Clinical Perspectives and Targeted Therapies in Apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis
Author: Rupinder K. Sodhi,Jitender Madan
Publsiher: Academic Press
Total Pages: 432
Release: 2020-10-30
ISBN 10: 0128157631
ISBN 13: 9780128157633
Language: EN, FR, DE, ES & NL

Clinical Perspectives and Targeted Therapies in Apoptosis Book Review:

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Cell Death

Cell Death
Author: Tobias Ntuli
Publsiher: BoD – Books on Demand
Total Pages: 446
Release: 2015-12-16
ISBN 10: 9535122363
ISBN 13: 9789535122364
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Targeted Therapy in Translational Cancer Research

Targeted Therapy in Translational Cancer Research
Author: Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson,Maurie Markman
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2015-12-21
ISBN 10: 1118468570
ISBN 13: 9781118468579
Language: EN, FR, DE, ES & NL

Targeted Therapy in Translational Cancer Research Book Review:

Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Translational Oncology: Targeted Therapy in Translational Cancer Research provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on targeted cancer therapies. Beginning with a chapter introducing the “Bench to Bedside and Back” paradigm, an overview is presented of the exponential growth in the field of translational medicine, including historical perspectives and recent progress. Following the introduction, subsequent chapters review the progress of targeted therapy within three major categories: hematological malignancies, solid tumors, and hereditary cancers. Each of these categories comprises a single a chapter with subsections that discuss specific cancer types. Following this is a chapter on targeted and functional imaging that reviews progress in the different modalities of anatomical and molecular imaging used to complement targeted therapy. The next chapter discusses the need to combine individual agents with existing therapies or in novel combinations in order to overcome drug resistance. Following this is a chapter presenting the challenges in drug development and the selection of targets for cancer therapeutics. The final chapter offers perspectives on personalized medicine and presents future challenges in the investigation of optimal combinations and the identification of biomarkers that can provide both predictive and prognostic information for tailoring targeted therapies to individual patients.

Dendrimers

Dendrimers
Author: Claudia Maria Simonescu
Publsiher: BoD – Books on Demand
Total Pages: 174
Release: 2018-04-25
ISBN 10: 1789230586
ISBN 13: 9781789230581
Language: EN, FR, DE, ES & NL

Dendrimers Book Review:

Dendrimers are defined as nanoscale macromolecules having a particular architecture consisting of treelike arms or branches. They are characterized by special properties that make them promising candidates in medicine, biology, materials science, synthetic organic chemistry, biotechnology, environmental engineering, optics, electronics, catalysis, electrochemistry, photochemistry, and sensors and even for production of cosmetics and personal care products. The dendrimers research field is growing day by day, and scientists are exploring new synthesis and functionalization methods in order to improve and to determine new properties and thus new applications. The main purpose of this book is to highlight the issues regarding properties and applications of dendrimers in the field of biology, medicine, liquid crystal devices, electronics, quantum devices, and self-healing technology.

Current Understanding of Apoptosis

Current Understanding of Apoptosis
Author: Yusuf Tutar,Lutfi Tutar
Publsiher: BoD – Books on Demand
Total Pages: 160
Release: 2018-08-29
ISBN 10: 1789235006
ISBN 13: 9781789235005
Language: EN, FR, DE, ES & NL

Current Understanding of Apoptosis Book Review:

Apoptosis is an essential biochemical process in cell turnover, development, and chemical-induced cell death. Current knowledge and ongoing research of apoptosis highlight our understanding in designing the therapeutic approaches for several diseases. This book covers four main sections: "Apoptosis and Necrosis," "Apoptosis Inducers," "Proteasome and Signaling Pathways in Apoptosis," and "Radiation-Based Apoptosis." The first section implicitly describes the differences between apoptosis and necrosis processes. The following section elaborates the small molecule-induced apoptosis. Then, the third section deals with proteasome and signaling pathways and finally, resistance to chemotherapy and electromagnetic radiation is covered in the last section. Overall, the book deals with pathways for manipulating apoptosis and provides a unique perspective to the scientists.

Cell Biology

Cell Biology
Author: Stevo Najman
Publsiher: BoD – Books on Demand
Total Pages: 206
Release: 2016-01-20
ISBN 10: 9535122428
ISBN 13: 9789535122425
Language: EN, FR, DE, ES & NL

Cell Biology Book Review:

Cell biology is a multidisciplinary scientific field that its modern expansion in new knowledge and applications owes to important support of new technologies with the rapid development, such as ICTs. By integrating knowledge from nano-, molecular, micro-, and macroareas, it represents a strong foundation for almost all biological sciences and disciplines, as well as for biomedical research and application. This book is a compilation of inspiring reviews/original studies, which are divided into sections: New Methods in Cell Biology, Molecular and Cellular Regulatory Mechanisms, and Cellular Basis of Disease and Therapy. The book will be very useful for students and beginners to gain insight into new area, as well as for experts and scientists to find new facts and expand their scientific horizons through biological sciences and biomedicine.

Physiologic and Pathologic Angiogenesis

Physiologic and Pathologic Angiogenesis
Author: Dan Simionescu,Agneta Simionescu
Publsiher: BoD – Books on Demand
Total Pages: 464
Release: 2017-04-05
ISBN 10: 9535130234
ISBN 13: 9789535130239
Language: EN, FR, DE, ES & NL

Physiologic and Pathologic Angiogenesis Book Review:

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Pharmaceutical Perspectives of Cancer Therapeutics

Pharmaceutical Perspectives of Cancer Therapeutics
Author: Yi Lu,Ram I. Mahato
Publsiher: Springer Science & Business Media
Total Pages: 694
Release: 2009-06-23
ISBN 10: 9781441901316
ISBN 13: 1441901310
Language: EN, FR, DE, ES & NL

Pharmaceutical Perspectives of Cancer Therapeutics Book Review:

Pharmaceutical Perspectives of Cancer Therapeutics covers a wide variety of therapeutic approaches including gene therapy, immunological therapy; cancer vaccines; strategy for solid tumors as well as for hematological cancers; methods to suppress tumor angiogenesis and metastasis; development and utilization of relevant animal models; introduction of new concepts such as cancer stem cells and new technologies, such as DNA and tissue microarrays; and RNA interference. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, as well as the utilization of imaging in cancer therapy are also discussed. The use of synthetic carriers, such as lipids, polymers, and peptides for delivery and targeting of small molecules, proteins, and nucleic acids to cancer cells in vivo are discussed. Pharmaceutical Perspectives of Cancer Therapeutics also includes cancer therapy modality in surgery, chemotherapy, and radiotherapy, as well as in combination or multi-modality, giving our book a more focused view of cancer therapy.

Nanoparticle Drug Delivery Systems for Cancer Treatment

Nanoparticle Drug Delivery Systems for Cancer Treatment
Author: Hala Gali-Muhtasib,Racha Chouaib
Publsiher: CRC Press
Total Pages: 326
Release: 2020-02-19
ISBN 10: 1000681416
ISBN 13: 9781000681413
Language: EN, FR, DE, ES & NL

Nanoparticle Drug Delivery Systems for Cancer Treatment Book Review:

In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.

Oral and Maxillofacial Surgery

Oral and Maxillofacial Surgery
Author: Raymond J. Fonseca
Publsiher: Saunders
Total Pages: 1004
Release: 2009
ISBN 10: 9781416066552
ISBN 13: 1416066551
Language: EN, FR, DE, ES & NL

Oral and Maxillofacial Surgery Book Review:

This comprehensive resource provides in-depth information to help you perfect your oral and maxillofacial surgical technique and provide state-of-the-art care for your patients. The full scope of the field is represented with up-to-date, evidence-based coverage of every surgical procedure performed today. Volume I: Anesthesia and Pain Control, Dentoalveolar Surgery, Practice Management, Implant Surgery brings you authoritative coverage of office-based procedures, including extractions, implants, and biopsies. [editor].

Targeted Therapies in Breast Cancer

Targeted Therapies in Breast Cancer
Author: George W. Sledge, Jr.,Jose Baselga
Publsiher: Unknown
Total Pages: 100
Release: 2013-04-15
ISBN 10: 9781846920660
ISBN 13: 1846920663
Language: EN, FR, DE, ES & NL

Targeted Therapies in Breast Cancer Book Review:

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Targeted Therapies in Oncology Second Edition

Targeted Therapies in Oncology  Second Edition
Author: Giuseppe Giaccone,Jean-Charles Soria
Publsiher: CRC Press
Total Pages: 498
Release: 2013-10-21
ISBN 10: 1842145452
ISBN 13: 9781842145456
Language: EN, FR, DE, ES & NL

Targeted Therapies in Oncology Second Edition Book Review:

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

Targeted Therapies

Targeted Therapies
Author: Daniel Gioeli
Publsiher: Springer Science & Business Media
Total Pages: 202
Release: 2011-06-02
ISBN 10: 9781607614784
ISBN 13: 1607614782
Language: EN, FR, DE, ES & NL

Targeted Therapies Book Review:

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

BMJ

BMJ
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2001
ISBN 10:
ISBN 13: UCLA:L0081976219
Language: EN, FR, DE, ES & NL

BMJ Book Review:

Complications in Neuroanesthesia

Complications in Neuroanesthesia
Author: Hemanshu Prabhakar
Publsiher: Academic Press
Total Pages: 500
Release: 2016-02-11
ISBN 10: 0128041137
ISBN 13: 9780128041130
Language: EN, FR, DE, ES & NL

Complications in Neuroanesthesia Book Review:

Complications in Neuroanesthesia focuses on complications that may arise related to neuroanesthesia practice and discusses its various causes. Each complication is written as a separate chapter, and the pathophysiology and mechanisms of each complication, as well as measures for diagnosis, treatment and prevention are discussed. Towards the end of the book, several case scenarios are provided to the readers that challenge readers to diagnose the possible complication for each case. Chapters include brain and spinal cord problems, cardiovascular and hematological problems, and nerve and muscle problems. Written in a standard format, Complications in Neuroanesthesia provides quick and easy access to understanding problems in neuroanesthesia. It provides insight into all possible complications occurring during perioperative management of neurosurgical and neurologic patients. It is useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, and neurology by providing an understanding of preventable mishaps that may occur in neurosurgical or neurologic patients. Quick and easy reference for understanding problems in neuroanesthesia Provides comprehensive insights into all possible complications occurring during perioperative management of neurosurgical and neurologic patients Includes useful section with clinical case studies of complications in neuroanesthesia

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
Author: Stephen Neidle
Publsiher: Elsevier
Total Pages: 496
Release: 2011-04-28
ISBN 10: 9780080554952
ISBN 13: 0080554954
Language: EN, FR, DE, ES & NL

Cancer Drug Design and Discovery Book Review:

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories

Neuroblastoma

Neuroblastoma
Author: Chandrika Gowda
Publsiher: BoD – Books on Demand
Total Pages: 168
Release: 2017-10-25
ISBN 10: 953513583X
ISBN 13: 9789535135838
Language: EN, FR, DE, ES & NL

Neuroblastoma Book Review:

Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary objective of this book is to provide the readers with a comprehensive review of neuroblastoma, from clinical aspects and the currently available treatment to recent advancements and future directions in the field of NBL treatment. The topics and chapters have been compiled keeping in mind a diverse group of readers in different areas of specialty such as pediatric oncology, surgery, radiation oncology, and immunology, as well as physician scientists and basic researchers working in the field of neuroblastoma.

Apoptosis

Apoptosis
Author: Douglas R. Green
Publsiher: Cambridge University Press
Total Pages: 329
Release: 2011-08-22
ISBN 10: 1139498738
ISBN 13: 9781139498739
Language: EN, FR, DE, ES & NL

Apoptosis Book Review:

Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.

Colorectal Cancer

Colorectal Cancer
Author: Luis Rodrigo
Publsiher: BoD – Books on Demand
Total Pages: 440
Release: 2016-09-07
ISBN 10: 9535125443
ISBN 13: 9789535125440
Language: EN, FR, DE, ES & NL

Colorectal Cancer Book Review:

Colorectal cancer (CRC) is a major health problem because it represents around 10% of all cancers and achieves a worldwide estimate of 1.4 million newly diagnosed cases annually, resulting in approximately 700,000 deaths. Approximately 19-31% of patients present liver metastases. At diagnosis, a further 23-38% will develop extra-hepatic disease. Over the past decade, the widespread use of modern chemotherapeutic and biological agents, combined with laparoscopic surgical techniques, has improved the prognosis of metastatic CRC. A better understanding of the biology of the tumor, along with high efficiency of diagnostic and therapeutic methods, as well as the spread of screening programs, will improve the survival of the CRC patients in the near future.

Systems Biology of Apoptosis

Systems Biology of Apoptosis
Author: Inna N. Lavrik
Publsiher: Springer Science & Business Media
Total Pages: 204
Release: 2012-09-13
ISBN 10: 1461440092
ISBN 13: 9781461440093
Language: EN, FR, DE, ES & NL

Systems Biology of Apoptosis Book Review:

Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.