Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
Author: Anonim
Publsiher: Academic Press
Total Pages: 226
Release: 2019-07-30
ISBN 10: 012816574X
ISBN 13: 9780128165744
Language: EN, FR, DE, ES & NL

Cellular and Animal Models in Human Genomics Research Book Review:

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author: P. Michael Conn
Publsiher: Academic Press
Total Pages: 1108
Release: 2013-05-29
ISBN 10: 0124159125
ISBN 13: 9780124159129
Language: EN, FR, DE, ES & NL

Animal Models for the Study of Human Disease Book Review:

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publsiher: National Academies Press
Total Pages: 138
Release: 2018-05-29
ISBN 10: 0309471192
ISBN 13: 9780309471190
Language: EN, FR, DE, ES & NL

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine Book Review:

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.

Advances in Animal Genomics

Advances in Animal Genomics
Author: Sukanta Mondal,Ram Lakhan Singh
Publsiher: Academic Press
Total Pages: 328
Release: 2020-11-25
ISBN 10: 0128206128
ISBN 13: 9780128206126
Language: EN, FR, DE, ES & NL

Advances in Animal Genomics Book Review:

Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches which have enabled to produce huge genomic and transcriptomic resources globally on a genome-wide scale. This book is an important resource for researchers, students, educators and professionals in agriculture, veterinary and biotechnology sciences that enables them to solve problems regarding sustainable development with the help of current innovative biotechnologies. Integrates basic and advanced concepts of animal biotechnology and presents future developments Describes current high-throughput next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches for sustainable livestock production Illustrates integrated strategies to dissect and decode the molecular and gene regulatory networks involved in complex quantitative yield and stress tolerance traits in livestock Ensures readers will gain a strong grasp of biotechnology for sustainable livestock production with its well-illustrated discussion

Animal Models and Human Reproduction

Animal Models and Human Reproduction
Author: Heide Schatten,Gheorghe M. Constantinescu
Publsiher: John Wiley & Sons
Total Pages: 600
Release: 2017-01-13
ISBN 10: 1118881346
ISBN 13: 9781118881347
Language: EN, FR, DE, ES & NL

Animal Models and Human Reproduction Book Review:

Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.

Cancer Genomics

Cancer Genomics
Author: Jason N. Berman,Priscilla P.L. Chiu,Graham Dellaire
Publsiher: Elsevier Inc. Chapters
Total Pages: 510
Release: 2013-11-21
ISBN 10: 0128061057
ISBN 13: 9780128061053
Language: EN, FR, DE, ES & NL

Cancer Genomics Book Review:

Genome-wide association (GWA) studies and tumor-specific epigenome, transcriptome and genome sequencing projects are generating an ever-growing list of susceptibility alleles, as well as putative gain- and loss-of-function gene mutations associated with cancer. These genetic changes ultimately need to be validated to determine their contribution to the initiation, progression and likelihood of treatment response for various cancers. The bottle-neck is no longer obtaining sequence data or completion of the GWA studies, but rather the ability efficiently to validate candidate genes identified by these projects. In vivo studies in animal models are the “gold standard” for validation of these candidate drivers and modifiers of cancer. Furthermore, once a gene product or molecular pathway has been validated as playing an important role in the development or progression of cancer, animal models provide the necessary preclinical data for evaluation of the efficacy and toxicity of new therapeutics targeting that gene or pathway. As such, animal models play an essential role in cancer research by facilitating the translation of genomic discoveries into preclinical studies that precede new targeted therapies for cancer. In this chapter, we will discuss vertebrate and invertebrate animal models as they apply to cancer genomics, as well as key technologies employed. In particular, we will focus on the use of murine and zebrafish human tumor xenografts and transgenic models.

Mouse Cell Culture

Mouse Cell Culture
Author: Ivan Bertoncello
Publsiher: Humana Press
Total Pages: 315
Release: 2019-02-20
ISBN 10: 9781493990856
ISBN 13: 1493990853
Language: EN, FR, DE, ES & NL

Mouse Cell Culture Book Review:

This volume describes cell culture protocols for the maintenance, propagation, manipulation, and analysis of primary explanted cells from various mouse organ systems. After introductory chapters that examine the applicability of mouse models as a discovery tool and describe critical factors and variables that influence cell culture endpoints, protocol chapters explore cell culture methodologies for specific mouse cell types and lineages. Written in the highly successful Methods in Molecular Biology series format, these chapters include introductions to their respective topics, comprehensive lists of the essential materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mouse Cell Culture: Methods and Protocols aims to ensure successful results utilizing these protocols in further studies, leading to the identification of key factors, genes, and cellular pathways regulating cell lineage commitment and differentiation, modeling disease, and identifying novel therapeutic targets.

Alternatives To Animal Testing

Alternatives To Animal Testing
Author: R E Hester,R M Harrison
Publsiher: Royal Society of Chemistry
Total Pages: 136
Release: 2007-10-31
ISBN 10: 1847552455
ISBN 13: 9781847552457
Language: EN, FR, DE, ES & NL

Alternatives To Animal Testing Book Review:

Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include; the safety evaluation of chemicals, international validation and barriers to the validation of alternative tests, in vitro testing for endocrine disruptors, intelligent approaches to safety evaluation of chemicals, alternative tests and the regulatory framework. The book provides an up-to-date discussion of the current state of development of alternatives to animal testing and is ideal for professionals and academics in the field. It would also be of use for graduate students wishing to pursue a career in the pharmaceutical and cosmetic industries.

What Will We Do If We Don t Experiment on Animals

What Will We Do If We Don t Experiment on Animals
Author: Jean Swingle Greek,C. Ray Greek
Publsiher: Trafford Publishing
Total Pages: 261
Release: 2004
ISBN 10: 1412020581
ISBN 13: 9781412020589
Language: EN, FR, DE, ES & NL

What Will We Do If We Don t Experiment on Animals Book Review:

Drs. Greek have written 2 books on why using animals as models for humans is not the best way to conduct medical research and drug testing. During their lectures and debates, the most commonly asked question was, "Well. What will we use if we don't use animals?" What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century is the answer to that question. Drs. Greek explain briefly why one species cannot predict drug response for another and describe what research and testing methods should be used today instead of animals. They also describe where our biomedical research dollars should be spent if we are to have cures for cancer, AIDS, and Alzheimer's. This book will appeal to science-trained and general audiences, animal lovers and science readers, public policy analysts, students, patients and patient support groups, and government watchdog groups. What Will We Do If We Don't Experiment On Animals? Medical Research for the Twenty-first Century takes medical research out of the nineteenth and into the 21st century.

CRISPR in Animals and Animal Models

CRISPR in Animals and Animal Models
Author: Anonim
Publsiher: Academic Press
Total Pages: 148
Release: 2017-11-10
ISBN 10: 0128125071
ISBN 13: 9780128125076
Language: EN, FR, DE, ES & NL

CRISPR in Animals and Animal Models Book Review:

CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges. Accessible to students and researchers alike Written by leading authorities in the field

Animal Biotechnology

Animal Biotechnology
Author: Ashish Verma,Anchal Singh
Publsiher: Academic Press
Total Pages: 668
Release: 2013-11-04
ISBN 10: 0123914345
ISBN 13: 9780123914347
Language: EN, FR, DE, ES & NL

Animal Biotechnology Book Review:

Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field. Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences. Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseases Provides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering

Animal Models of Speech and Language Disorders

Animal Models of Speech and Language Disorders
Author: Santosh A. Helekar
Publsiher: Springer Science & Business Media
Total Pages: 295
Release: 2013-10-17
ISBN 10: 1461484006
ISBN 13: 9781461484004
Language: EN, FR, DE, ES & NL

Animal Models of Speech and Language Disorders Book Review:

Basic research over the last decade or two has uncovered similarities between speech, especially its sensori-motor aspects, and vocal communication in several non-human species. The most comprehensive studies so far have been conducted in songbirds. Songbirds offer us a model system to study the interactions between developmental or genetic predispositions and tutor-dependent influences, on the learning of vocal communication. Songbird research has elucidated cellular and molecular mechanisms underlying learning and production of vocal patterns, perception of vocal sounds, vocal motor control and vocal neuromotor plasticity. More recently, the entire genome of the songbird zebra finch has been sequenced. These discoveries, along with the identification of several genes implicated in familial human speech and language disorders, have made it possible to look for analogues of speech and language dysfunction in zebra finches, at least at the perceptual and sensori-motor levels. Two approaches in particular have led us closer to the development of animal models of human speech conditions, namely developmental stuttering and a familial verbal dyspraxia associated with a mutation in the gene for the transcription factor FoxP2. Work on other animals that show developmental sensori-motor learning of vocal sounds used for communication have also shown significant progress, leading to the possibility of development of models of speech and language dysfunction in them. Among mammals, the principal ones include dolphins and whales. In non-human primates, while vocal learning per se is not very prominent, investigations on their communicative abilities have thrown some light on the rudiments of language. These considerations make the publication of a book focused on animal models of speech and language disorders, detailing the overall investigative approach of neurobehavioral studies in animals capable of vocal communication and learned vocalizations, a much-needed and worthwhile project. It would serve as a unifying review of research in this new multidisciplinary frontier, spanning the molecular to the behavioral, for clinicians and researchers, as well as a teaching resource for advanced speech pathology and neuroscience students. This book will also be the first of its kind.

Handbook of Models for Human Aging

Handbook of Models for Human Aging
Author: P. Michael Conn
Publsiher: Elsevier
Total Pages: 1075
Release: 2011-04-28
ISBN 10: 9780080460062
ISBN 13: 0080460062
Language: EN, FR, DE, ES & NL

Handbook of Models for Human Aging Book Review:

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

From Animal Models to Human Genetics

From Animal Models to Human Genetics
Author: Karsten Conrad
Publsiher: Unknown
Total Pages: 611
Release: 2004
ISBN 10: 9783899671483
ISBN 13: 3899671481
Language: EN, FR, DE, ES & NL

From Animal Models to Human Genetics Book Review:

Functional Analysis of the Human Genome

Functional Analysis of the Human Genome
Author: F. Farzaneh,D. N. Cooper
Publsiher: Garland Science
Total Pages: 256
Release: 2020-09-11
ISBN 10: 1000140962
ISBN 13: 9781000140965
Language: EN, FR, DE, ES & NL

Functional Analysis of the Human Genome Book Review:

An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures.

An Introduction to Molecular Medicine and Gene Therapy

An Introduction to Molecular Medicine and Gene Therapy
Author: Thomas F. Kresina
Publsiher: John Wiley & Sons
Total Pages: 416
Release: 2004-04-07
ISBN 10: 0471461040
ISBN 13: 9780471461043
Language: EN, FR, DE, ES & NL

An Introduction to Molecular Medicine and Gene Therapy Book Review:

Gene therapy, or the use of genetic manipulation for diseasetreatment, is derived from advances in genetics, molecular biology,clinical medicine, and human genomics. Molecular medicine, theapplication of molecular biological techniques to disease treatmentand diagnosis, is derived from the development of human organtransplantation, pharmacotherapy, and elucidation of the humangenome. An Introduction to Molecular Medicine and GeneTherapy provides a basis for interpreting new clinical andbasic research findings in the areas of cloning, gene transfer, andtargeting; the applications of genetic medicine to clinicalconditions; ethics and governmental regulations; and the burgeoningfields of genomics, biotechnology, and bioinformatics. By dividingthe material into three sections - an introduction to basicscience, a review of clinical applications, and a discussion of theevolving issues related to gene therapy and molecular medicine-thiscomprehensive manual describes the basic approaches to the broadrange of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine andGene Therapy: Covers new frontiers in gene therapy, animal models, vectors,gene targeting, and ethical/legal considerations Provides organ-based reviews of current studies in gene therapyfor monogenetic, multifactoral or polygenic disorders, andinfectious diseases Includes bold-faced terms, key concepts, summaries, and listsof helpful references by subject in each chapter Contains appendices on commercial implications and a review ofthe history of gene therapy This textbook offers a clear, concise writing style, drawingupon the expertise of the authors, all renowned researchers intheir respective specialties of molecular medicine. Researchers ingenetics and molecular medicine will all find An Introductionto Molecular Medicine and Gene Therapy to be an essentialguide to the rapidly evolving field of gene therapy and itsapplications in molecular medicine.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author: Lina Badimon,Laura Casani,Gemma Vilahur
Publsiher: Elsevier Inc. Chapters
Total Pages: 1108
Release: 2013-05-29
ISBN 10: 0128072008
ISBN 13: 9780128072004
Language: EN, FR, DE, ES & NL

Animal Models for the Study of Human Disease Book Review:

Experimental approaches to understand the pathophysiology of atherosclerosis and thrombosis involve the combination of both cellular and animal approaches. Animals have been instrumental in biomedical research in order to provide a better understanding on the mechanisms that have already been outlined in in vitro studies. Atherosclerosis studies were firstly carried out in rodents using diet-induced atherosclerosis approaches. However, these diets were un-physiological and the developed lesions were often limited in size, composition, and location largely differing from humans. During the last years, with the advent of molecular genetics and genetic manipulation techniques, the development of gene-engineered animals has allowed an explosion in the number of models resulting in a tremendous progress in the understanding of both atherosclerosis and thrombosis. However, direct translation from rodents to humans has to be taken with caution because of the well-reported species-related differences. Although there is no known animal model for human disease, large animal models have demonstrated better suitability for translation to humans. For instance swine, a species that spontaneously develops atherosclerosis and thrombosis, are more closely mimics of the macrovascular-related thrombotic complications found in humans. This book chapter provides an in depth overview of the currently available small and large animal modelsof atherosclerosis and thrombosis and examinestheir applicability for translational research purposes as well as highlights species-related differences with humans.

Scientific and Medical Aspects of Human Reproductive Cloning

Scientific and Medical Aspects of Human Reproductive Cloning
Author: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Engineering, and Public Policy
Publsiher: National Academies Press
Total Pages: 294
Release: 2002-06-17
ISBN 10: 0309076374
ISBN 13: 9780309076371
Language: EN, FR, DE, ES & NL

Scientific and Medical Aspects of Human Reproductive Cloning Book Review:

Human reproductive cloning is an assisted reproductive technology that would be carried out with the goal of creating a newborn genetically identical to another human being. It is currently the subject of much debate around the world, involving a variety of ethical, religious, societal, scientific, and medical issues. Scientific and Medical Aspects of Human Reproductive Cloning considers the scientific and medical sides of this issue, plus ethical issues that pertain to human-subjects research. Based on experience with reproductive cloning in animals, the report concludes that human reproductive cloning would be dangerous for the woman, fetus, and newborn, and is likely to fail. The study panel did not address the issue of whether human reproductive cloning, even if it were found to be medically safe, would beâ€"or would not beâ€"acceptable to individuals or society.

Targeted Genome Editing Using Site Specific Nucleases

Targeted Genome Editing Using Site Specific Nucleases
Author: Takashi Yamamoto
Publsiher: Springer
Total Pages: 205
Release: 2015-01-05
ISBN 10: 4431552278
ISBN 13: 9784431552277
Language: EN, FR, DE, ES & NL

Targeted Genome Editing Using Site Specific Nucleases Book Review:

This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

Animal Models of Human Disease

Animal Models of Human Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 550
Release: 2011-03-04
ISBN 10: 0123848792
ISBN 13: 9780123848796
Language: EN, FR, DE, ES & NL

Animal Models of Human Disease Book Review:

Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields