Carbohydrates in Drug Discovery and Development

Carbohydrates in Drug Discovery and Development
Author: Vinod K. Tiwari
Publsiher: Elsevier
Total Pages: 714
Release: 2020-07-31
ISBN 10: 0128166762
ISBN 13: 9780128166765
Language: EN, FR, DE, ES & NL

Carbohydrates in Drug Discovery and Development Book Review:

Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.

Carbohydrate based Drug Discovery

Carbohydrate based Drug Discovery
Author: Chi-Huey Wong
Publsiher: John Wiley & Sons
Total Pages: 980
Release: 2006-03-06
ISBN 10: 3527605789
ISBN 13: 9783527605781
Language: EN, FR, DE, ES & NL

Carbohydrate based Drug Discovery Book Review:

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics

Carbohydrate Chemistry  State Of The Art And Challenges For Drug Development   An Overview On Structure  Biological Roles  Synthetic Methods And Application As Therapeutics
Author: Laura Cipolla
Publsiher: World Scientific
Total Pages: 536
Release: 2015-07-23
ISBN 10: 1783267216
ISBN 13: 9781783267217
Language: EN, FR, DE, ES & NL

Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics Book Review:

The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.

Carbohydrate based Drug Discovery 2 Volume Set

Carbohydrate based Drug Discovery  2 Volume Set
Author: Chi-Huey Wong
Publsiher: John Wiley & Sons
Total Pages: 980
Release: 2003-10-17
ISBN 10: 3527306323
ISBN 13: 9783527306329
Language: EN, FR, DE, ES & NL

Carbohydrate based Drug Discovery 2 Volume Set Book Review:

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Carbohydrates in Drug Design and Discovery

Carbohydrates in Drug Design and Discovery
Author: Jesus Jimenez-Barbero,F. Javier Canada,Sonsoles Martin-Santamaria
Publsiher: Royal Society of Chemistry
Total Pages: 320
Release: 2015-03-30
ISBN 10: 1849739994
ISBN 13: 9781849739993
Language: EN, FR, DE, ES & NL

Carbohydrates in Drug Design and Discovery Book Review:

In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.

Carbohydrate Recognition

Carbohydrate Recognition
Author: Binghe Wang,Geert-Jan Boons
Publsiher: John Wiley & Sons
Total Pages: 440
Release: 2011-09-09
ISBN 10: 9781118017579
ISBN 13: 1118017579
Language: EN, FR, DE, ES & NL

Carbohydrate Recognition Book Review:

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Carbohydrates 2018

Carbohydrates 2018
Author: Amélia Pilar Rauter,Nuno Manuel Xavier
Publsiher: MDPI
Total Pages: 172
Release: 2020-03-25
ISBN 10: 3039283162
ISBN 13: 9783039283163
Language: EN, FR, DE, ES & NL

Carbohydrates 2018 Book Review:

This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Carbohydrate Based Vaccines and Immunotherapies

Carbohydrate Based Vaccines and Immunotherapies
Author: Zhongwu Guo,Geert-Jan Boons
Publsiher: John Wiley & Sons
Total Pages: 512
Release: 2009-06-17
ISBN 10: 0470473274
ISBN 13: 9780470473276
Language: EN, FR, DE, ES & NL

Carbohydrate Based Vaccines and Immunotherapies Book Review:

The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.

Carbohydrate based Synthetic Methodology and Polymer Development

Carbohydrate based Synthetic Methodology and Polymer Development
Author: Vishwanath Venkatesh Gaitonde
Publsiher: Unknown
Total Pages: 165
Release: 2015
ISBN 10: 1928374650XXX
ISBN 13: OCLC:971624560
Language: EN, FR, DE, ES & NL

Carbohydrate based Synthetic Methodology and Polymer Development Book Review:

Carbohydrates are some of the most abundant organic molecules on earth. They are ubiquitous compounds, most commonly known for providing energy for working and are biologically stockpiled as glycogen. Modern Era advancement in disciplines of glycomics, glycobiology, and bio-renewable studies has played a pivotal role in generating robust interest in the study of carbohydrate chemistry. The advances in the field have progressed to cover an expansive range of scientific areas. For example, there is strong interest in i) developing synthetic methodology, ii) understanding reactivity, iii) performing structural studies, iv) exploring enzyme catalysis, v) biological and medical applications, as well as exploiting their use in food and polymer industries. From a biological perspective it is recognized that carbohydrates play a fundamental role in cell recognition, cell-cell interaction, cell differentiation, cell growth, survival of living cells and organisms. Synthetically, a variety of natural products and antibiotics contains carbohydrate moieties, providing a vast platform for glyco-based synthesis. In addition, biochemical inquiries over last few decades have established the association of carbohydrates with various disease conditions and identified glycan(s) as untapped tools in drug discovery. Development of the carbohydrate-based drug discovery can be categorized by one of the following approaches. i) producing native glycans with desired biological activity, ii) structural modification via glycomimetic approaches, iii) generating a glyco-scaffold for achieving carbohydrate diversity, and iv) developing glyco-fused therapeutics. The scope of work covered in this dissertation covers several carbohydrate-related areas. First, we desired to i) develop a series of ß-glycosyl amide linkages demonstrating the use of ß-glycosyl-2,4-dinitrobenzenesulfonamides as key intermediates in the chemoselective formation of these motifs, ii) produce glycosyl fluoride moieties to study their potential inhibitory activity against Mycobacterium tuberculosis (Mtb) GlgE, iii) generate oligosaccharides to study their interaction with the glucan binding site of Mtb GlgE, and iv) demonstrate the utilization of furfural (degradation product of pentose sugars from hemicellulose, bio-resource) to access a bisfuran monomer, in order to generate furan based polymeric materials. Glycosyl amide linkages are key motifs found in glycosyl amino acids, N-linked glycopeptides besides several natural products. Some of the popular strategies to access these linkages include Lansbury aspartylation involving direct coupling of glycosylamine with activated aspartic acid on protected amino acid. Alternatively, a route to access ß-glycosyl amide linkage is via Staudinger reduction-acylation or traceless Staudinger ligation of ß-glycosyl azide. This method ends up producing a mixture of a/ß glycosyl amides. 2,4-Dinitrobenzenesulfonyl chloride (dNBS-Cl) has been used to protect the primary amines producing the 2,4-dinitrobenzenesulfonamides (dNBS-NH2, dNBS). dNBS can be used to produce secondary amines and diamines as noted by Fukuyama et al. dNBS were later explored for producing amides, thioamides, ureas, and thioureas, and only very recently this strategy has been taken as a possible chemoselective approach to form peptide linkage and neoglycoconjugates. To further this chemistry in our chemoselective studies producing the ß-glycosyl amides, we explored the scope of this methodology by reacting a series of ß-dNBS glycosides with thioacetic acid. The N-glycosyl-2,4-dinitrobenzenesulfonamides were accessed via benzoyl-protected ß-glycosyl azides. The azides were i) reduced with Adams' catalyst to the corresponding amines, ii) the glycosylamines were sulfonated with 2,4-dinitrobenzenesulfonyl chloride to form N-glycosyl-2,4-dinitrobenzenesulfonamides in moderate yields, and iii) the ß-glycosyl amides were then prepared in 67 - 81 % yields by treatment of the sulfonamides with thioacetic acid and cesium carbonate. The conversion of the glycosylsulfonamide to the glycosyl amide proceeded with high stereoselectivity. A second project area involved new approaches to preapare oligosaccharide. Mtb is the causative agent of tuberculosis (TB), which is one of the leading cause of death due to an infectious disease. Designing susbtrates, inhibitors and biochemical probes to understand and overcome this disease condition is of significant interest. Mtb GlgE an a-1,4-glucan: phosphate maltosyltransferase is a genetically validated tuberculosis target. Underlining this target, we designed glycosyl fluoride derivatives, as biochemical probes to determine the active-site residues and better understand the Mtb GlgE catalytic mechanism. 5-fluoro-L-idosyl fluoride, an epimer of 5-fluoro-D-glucosyl fluoride has been synthesized over 5-steps. Starting with D-glucose a key step was photobromination at the C-5 using NBS and AIBN followed by substituting the bromide with fluoride using AgF. Mtb GlgE transfers the maltosyl units on to the elongating the a-1,4-glucan polymer. As a concurrent project we sought to access the oligosaccharide units mimicking the a-glucan polymer in the Mtb GlgE. The oligosaccharides are envisioned to be useful for probing the a-glucan binding site. During the oligosaccharide synthesis, we propose a stereoselective glycosylation strategy was pursued applying a preactivation methodology. Starting with D-maltose, the building blocks for the a-1,4-glucan oligosaccharide were accessed via a divergent synthetic route by creating the donor (4',6'-O-benzylidene-ß-maltosyl thioglycoside) and the acceptor (4'-OH-ß-maltosyl thioglycoside) substrates. During synthesis the donor is first accessed, which was further regioselectively reduced at the 4',6'-O-benzylidene to create 4'-OH (non-reducing end), generating the acceptor substrate. Glycosylation between the donor and acceptor substrate is then envisioned to proceed using a [2+2] preactivated method to build the tetrasachharide unit. This tetrasaccharide on regioselective reduction at the 4',6'-O-benzylidene creates the 4'-OH (non-reducing end), which then acts as a template to produce [4+2] hexasaccharide and/or [4+4] octasaccharide, and so on to access a-1,4-glucan oligosaccharide units of desired length. In a final area of research, carbohydrates were explored as feedstocks for polymer synthesis Starch is commonly understood as a first generation biorenewable feedstock and lignocellulose as second generation biorenewable. Lignocellulose consists of cellulose (40 -- 45 %), hemicellulose (24 -- 40 %), and lignin (18 -- 25 %). Hemicellulose consists chiefly of the pentose sugar xylose and arabinose. The degradation of these pentose sugars yields furfural. The latter is considered to be a leading candidate for bio-renewable building blocks and as a platform chemical for its application in diverse commercial sectors. In the same direction there is a substantial interest and progress in the utilization of this bio-based feedstock to fulfill the growing demands in the sector of fuel, chemical, pharmaceutical and polymer industries. As a part of our preliminary investigation, starting with commercial furfural, we have designed a four steps synthetic route to access a bisfuran diol (BFD) as a monomer feedstock to generate polymeric materials. Starting with commercial furfural i) reaction with 1,2-ethanedithiol in recyclable glycerol produced the 1,3-dithiane protected furfural in 93 % yield after distillation, ii) treatment with acetone and 50% aqueous sulfuric acid produced a dimerized Friedel Crafts product in 58% yield, iii) deprotection of the 1,3-dithiane was accomplished using selenium dioxide along with acetic acid to generate dialdehyde in 90% yield, and iv) the penultimate dialdehyde was reduced to afford the final diol, the BFD in 96 % yield. BFD was crystallized in the monoclinic space group and X-ray studies were undertaken to understand the molecular arrangement in space, hydrogen bonding and packing of the molecule. These set of data were compared with Bisphenol A (BPA, a known endocrine disruptor), and its known derivatives to predict the potential estrogenic or anti-estrogenic activities in BFD. Further, BFD was employed in polymerization studies to successfully generate bisfuran polyester (BFPE-1), a low-molecular weight novel polyester material of amorphous nature.

The Organic Chemistry of Sugars

The Organic Chemistry of Sugars
Author: Daniel E. Levy,Peter Fügedi
Publsiher: CRC Press
Total Pages: 904
Release: 2005-09-21
ISBN 10: 1420027956
ISBN 13: 9781420027952
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Sugars Book Review:

Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonst

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products
Author: Goutam Brahmachari
Publsiher: Elsevier
Total Pages: 332
Release: 2016-10-11
ISBN 10: 0128096926
ISBN 13: 9780128096925
Language: EN, FR, DE, ES & NL

Discovery and Development of Antidiabetic Agents from Natural Products Book Review:

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

The Organic Chemistry of Sugars

The Organic Chemistry of Sugars
Author: Taylor & Francis Group
Publsiher: CRC Press
Total Pages: 904
Release: 2021-06-30
ISBN 10: 9781032099903
ISBN 13: 1032099909
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Sugars Book Review:

Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonstrating the methods and strategies that apply mainstream organic chemistry to the chemical modification of sugars. The book first describes the discovery, development, and impact of carbohydrates, followed by a discussion of protecting group strategies, glycosylation techniques, and oligosaccharide syntheses. Several chapters focus on reactions that convert sugars and carbohydrates to non-carbohydrate molecules including the substitution of sugar hydroxyl groups to new groups of synthetic or biological interest, cyclitols and carbasugars, as well as endocyclic heteroatom substitutions. Subsequent chapters demonstrate the use of sugars in chiral catalysis, their roles as convenient starting materials for complex syntheses involving multiple stereogenic centers, and syntheses for monosaccharides. The final chapters focus on new and emerging technologies, including approaches to combinatorial carbohydrate chemistry, the biological importance and chemical synthesis of glycopeptides, and the medicinally significant concept of glycomimetics. Presenting the organic chemistry of sugars as a solution to many complex synthetic challenges, The Organic Chemistry of Sugars provides a comprehensive treatment of the manipulation of sugars and their importance in mainstream organic chemistry. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Carbohydrate Chemistry

Carbohydrate Chemistry
Author: Laura Cipolla
Publsiher: Unknown
Total Pages: 506
Release: 2015
ISBN 10: 9781783267194
ISBN 13: 1783267194
Language: EN, FR, DE, ES & NL

Carbohydrate Chemistry Book Review:

The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications. Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.

Carbohydrates in Drug Design and Discovery

Carbohydrates in Drug Design and Discovery
Author: Jesús Jímenez-Barbero,F. Javier Cañada,Sonsoles Martin-Santamaría
Publsiher: Royal Society of Chemistry
Total Pages: 320
Release: 2015-04-10
ISBN 10: 1849739390
ISBN 13: 9781849739399
Language: EN, FR, DE, ES & NL

Carbohydrates in Drug Design and Discovery Book Review:

In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.

Carbohydrate Drug Design

Carbohydrate Drug Design
Author: Anatoliĭ Alekseevich Klesov,Zbigniew J. Witczak,David Platt
Publsiher: Amer Chemical Society
Total Pages: 323
Release: 2006
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015064134219
Language: EN, FR, DE, ES & NL

Carbohydrate Drug Design Book Review:

It is becoming more obvious in recent years that carbohydrates present a new dimension in drug design for targeting specific diseases. Carbohydrates birthed a whole new vocabulary into chemistry, biochemistry and related disciplines -- a new language in the form of distinct characters and images providing professional chemists not in the area of carbohydrates to become familiar and knowledgeable on the topic. Carbohydrate Drug Design provides the indispensable understanding of the mutual challenge between carbohydrate-based drugs and the deadly diseases which they target. Carbohydrate Drug Design discusses pre-clinical studies and clinical trials of carbohydrate-based drugs, drug delivery and pain managements, biocompatibility, clearance and metabolic pathways of carbohydrate drugs, and actual medical devices employing carbohydrates. The invasion of cancer cells, protein-glycan interactions and their inhibitors, new carbohydrate-based therapeutics, crystal structure of antibodies with unusually high affinity for carbohydrates, and a number of other features of carbohydrate drugs are also comprehensively covered. Galactomannans and hyaluronans, as well as thio-, imino- and carba-sugars are particularly considered in respect to their structural and functional impacts.

Carbohydrates 2018

Carbohydrates 2018
Author: Nuno Manuel Xavier,Amélia Pilar Rauter
Publsiher: Unknown
Total Pages: 172
Release: 2020
ISBN 10: 9783039283170
ISBN 13: 3039283170
Language: EN, FR, DE, ES & NL

Carbohydrates 2018 Book Review:

This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer's disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Click Chemistry in Glycoscience

Click Chemistry in Glycoscience
Author: Zbigniew J. Witczak,Roman Bielski
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2013-02-04
ISBN 10: 1118526899
ISBN 13: 9781118526897
Language: EN, FR, DE, ES & NL

Click Chemistry in Glycoscience Book Review:

Lays the foundation for new methods and applications ofcarbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps ResearchInstitute in 2001, click chemistry mimics nature, givingresearchers the tools needed to generate new substances quickly andreliably by joining small units together. With contributions frommore than thirty pioneering researchers in the field, this textexplores the many promising applications of click chemistry inglycoscience. Readers will learn both the basic concepts ofcarbohydrate click chemistry as well as its many biomedicalapplications, including synthetic antigens, analogs of cell-surfacereceptors, immobilized enzymes, targeted drug delivery systems, andmultivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range ofmethodologies and strategies that have emerged from this rapidlyevolving field. Each chapter describes new approaches, ideas,consequences, and applications resulting from the introduction ofclick processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recentfindings published in the literature. Diagrams and figuresthroughout the book enable readers to more easily grasp complexconcepts and reaction processes. At the end of each chapter,references lead to the primary literature for further investigationof individual topics. The application of click chemistry to carbohydrates hastremendous implications for research. With this book as theirguide, researchers have a solid foundation from which they candevelop new methods and applications of carbohydrate clickchemistry, including new carbohydrate-based therapeutics.

Fundamentals of Medicinal Chemistry

Fundamentals of Medicinal Chemistry
Author: Gareth Thomas
Publsiher: John Wiley & Sons
Total Pages: 302
Release: 2004-04-20
ISBN 10: 0470871695
ISBN 13: 9780470871690
Language: EN, FR, DE, ES & NL

Fundamentals of Medicinal Chemistry Book Review:

Provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. The title begins by reviewing the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms. An overview of medicinal chemistry is followed by chapters covering the discovery and design of drugs, pharmacokinetics and drug metabolism, The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing the final product. The text assumes little in the way of prior biological knowledge. relevant biology is included through biological topics, examples and the Appendices. Incorporates summary sections, examples, applications and problems Each chapter contains an additional summary section and solutions to the questions are provided at the end of the text Invaluable for undergraduates studying within the chemical, pharmaceutical and life sciences.

Carbohydrate spiro heterocycles

Carbohydrate spiro heterocycles
Author: László Somsák
Publsiher: Springer Nature
Total Pages: 295
Release: 2019-10-26
ISBN 10: 3030319423
ISBN 13: 9783030319427
Language: EN, FR, DE, ES & NL

Carbohydrate spiro heterocycles Book Review:

This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring. The chapters contributed deal with methodological peculiarities of syntheses of natural and artificial sugar derived spirocycles as well as their biological applications and other utilities including marketed drugs. Carbohydrates are ubiquitous molecules in nature and participate in a vast number of biological interactions. Especially their conjugates with practically all kinds of primary and secondary metabolic small molecules (and also biomacromolecules) representing valuable tools for glycobiology research and also lead compounds for drug discovery. While monosaccharides per se appear as heterocycles, their natural conjugates frequently exhibit spiro(hetero)cyclic derivatives, in many cases of high therapeutical relevance. As a consequence, the field of carbohydrate-spiro-heterocycles attracts intense interest from both chemical and biomedical aspects therefore this volume will be of interest for synthetic and medicinal chemists and (glyco)biologists, as well as researchers involved in various biomedical fields.

Comprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III
Author: Anonim
Publsiher: Elsevier
Total Pages: 4536
Release: 2017-06-03
ISBN 10: 0128032014
ISBN 13: 9780128032015
Language: EN, FR, DE, ES & NL

Comprehensive Medicinal Chemistry III Book Review:

Comprehensive Medicinal Chemistry III provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs