Carbonic Anhydrases As Biocatalysts

Carbonic Anhydrases As Biocatalysts
Author: Claudiu T. Supuran,Giuseppina De Simone
Publsiher: Elsevier
Total Pages: 398
Release: 2015-01-08
ISBN 10: 9780444632586
ISBN 13: 0444632581
Language: EN, FR, DE, ES & NL

Carbonic Anhydrases As Biocatalysts Book Review:

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts
Author: Claudiu T Supuran,Giuseppina De Simone
Publsiher: Elsevier
Total Pages: 398
Release: 2015-01-14
ISBN 10: 0444632638
ISBN 13: 9780444632630
Language: EN, FR, DE, ES & NL

Carbonic Anhydrases as Biocatalysts Book Review:

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic Anhydrases

Carbonic Anhydrases
Author: Claudiu Supuran,Alessio Nocentini
Publsiher: Academic Press
Total Pages: 560
Release: 2019-07-17
ISBN 10: 0128167459
ISBN 13: 9780128167458
Language: EN, FR, DE, ES & NL

Carbonic Anhydrases Book Review:

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health. Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs. Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications Describes the current biotechnological applications of CAs, including processes for CO2 capture Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology

Biocatalysis

Biocatalysis
Author: Gonzalo de Gonzalo,Pablo Domínguez de María
Publsiher: Royal Society of Chemistry
Total Pages: 511
Release: 2017-11-02
ISBN 10: 1782626190
ISBN 13: 9781782626190
Language: EN, FR, DE, ES & NL

Biocatalysis Book Review:

Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
Author: Peter Grunwald
Publsiher: CRC Press
Total Pages: 774
Release: 2019-06-27
ISBN 10: 1000020940
ISBN 13: 9781000020946
Language: EN, FR, DE, ES & NL

Pharmaceutical Biocatalysis Book Review:

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism
Author: Claudiu T. Supuran
Publsiher: MDPI
Total Pages: 184
Release: 2019-04-08
ISBN 10: 3038978000
ISBN 13: 9783038978008
Language: EN, FR, DE, ES & NL

Carbonic Anhydrases and Metabolism Book Review:

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological demands for its conversion to ionic, soluble species is very high. Inhibition of the CAs has pharmacological applications in many fields, such as antiglaucoma, anticonvulsant, antiobesity, and anticancer agents/diagnostic tools, but is also emerging for designing anti-infectives, i.e., antifungal, antibacterial, and antiprotozoan agents with a novel mechanism of action. Mitochondrial CAs are implicated in de novo lipogenesis, and thus selective inhibitors of such enzymes may be useful for the development of new antiobesity drugs. As tumor metabolism is diverse compared to that of normal cells, ultimately, relevant contributions on the role of the tumor-associated isoforms CA IX and XII in these phenomena have been published and the two isoforms have been validated as novel antitumor/antimetastatic drug targets, with antibodies and small-molecule inhibitors in various stages of clinical development. CAs also play a crucial role in other metabolic processes connected with urea biosynthesis, gluconeogenesis, and so on, since many carboxylation reactions catalyzed by acetyl-coenzyme A carboxylase or pyruvate carboxylase use bicarbonate, not CO2, as a substrate. In organisms other than mammals, e.g., plants, algae, and cyanobacteria, CAs are involved in photosynthesis, whereas in many parasites (fungi, protozoa), they are involved in the de novo synthesis of important metabolites (lipids, nucleic acids, etc.). The metabolic effects related to interference with CA activity, however, have been scarcely investigated. The present Special Issue of Metabolites aims to fill this gap by presenting the latest developments in the field of CAs and their role in metabolism.

Enzymes in Food Biotechnology

Enzymes in Food Biotechnology
Author: Mohammed Kuddus
Publsiher: Academic Press
Total Pages: 909
Release: 2018-08-23
ISBN 10: 0128132817
ISBN 13: 9780128132814
Language: EN, FR, DE, ES & NL

Enzymes in Food Biotechnology Book Review:

Enzymes in Food Biotechnology: Production, Applications, and Future Prospects presents a comprehensive review of enzyme research and the potential impact of enzymes on the food sector. This valuable reference brings together novel sources and technologies regarding enzymes in food production, food processing, food preservation, food engineering and food biotechnology that are useful for researchers, professionals and students. Discussions include the process of immobilization, thermal and operational stability, increased product specificity and specific activity, enzyme engineering, implementation of high-throughput techniques, screening to relatively unexplored environments, and the development of more efficient enzymes. Explores recent scientific research to innovate novel, global ideas for new foods and enzyme engineering Provides fundamental and advanced information on enzyme research for use in food biotechnology, including microbial, plant and animal enzymes Includes recent cutting-edge research on the pharmaceutical uses of enzymes in the food industry

Carbonic Anhydrase Mechanism Regulation Links to Disease and Industrial Applications

Carbonic Anhydrase  Mechanism  Regulation  Links to Disease  and Industrial Applications
Author: Susan C. Frost,Robert McKenna
Publsiher: Springer Science & Business Media
Total Pages: 430
Release: 2013-10-22
ISBN 10: 9400773595
ISBN 13: 9789400773592
Language: EN, FR, DE, ES & NL

Carbonic Anhydrase Mechanism Regulation Links to Disease and Industrial Applications Book Review:

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

The Carbonic Anhydrases

The Carbonic Anhydrases
Author: W.R. Chegwidden,N.D. Carter,Y.H. Edwards
Publsiher: Birkhäuser
Total Pages: 619
Release: 2013-11-11
ISBN 10: 303488446X
ISBN 13: 9783034884464
Language: EN, FR, DE, ES & NL

The Carbonic Anhydrases Book Review:

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...

Green Solvents for Organic Synthesis

Green Solvents for Organic Synthesis
Author: V. K. Ahluwalia,Ranbir S. Varma
Publsiher: Alpha Science International, Limited
Total Pages: 346
Release: 2009
ISBN 10:
ISBN 13: UOM:39015084161812
Language: EN, FR, DE, ES & NL

Green Solvents for Organic Synthesis Book Review:

Solvents play an important role in organic synthesis. Most of the common organic solvents which have been used for organic synthesis include benzene, chloroform, toluene, carbon tetrachloride etc. Most of these are volatile (VOC) and have undesirable properties like toxicity or being harmful to the environment or may be obtained from non renewable petroleum sources. This book describes some of the most important green solvents, their merits and demerits. These green solvents include water, supercritical carbon dioxide, ionic liquids, polyethylene glycol and its solutions and the Florous Phase Technique. A large number of representative synthetic applications for each of the green solvents are described.

Advances in Organic Synthesis Volume 12

Advances in Organic Synthesis  Volume 12
Author: Atta-ur-Rahman
Publsiher: Bentham Science Publishers
Total Pages: 269
Release: 2018-12-08
ISBN 10: 1681086808
ISBN 13: 9781681086804
Language: EN, FR, DE, ES & NL

Advances in Organic Synthesis Volume 12 Book Review:

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential reading for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. This volume presents the following reviews: • Stereoselective Methodologies for the Synthesis of Acyclic Polyisoprenoids • Monosubstituted Ferrocene-Containing Thermotropic Liquid Crystals • Progress in the Chemistry of Phosphorothioates • Kinetic Resolution Using Diastereoselective Acylating Agents as a Synthetic Approach to Enantiopure Amines • Advances in the Synthesis of Functional α-Organyl gem-Bisphosphonates for Biomedical Applications.

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
Author: Peter Grunwald
Publsiher: CRC Press
Total Pages: 460
Release: 2020-11-02
ISBN 10: 1000067378
ISBN 13: 9781000067378
Language: EN, FR, DE, ES & NL

Pharmaceutical Biocatalysis Book Review:

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase, related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer, β-Lactams and related compounds as antibacterials, non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases, and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy.

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
Author: Peter Grunwald
Publsiher: CRC Press
Total Pages: 774
Release: 2019-06-27
ISBN 10: 1000021289
ISBN 13: 9781000021288
Language: EN, FR, DE, ES & NL

Pharmaceutical Biocatalysis Book Review:

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Pharmaceutical Biocatalysis

Pharmaceutical Biocatalysis
Author: Peter Grunwald
Publsiher: CRC Press
Total Pages: 424
Release: 2020-11-26
ISBN 10: 1000067408
ISBN 13: 9781000067408
Language: EN, FR, DE, ES & NL

Pharmaceutical Biocatalysis Book Review:

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.

Biocatalytic Performance of Carbonic Anhydrase Immobilized Within Polyurethane Foam in Water miscible Organic Solvents

Biocatalytic Performance of Carbonic Anhydrase Immobilized Within Polyurethane Foam in Water miscible Organic Solvents
Author: İlyasa Umur Ayaz
Publsiher: Unknown
Total Pages: 146
Release: 2013
ISBN 10:
ISBN 13: OCLC:879030264
Language: EN, FR, DE, ES & NL

Biocatalytic Performance of Carbonic Anhydrase Immobilized Within Polyurethane Foam in Water miscible Organic Solvents Book Review:

The effects of water-miscible organic solvents such as acetonitrile and ethanol on the activity of free and immobilized bovine carbonic anhydrase (CA) were investigated. The CA was covalently immobilized within polyurethane (PU) foam by cross-linking. Although PU foam holds water almost 12 times of its weight, it was found that adsorption isotherm of moisture on PU foam was a Type III indicating that water and PU foam were non-interacting to each other. The activities for the free and immobilized CA were estimated using para-nitrophenyl acetate (p-NPA) as the substrate. The enzyme activities were estimated in increasing volume percents of organic solvent in Tris buffer (10-90%). p-NP, which is one of the products of the hydrolysis reaction of p-NPA, was characterized in the presence of organic solvents and it was observed that its aborptivities were decreased significantly as the organic solvent percentages were increased indicating that p-NP and the water-miscible organic solvent form a complex through mostly a hydrogen bonding. The free CA showed decreasing activity up to critical percentages of organic solvent (40-60%), and then exhibited an increasing activity. The immobilized CA showed decreasing activity in acetonitrile at percentages up to 50%, and then lost its total activity at higher acetonitrile percentages, however, the immobilized CA exhibited no activity in ethanol at percentages above 10%. Stability tests showed that the immobilized CA was dramatically inactivated in the organic solvents at percentages above 30% in shorter times. It was concluded that the water-miscible organic solvents severely perturbed the active site of the enzyme, thus denaturating the enzyme.

Industrial Biocatalysis

Industrial Biocatalysis
Author: Peter Grunwald
Publsiher: CRC Press
Total Pages: 1232
Release: 2014-12-11
ISBN 10: 9814463892
ISBN 13: 9789814463898
Language: EN, FR, DE, ES & NL

Industrial Biocatalysis Book Review:

Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.

Enzymes from Extreme Environments

Enzymes from Extreme Environments
Author: Noha M. Mesbah,Felipe Sarmiento
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2016-08-05
ISBN 10: 2889198308
ISBN 13: 9782889198306
Language: EN, FR, DE, ES & NL

Enzymes from Extreme Environments Book Review:

Enzymes are nature’s biocatalysts empowered with high catalytic power and remarkable substrate specificity. Enzymes perform a wide range of functions throughout nature, and guide the biochemistry of life with great precision. The majority of enzymes perform under conditions considered normal for mesophilic, neutrophilic, terrestrial microorganisms. However, the Earth’s biosphere contains several regions that are extreme in comparison, such as hypersaline lakes and pools, hydrothermal vents, cold oceans, dry deserts and areas exposed to intensive radiation. These areas are inhabited by a large number of extremophilic microorganisms which produce enzymes capable of functioning in unusual conditions. There is an increasing biotechnological and industrial demand for enzymes stable and functioning in harsh conditions, and over the past decade screening for, isolation and production of enzymes with unique and extreme properties has become one of the foremost areas of biotechnology research. The development of advanced molecular biology tools has facilitated the quest for production of enzymes with optimized and extreme features. These tools include large-scale screening for potential genes using metagenomics, engineering of enzymes using computational techniques and site-directed mutagenesis and molecular evolution techniques. The goal of this Research Topic is to present reports on latest advances in enzymes from all types of extreme environments. Contributions dealing with isolation of enzymes from extremophilic microorganisms or directly from natural environments, screening for and expression of enzymes with extreme properties using metagenomic approaches are welcome. In addition, contributions dealing with all forms of biocatalyst production and improvement are welcome, such as fermentation technology, protein engineering, directed evolution, rational design, and immobilization techniques.

Chemo Biological Systems for CO2 Utilization

Chemo Biological Systems for CO2 Utilization
Author: Ashok Kumar,Swati Sharma
Publsiher: CRC Press
Total Pages: 302
Release: 2020-09-21
ISBN 10: 1000174824
ISBN 13: 9781000174823
Language: EN, FR, DE, ES & NL

Chemo Biological Systems for CO2 Utilization Book Review:

Chemo-Biological Systems for CO2 Utilization describes the most recent advanced tools and techniques for carbon dioxide capture and its utilization. It discusses and compares the advantages of different systems and aids researchers and industrialists in understanding energy generation in the form of biofuels, bioelectricity, or biogas using chemicals; nanomaterials; and microbial, enzymatic, and chemo-enzymatic-integrated systems. It describes the importance and utilization of CO2 in living systems, and provides an overview of the various fundamental methods, policies, and techniques involved in CO2 conversion. Emphasis is placed on the production of value-added products using CO2, including biomethanol, industrial carbonates, and liquid or gaseous fuels. Features: Explains the correlations between microbial, biological, and chemical products and their roles in the conversion of CO2 into usable energy and related products. Being suitable for a broad audience, it addresses fundamental treatment methods for reusing environmental waste materials. Aids in decision-making and policy planning for environmental professionals. The information provided throughout this book will help researchers and professionals working in various industries to better understand the conversion of CO2 into energy-based products. Chemo-Biological Systems for CO2 Utilization also serves as a useful guide to seek alternative methods for clean energy and mitigating global climate change.

Handbook of Carbohydrate Modifying Biocatalysts

Handbook of Carbohydrate Modifying Biocatalysts
Author: Peter Grunwald
Publsiher: CRC Press
Total Pages: 1056
Release: 2016-11-25
ISBN 10: 1351733974
ISBN 13: 9781351733977
Language: EN, FR, DE, ES & NL

Handbook of Carbohydrate Modifying Biocatalysts Book Review:

This book provides an actual overview of the structure, function, and application of carbohydrate-modifying biocatalysts. Carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure. Meanwhile, the situation changed with increasing knowledge about the key role carbohydrates play in biological processes such as recognition, signal transduction, immune responses, and others. An outcome of research activities in glycoscience is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases. Furthermore, the employment of carbohydrate-modifying biocatalysts—enzymes as well as microorganisms—will contribute significantly to the development of environmentally friendly processes boosting a shift of the chemical industry from petroleum- to bio-based production of chemicals from renewable resources. The updated content of the second edition of this book has been extended by discussing the current state of the art of using recombinantly expressed carbohydrate-modifying biocatalysts and the synthesis of minicellulosomes in connection with consolidated bioprocessing of lignocellulosic material. Furthermore, a synthetic biology approach for using DAHP-dependent aldolases to catalyze asymmetric aldol reactions is presented.

Microorganisms in Environmental Management

Microorganisms in Environmental Management
Author: T. Satyanarayana,Bhavdish Narain Johri,Anil Prakash
Publsiher: Springer Science & Business Media
Total Pages: 819
Release: 2012-01-02
ISBN 10: 940072229X
ISBN 13: 9789400722293
Language: EN, FR, DE, ES & NL

Microorganisms in Environmental Management Book Review:

Microbes and their biosynthetic capabilities have been invaluable in finding solutions for several intractable problems mankind has encountered in maintaining the quality of the environment. They have, for example, been used to positive effect in human and animal health, genetic engineering, environmental protection, and municipal and industrial waste treatment. Microorganisms have enabled feasible and cost-effective responses which would have been impossible via straightforward chemical or physical engineering methods. Microbial technologies have of late been applied to a range of environmental problems, with considerable success. This survey of recent scientific progress in usefully applying microbes to both environmental management and biotechnology is informed by acknowledgement of the polluting effects on the world around us of soil erosion, the unwanted migration of sediments, chemical fertilizers and pesticides, and the improper treatment of human and animal wastes. These harmful phenomena have resulted in serious environmental and social problems around the world, problems which require us to look for solutions elsewhere than in established physical and chemical technologies. Often the answer lies in hybrid applications in which microbial methods are combined with physical and chemical ones. When we remember that these highly effective microorganisms, cultured for a variety of applications, are but a tiny fraction of those to be found in the world around us, we realize the vastness of the untapped and beneficial potential of microorganisms. At present, comprehending the diversity of hitherto uncultured microbes involves the application of metagenomics, with several novel microbial species having been discovered using culture-independent approaches. Edited by recognized leaders in the field, this penetrating assessment of our progress to date in deploying microorganisms to the advantage of environmental management and biotechnology will be widely welcomed.