Chromatin

Chromatin
Author: Alan P. Wolffe
Publsiher: Academic Press
Total Pages: 447
Release: 2012-12-02
ISBN 10: 0080926606
ISBN 13: 9780080926605
Language: EN, FR, DE, ES & NL

Chromatin Book Review:

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active involvement in the processes of DNA transcription, replication and repair. This book consistently interrelates the structure of eukaryotic DNA with the nuclear processes it undergoes, and will be essential reading for students and molecular biologists who want to really understand how DNA works. Written in a clear and concise fashion Includes 60 new illustrations Extensively rewritten Brings the reader up-to-date with the remarkable progress in chromatin research over the past three years.

Chromatin

Chromatin
Author: Kensal E. van Holde
Publsiher: Springer Science & Business Media
Total Pages: 497
Release: 2012-12-06
ISBN 10: 1461234905
ISBN 13: 9781461234906
Language: EN, FR, DE, ES & NL

Chromatin Book Review:

Contemporary views on the structure and function of chromatin are presented and the history of the development of these ideas as well as the nature of the nucleic acid and protein components of chromatin are reviewed. The structure of chromatin is studied at several levels, and its modes of transcription and replication are analyzed. Chromatin provides researchers with a critical evaluation of current knowledge. It combines much information that has never before been assembled, and evaluates and interrelates it in a critical way. This has not been done before so that readers are not only provided with an overview, but with extensive references to the literature (there are about 2000 references in all).

Chromatin and Chromatin Remodeling Enzymes

Chromatin and Chromatin Remodeling Enzymes
Author: Carl Wu,C. David Allis
Publsiher: Elsevier
Total Pages: 540
Release: 2004-02-20
ISBN 10: 0080497136
ISBN 13: 9780080497136
Language: EN, FR, DE, ES & NL

Chromatin and Chromatin Remodeling Enzymes Book Review:

DNA in the nucleus of plant and animal cells is stored in the form of chromatin. Chromatin and the Chromatin remodellng enzymes play an important role in gene transcription. *Histone Bioinformatics *Biochemistry of histones, nucleosomes and chromatin *Molecular cytology of chromatin functions

Protein Complexes that Modify Chromatin

Protein Complexes that Modify Chromatin
Author: Jerry L. Workman
Publsiher: Springer Science & Business Media
Total Pages: 298
Release: 2012-12-06
ISBN 10: 3642557473
ISBN 13: 9783642557477
Language: EN, FR, DE, ES & NL

Protein Complexes that Modify Chromatin Book Review:

An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans acting factors. Our view of eukaryotic chromosomes has evolved dra matically over the last decade. The picture of chromosomes that is emerging is that of dynamic breathing organelles actively regulating the flow of genetic information from the genome. Indeed chromatin is so fluid that even maintaining gene quiescence is an active process and is tightly regulated. Chromatin dynamics is a consequence of protein complexes that modify histones, remove histone modifications, mobi lize nucleosomes or stabilize nucleosomes. Awide variety of such com plexes have now been described. Some are abundant and may play glo bal roles in chromosome fluidity and function. Others are more rare and specialized for specific functions at discreet loci. Moreover, several complexes share biochemical activities and genetic studies suggest overlapping functions in vivo. Many components of these complexes were first revealed in genetic screens, while others were discovered by novel cell biological or biochemical approaches.

Nucleosomes Histones and Chromatin

Nucleosomes  Histones and Chromatin
Author: Anonim
Publsiher: Academic Press
Total Pages: 390
Release: 2012-12-31
ISBN 10: 012391941X
ISBN 13: 9780123919410
Language: EN, FR, DE, ES & NL

Nucleosomes Histones and Chromatin Book Review:

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 2 volumes covering nucleosomes, histones and chromatin, it has chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins. Continues the legacy of this premier serial by containing quality chapters authored by leaders in the field The first of 2 volumes covering nucleosomes, histones and chromatin Chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins

Chromatin Protocols

Chromatin Protocols
Author: Srikumar P. Chellappan
Publsiher: Humana
Total Pages: 416
Release: 2016-08-23
ISBN 10: 9781493956265
ISBN 13: 1493956264
Language: EN, FR, DE, ES & NL

Chromatin Protocols Book Review:

Significant advancements have been made in the study of chromatin structure and function over the past fifty years but none as spectacular as those made in the last decade due to the development of novel techniques and the ability to sequence large stretches of DNA. In Chromatin Protocols, Second Edition, expert researchers delineate these cutting-edge techniques via step-by-step laboratory methods and protocols, which encompass a wide array of topics from the isolation of nucleosomes, assembly of nucleosomes and study of the basic chromatin structure to detailed analysis of histone modifications and chromatin function. Written in the highly successful Methods in Molecular BiologyTM series style, chapters include brief introductions to the subjects, lists of the necessary materials and reagents, readily reproducible protocols, and Notes sections which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Chromatin Protocols, Second Edition is a valuable tool for scientists studying various aspects of chromatin function and an ideal guide to aid in the development of new techniques as well as new ideas in the field of chromatin biology.

The Structure and Function of Chromatin

The Structure and Function of Chromatin
Author: David W. FitzSimons,G. E. W. Wolstenholme
Publsiher: John Wiley & Sons
Total Pages: 192
Release: 2009-09-16
ISBN 10: 0470717785
ISBN 13: 9780470717783
Language: EN, FR, DE, ES & NL

The Structure and Function of Chromatin Book Review:

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Nucleosomes Histones and Chromatin

Nucleosomes  Histones and Chromatin
Author: Anonim
Publsiher: Academic Press
Total Pages: 408
Release: 2012-12-31
ISBN 10: 0123919398
ISBN 13: 9780123919397
Language: EN, FR, DE, ES & NL

Nucleosomes Histones and Chromatin Book Review:

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volume covers nucleosomes, histones and chromatin and has chapters on dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA, digital DNase technology, and genome-wide analysis of chromatin transition. Contains quality chapters authored by leaders in the field The volume covers nucleosomes, histones and chromatin Has chapters on dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA, digital DNase technology, and genome-wide analysis of chromatin transition

Fundamentals of Chromatin

Fundamentals of Chromatin
Author: Jerry L. Workman,Susan M. Abmayr
Publsiher: Springer Science & Business Media
Total Pages: 587
Release: 2013-12-04
ISBN 10: 1461486246
ISBN 13: 9781461486244
Language: EN, FR, DE, ES & NL

Fundamentals of Chromatin Book Review:

​​​​​​​​​​​​​While there has been an increasing number of books on various aspects of epigenetics, there has been a gap over the years in books that provide a comprehensive understanding of the fundamentals of chromatin. ​Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. Its primary function is to package DNA to fit into the cell, to strengthen the DNA to prevent damage, to allow mitosis and meiosis, and to control the expression of genes and DNA replication. The audience for this book is mainly newly established scientists ​and graduate students. Rather than going into the more specific areas of recent research on chromatin the chapters in this book give a strong, updated groundwork about the topic. Some the fundamentals that this book will cover include the structure of chromatin and biochemistry and the enzyme complexes that manage it.

Sperm Chromatin

Sperm Chromatin
Author: Armand Zini,Ashok Agarwal
Publsiher: Springer Science & Business Media
Total Pages: 512
Release: 2011-08-04
ISBN 10: 9781441968579
ISBN 13: 1441968571
Language: EN, FR, DE, ES & NL

Sperm Chromatin Book Review:

Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Chromatin

Chromatin
Author: Hannah Gould
Publsiher: Oxford University Press, USA
Total Pages: 231
Release: 1998
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015047072353
Language: EN, FR, DE, ES & NL

Chromatin Book Review:

Chromatin comprises the complex of nucleic acids and proteins that make up the chromosomes, and regulation of its structure is increasingly recognized as an important factor in gene expression. Researchers from related fields needing an introduction to the methodology of chromatin will findthis book invaluable, as will experienced workers. Contents: Isolation and fractionation of chromatin and linker histones; Extraction and separation of core histones and non-histone chromosomal proteins; Mapping chromatin structure in Drosophila; In vivo footprint and chromatin analysis by LMPCR; Analysis of nuclear scaffold attachment regions;Electron microscopy of chromatin; Counting nucleosome cores on circular DNA using topoisomerase I; In vitro reconstitution of chromatin and analysis of nucleosome positioning; Transcriptional and structural analysis of chromatin assembled in vivo; An assembly of chromatin and nuclear structures inXenopus egg extracts; Appendix: List of Suppliers; Index

Chromatin Regulation and Dynamics

Chromatin Regulation and Dynamics
Author: Anita Göndör
Publsiher: Academic Press
Total Pages: 496
Release: 2016-10-25
ISBN 10: 0128034025
ISBN 13: 9780128034026
Language: EN, FR, DE, ES & NL

Chromatin Regulation and Dynamics Book Review:

Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Chromatin Signaling and Neurological Disorders

Chromatin Signaling and Neurological Disorders
Author: Anonim
Publsiher: Academic Press
Total Pages: 378
Release: 2019-05-24
ISBN 10: 0128137975
ISBN 13: 9780128137970
Language: EN, FR, DE, ES & NL

Chromatin Signaling and Neurological Disorders Book Review:

Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases. In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research. Examines specific chromatin signaling factors that regulate spinal muscular atrophy, ulbospinal muscular atrophy, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, multiple sclerosis, Angelman syndrome, Rader-Willi syndrome, and more Contains chapter contributions from international experts who speak to the clinical significance of recent findings and the implications for the development of epigenetics-based therapeutics Provides researchers, students and clinicians with approaches to better interpret and employ new diagnostic studies for treating neurological disorders

Bacterial Chromatin

Bacterial Chromatin
Author: Remus T. Dame
Publsiher: Humana
Total Pages: 419
Release: 2019-12-10
ISBN 10: 9781493993628
ISBN 13: 1493993623
Language: EN, FR, DE, ES & NL

Bacterial Chromatin Book Review:

This volume brings together a wide range of methods to explore the structure and function of bacterial chromatin from molecular to the cellular scale. Chapters detail experimental protocols of in vivo and in vitro approaches, approaches to genome structure modeling, and data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

Systems Analysis of Chromatin Related Protein Complexes in Cancer

Systems Analysis of Chromatin Related Protein Complexes in Cancer
Author: Andrew Emili,Jack Greenblatt,Shoshana Wodak
Publsiher: Springer Science & Business Media
Total Pages: 316
Release: 2013-08-13
ISBN 10: 1461479312
ISBN 13: 9781461479314
Language: EN, FR, DE, ES & NL

Systems Analysis of Chromatin Related Protein Complexes in Cancer Book Review:

​​​​​​​​​​​​​​​​​​​​​​​ Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.

Bacterial Chromatin

Bacterial Chromatin
Author: Claudio O. Gualerzi,Cynthia L. Pon
Publsiher: Springer
Total Pages: 227
Release: 2011-11-19
ISBN 10: 9783642712685
ISBN 13: 3642712681
Language: EN, FR, DE, ES & NL

Bacterial Chromatin Book Review:

This book brings together various contributions aimed at the elucida tion of the structural and functional organization of the bacterial nucleoid. Most of these papers, spanning the fields of physical chemistry through biochemistry to genetics, were presented at the session on bac terial chromatin during the Symposium "Selected topics on chromatin structure and function" held at the University of Camerino, Italy, at the end of May 1985. Times when the bacterial DNA was regarded as "naked" or, at most, complexed with polyamines, and when the absence of histones and organized chromatin was considered to be a distinct feature of the pro karyotic cell, now appear remote. Our concepts of how DNA is packaged in bacteria are changing rapidly. Studies on the structure of the bacterial nucleoid are not new. Recently, however, investigations in this field have flourished again, leading to some important contributions such as the elucidation of the three-dimensional structure of what appears to be the major protein constituent of the bacterial nucleoid or the development of methods to titrate the extent of DNA supercoiling within the bacterial cell.

Chromatin Structure and Gene Expression

Chromatin Structure and Gene Expression
Author: Sarah C. Elgin,Sarah C. R. Elgin,Jerry L. Workman
Publsiher: Frontiers in Molecular Biology
Total Pages: 328
Release: 2000
ISBN 10: 9780199638901
ISBN 13: 019963890X
Language: EN, FR, DE, ES & NL

Chromatin Structure and Gene Expression Book Review:

Chromosome structure plays a central role in regulation of gene expression. Chromatin Structure and Gene Expression Second Edition examines chromatin from the crystal structure of the nucleosome to the spacial organization of chromosomes, integrating biochemical and genetic evidence to examine the macromolecular complexes that modify chromatin structure to achieve gene regulation.

Chromatin Signaling and Diseases

Chromatin Signaling and Diseases
Author: Olivier Binda,Martin Ernesto Fernandez-Zapico
Publsiher: Academic Press
Total Pages: 466
Release: 2016-08-06
ISBN 10: 012802609X
ISBN 13: 9780128026090
Language: EN, FR, DE, ES & NL

Chromatin Signaling and Diseases Book Review:

Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling

Chromatin

Chromatin
Author: A. Wolffe
Publsiher: Unknown
Total Pages: 299
Release: 1995
ISBN 10: 1928374650XXX
ISBN 13: UVA:X004070035
Language: EN, FR, DE, ES & NL

Chromatin Book Review:

Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure and assembly of chromatin and its involvement in the processes of DNA transcription, replication and repair. Constantly interrelating the structure of eukaryotic DNA with the nuclear processes it undergoes, CHROMATIN: Structure and Function is essential reading for students and molecular biologists who want to really understand how DNA works.

Functional Analysis of DNA and Chromatin

Functional Analysis of DNA and Chromatin
Author: Juan Carlos Stockert,Jesús Espada,Alfonso Blázquez-Castro
Publsiher: Humana Press
Total Pages: 365
Release: 2016-08-23
ISBN 10: 9781493960484
ISBN 13: 1493960482
Language: EN, FR, DE, ES & NL

Functional Analysis of DNA and Chromatin Book Review:

In Functional Analysis of DNA and Chromatin, expert researchers in the field provide an overview of standard and more recent methods for the functional analysis of the genetic material. These include methods on DNA-dye binding modes, chromatin staining, nuclear dispersion assays, DNA labeling in vivo, sister chromatid exchanges, FISH, DNA and chromatin imaging by fluorescence, electron and atomic force microscopy, detection of apoptotic DNA, cytosine methylation and hydroxy-methylation, DNA thermophoresis, improved methods for histone analysis, chromatin immunoprecipitation, and analysis of rDNA genes and chromatin-associated RNA. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Functional Analysis of DNA and Chromatin seeks to aid scientists in the further study of cellular and molecular biology of the nucleus.