Computer Aided Vaccine Design

Computer Aided Vaccine Design
Author: Joo Chuan Tong,Shoba Ranganathan
Publsiher: Elsevier
Total Pages: 164
Release: 2013-07-31
ISBN 10: 1908818417
ISBN 13: 9781908818416
Language: EN, FR, DE, ES & NL

Computer Aided Vaccine Design Book Review:

Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics. Essential reading for any biologist who wants to understand methods of computer-aided vaccine design Description of available data sources and publicly available software, with detailed analysis of strengths and weaknesses Theoretical concepts and practical examples of database design and development for a virtual screening campaign

Computer Aided Drug Design

Computer Aided Drug Design
Author: Dev Bukhsh Singh
Publsiher: Springer Nature
Total Pages: 306
Release: 2020-10-09
ISBN 10: 9811568154
ISBN 13: 9789811568152
Language: EN, FR, DE, ES & NL

Computer Aided Drug Design Book Review:

This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.

Scientific Modeling and Simulations

Scientific Modeling and Simulations
Author: Sidney Yip,Tomas Diaz Rubia
Publsiher: Springer Science & Business Media
Total Pages: 402
Release: 2010-04-07
ISBN 10: 1402097417
ISBN 13: 9781402097416
Language: EN, FR, DE, ES & NL

Scientific Modeling and Simulations Book Review:

Although computational modeling and simulation of material deformation was initiated with the study of structurally simple materials and inert environments, there is an increasing demand for predictive simulation of more realistic material structure and physical conditions. In particular, it is recognized that applied mechanical force can plausibly alter chemical reactions inside materials or at material interfaces, though the fundamental reasons for this chemomechanical coupling are studied in a material-speci c manner. Atomistic-level s- ulations can provide insight into the unit processes that facilitate kinetic reactions within complex materials, but the typical nanosecond timescales of such simulations are in contrast to the second-scale to hour-scale timescales of experimentally accessible or technologically relevant timescales. Further, in complex materials these key unit processes are “rare events” due to the high energy barriers associated with those processes. Examples of such rare events include unbinding between two proteins that tether biological cells to extracellular materials [1], unfolding of complex polymers, stiffness and bond breaking in amorphous glass bers and gels [2], and diffusive hops of point defects within crystalline alloys [3].

The Design and Development of Novel Drugs and Vaccines

The Design and Development of Novel Drugs and Vaccines
Author: Tarun Kumar Bhatt,Surendra Nimesh
Publsiher: Academic Press
Total Pages: 308
Release: 2021-01-21
ISBN 10: 0128214759
ISBN 13: 9780128214756
Language: EN, FR, DE, ES & NL

The Design and Development of Novel Drugs and Vaccines Book Review:

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies Reviews the most current, cutting-edge research available on vaccine and drug design and development

Vaccine Design

Vaccine Design
Author: Rino Rappuoli,Fabio Bagnoli
Publsiher: Caister Academic Press
Total Pages: 380
Release: 2011
ISBN 10: 9781904455745
ISBN 13: 1904455743
Language: EN, FR, DE, ES & NL

Vaccine Design Book Review:

In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.

Vaccines

Vaccines
Author: Farhat Afrin,Hassan Hemeg,Hani Ozbak
Publsiher: BoD – Books on Demand
Total Pages: 192
Release: 2017-09-06
ISBN 10: 9535134752
ISBN 13: 9789535134756
Language: EN, FR, DE, ES & NL

Vaccines Book Review:

Microbes that elude host's defenses and have developed resistance to the existing antibiotic arsenal continuously invade the human body. Cure for such diseases is inevitable as it may result in high morbidity and mortality, if not properly treated. Vaccination represents the most cost-effective way for disease prevention. Vaccines activate sentinels of the immune system including macrophages and T, B, and dendritic cells to release a battery of effector molecules and cytokines and ward off infection. For long-lasting protection, the memory cells also need to be evoked. This book encompasses biotechnological vaccines in clinical use, cocooning, disease resurgence postvaccination and other vaccine adverse effects, prospects of therapeutic versus prophylactic vaccines, and design of effective vaccines using bioinformatic tools and engineering molecular pattern interactions.

Biologically Active Peptides

Biologically Active Peptides
Author: David B. Weiner,William V. Williams
Publsiher: CRC Press
Total Pages: 374
Release: 1993-11-04
ISBN 10: 9780877629351
ISBN 13: 0877629358
Language: EN, FR, DE, ES & NL

Biologically Active Peptides Book Review:

Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Comprehensive Medicinal Chemistry II

Comprehensive Medicinal Chemistry II
Author: David J Triggle,John B Taylor
Publsiher: Elsevier
Total Pages: 7200
Release: 2006-12-29
ISBN 10: 0080445136
ISBN 13: 9780080445137
Language: EN, FR, DE, ES & NL

Comprehensive Medicinal Chemistry II Book Review:

The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Bioinformatics for Vaccinology

Bioinformatics for Vaccinology
Author: Darren R. Flower
Publsiher: John Wiley & Sons
Total Pages: 302
Release: 2008-10-13
ISBN 10: 0470699825
ISBN 13: 9780470699829
Language: EN, FR, DE, ES & NL

Bioinformatics for Vaccinology Book Review:

“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

Immunoinformatics

Immunoinformatics
Author: Christian Schönbach,Shoba Ranganathan,Vladimir Brusic
Publsiher: Springer Science & Business Media
Total Pages: 200
Release: 2007-11-21
ISBN 10: 0387729682
ISBN 13: 9780387729688
Language: EN, FR, DE, ES & NL

Immunoinformatics Book Review:

In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.

Annual Report

Annual Report
Author: India. Department of Scientific & Industrial Research
Publsiher: Unknown
Total Pages: 329
Release: 2005
ISBN 10:
ISBN 13: UOM:39015066160477
Language: EN, FR, DE, ES & NL

Annual Report Book Review:

Chemical Process Design and Simulation Aspen Plus and Aspen Hysys Applications

Chemical Process Design and Simulation  Aspen Plus and Aspen Hysys Applications
Author: Juma Haydary
Publsiher: John Wiley & Sons
Total Pages: 448
Release: 2019-01-03
ISBN 10: 1119311438
ISBN 13: 9781119311430
Language: EN, FR, DE, ES & NL

Chemical Process Design and Simulation Aspen Plus and Aspen Hysys Applications Book Review:

A comprehensive and example oriented text for the study of chemical process design and simulation Chemical Process Design and Simulation is an accessible guide that offers information on the most important principles of chemical engineering design and includes illustrative examples of their application that uses simulation software. A comprehensive and practical resource, the text uses both Aspen Plus and Aspen Hysys simulation software. The author describes the basic methodologies for computer aided design and offers a description of the basic steps of process simulation in Aspen Plus and Aspen Hysys. The text reviews the design and simulation of individual simple unit operations that includes a mathematical model of each unit operation such as reactors, separators, and heat exchangers. The author also explores the design of new plants and simulation of existing plants where conventional chemicals and material mixtures with measurable compositions are used. In addition, to aid in comprehension, solutions to examples of real problems are included. The final section covers plant design and simulation of processes using nonconventional components. This important resource: Includes information on the application of both the Aspen Plus and Aspen Hysys software that enables a comparison of the two software systems Combines the basic theoretical principles of chemical process and design with real-world examples Covers both processes with conventional organic chemicals and processes with more complex materials such as solids, oil blends, polymers and electrolytes Presents examples that are solved using a new version of Aspen software, ASPEN One 9 Written for students and academics in the field of process design, Chemical Process Design and Simulation is a practical and accessible guide to the chemical process design and simulation using proven software.

Composites in Biomedical Applications

Composites in Biomedical Applications
Author: S. M. Sapuan,Y. Nukman,N.A. Abu Osman,R.A. Ilyas
Publsiher: CRC Press
Total Pages: 302
Release: 2020-09-27
ISBN 10: 1000175170
ISBN 13: 9781000175172
Language: EN, FR, DE, ES & NL

Composites in Biomedical Applications Book Review:

Composites in Biomedical Applications presents a comprehensive overview on recent developments in composites and their use in biomedical applications. It features cutting-edge developments to encourage further advances in the field of composite research. Highlights a completely new research theme in polymer-based composite materials Outlines a broad range of different research fields, including polymer and natural fiber reinforcement used in the development of composites for biomedical applications Discusses advanced techniques for the development of composites and biopolymer-based composites Covers fatigue behavior, conceptual design in ergonomics design application, tissue regeneration or replacement, and skeletal bone repair of polymer composites Details the latest developments in synthesis, preparation, characterization, material evaluation, and future challenges of composite applications in the biomedical field This book is a comprehensive resource for advanced students and scientists pursuing research in the broad fields of composite materials, polymers, organic or inorganic hybrid materials, and nano-assembly.

Computer aided Molecular Design

Computer aided Molecular Design
Author: William Graham Richards
Publsiher: Vch Pub
Total Pages: 266
Release: 1989
ISBN 10:
ISBN 13: UOM:39015054001550
Language: EN, FR, DE, ES & NL

Computer aided Molecular Design Book Review:

Zika Virus Surveillance Vaccinology and Anti Zika Drug Discovery

Zika Virus Surveillance  Vaccinology  and Anti Zika Drug Discovery
Author: Subhash C. Basak,Ashesh Nandy
Publsiher: Unknown
Total Pages: 176
Release: 2019-03-15
ISBN 10: 9781536149708
ISBN 13: 1536149705
Language: EN, FR, DE, ES & NL

Zika Virus Surveillance Vaccinology and Anti Zika Drug Discovery Book Review:

The bubonic plague, smallpox, HIV/AIDS, malaria, and influenza are some of the worst epidemics/pandemics that afflicted human beings from antiquity to modern times, killing millions of people. The mosquito-borne human-infecting viruses, rotavirus, and the seasonal influenza regularly affect lives across continents in the millions. Currently, we are facing various disease-inducing organisms of the Flavivirus family the Yellow fever virus (YFV), West Nile virus (WNV), Japanese encephalitis virus (JEV), Tick-borne encephalitis virus (TBEV), Dengue virus (DENV) and Zika virus (ZIKV). Zika virus was first isolated from a febrile rhesus monkey in the Zika forest of Uganda in 1947. It drew out heightened attention following the large number of microcephaly in newborn babies in Latin America in 2015. On 1 February 2016, WHO declared that the association of Zika infection with clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern. Although the severity and number of ZIKV afflicted cases have gone down lately, the public health community worldwide is keeping a watchful eye on it. ZIKV is an enveloped virus with a positive-sense RNA genome that translates into a single polypeptide, which then gets cleaved into three structural and seven nonstructural viral proteins. As compared to the earlier centuries, we have an expanding repertoire of diverse and fast acting technologies available at our hand to manage and mitigate emerging diseases. Completion of the Human Genome Project has given rise to sequencing methods which can quickly determine the genetic sequence of an alarming pathogen. Following Moores law, the power of computers, essential for data analysis and visualization, has grown substantially with time. The combination of genomic data of pathogens, computational modeling methods, and data driven methodologies can lead to a generic approach of surveillance, mitigation, vaccine design as well as new drug discovery for emerging pathogens. The four pillars of this may consist of: a) Epidemiological approaches for the characterization of carriers of next possible emerging pathogens; b) Fast computational sequence comparison methods for the characterization of emerging pathogens to understand how novel or severe they could be; c) Once the sequences of the pathogen have been determined, computer-aided vaccine design (CAVD) methods can be used to suggest a set of probable vaccine candidates for quick synthesis and testing in the laboratory; and d) Computer-assisted design of novel therapeutics and their laboratory testing as well as repurposing of already existing FDA-approved drugs. A combination of different classes of methods in vivo, in vitro and in silico will be needed to tackle suddenly emerging viruses like the Zika virus. As in many other fields of biomedical research, high throughput and low cost in silico technologies may provide the first line of defense against such emerging pathogens providing decision support systems for the judicious applications of medium throughput in vitro methods and low throughput as well as costly in vivo techniques. An emerging trend in many scientific disciplines is a strong tendency of being transformed into some form of information science. The editors of this book sincerely hope that the four-pronged computer-assisted approach described in this book will help in managing and mitigating emerging infectious diseases like Zika.

Annual Report Council of Scientific and Industrial Research

Annual Report   Council of Scientific and Industrial Research
Author: Council of Scientific & Industrial Research (India)
Publsiher: Unknown
Total Pages: 329
Release: 2004
ISBN 10:
ISBN 13: UIUC:30112075347127
Language: EN, FR, DE, ES & NL

Annual Report Council of Scientific and Industrial Research Book Review:

Citrus

Citrus
Author: Pierre Laszlo
Publsiher: University of Chicago Press
Total Pages: 252
Release: 2008-10
ISBN 10: 0226470288
ISBN 13: 9780226470283
Language: EN, FR, DE, ES & NL

Citrus Book Review:

Laszlo traces the spectacular rise and spread of citrus across the globe, from southeast Asia in 4000 BC to modern Spain and Portugal, whose explorers inroduced the fruit to the Americas. This book explores the numerous roles that citrus has played in agriculture, horticulture, cooking, nutrition, religion, and art.

Modelling Drying Processes

Modelling Drying Processes
Author: Xiao Dong Chen,Aditya Putranto
Publsiher: Cambridge University Press
Total Pages: 329
Release: 2013-05-23
ISBN 10: 1107354862
ISBN 13: 9781107354869
Language: EN, FR, DE, ES & NL

Modelling Drying Processes Book Review:

This comprehensive summary of the state of the art and the ideas behind the reaction engineering approach (REA) to drying processes is an ideal resource for researchers, academics and industry practitioners. Starting with the formulation, modelling and applications of the lumped-REA, it goes on to detail the use of the REA to describe local evaporation and condensation, and its coupling with equations of conservation of heat and mass transfer, called the spatial-REA, to model non-equilibrium multiphase drying. Finally, it summarises other established drying models, discussing their features, limitations and comparisons with the REA. Application examples featured throughout help fine-tune the models and implement them for process design and the evaluation of existing drying processes and product quality during drying. Further uses of the principles of REA are demonstrated, including computational fluid dynamics-based modelling, and further expanded to model other simultaneous heat and mass transfer processes.

Leaky Bodies and Boundaries

Leaky Bodies and Boundaries
Author: Margrit Shildrick
Publsiher: Routledge
Total Pages: 264
Release: 2015-12-22
ISBN 10: 1136184627
ISBN 13: 9781136184628
Language: EN, FR, DE, ES & NL

Leaky Bodies and Boundaries Book Review:

Drawing on postmodernist analyses, Leaky Bodies and Boundaries presents a feminist investigation into the marginalization of women within western discourse that denies female moral agency and embodiment. With reference to contemporary and historical issues in biomedicine, the book argues that the boundaries of both the subject and the body are no longer secure. The aim is both to valorise women and to suggest that 'leakiness' may be the very ground for a postmodern feminist ethic. The contribution made by Leaky Bodies and Boundaries is to go beyond modernist feminisms to radically displace the mechanisms by which women are devalued. The anxiety that postmodernism cannot yield an ethics, nor advance feminist concerns is addressed. This book will provide invaluable reading for those studying feminist philosophy, cultural studies and sociology.

Encyclopedia of Supramolecular Chemistry

Encyclopedia of Supramolecular Chemistry
Author: J. L. Atwood,University Research Professor Department of Chemistry Jerry L Atwood,Jonathan W. Steed
Publsiher: CRC Press
Total Pages: 1670
Release: 2004
ISBN 10: 9780824747244
ISBN 13: 0824747240
Language: EN, FR, DE, ES & NL

Encyclopedia of Supramolecular Chemistry Book Review:

Covers the fundamentals of supramolecular chemistry; supramolecular advancements and methods in the areas of chemistry, biochemistry, biology, environmental and materials science and engineering, physics, computer science, and applied mathematics.