Companion and Complementary Diagnostics

Companion and Complementary Diagnostics
Author: Jan Trøst Jørgensen
Publsiher: Academic Press
Total Pages: 508
Release: 2019-05-08
ISBN 10: 0128135409
ISBN 13: 9780128135402
Language: EN, FR, DE, ES & NL

Companion and Complementary Diagnostics Book Review:

Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic

Companion and Complementary Diagnostics

Companion and Complementary Diagnostics
Author: Jan Trøst Jørgensen
Publsiher: Academic Press
Total Pages: 305
Release: 2019-04-15
ISBN 10: 9780128135396
ISBN 13: 0128135395
Language: EN, FR, DE, ES & NL

Companion and Complementary Diagnostics Book Review:

Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic

Companion Diagnostics CDx in Precision Medicine

Companion Diagnostics  CDx  in Precision Medicine
Author: Il-Jin Kim
Publsiher: CRC Press
Total Pages: 256
Release: 2019-03-06
ISBN 10: 1000007219
ISBN 13: 9781000007213
Language: EN, FR, DE, ES & NL

Companion Diagnostics CDx in Precision Medicine Book Review:

There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.

Drug Diagnostics Co Development in Oncology

Drug Diagnostics Co Development in Oncology
Author: Jan Trøst Jørgensen
Publsiher: Frontiers E-books
Total Pages: 329
Release: 2014-11-07
ISBN 10: 2889193322
ISBN 13: 9782889193325
Language: EN, FR, DE, ES & NL

Drug Diagnostics Co Development in Oncology Book Review:

The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen receptor modulator tamoxifen was developed in the 1970’s for the treatment of breast cancer a positive correlation between receptor status and treatment outcome was found. As a result of this research, it was suggested to use the estrogen-receptor assay as a diagnostic test for selection of patients for tamoxifen treatment. Despite this suggestion was put forward nearly 40 years ago the adaptation of the drug-diagnostic co-development model has been relatively slow and it is only within the last decade that it has gained more widespread acceptance. The parallel development of the monoclonal antibody trastuzumab (Herceptin®, Roche/Genentech) and the immunohistochemistry assay for HER2 protein overexpression (HercepTest™, Dako) seems to have served as an inspiration to a number of stakeholders such as pharma and diagnostic companies, regulatory agencies, and academia. In recent years we have seen an increasing number of oncology drug development projects that have taken advantage of the drug-diagnostic co-development model, as outline below. Most of the new targeted anti-cancer drugs that have been introduced in recent years, such as BRAF-, ALK-, EGFR- and HER2-inhibitors, are more or less all a product of the drugdiagnostic co-development model. These drugs have shown remarkable high response rates in selected groups of patients within cancer diseases with great unmet medical needs. This Research Topic on Drug-Diagnostic Co-Development in Oncology aims to provide you with an insight into some of the diverse activities that constitute this new research area.

Companion Diagnostics CDx in Precision Medicine

Companion Diagnostics  CDx  in Precision Medicine
Author: Il-Jin Kim
Publsiher: CRC Press
Total Pages: 256
Release: 2019-03-06
ISBN 10: 1000007219
ISBN 13: 9781000007213
Language: EN, FR, DE, ES & NL

Companion Diagnostics CDx in Precision Medicine Book Review:

There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.

Predictive Biomarkers in Oncology

Predictive Biomarkers in Oncology
Author: Sunil Badve,George Louis Kumar
Publsiher: Springer
Total Pages: 642
Release: 2018-12-06
ISBN 10: 3319952285
ISBN 13: 9783319952284
Language: EN, FR, DE, ES & NL

Predictive Biomarkers in Oncology Book Review:

“Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.

An R Companion to Applied Regression

An R Companion to Applied Regression
Author: John Fox,Sanford Weisberg
Publsiher: SAGE Publications
Total Pages: 608
Release: 2018-09-27
ISBN 10: 1544336454
ISBN 13: 9781544336459
Language: EN, FR, DE, ES & NL

An R Companion to Applied Regression Book Review:

An R Companion to Applied Regression is a broad introduction to the R statistical computing environment in the context of applied regression analysis. John Fox and Sanford Weisberg provide a step-by-step guide to using the free statistical software R, an emphasis on integrating statistical computing in R with the practice of data analysis, coverage of generalized linear models, and substantial web-based support materials. The Third Edition includes a new chapter on mixed-effects models, new and updated data sets, and a de-emphasis on statistical programming, while retaining a general introduction to basic R programming. The authors have substantially updated both the car and effects packages for R for this new edition, and include coverage of RStudio and R Markdown.

Diagnostic Molecular Biology

Diagnostic Molecular Biology
Author: Chang-Hui Shen
Publsiher: Academic Press
Total Pages: 471
Release: 2019-04-02
ISBN 10: 012802867X
ISBN 13: 9780128028674
Language: EN, FR, DE, ES & NL

Diagnostic Molecular Biology Book Review:

Diagnostic Molecular Biology describes the fundamentals of molecular biology in a clear, concise manner to aid in the comprehension of this complex subject. Each technique described in this book is explained within its conceptual framework to enhance understanding. The targeted approach covers the principles of molecular biology including the basic knowledge of nucleic acids, proteins, and genomes as well as the basic techniques and instrumentations that are often used in the field of molecular biology with detailed procedures and explanations. This book also covers the applications of the principles and techniques currently employed in the clinical laboratory. • Provides an understanding of which techniques are used in diagnosis at the molecular level • Explains the basic principles of molecular biology and their application in the clinical diagnosis of diseases • Places protocols in context with practical applications

Diagnosis and Management of Lameness in the Horse E Book

Diagnosis and Management of Lameness in the Horse   E Book
Author: Michael W. Ross,Sue J. Dyson
Publsiher: Elsevier Health Sciences
Total Pages: 1424
Release: 2010-11-11
ISBN 10: 1437711766
ISBN 13: 9781437711769
Language: EN, FR, DE, ES & NL

Diagnosis and Management of Lameness in the Horse E Book Book Review:

Covering many different diagnostic tools, this essential resource explores both traditional treatments and alternative therapies for conditions that can cause gait abnormalities in horses. Broader in scope than any other book of its kind, this edition describes equine sporting activities and specific lameness conditions in major sport horse types, and includes up-to-date information on all imaging modalities. This title includes additional digital media when purchased in print format. For this digital book edition, media content may not be included. Cutting-edge information on diagnostic application for computed tomography and magnetic resonance imaging includes the most comprehensive section available on MRI in the live horse. Coverage of traditional treatment modalities also includes many aspects of alternative therapy, with a practical and realistic perspective on prognosis. An examination of the various types of horses used in sports describes the lameness conditions to which each horse type is particularly prone, as well as differences in prognosis. Guidelines on how to proceed when a diagnosis cannot easily be reached help you manage conditions when faced with the limitations of current diagnostic capabilities. Clinical examination and diagnostic analgesia are given a special emphasis. Practical, hands-on information covers a wide range of horse types from around the world. A global perspective is provided by a team of international authors, editors, and contributors. A full-color insert shows thermography images. Updated chapters include the most current information on topics such as MRI, foot pain, stem cell therapy, and shock wave treatment. Two new chapters include The Biomechanics of the Equine Limb and its Effect on Lameness and Clinical Use of Stem Cells, Marrow Components, and Other Growth Factors. The chapter on the hock has been expanded substantially, and the section on lameness associated with the foot has been completely rewritten to include state-of-the-art information based on what has been learned from MRI. Many new figures appear throughout the book.

Molecular Targeted Therapy of Lung Cancer

Molecular Targeted Therapy of Lung Cancer
Author: Yuichi Takiguchi
Publsiher: Springer
Total Pages: 327
Release: 2017-01-24
ISBN 10: 9811020027
ISBN 13: 9789811020025
Language: EN, FR, DE, ES & NL

Molecular Targeted Therapy of Lung Cancer Book Review:

This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

A Buyer s and User s Guide to Astronomical Telescopes and Binoculars

A Buyer s and User s Guide to Astronomical Telescopes and Binoculars
Author: James Mullaney
Publsiher: Springer Science & Business Media
Total Pages: 223
Release: 2013-10-10
ISBN 10: 1461487331
ISBN 13: 9781461487333
Language: EN, FR, DE, ES & NL

A Buyer s and User s Guide to Astronomical Telescopes and Binoculars Book Review:

Amateur astronomers of all skill levels are always contemplating their next telescope, and this book points the way to the most suitable instruments. Similarly, those who are buying their first telescopes – and these days not necessarily a low-cost one – will be able to compare and contrast different types and manufacturers. This exciting and revised new guide provides an extensive overview of binoculars and telescopes. It includes detailed up-to-date information on sources, selection and use of virtually every major type, brand, and model on today’s market, a truly invaluable treasure-trove of information and helpful advice for all amateur astronomers. Originally written in 2006, much of the first edition is inevitably now out of date, as equipment advances and manufacturers come and go. This second edition not only updates all the existing sections of “A Buyer’s and User’s Guide to Astronomical Telescopes and Binoculars” but adds two new ones: Astro-imaging and Professional-Amateur collaboration. Thanks to the rapid and amazing developments that have been made in digital cameras – not those specialist cool-chip astronomical cameras, not even DSLRs, but regular general-purpose vacation cameras – it is easily possible to image all sorts of astronomical objects and fields. Technical developments, including the Internet, have also made it possible for amateur astronomers to make a real contribution to science by working with professionals. Selecting the right device for a variety of purposes can be an overwhelming task in a market crowded with observing options, but this comprehensive guide clarifies the process. Anyone planning to purchase binoculars or telescopes for astronomy – whether as a first instrument or as an upgrade to the next level – will find this book a treasure-trove of information and advice. It also supplies the reader with many useful hints and tips on using astronomical telescopes or binoculars to get the best possible results from your purchase.

Diagnosis of Endometrial Biopsies and Curettings

Diagnosis of Endometrial Biopsies and Curettings
Author: Michael Mazur,Robert J. Kurman
Publsiher: Springer Science & Business Media
Total Pages: 260
Release: 2013-04-17
ISBN 10: 1475739435
ISBN 13: 9781475739435
Language: EN, FR, DE, ES & NL

Diagnosis of Endometrial Biopsies and Curettings Book Review:

A logical approach to formulating a pathologic diagnosis from the diverse array of tissue received in the surgical pathology laboratory. The authors are both prominent gynaecologic pathologists, and this book is the result of their long-running Short Course presented at the International Academy of Pathology. Illustrations show typical artefacts and distortion and explain their impact on diagnostic interpretation, and each chapter includes a section on "Clinical Queries and Reporting" that summarises the features to be discussed in the final pathology report. Here is a strongly didactic approach to one of the most frequently ordered pathological examinations. You find superb illustrations on virtually every page and fast answers to everyday questions since emphasis is placed on clinically relevant material: commonly encountered specimens, common problems and common diagnostic issues.

New Drugs and Targets for Asthma and COPD

New Drugs and Targets for Asthma and COPD
Author: T.T. Hansel,P.J. Barnes
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 324
Release: 2010-08-31
ISBN 10: 3805595670
ISBN 13: 9783805595674
Language: EN, FR, DE, ES & NL

New Drugs and Targets for Asthma and COPD Book Review:

Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.

Ensuring Innovation in Diagnostics for Bacterial Infection

Ensuring Innovation in Diagnostics for Bacterial Infection
Author: Chantal Morel,Lindsay McClure,Suzanne Edwards,Dale Sandberg
Publsiher: World Health Organization
Total Pages: 317
Release: 2016
ISBN 10: 9289050365
ISBN 13: 9789289050364
Language: EN, FR, DE, ES & NL

Ensuring Innovation in Diagnostics for Bacterial Infection Book Review:

The inappropriate use of antibiotics is a primary cause of the ongoing increase in drug resistance among pathogenic bacteria. The resulting decrease in the efficacy of antibiotics threatens our ability to combat infectious diseases. Rapid, point-of-care tests to identify pathogens and better target the appropriate treatment could greatly improve the use of antibiotics. Yet there are few such tests currently available or being developed despite the rapid pace of medical innovation. Clearly something is inhibiting the much-needed development of new and more convenient diagnostic tools. This study delineates priorities for developing diagnostics to improve antibiotic prescription and use with the goal of managing and curbing the expansion of drug resistance. It calls for new approaches, particularly in the provision of diagnostic devices, and, in doing so, outlines some of the inadequacies in health, science and policy initiatives that have led to the dearth of such devices. The authors make the case that there is a clear and urgent need for innovation, not only in the technology of diagnosis, but also in public policy and medical practice to support the availability and use of better diagnostic tools. This book explores the complexities of the diagnostics market from the perspective of both supply and demand, unearthing interesting bottlenecks, some obvious, some more subtle. It calls for a multifaceted and broad policy response, and an overhaul of current practice, so that the growth of bacterial resistance can be stemmed.

3 D Structural Geology

3 D Structural Geology
Author: Richard H. Groshong
Publsiher: Springer Science & Business Media
Total Pages: 400
Release: 2006-07-09
ISBN 10: 9783540310556
ISBN 13: 354031055X
Language: EN, FR, DE, ES & NL

3 D Structural Geology Book Review:

The book includes new material, in particular examples of 3-D models and techniques for using kinematic models to predict fault and ramp-anticline geometry. The book is geared toward the professional user concerned about the accuracy of an interpretation and the speed with which it can be obtained from incomplete data. Numerous analytical solutions are given that can be easily implemented with a pocket calculator or a spreadsheet.

Nanotechnology Enabled Sensors

Nanotechnology Enabled Sensors
Author: Kourosh Kalantar-zadeh,Benjamin Fry
Publsiher: Springer Science & Business Media
Total Pages: 492
Release: 2007-09-19
ISBN 10: 0387680233
ISBN 13: 9780387680231
Language: EN, FR, DE, ES & NL

Nanotechnology Enabled Sensors Book Review:

Nanotechnology provides tools for creating functional materials, devices, and systems by controlling materials at the atomic and molecular scales and making use of novel properties and phenomena. Nanotechnology-enabled sensors find applications in several fields such as health and safety, medicine, process control and diagnostics. This book provides the reader with information on how nanotechnology enabled sensors are currently being used and how they will be used in the future in such diverse fields as communications, building and facilities, medicine, safety, and security, including both homeland defense and military operations.

Molecular Diagnostics Promises and Possibilities

Molecular Diagnostics  Promises and Possibilities
Author: Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Publsiher: Springer Science & Business Media
Total Pages: 520
Release: 2010-01-29
ISBN 10: 9789048132614
ISBN 13: 9048132614
Language: EN, FR, DE, ES & NL

Molecular Diagnostics Promises and Possibilities Book Review:

A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

A Changing World

A Changing World
Author: Felix Kienast,Otto Wildi,Sucharita Ghosh
Publsiher: Springer Science & Business Media
Total Pages: 296
Release: 2007-03-16
ISBN 10: 1402044364
ISBN 13: 9781402044366
Language: EN, FR, DE, ES & NL

A Changing World Book Review:

Modern landscape research uses a panoply of techniques to further our understanding of our changing world, including mathematics, statistics and advanced simulation techniques to combine empirical observations with known theories. This book identifies emerging fields and new challenges that are discussed within the framework of the ‘driving forces’ of Landscape Development. the book addresses all of the ‘hot topics’ in this important area of study and emphasizes major contemporary trends in these fields.

Introducing Biological Rhythms

Introducing Biological Rhythms
Author: Willard L. Koukkari,Robert B. Sothern
Publsiher: Springer Science & Business Media
Total Pages: 656
Release: 2007-07-29
ISBN 10: 1402047010
ISBN 13: 9781402047015
Language: EN, FR, DE, ES & NL

Introducing Biological Rhythms Book Review:

Introducing Biological Rhythms is a primer that serves to introduce individuals to the area of biological rhythms. It describes the major characteristics and discusses the implications and applications of these rhythms, while citing scientific results and references. Also, the primer includes essays that provide in-depth historic and other background information for those interested in more specific topics or concepts. It covers a basic cross-section of the field of chronobiology clearly enough so that it can be understood by a novice, or an undergraduate student, but that it would also be sufficiently technical and detailed for the scientist.

Toward Precision Medicine

Toward Precision Medicine
Author: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publsiher: National Academies Press
Total Pages: 142
Release: 2012-01-16
ISBN 10: 0309222222
ISBN 13: 9780309222228
Language: EN, FR, DE, ES & NL

Toward Precision Medicine Book Review:

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.