Telomere

Telomere
Author: Marcelo Larramendy
Publsiher: BoD – Books on Demand
Total Pages: 226
Release: 2016-11-23
ISBN 10: 9535127527
ISBN 13: 9789535127529
Language: EN, FR, DE, ES & NL

Telomere Book Review:

This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases
Author: Ryusaku Matsumoto
Publsiher: Anonim
Total Pages: 329
Release: 2016
ISBN 10:
ISBN 13: OCLC:1154231748
Language: EN, FR, DE, ES & NL

Telomeres and Cellular Senescence in Metabolic and Endocrine Diseases Book Review:

A number of observations suggest a close connection between telomere length and mortality and age-related disease, suggesting that telomere length is a useful marker of individual biological aging and the shortening of telomere length is causally related with the pathogenesis in age-related diseases. To date, the significance of telomere length in metabolic and endocrine diseases has also been clarified. It has been reported that obesity, type 2 diabetes mellitus (T2DM), NAFLD, and hypertension were associated with shortened telomere length. In endocrine diseases, polycystic ovary syndrome (PCOS), Cushing's syndrome, and acromegaly were associated with shortened telomere length. In these conditions, an increased oxidative stress associated with the metabolic and hormonal abnormalities appears to play a pivotal role in the shortened telomere length. Recently, a large population-based study demonstrated that shortened telomeres at baseline were associated with an increased risk of metabolic diseases, suggesting that the shortened telomere itself plays a causal role for the onset or development of the metabolic diseases. In this chapter, the pathophysiological role of shortened telomere length in metabolic and endocrine diseases and the significance of cellular senescence are discussed.

Senolytics in Disease Ageing and Longevity

Senolytics in Disease  Ageing and Longevity
Author: Daniel Muñoz-Espin,Marco Demaria
Publsiher: Springer Nature
Total Pages: 222
Release: 2020-04-27
ISBN 10: 3030449033
ISBN 13: 9783030449032
Language: EN, FR, DE, ES & NL

Senolytics in Disease Ageing and Longevity Book Review:

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Aging

Aging
Author: L. Robert,T. Fulop
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 224
Release: 2014-05-16
ISBN 10: 3318026530
ISBN 13: 9783318026535
Language: EN, FR, DE, ES & NL

Aging Book Review:

Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.

Oxidative Stress in Heart Diseases

Oxidative Stress in Heart Diseases
Author: Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit
Publsiher: Springer Nature
Total Pages: 596
Release: 2019-11-06
ISBN 10: 9811382735
ISBN 13: 9789811382734
Language: EN, FR, DE, ES & NL

Oxidative Stress in Heart Diseases Book Review:

This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Innovative Medicine

Innovative Medicine
Author: Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publsiher: Springer
Total Pages: 339
Release: 2015-10-13
ISBN 10: 4431556516
ISBN 13: 9784431556510
Language: EN, FR, DE, ES & NL

Innovative Medicine Book Review:

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Cancer and Aging

Cancer and Aging
Author: M. Extermann
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 178
Release: 2013-01-18
ISBN 10: 3318023078
ISBN 13: 9783318023077
Language: EN, FR, DE, ES & NL

Cancer and Aging Book Review:

Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
Author: Suresh I.S. Rattan,Leonard Hayflick
Publsiher: Springer
Total Pages: 364
Release: 2016-05-09
ISBN 10: 3319262394
ISBN 13: 9783319262390
Language: EN, FR, DE, ES & NL

Cellular Ageing and Replicative Senescence Book Review:

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging
Author: Marco Malavolta,Eugenio Mocchegiani
Publsiher: Academic Press
Total Pages: 784
Release: 2016-04-15
ISBN 10: 0128018275
ISBN 13: 9780128018279
Language: EN, FR, DE, ES & NL

Molecular Basis of Nutrition and Aging Book Review:

Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging Explores how nutritional factors are involved in the pathogenesis of aging across body systems Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

Novel Insights Into the Contribution of Cellular Senescence to Cancer Therapy

Novel Insights Into the Contribution of Cellular Senescence to Cancer Therapy
Author: Tareq Saleh
Publsiher: Anonim
Total Pages: 329
Release: 2018
ISBN 10:
ISBN 13: OCLC:1103925031
Language: EN, FR, DE, ES & NL

Novel Insights Into the Contribution of Cellular Senescence to Cancer Therapy Book Review:

Cellular senescence a specialized form of growth arrest that contributes to the pathogenesis of several aging-related disorders including cancer. While by definition tumor cells are considered immortalized, they can undergo senescence when exposed to conventional and targeted cancer therapy. Therapy-Induced Senescence (TIS) represents a fundamental response to therapy and impacts its outcomes. However, TIS has been considered a positive therapeutic goal since senescent tumor cells are expected to enter a state of permanent growth abrogation. In this work we examined the hypothesis that a subpopulation of senescent cells can re-acquire proliferative potential after a state of senescent dormancy, indicating that senescence is not obligatorily an irreversible process. Our observations indicate that H460 non-small cell lung cancer cells induced into senescence by exposure to etoposide, and enriched based on Îø-galactosidase staining and size, were shown to recover reproductive capacity, which was accompanied by resolution of the DNA-damage-response (downregulation of p53 and p21Cip1 induction), attenuation of the Senescence-associated Secretory Phenotype (SASP). To overcome the reservation that the newly dividing cells may not have been derived from the senescent population and in an effort to establish that escape from TIS is feasible, tumor cells induced into senescence by chemotherapy were enriched for senescence by flow cytometry; the subsequent division of senescent cells was demonstrable utilizing both real-time, live microscopy and High Speed Live Cell Interferometry (HSLCI). Furthermore, sorted senescent cells were observed to form tumors when implanted in immune deficient mice and with a significant delay in immunecompetent mice. As chemotherapy induced senescent cells have been identified in patient tumors, it is reasonable to propose that tumor cells that escape from senescence could contribute to disease recurrence. In addition, therapy-induced senescence could prove to reflect one form of tumor dormancy. Recently, ABT263 has been used as a senolytic drug, effectively eliminating senescent cells from aging-related animal models. Here, we utilize ABT263 in a two-hit approach to eliminate senescent tumor cells that persistent after exposure to chemotherapy. ABT263 results in the killing of senescent tumor cells in a concentration-dependent manner and shifts the response towards apoptotic cell death. Furthermore, sequential administration of ABT263 interferes with the ability of senescent tumor cells to recover growth potential. These results indicate that senescent tumor cells can contribute to cancer relapse by acquiring proliferative properties and that senolytic therapy allows for the clearance of dormant senescent tumor cells and will potentially decrease cancer recurrence rates.

Protein Expression in Down Syndrome Brain

Protein Expression in Down Syndrome Brain
Author: G. Lubec
Publsiher: Springer Science & Business Media
Total Pages: 374
Release: 2001-10-15
ISBN 10: 9783211837320
ISBN 13: 3211837329
Language: EN, FR, DE, ES & NL

Protein Expression in Down Syndrome Brain Book Review:

When we worked on Down Syndrome brain in the past we have been focus ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz ing the long unpredictable way from RNA to protein. The availability of fetal samples along with the proteomic appproach stimulated and reinforced studies on Down Syndrome brain. And indeed, it was found out that some observations on aberrant protein expression in adult Down Syndrome brain could not be verified in the fetal samples indi cating that neurodegeneration in adult Down Syndrome brain may have been responsible rather than trisomy 21. Using brains from the early second trimester of gestation led to the generation of a series of clues for the under standing of aberrant wiring of the brain in Down Syndrome and enabled the determination of altered key functions in early life; e. g. undetectably low drebrin was observed in Down Syndrome cortex, an integral constituent and marker for dendritic spines, main effectors of cross-talk between neurons. In addition, evaluation of the nature of the neuronal deficits in terms of neuro transmission markers could be established as well as neuronal density in fetal Down Syndrome cortex.

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer
Author: K. Lenhard Rudolph
Publsiher: Springer Science & Business Media
Total Pages: 330
Release: 2007-11-07
ISBN 10: 354073709X
ISBN 13: 9783540737094
Language: EN, FR, DE, ES & NL

Telomeres and Telomerase in Aging Disease and Cancer Book Review:

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Frailty and Cardiovascular Diseases

Frailty and Cardiovascular Diseases
Author: Nicola Veronese
Publsiher: Springer Nature
Total Pages: 154
Release: 2020-01-01
ISBN 10: 3030333302
ISBN 13: 9783030333300
Language: EN, FR, DE, ES & NL

Frailty and Cardiovascular Diseases Book Review:

This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients.

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging
Author: M. A. Hayat
Publsiher: Academic Press
Total Pages: 430
Release: 2016-12-28
ISBN 10: 0128094273
ISBN 13: 9780128094273
Language: EN, FR, DE, ES & NL

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Book Review:

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Handbook of Models for Human Aging

Handbook of Models for Human Aging
Author: P. Michael Conn
Publsiher: Elsevier
Total Pages: 1075
Release: 2011-04-28
ISBN 10: 9780080460062
ISBN 13: 0080460062
Language: EN, FR, DE, ES & NL

Handbook of Models for Human Aging Book Review:

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Overweight and the Metabolic Syndrome

Overweight and the Metabolic Syndrome
Author: George A. Bray,Louisiana State University,Donna Ryan
Publsiher: Springer Science & Business Media
Total Pages: 336
Release: 2007-02-16
ISBN 10: 0387321640
ISBN 13: 9780387321646
Language: EN, FR, DE, ES & NL

Overweight and the Metabolic Syndrome Book Review:

This timely book provides an overview of topics related to obesity. These include associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity. The volume covers evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic.

Cellular Aging and Cell Death

Cellular Aging and Cell Death
Author: Nikki J. Holbrook,George R. Martin,Richard A. Lockshin
Publsiher: John Wiley & Sons
Total Pages: 336
Release: 1995-12-20
ISBN 10: 9780471121237
ISBN 13: 0471121231
Language: EN, FR, DE, ES & NL

Cellular Aging and Cell Death Book Review:

Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.

Endothelial Dysfunction

Endothelial Dysfunction
Author: Helena Lenasi
Publsiher: BoD – Books on Demand
Total Pages: 430
Release: 2018-10-24
ISBN 10: 1789842530
ISBN 13: 9781789842531
Language: EN, FR, DE, ES & NL

Endothelial Dysfunction Book Review:

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Cellular Senescence and Tumor Suppression

Cellular Senescence and Tumor Suppression
Author: Peter D. Adams,John M. Sedivy
Publsiher: Springer Science & Business Media
Total Pages: 272
Release: 2010-01-23
ISBN 10: 9781441910752
ISBN 13: 1441910751
Language: EN, FR, DE, ES & NL

Cellular Senescence and Tumor Suppression Book Review:

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

New Trends in Vascular Inflammation Research From Biology to Therapy

New Trends in Vascular Inflammation Research  From Biology to Therapy
Author: Masanori Aikawa,Ichiro Manabe,Nikolaus Marx
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2019-10-17
ISBN 10: 2889456374
ISBN 13: 9782889456376
Language: EN, FR, DE, ES & NL

New Trends in Vascular Inflammation Research From Biology to Therapy Book Review: