Cellular Senescence and Inflammation in Aging and Age related Disease

Cellular Senescence and Inflammation in Aging and Age related Disease
Author: Tobias Wijshake
Publsiher: Unknown
Total Pages: 135
Release: 2015
ISBN 10: 9789036777568
ISBN 13: 9036777569
Language: EN, FR, DE, ES & NL

Cellular Senescence and Inflammation in Aging and Age related Disease Book Review:

Telomere

Telomere
Author: Marcelo Larramendy
Publsiher: BoD – Books on Demand
Total Pages: 226
Release: 2016-11-23
ISBN 10: 9535127527
ISBN 13: 9789535127529
Language: EN, FR, DE, ES & NL

Telomere Book Review:

This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
Author: Suresh I.S. Rattan,Leonard Hayflick
Publsiher: Springer
Total Pages: 364
Release: 2016-05-09
ISBN 10: 3319262394
ISBN 13: 9783319262390
Language: EN, FR, DE, ES & NL

Cellular Ageing and Replicative Senescence Book Review:

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Senescence and Senescence Related Disorders

Senescence and Senescence Related Disorders
Author: Wang Zhiwei,Hiroyuki Inuzuka
Publsiher: BoD – Books on Demand
Total Pages: 160
Release: 2013-02-20
ISBN 10: 9535109979
ISBN 13: 9789535109976
Language: EN, FR, DE, ES & NL

Senescence and Senescence Related Disorders Book Review:

Senescence is a biological process that causes a progressive deterioration of structure and function of all organs chronologically. Recent studies have revealed the detailed molecular mechanisms of senescence using cell culture system and experimental organisms. It is thought that senescence is a potential cause for the development of various age-related disorders such as cancer, cardiovascular and neurodegenerative disorders. This book discusses in detail senescence and its related diseases by distinguished researchers and practicing clinicians. The cumulative knowledge from the studies could lead to developing new approaches for anti-senescence interventions.

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration
Author: Phillip K. Peterson,Michal Toborek
Publsiher: Springer
Total Pages: 600
Release: 2014-07-08
ISBN 10: 149391071X
ISBN 13: 9781493910717
Language: EN, FR, DE, ES & NL

Neuroinflammation and Neurodegeneration Book Review:

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Cellular Senescence in Disease

Cellular Senescence in Disease
Author: Manuel Serrano,Daniel Munos
Publsiher: Academic Press
Total Pages: 350
Release: 2021-09-15
ISBN 10: 9780128225141
ISBN 13: 0128225149
Language: EN, FR, DE, ES & NL

Cellular Senescence in Disease Book Review:

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities Provides a thorough introduction to Cellular Senescence Covers all major pathologies for which cellular senescence has shown evidence of involvement Focuses on possible therapeutic pathways Edited and authored by worldwide experts

Handbook on Immunosenescence

Handbook on Immunosenescence
Author: Tamas Fulop,Claudio Franceschi,Katsuiki Hirokawa,Graham Pawelec
Publsiher: Springer Science & Business Media
Total Pages: 1693
Release: 2009-02-27
ISBN 10: 1402090633
ISBN 13: 9781402090639
Language: EN, FR, DE, ES & NL

Handbook on Immunosenescence Book Review:

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Protein Expression in Down Syndrome Brain

Protein Expression in Down Syndrome Brain
Author: G. Lubec
Publsiher: Springer Science & Business Media
Total Pages: 374
Release: 2001-10-15
ISBN 10: 9783211837320
ISBN 13: 3211837329
Language: EN, FR, DE, ES & NL

Protein Expression in Down Syndrome Brain Book Review:

When we worked on Down Syndrome brain in the past we have been focus ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz ing the long unpredictable way from RNA to protein. The availability of fetal samples along with the proteomic appproach stimulated and reinforced studies on Down Syndrome brain. And indeed, it was found out that some observations on aberrant protein expression in adult Down Syndrome brain could not be verified in the fetal samples indi cating that neurodegeneration in adult Down Syndrome brain may have been responsible rather than trisomy 21. Using brains from the early second trimester of gestation led to the generation of a series of clues for the under standing of aberrant wiring of the brain in Down Syndrome and enabled the determination of altered key functions in early life; e. g. undetectably low drebrin was observed in Down Syndrome cortex, an integral constituent and marker for dendritic spines, main effectors of cross-talk between neurons. In addition, evaluation of the nature of the neuronal deficits in terms of neuro transmission markers could be established as well as neuronal density in fetal Down Syndrome cortex.

Aging

Aging
Author: L. Robert,T. Fulop
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 224
Release: 2014-05-16
ISBN 10: 3318026530
ISBN 13: 9783318026535
Language: EN, FR, DE, ES & NL

Aging Book Review:

Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.

How and why We Age

How and why We Age
Author: Leonard Hayflick
Publsiher: Unknown
Total Pages: 377
Release: 1996-01-01
ISBN 10: 9780345401557
ISBN 13: 0345401557
Language: EN, FR, DE, ES & NL

How and why We Age Book Review:

A cell biologist who has studied the aging process for thirty years answers the big questions about aging, dispels the myths, and discusses the desirability of living longer

Senescence

Senescence
Author: Jolanta Dorszewska,Wojciech Kozubski
Publsiher: BoD – Books on Demand
Total Pages: 166
Release: 2017-08-30
ISBN 10: 9535134612
ISBN 13: 9789535134619
Language: EN, FR, DE, ES & NL

Senescence Book Review:

In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.

Frailty and Cardiovascular Diseases

Frailty and Cardiovascular Diseases
Author: Nicola Veronese
Publsiher: Springer Nature
Total Pages: 154
Release: 2020-01-01
ISBN 10: 3030333302
ISBN 13: 9783030333300
Language: EN, FR, DE, ES & NL

Frailty and Cardiovascular Diseases Book Review:

This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients.

Senolytics in Disease Ageing and Longevity

Senolytics in Disease  Ageing and Longevity
Author: Daniel Muñoz-Espin,Marco Demaria
Publsiher: Springer
Total Pages: 222
Release: 2021-05-12
ISBN 10: 9783030449056
ISBN 13: 303044905X
Language: EN, FR, DE, ES & NL

Senolytics in Disease Ageing and Longevity Book Review:

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

HIV and Aging

HIV and Aging
Author: M. Brennan-Ing,R.F. DeMarco
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 244
Release: 2016-11-22
ISBN 10: 3318059463
ISBN 13: 9783318059465
Language: EN, FR, DE, ES & NL

HIV and Aging Book Review:

Despite decades of attention on building a global HIV research and programming agenda, HIV in older populations has generally been neglected until recently. This new book focuses on HIV and aging in the context of ageism with regard to prevention, treatment guidelines, funding, and the engagement of communities and health and social service organizations. The lack of perceived HIV risk in late adulthood among older people themselves, as well on the part of providers and society in general, has led to a lack of investment in education, testing, and programmatic responses. Ageism perpetuates the invisibility of older adults and, in turn, renders current medical and social service systems unprepared to respond to patients’ needs. While ageism may lead to some advantages – discounts for services, for example – it is the negative aspects that must be addressed when determining the appropriate community-level response to the epidemic.

Endothelial Dysfunction

Endothelial Dysfunction
Author: Helena Lenasi
Publsiher: BoD – Books on Demand
Total Pages: 430
Release: 2018-10-24
ISBN 10: 1789842530
ISBN 13: 9781789842531
Language: EN, FR, DE, ES & NL

Endothelial Dysfunction Book Review:

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Oxidative Stress in Heart Diseases

Oxidative Stress in Heart Diseases
Author: Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit
Publsiher: Springer Nature
Total Pages: 596
Release: 2019-11-06
ISBN 10: 9811382735
ISBN 13: 9789811382734
Language: EN, FR, DE, ES & NL

Oxidative Stress in Heart Diseases Book Review:

This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Human Aging

Human Aging
Author: Calogero Caruso,Giuseppina Candore
Publsiher: Academic Press
Total Pages: 382
Release: 2021-05-21
ISBN 10: 0128227370
ISBN 13: 9780128227374
Language: EN, FR, DE, ES & NL

Human Aging Book Review:

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease
Author: Sofía Ferreira-González
Publsiher: Unknown
Total Pages: 135
Release: 2017
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1064656338
Language: EN, FR, DE, ES & NL

Cellular Senescence Exacerbates Injury and Impairs Regeneration in Biliary Disease Book Review:

Cellular Senescence and Tumor Suppression

Cellular Senescence and Tumor Suppression
Author: Peter D. Adams,John M. Sedivy
Publsiher: Springer Science & Business Media
Total Pages: 272
Release: 2010-01-23
ISBN 10: 9781441910752
ISBN 13: 1441910751
Language: EN, FR, DE, ES & NL

Cellular Senescence and Tumor Suppression Book Review:

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Hepatocellular Carcinoma

Hepatocellular Carcinoma
Author: Costin Teodor Streba,Cristin Constantin Vere,Ion Rogoveanu
Publsiher: BoD – Books on Demand
Total Pages: 200
Release: 2018-11-28
ISBN 10: 1789842735
ISBN 13: 9781789842739
Language: EN, FR, DE, ES & NL

Hepatocellular Carcinoma Book Review:

Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed.