healthcare Informatics Book Review:

Through its use of real clinical examples, this book provides an explanation of the project management process tailored for nurses. It first describes, in detail, the project management process along with its relationship to the phases of the project life cycle. Coverage includes the tools available to successfully complete each phase of the project management process and advance the project life cycle. With the aid of case studies and project examples, the book then examines how to apply these principles in the day-to-day work of the nurse, whether manager, staff nurse, educator, researcher, or informatician.

3 D Structural Geology

3 D Structural Geology
Author: Richard H. Groshong
Publsiher: Springer Science & Business Media
Total Pages: 400
Release: 2006-07-09
ISBN 10: 9783540310556
ISBN 13: 354031055X
Language: EN, FR, DE, ES & NL

3 D Structural Geology Book Review:

The book includes new material, in particular examples of 3-D models and techniques for using kinematic models to predict fault and ramp-anticline geometry. The book is geared toward the professional user concerned about the accuracy of an interpretation and the speed with which it can be obtained from incomplete data. Numerous analytical solutions are given that can be easily implemented with a pocket calculator or a spreadsheet.

Nanotechnology Enabled Sensors

Nanotechnology Enabled Sensors
Author: Kourosh Kalantar-zadeh,Benjamin Fry
Publsiher: Springer Science & Business Media
Total Pages: 492
Release: 2007-09-19
ISBN 10: 0387680233
ISBN 13: 9780387680231
Language: EN, FR, DE, ES & NL

Nanotechnology Enabled Sensors Book Review:

Nanotechnology provides tools for creating functional materials, devices, and systems by controlling materials at the atomic and molecular scales and making use of novel properties and phenomena. Nanotechnology-enabled sensors find applications in several fields such as health and safety, medicine, process control and diagnostics. This book provides the reader with information on how nanotechnology enabled sensors are currently being used and how they will be used in the future in such diverse fields as communications, building and facilities, medicine, safety, and security, including both homeland defense and military operations.

Pharmacology in Drug Discovery and Development

Pharmacology in Drug Discovery and Development
Author: Terry Kenakin
Publsiher: Academic Press
Total Pages: 350
Release: 2016-10-21
ISBN 10: 0128037539
ISBN 13: 9780128037539
Language: EN, FR, DE, ES & NL

Pharmacology in Drug Discovery and Development Book Review:

Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery. Includes example-based cases that illustrate how the pharmacological concepts discussed in this book lead to practical outcomes for further research Provides vignettes on those researchers and scientists who have contributed significantly to the fields of pharmacology and drug discovery throughout history Offers sample questions throughout the book and an appendix containing answers for self-testing and retention

A Changing World

A Changing World
Author: Felix Kienast,Otto Wildi,Sucharita Ghosh
Publsiher: Springer Science & Business Media
Total Pages: 296
Release: 2007-03-16
ISBN 10: 1402044364
ISBN 13: 9781402044366
Language: EN, FR, DE, ES & NL

A Changing World Book Review:

Modern landscape research uses a panoply of techniques to further our understanding of our changing world, including mathematics, statistics and advanced simulation techniques to combine empirical observations with known theories. This book identifies emerging fields and new challenges that are discussed within the framework of the ‘driving forces’ of Landscape Development. the book addresses all of the ‘hot topics’ in this important area of study and emphasizes major contemporary trends in these fields.

Introducing Biological Rhythms

Introducing Biological Rhythms
Author: Willard L. Koukkari,Robert B. Sothern
Publsiher: Springer Science & Business Media
Total Pages: 656
Release: 2007-07-29
ISBN 10: 1402047010
ISBN 13: 9781402047015
Language: EN, FR, DE, ES & NL

Introducing Biological Rhythms Book Review:

Introducing Biological Rhythms is a primer that serves to introduce individuals to the area of biological rhythms. It describes the major characteristics and discusses the implications and applications of these rhythms, while citing scientific results and references. Also, the primer includes essays that provide in-depth historic and other background information for those interested in more specific topics or concepts. It covers a basic cross-section of the field of chronobiology clearly enough so that it can be understood by a novice, or an undergraduate student, but that it would also be sufficiently technical and detailed for the scientist.

Tutorials in Chemoinformatics

Tutorials in Chemoinformatics
Author: Alexandre Varnek
Publsiher: John Wiley & Sons
Total Pages: 488
Release: 2017-06-22
ISBN 10: 1119137985
ISBN 13: 9781119137986
Language: EN, FR, DE, ES & NL

Tutorials in Chemoinformatics Book Review:

30 tutorials and more than 100 exercises in chemoinformatics, supported by online software and data sets Chemoinformatics is widely used in both academic and industrial chemical and biochemical research worldwide. Yet, until this unique guide, there were no books offering practical exercises in chemoinformatics methods. Tutorials in Chemoinformatics contains more than 100 exercises in 30 tutorials exploring key topics and methods in the field. It takes an applied approach to the subject with a strong emphasis on problem-solving and computational methodologies. Each tutorial is self-contained and contains exercises for students to work through using a variety of software packages. The majority of the tutorials are divided into three sections devoted to theoretical background, algorithm description and software applications, respectively, with the latter section providing step-by-step software instructions. Throughout, three types of software tools are used: in-house programs developed by the authors, open-source programs and commercial programs which are available for free or at a modest cost to academics. The in-house software and data sets are available on a dedicated companion website. Key topics and methods covered in Tutorials in Chemoinformatics include: Data curation and standardization Development and use of chemical databases Structure encoding by molecular descriptors, text strings and binary fingerprints The design of diverse and focused libraries Chemical data analysis and visualization Structure-property/activity modeling (QSAR/QSPR) Ensemble modeling approaches, including bagging, boosting, stacking and random subspaces 3D pharmacophores modeling and pharmacological profiling using shape analysis Protein-ligand docking Implementation of algorithms in a high-level programming language Tutorials in Chemoinformatics is an ideal supplementary text for advanced undergraduate and graduate courses in chemoinformatics, bioinformatics, computational chemistry, computational biology, medicinal chemistry and biochemistry. It is also a valuable working resource for medicinal chemists, academic researchers and industrial chemists looking to enhance their chemoinformatics skills.