Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
Author: Anonim
Publsiher: Academic Press
Total Pages: 226
Release: 2019-07-30
ISBN 10: 012816574X
ISBN 13: 9780128165744
Language: EN, FR, DE, ES & NL

Cellular and Animal Models in Human Genomics Research Book Review:

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author: P. Michael Conn
Publsiher: Academic Press
Total Pages: 1108
Release: 2013-05-29
ISBN 10: 0124159125
ISBN 13: 9780124159129
Language: EN, FR, DE, ES & NL

Animal Models for the Study of Human Disease Book Review:

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine
Author: National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publsiher: National Academies Press
Total Pages: 138
Release: 2018-05-29
ISBN 10: 0309471192
ISBN 13: 9780309471190
Language: EN, FR, DE, ES & NL

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine Book Review:

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.

Advances in Animal Genomics

Advances in Animal Genomics
Author: Sukanta Mondal,Ram Lakhan Singh
Publsiher: Academic Press
Total Pages: 328
Release: 2020-11-25
ISBN 10: 0128206128
ISBN 13: 9780128206126
Language: EN, FR, DE, ES & NL

Advances in Animal Genomics Book Review:

Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches which have enabled to produce huge genomic and transcriptomic resources globally on a genome-wide scale. This book is an important resource for researchers, students, educators and professionals in agriculture, veterinary and biotechnology sciences that enables them to solve problems regarding sustainable development with the help of current innovative biotechnologies. Integrates basic and advanced concepts of animal biotechnology and presents future developments Describes current high-throughput next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches for sustainable livestock production Illustrates integrated strategies to dissect and decode the molecular and gene regulatory networks involved in complex quantitative yield and stress tolerance traits in livestock Ensures readers will gain a strong grasp of biotechnology for sustainable livestock production with its well-illustrated discussion

Functional Analysis of the Human Genome

Functional Analysis of the Human Genome
Author: F. Farzaneh,D. N. Cooper
Publsiher: Garland Science
Total Pages: 256
Release: 2020-09-11
ISBN 10: 1000140962
ISBN 13: 9781000140965
Language: EN, FR, DE, ES & NL

Functional Analysis of the Human Genome Book Review:

An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures.

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
Author: Asfar Azmi,Ramzi M. Mohammad
Publsiher: Academic Press
Total Pages: 470
Release: 2019-04-16
ISBN 10: 0128147059
ISBN 13: 9780128147054
Language: EN, FR, DE, ES & NL

Animal Models in Cancer Drug Discovery Book Review:

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Human Genome Editing

Human Genome Editing
Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publsiher: National Academies Press
Total Pages: 328
Release: 2017-08-13
ISBN 10: 0309452880
ISBN 13: 9780309452885
Language: EN, FR, DE, ES & NL

Human Genome Editing Book Review:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Animal Models in Biomedical Research

Animal Models in Biomedical Research
Author: Anonim
Publsiher: DIANE Publishing
Total Pages: 80
Release: 1993-07
ISBN 10: 9781568069241
ISBN 13: 1568069243
Language: EN, FR, DE, ES & NL

Animal Models in Biomedical Research Book Review:

Experimental Animal Models of Human Diseases

Experimental Animal Models of Human Diseases
Author: Bartholomew Ibeh
Publsiher: BoD – Books on Demand
Total Pages: 408
Release: 2018-05-23
ISBN 10: 1789231647
ISBN 13: 9781789231649
Language: EN, FR, DE, ES & NL

Experimental Animal Models of Human Diseases Book Review:

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Genomics Circuits and Pathways in Clinical Neuropsychiatry

Genomics  Circuits  and Pathways in Clinical Neuropsychiatry
Author: Thomas Lehner,Bruce L. Miller,Matthew W. State
Publsiher: Academic Press
Total Pages: 796
Release: 2016-06-07
ISBN 10: 0128005300
ISBN 13: 9780128005309
Language: EN, FR, DE, ES & NL

Genomics Circuits and Pathways in Clinical Neuropsychiatry Book Review:

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1979
ISBN 10:
ISBN 13: STANFORD:36105119623713
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Cardiovascular Disease

Cardiovascular Disease
Author: Qing Wang
Publsiher: Springer Science & Business Media
Total Pages: 400
Release: 2006
ISBN 10: 1597452130
ISBN 13: 9781597452137
Language: EN, FR, DE, ES & NL

Cardiovascular Disease Book Review:

The two volumes of Cardiovascular Disease: Methods and Protocols provide comprehensive coverage of both basic and advanced approaches to the study and characterization of cardiovascular disease. In Volume 1: Genetics and Volume 2: Molecular Medicine, highly experienced cardiovascular researchers describe in detail the most important techniques in molecular medicine that are employed in genetic, molecular, cellular, structural, and physiological studies of cardiovascular disease.

CRISPR in Animals and Animal Models

CRISPR in Animals and Animal Models
Author: Anonim
Publsiher: Academic Press
Total Pages: 148
Release: 2017-11-10
ISBN 10: 0128125071
ISBN 13: 9780128125076
Language: EN, FR, DE, ES & NL

CRISPR in Animals and Animal Models Book Review:

CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges. Accessible to students and researchers alike Written by leading authorities in the field

Leucine Rich Repeat Kinase 2 LRRK2

Leucine Rich Repeat Kinase 2  LRRK2
Author: Hardy J. Rideout
Publsiher: Springer
Total Pages: 271
Release: 2017-03-28
ISBN 10: 3319499696
ISBN 13: 9783319499697
Language: EN, FR, DE, ES & NL

Leucine Rich Repeat Kinase 2 LRRK2 Book Review:

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Mouse Models for Drug Discovery

Mouse Models for Drug Discovery
Author: Gabriele Proetzel,Michael V. Wiles
Publsiher: Humana
Total Pages: 421
Release: 2016-08-23
ISBN 10: 9781493961214
ISBN 13: 1493961217
Language: EN, FR, DE, ES & NL

Mouse Models for Drug Discovery Book Review:

As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.

Pain Genetics

Pain Genetics
Author: Inna Belfer,Luda Diatchenko
Publsiher: John Wiley & Sons
Total Pages: 204
Release: 2013-11-15
ISBN 10: 1118398858
ISBN 13: 9781118398852
Language: EN, FR, DE, ES & NL

Pain Genetics Book Review:

Pain Genetics: Basic to Translational Science is atimely synthesis of the key areas of research informing ourunderstanding of the genetic basis of pain. The book opens withfoundational information on basic genetic mechanisms underlyingpain perception and progresses recently discovered complex conceptsfacing the field. The coverage is wide-ranging and will serves asan excellent entry point into understating the genetics of pain aswell as providing a single resource for established researcherslooking for a better understanding of the diverse strands ofresearch going on in the area. With contributors painstakingly selected to provide a broad rangeof perspectives and research, Pain Genetics willbe a valuable resource for geneticists, neuroscientists, andbiomedical professionals alike.

Toxicity Testing in the 21st Century

Toxicity Testing in the 21st Century
Author: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents
Publsiher: National Academies Press
Total Pages: 216
Release: 2007-11-05
ISBN 10: 0309151732
ISBN 13: 9780309151733
Language: EN, FR, DE, ES & NL

Toxicity Testing in the 21st Century Book Review:

Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

The Human Mitochondrial Genome

The Human Mitochondrial Genome
Author: Giuseppe Gasparre,Anna Maria Porcelli
Publsiher: Academic Press
Total Pages: 596
Release: 2020-07-23
ISBN 10: 0128226420
ISBN 13: 9780128226421
Language: EN, FR, DE, ES & NL

The Human Mitochondrial Genome Book Review:

The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists

Handbook of Models for Human Aging

Handbook of Models for Human Aging
Author: P. Michael Conn
Publsiher: Academic Press
Total Pages: 1075
Release: 2006
ISBN 10: 0123693918
ISBN 13: 9780123693914
Language: EN, FR, DE, ES & NL

Handbook of Models for Human Aging Book Review:

This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. *Utilizes a multidisciplinary approach *Shows tricks and approaches not available in primary publications *First volume of its kind to combine both methods of study for human aging and animal models *Over 200 illustrations

Drosophila melanogaster

Drosophila melanogaster
Author: Farzana Khan Perveen
Publsiher: BoD – Books on Demand
Total Pages: 268
Release: 2018-02-28
ISBN 10: 9535138537
ISBN 13: 9789535138532
Language: EN, FR, DE, ES & NL

Drosophila melanogaster Book Review:

This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.