Chemical Biology of the Genome

Chemical Biology of the Genome
Author: Siddhartha Roy,Tapas K. Kundu
Publsiher: Academic Press
Total Pages: 350
Release: 2021-05-14
ISBN 10: 0128176458
ISBN 13: 9780128176450
Language: EN, FR, DE, ES & NL

Chemical Biology of the Genome Book Review:

Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery

Chemical Genomics

Chemical Genomics
Author: Haian Fu
Publsiher: Cambridge University Press
Total Pages: 344
Release: 2012-02-13
ISBN 10: 1107377587
ISBN 13: 9781107377585
Language: EN, FR, DE, ES & NL

Chemical Genomics Book Review:

Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.

Advancing Development of Synthetic Gene Regulators

Advancing Development of Synthetic Gene Regulators
Author: Anandhakumar Chandran
Publsiher: Springer
Total Pages: 114
Release: 2017-09-19
ISBN 10: 9811065470
ISBN 13: 9789811065477
Language: EN, FR, DE, ES & NL

Advancing Development of Synthetic Gene Regulators Book Review:

This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.

Chemical Biology of Natural Products

Chemical Biology of Natural Products
Author: David J. Newman,Gordon M. Cragg,Paul Grothaus
Publsiher: CRC Press
Total Pages: 622
Release: 2017-09-22
ISBN 10: 1351643282
ISBN 13: 9781351643283
Language: EN, FR, DE, ES & NL

Chemical Biology of Natural Products Book Review:

Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Chemical Genomics

Chemical Genomics
Author: Stefan Jaroch,Hilmar Weinmann
Publsiher: Springer Science & Business Media
Total Pages: 179
Release: 2007-05-26
ISBN 10: 3540376356
ISBN 13: 9783540376354
Language: EN, FR, DE, ES & NL

Chemical Genomics Book Review:

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

The Chemical Biology of Long Noncoding RNAs

The Chemical Biology of Long Noncoding RNAs
Author: Stefan Jurga,Jan Barciszewski
Publsiher: Springer Nature
Total Pages: 545
Release: 2020-10-01
ISBN 10: 303044743X
ISBN 13: 9783030447434
Language: EN, FR, DE, ES & NL

The Chemical Biology of Long Noncoding RNAs Book Review:

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine
Author: Sheng Ding
Publsiher: John Wiley & Sons
Total Pages: 272
Release: 2008-02-08
ISBN 10: 0470199121
ISBN 13: 9780470199121
Language: EN, FR, DE, ES & NL

Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine Book Review:

Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions. This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, chemical genomics, and more. Applications covered encompass self-renewal, differentiation, reprogramming, and regeneration in model organisms. This is a premier reference for practicing professionals involved in stem cell research and students.

Chemical Genomics

Chemical Genomics
Author: Edward D. Zanders
Publsiher: Humana Press
Total Pages: 280
Release: 2010-10-28
ISBN 10: 9781617375415
ISBN 13: 1617375411
Language: EN, FR, DE, ES & NL

Chemical Genomics Book Review:

Chemical genomics is an exciting new field that aims to transform biolo- cal chemistry into a high-throughput industrialized process, much in the same way that molecular biology has been transformed by genomics. The inter- tion of small organic molecules with biological systems (mostly proteins) underpins drug discovery in the pharmaceutical and biotechnology industries, and therefore a volume of laboratory protocols that covers the key aspects of chemical genomics would be of use to biologists and chemists in these orga- zations. Academic scientists have been exploring the functions of proteins using small molecules as probes for many years and therefore would also b- efit from sharing ideas and laboratory procedures. Whatever the organizational backgrounds of the scientists involved, the challenges of extracting the ma- mum human benefit from genome sequencing projects remains considerable, and one where it is increasingly recognized that chemical genomics will play an important part. Chemical Genomics: Reviews and Protocols is divided into two sections, the first being a series of reviews to describe what chemical genomics is about and to set the scene for the protocol chapters. The subject is introduced by Paul Caron, who explains the various flavors of chemical genomics. This is f- lowed by Lutz Weber and Philip Dean who cover the interaction between organic molecules and protein targets from the different perspectives of la- ratory experimentation and in silico design. The protocols begin with the me- ods developed in Christopher Lowes’ laboratory (Roque et al.

Chemogenomics and Chemical Genetics

Chemogenomics and Chemical Genetics
Author: ERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère
Publsiher: Springer Science & Business Media
Total Pages: 256
Release: 2011-06-21
ISBN 10: 3642196152
ISBN 13: 9783642196157
Language: EN, FR, DE, ES & NL

Chemogenomics and Chemical Genetics Book Review:

Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage and mathematical treatment of the data. “Chemogenomics and Chemical Genetics” is an introductory manual presenting methods and concepts making up the basis for this recent discipline. This book is dedicated to biologists, chemists and computer scientist beginners. It is organized in brief, illustrated chapters with practical examples. Clear definitions of biological, chemical and IT concepts are given in a glossary section to help readers who are not familiar with one of these disciplines. "Chemogenomics and Chemical Genetics" should therefore be helpful for students (from Bachelor's degree level), technological platform engineers, and researchers in biology, chemistry, bioinformatics, cheminformatics, both in biotech and academic laboratories.

Drug Discovery from Natural Products

Drug Discovery from Natural Products
Author: Olga Genilloud,Francisca Vicente
Publsiher: Royal Society of Chemistry
Total Pages: 432
Release: 2012-08-21
ISBN 10: 184973495X
ISBN 13: 9781849734950
Language: EN, FR, DE, ES & NL

Drug Discovery from Natural Products Book Review:

This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of case studies from leading experts from industry and academia on key molecules and derivatives that have been chosen for their novelty in chemistry, biology and clinical applications. The book intends to reflect the current confluence of different disciplines in chemical biology and synthetic chemistry supported by a more profound knowledge of systems biology that ensures the concurrency and synergisms of expertise from different research fields that impact in the discovery of novel molecules. In the first section the chapters reflect recent approaches to exploit the biosynthetic potential of microbial resources (including genome mining, metagenomic and epigenetic approaches), as well as biosynthetic chemistry tools to respond to product supply and novel screening alternatives that have lead to the discovery of novel chemistry. The second part reviews, in the form of case studies, some examples of bioactive molecules in the important therapeutic areas of antiinfectives, oncology and antiparasitics.

Mass Spectrometry in Chemical Biology

Mass Spectrometry in Chemical Biology
Author: Norberto Peporine Lopes,Ricardo Roberto da Silva
Publsiher: Royal Society of Chemistry
Total Pages: 298
Release: 2017-11-22
ISBN 10: 1782625275
ISBN 13: 9781782625278
Language: EN, FR, DE, ES & NL

Mass Spectrometry in Chemical Biology Book Review:

Introduction; Introduction to mass spectrometry instrumentation and methods used in chemical biology; Metabolomics; Proteomics; Mass spectrometry to discover natural products; Applications of mass spectrometry in synthetic biology; Studying enzyme mechanisms using mass spectrometry: Introduction; Studying enzyme mechanisms using mass spectrometry: Applications; Databases; Future perspectives;

High Throughput Screening Methods

High Throughput Screening Methods
Author: Joshua A. Bittker,Nathan T. Ross
Publsiher: Royal Society of Chemistry
Total Pages: 396
Release: 2016-12-08
ISBN 10: 1782624716
ISBN 13: 9781782624714
Language: EN, FR, DE, ES & NL

High Throughput Screening Methods Book Review:

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

Chemical Biology of Nucleic Acids

Chemical Biology of Nucleic Acids
Author: Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
Publsiher: Springer Science & Business
Total Pages: 599
Release: 2014-04-22
ISBN 10: 3642544525
ISBN 13: 9783642544521
Language: EN, FR, DE, ES & NL

Chemical Biology of Nucleic Acids Book Review:

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

RNA Modification

RNA Modification
Author: Anonim
Publsiher: Academic Press
Total Pages: 408
Release: 2015-12-11
ISBN 10: 0128023317
ISBN 13: 9780128023310
Language: EN, FR, DE, ES & NL

RNA Modification Book Review:

RNA Modification provides a useful examination of the science and its role in biological regulation, the current frontier of life science research, and includes various RNA modications and their role in gene expression. It represents the most up-to-date knowledge and protocols available today. Dynamic RNA modifications and their roles in biological regulation are the current frontier of life science research This volume of Methods in Enzymology represents up to date knowledge and protocols

The DNA Replication Repair Interface

The DNA Replication Repair Interface
Author: Anonim
Publsiher: Academic Press
Total Pages: 452
Release: 2021-11-12
ISBN 10: 0323907342
ISBN 13: 9780323907347
Language: EN, FR, DE, ES & NL

The DNA Replication Repair Interface Book Review:

Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Includes the latest information on replication-coupled repair

Computational Genome Analysis

Computational Genome Analysis
Author: Richard C. Deonier,Simon Tavaré,Michael Waterman
Publsiher: Springer Science & Business Media
Total Pages: 535
Release: 2007-08-13
ISBN 10: 0387987851
ISBN 13: 9780387987859
Language: EN, FR, DE, ES & NL

Computational Genome Analysis Book Review:

This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.

Perilous Knowledge

Perilous Knowledge
Author: Tom Wilkie
Publsiher: Univ of California Press
Total Pages: 195
Release: 1993-01-01
ISBN 10: 9780520085534
ISBN 13: 0520085531
Language: EN, FR, DE, ES & NL

Perilous Knowledge Book Review:

The Human Genome Project has been called a scientific "search for the Holy Grail" or the genetics equivalent of the moon race. Thousands of researchers worldwide are analyzing the details of human DNA, hoping to identify all of the tens of thousands of human genes that are the blueprint for the human body. Physicist and writer Tom Wilkie offers a lively, compelling history of this scientifically fascinating and politically contentious undertaking. Beginning with the discovery of DNA by James Watson and Francis Crick in 1953, Wilkie's narrative unfolds with the intrigue of a detective story. He reviews in nontechnical terms the many step-by-step developments from different scientific teams that finally made it seem as if it would be possible to sequence the human genome. He goes on to consider the potential social consequences, good and bad, of learning to manipulate the human genetic code. What will happen as we try to prevent and cure disease or attempt to "improve" ourselves and our children by genetic means? A most readable introduction to the science of genetics and the potential consequences of the Human Genome Project, Perilous Knowledge provides background for the startling headlines that quite possibly signal changes to all human life in the next century. "After decades of painstaking research, seemingly disparate paths into the sciences of molecular biology, chemistry, biology and genetics have converged. Suddenly the scientists realize that they are . . . at the peak of a mountain where all the surrounding landscape is clear to their view. They are confident now that they can tackle one of the biggest and most profound issues in their science: unravelling the message of human inheritance."--from the Preface The Human Genome Project has been called a scientific "search for the Holy Grail" or the genetics equivalent of the moon race. Thousands of researchers worldwide are analyzing the details of human DNA, hoping to identify all of the tens of thousands of human genes that are the blueprint for the human body. Physicist and writer Tom Wilkie offers a lively, compelling history of this scientifically fascinating and politically contentious undertaking. Beginning with the discovery of DNA by James Watson and Francis Crick in 1953, Wilkie's narrative unfolds with the intrigue of a detective story. He reviews in nontechnical terms the many step-by-step developments from different scientific teams that finally made it seem as if it would be possible to sequence the human genome. He goes on to consider the potential social consequences, good and bad, of learning to manipulate the human genetic code. What will happen as we try to prevent and cure disease or attempt to "improve" ourselves and our children by genetic means? A most readable introduction to the science of genetics and the potential consequences of the Human Genome Project, Perilous Knowledge provides background for the startling headlines that quite possibly signal changes to all human life in the next century. "After decades of painstaking research, seemingly disparate paths into the sciences of molecular biology, chemistry, biology and genetics have converged. Suddenly the scientists realize that they are . . . at the peak of a mountain where all the surrounding landscape is clear to their view. They are confident now that they can tackle one of the biggest and most profound issues in their science: unravelling the message of human inheritance."--from the Preface

The Microbial Models of Molecular Biology

The Microbial Models of Molecular Biology
Author: Rowland H. Davis
Publsiher: Oxford University Press on Demand
Total Pages: 337
Release: 2003
ISBN 10: 0195154363
ISBN 13: 9780195154368
Language: EN, FR, DE, ES & NL

The Microbial Models of Molecular Biology Book Review:

Explains the role of simple biological model systems in the growth of molecular biology. This book presents the history of molecular biology, tracing the work in bacteriophages in E coli the role of other prokaryotic systems, the protozoan and algal models, and the move into eukaryotes with the fungal systems - Neurospora, Aspergillus and yeast.

Virtual Screening An Alternative or Complement to High Throughput Screening

Virtual Screening  An Alternative or Complement to High Throughput Screening
Author: Gerhard Klebe
Publsiher: Springer Science & Business Media
Total Pages: 295
Release: 2000-11-30
ISBN 10: 0792366336
ISBN 13: 9780792366331
Language: EN, FR, DE, ES & NL

Virtual Screening An Alternative or Complement to High Throughput Screening Book Review:

In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at Schloß Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this request which is summarized in this publication.

Darwin in the Genome

Darwin in the Genome
Author: Lynn Helena Caporale
Publsiher: Darwin in the Genome
Total Pages: 245
Release: 2003
ISBN 10: 0071378227
ISBN 13: 9780071378222
Language: EN, FR, DE, ES & NL

Darwin in the Genome Book Review:

Smart genomes--an enthralling account of revolutionary discoveries at the cutting edge of genomics research Written by a molecular biologist at the forefront of genomics research, Darwin in the Genome is an exciting account of one of the hottest new theories in biology today: evolution by natural selection inevitably leads to strategic mutations. In the struggle for survival, from pathogens to flowers, birds to orangutans, baker's yeast to people, the fittest genomes are those that evolve effective molecular strategies that respond to, and in fact anticipate, challenges and opportunities in their environments. Writing in a clear, accessible style, Lynn Caporale describes the emergence of genomic mutation strategies, which researchers are just beginning to uncover. She also spells out some of the more profound implications of these findings, including the importance of biodiversity, indeed human diversity, for survival, the possibility of bold new directions for medical research, and the inherent dangers of attempting to fix perceived "errors" in a human genome.