Clinical Perspectives and Targeted Therapies in Apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis
Author: Rupinder K. Sodhi,Jitender Madan
Publsiher: Academic Press
Total Pages: 432
Release: 2020-10-15
ISBN 10: 0128157631
ISBN 13: 9780128157633
Language: EN, FR, DE, ES & NL

Clinical Perspectives and Targeted Therapies in Apoptosis Book Review:

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Immunotherapy in Resistant Cancer From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer  From the Lab Bench Work to Its Clinical Perspectives
Author: Jorge Morales Montor,Mariana Segovia
Publsiher: Academic Press
Total Pages: 286
Release: 2020-10-01
ISBN 10: 0128220295
ISBN 13: 9780128220290
Language: EN, FR, DE, ES & NL

Immunotherapy in Resistant Cancer From the Lab Bench Work to Its Clinical Perspectives Book Review:

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy. Provides basic and clinical evidence based on molecular interactions and clinical studies to address the risks and benefits of cancer immunotherapy Presents the results of new immunotherapy trials, discussing the state-of-the-art in different types of cancer Discusses targeted therapies approved by the FDA, along with therapies with clinical potential used in basic studies

Targeted Therapies

Targeted Therapies
Author: Daniel Gioeli
Publsiher: Springer Science & Business Media
Total Pages: 202
Release: 2011-06-02
ISBN 10: 9781607614784
ISBN 13: 1607614782
Language: EN, FR, DE, ES & NL

Targeted Therapies Book Review:

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Biology Driven Targeted Therapy of Pediatric Soft Tissue and Bone Tumors Current Opportunities and Future Challenges

Biology Driven Targeted Therapy of Pediatric Soft Tissue and Bone Tumors  Current Opportunities and Future Challenges
Author: Thomas G. P. Grünewald,Simone Fulda
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-04-05
ISBN 10: 2889198197
ISBN 13: 9782889198191
Language: EN, FR, DE, ES & NL

Biology Driven Targeted Therapy of Pediatric Soft Tissue and Bone Tumors Current Opportunities and Future Challenges Book Review:

Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and be relevant for a broad readership. This Frontiers Research Topic intended to provide a platform for active and interdisciplinary discussion, to summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and to offer new perspectives on how to further promote and accelerate the translational process. It comprises high-quality original articles and timely reviews.

Gerontological Nursing

Gerontological Nursing
Author: Charlotte Eliopoulos
Publsiher: Lippincott Williams & Wilkins
Total Pages: 576
Release: 2020-12-22
ISBN 10: 1975161017
ISBN 13: 9781975161019
Language: EN, FR, DE, ES & NL

Gerontological Nursing Book Review:

Gerontological Nursing, Tenth Edition focuses on the content that students need to know for effective practice, offering engaging, evidence-based coverage of the aging process, factors contributing to healthy aging, and unique aspects of disease presentation and management in older adults. The tenth edition retains the text’s acclaimed holistic approach and logical overview of the aging process, with updated content throughout to help students confidently care for an increasingly diverse population. This edition also includes Next Generation NCLEX®-Style Case Studies and Questions, which help students review important concepts and practice for the next generation NCLEX®, as well as Unfolding Patient Stories that correlate directly to simulated patient scenarios in vSim® for Nursing for enhanced preparation for practice.

Cell Death

Cell Death
Author: Hao Wu
Publsiher: Springer Science & Business Media
Total Pages: 272
Release: 2013-11-19
ISBN 10: 1461493021
ISBN 13: 9781461493020
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

Handbook of Targeted Cancer Therapy

Handbook of Targeted Cancer Therapy
Author: Daniel D. Karp,Gerald S. Falchook
Publsiher: Lippincott Williams & Wilkins
Total Pages: 288
Release: 2014-09-09
ISBN 10: 1469894580
ISBN 13: 9781469894584
Language: EN, FR, DE, ES & NL

Handbook of Targeted Cancer Therapy Book Review:

Make optimal use of the latest personalized therapeutic strategies with Handbook of Targeted Cancer Therapy! This concise, practical oncology reference examines more than 140 targeted therapy agents for which clinical trial data are available, and explains when and how you can use them to most effectively combat cancer. Approach clinical challenges from any direction with separate sections on Targets by Organ Site, Carcinogenesis from the Perspective of Targeted Therapy, Molecular Targets and Pathways, and Targeted Therapy Agents. Find information easily thanks to a color-coded format and an intuitive organization. Access the complete contents online and on mobile devices, with regular updates to include newly approved treatments. Important state of the art cancer information for caregivers, researchers, other health care professionals, and even patients

Cell Death

Cell Death
Author: Tobias Ntuli
Publsiher: BoD – Books on Demand
Total Pages: 446
Release: 2015-12-16
ISBN 10: 9535122363
ISBN 13: 9789535122364
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Targeted Therapy in Translational Cancer Research

Targeted Therapy in Translational Cancer Research
Author: Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson,Maurie Markman
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2015-12-21
ISBN 10: 1118468570
ISBN 13: 9781118468579
Language: EN, FR, DE, ES & NL

Targeted Therapy in Translational Cancer Research Book Review:

Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Translational Oncology: Targeted Therapy in Translational Cancer Research provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on targeted cancer therapies. Beginning with a chapter introducing the “Bench to Bedside and Back” paradigm, an overview is presented of the exponential growth in the field of translational medicine, including historical perspectives and recent progress. Following the introduction, subsequent chapters review the progress of targeted therapy within three major categories: hematological malignancies, solid tumors, and hereditary cancers. Each of these categories comprises a single a chapter with subsections that discuss specific cancer types. Following this is a chapter on targeted and functional imaging that reviews progress in the different modalities of anatomical and molecular imaging used to complement targeted therapy. The next chapter discusses the need to combine individual agents with existing therapies or in novel combinations in order to overcome drug resistance. Following this is a chapter presenting the challenges in drug development and the selection of targets for cancer therapeutics. The final chapter offers perspectives on personalized medicine and presents future challenges in the investigation of optimal combinations and the identification of biomarkers that can provide both predictive and prognostic information for tailoring targeted therapies to individual patients.

Current Advances in the Science of Osteosarcoma

Current Advances in the Science of Osteosarcoma
Author: Anonim
Publsiher: Springer Nature
Total Pages: 135
Release: 2020
ISBN 10: 3030430855
ISBN 13: 9783030430856
Language: EN, FR, DE, ES & NL

Current Advances in the Science of Osteosarcoma Book Review:

This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Current Understanding of Apoptosis

Current Understanding of Apoptosis
Author: Yusuf Tutar,Lutfi Tutar
Publsiher: BoD – Books on Demand
Total Pages: 160
Release: 2018-08-29
ISBN 10: 1789235006
ISBN 13: 9781789235005
Language: EN, FR, DE, ES & NL

Current Understanding of Apoptosis Book Review:

Apoptosis is an essential biochemical process in cell turnover, development, and chemical-induced cell death. Current knowledge and ongoing research of apoptosis highlight our understanding in designing the therapeutic approaches for several diseases. This book covers four main sections: "Apoptosis and Necrosis," "Apoptosis Inducers," "Proteasome and Signaling Pathways in Apoptosis," and "Radiation-Based Apoptosis." The first section implicitly describes the differences between apoptosis and necrosis processes. The following section elaborates the small molecule-induced apoptosis. Then, the third section deals with proteasome and signaling pathways and finally, resistance to chemotherapy and electromagnetic radiation is covered in the last section. Overall, the book deals with pathways for manipulating apoptosis and provides a unique perspective to the scientists.

Nanomaterials for Tumor Targeting Theranostics

Nanomaterials for Tumor Targeting Theranostics
Author: Mingqian Tan,Aiguo Wu
Publsiher: World Scientific
Total Pages: 432
Release: 2016-02-22
ISBN 10: 981463543X
ISBN 13: 9789814635431
Language: EN, FR, DE, ES & NL

Nanomaterials for Tumor Targeting Theranostics Book Review:

Nanomaterials offer great potential for effective tumor diagnosis and therapy combing diagnostic agents and therapeutic drugs into one platform. In this book, the most recent progress of main nanomaterials and their applications in tumor targeting theranostics is presented. It summarizes the recent advances of current principal nanomaterials in tumor theranostics, including magnetic nanomaterials, quantum dots, mesoporous silica nanoparticles, gold nanomaterials, polymeric nanosystem, carbon nanomaterials, lipopolyplex nanoparticles, microbubbles, upconversion nanomaterials and dendrimers. It will enable readers to get a more realistic understanding of both the advantages and limitations of nanomaterials for potential tumor targeting theranosis. The publication of this book will accelerate the spread of ideas that are currently trickling through the scientific literature. Also a greater understanding of the potential and challenge of nanomaterials for tumor targeting theranostics is highly anticipated for practical clinical use. Contents:Nanomaterials as Therapeutic/Imaging Agent Delivery Vehicles for Tumor Targeting Theranostics (Mingqian Tan, Yanfang Wang, Xiaojie Song, and Yaqi Wu)Basics of Theranostics in Tumor (Huichao Zou, Yaohua Liu, and Shiguang Zhao)Magnetic Nanomaterials for Tumor Targeting Theranostics (Leyong Zeng, Zheyu Shen, and Aiguo Wu)Quantum Dots (QDs) for Tumor Targeting Theranostics (Yufei Ma, He Shen, Mengxin Zhang, and Zhijun Zhang)Mesoporous Silica Nanoparticles (MSNs) for Cancer Theranostics (Yu Hsia, Maharajan Sivasubramanian, Nai-Tzu Chen, and Leu-Wei Lo)Surface Enhanced Raman Scattering (SERS) Nanoprobes as Cancer Theranostics (Meikun Fan)Polymeric Nanosystems for Targeted Theranostics (Yongyong Li, Huiyun Wen, Haiqing Dong, Aijun Shen, Tianbin Ren, and Donglu Shi)Carbon Nanomaterials for Tumor Targeting Theranostics (João M M Leitão, Eliana F C Simões, and Joaquim C G Esteves da Silva)Lipopolyplex Nanoparticles for Tumor Targeting Theranostics (Fengying Dai and Xin Zhang)Microbubbles for Tumor Targeting Theranostics (Daming Yong, Xuejing Wang, Lei Wang, and Xiaojun Han)Upconversion Nanomaterials for Tumor Targeting Theranostics (Wei Wang)Functional Dendrimers as Nanoscale Theranostic Vehicles for Cancer Treatment (Kui Luo and Zhongwei Gu)Protein-based Nanoparticles for Tumor Targeting Theranostics (Yang Liu, Hao Wu, and Huihui Wang)Conclusions and Future Perspectives (Shanmin Gao and Narayan S Hosmane) Readership: Advanced undergraduates, graduate students, chemists, materials scientists, biomedical engineers, pharmacologists, biologists, doctors and oncologists in nanomaterials, nanobiotechnology, nanomedicine, tumor theranostics, tumor targeting, tumor diagnosis, tumor imaging, and tumor therapy. Key Features:One of the first books to comprehensively describe main nanomaterials for tumor targeting theranosticsFocuses on the combination of therapeutic and diagnostic applications of current principal nanomaterials, providing descriptions of cutting-edge discoveries along with perspectivesChapter contributors are internationally renowned scientists who are experts in their own research arena of nanomaterialsKeywords:Nanomaterials;Tumor Theranostics;Tumor Targeting;Tumor Diagnosis;Tumor Imaging;Tumor Therapy

Human Tumor Derived p53 Mutants A Growing Family of Oncoproteins

Human Tumor Derived p53 Mutants  A Growing Family of Oncoproteins
Author: Ygal Haupt,Giovanni Blandino
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-08-10
ISBN 10: 2889199614
ISBN 13: 9782889199617
Language: EN, FR, DE, ES & NL

Human Tumor Derived p53 Mutants A Growing Family of Oncoproteins Book Review:

TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation.

Targeted Therapies in Oncology Second Edition

Targeted Therapies in Oncology  Second Edition
Author: Giuseppe Giaccone,Jean-Charles Soria
Publsiher: CRC Press
Total Pages: 498
Release: 2013-10-21
ISBN 10: 1842145452
ISBN 13: 9781842145456
Language: EN, FR, DE, ES & NL

Targeted Therapies in Oncology Second Edition Book Review:

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

Targeted Therapies in Cancer

Targeted Therapies in Cancer
Author: Manfred Dietel
Publsiher: Springer Science & Business Media
Total Pages: 262
Release: 2007-06-10
ISBN 10: 3540460918
ISBN 13: 9783540460916
Language: EN, FR, DE, ES & NL

Targeted Therapies in Cancer Book Review:

From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
Author: Stephen Neidle
Publsiher: Academic Press
Total Pages: 640
Release: 2013-09-30
ISBN 10: 0123972280
ISBN 13: 9780123972286
Language: EN, FR, DE, ES & NL

Cancer Drug Design and Discovery Book Review:

Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research. Provides a clinical perspective on the development of new molecularly targeted anticancer agents with the latest and most promising chemotherapeutic approaches Offers a broad view of where the field is going, what tools drug discovery is using to produce new agents and how they are evaluated in the laboratory and clinic Features 6 new chapters devoted to advances in technology and successful anticancer therapies, such as cancer genomics and personalized medicine, DNA-targeted agents, B-Raf inhibitors and more Each chapter includes extensive references to the primary and review literature, as well as to relevant web-based sources

Targeted Therapies in Breast Cancer

Targeted Therapies in Breast Cancer
Author: George W. Sledge, Jr.,Jose Baselga
Publsiher: Unknown
Total Pages: 100
Release: 2013-04-15
ISBN 10: 9781846920660
ISBN 13: 1846920663
Language: EN, FR, DE, ES & NL

Targeted Therapies in Breast Cancer Book Review:

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Advanced Drug Delivery Systems in the Management of Cancer

Advanced Drug Delivery Systems in the Management of Cancer
Author: Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publsiher: Elsevier
Total Pages: 572
Release: 2021-06-24
ISBN 10: 0323900798
ISBN 13: 9780323900799
Language: EN, FR, DE, ES & NL

Advanced Drug Delivery Systems in the Management of Cancer Book Review:

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Advances in Targeted Cancer Therapy

Advances in Targeted Cancer Therapy
Author: Richard M. Schultz
Publsiher: Springer Science & Business Media
Total Pages: 303
Release: 2006-01-24
ISBN 10: 3764374144
ISBN 13: 9783764374143
Language: EN, FR, DE, ES & NL

Advances in Targeted Cancer Therapy Book Review:

There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.

Novel Therapeutic Targets and Emerging Treatments for Fibrosis

Novel Therapeutic Targets and Emerging Treatments for Fibrosis
Author: Chrishan S. Samuel,Timothy D. Hewitson
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-01-12
ISBN 10: 2889453723
ISBN 13: 9782889453726
Language: EN, FR, DE, ES & NL

Novel Therapeutic Targets and Emerging Treatments for Fibrosis Book Review:

For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs. Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder. This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level.