Cancer Leading Proteases

Cancer Leading Proteases
Author: Satya Prakash Gupta
Publsiher: Academic Press
Total Pages: 526
Release: 2020-02-03
ISBN 10: 0128181680
ISBN 13: 9780128181683
Language: EN, FR, DE, ES & NL

Cancer Leading Proteases Book Review:

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

Pathophysiological Aspects of Proteases

Pathophysiological Aspects of Proteases
Author: Sajal Chakraborti,Naranjan S. Dhalla
Publsiher: Springer
Total Pages: 671
Release: 2017-11-15
ISBN 10: 9811061416
ISBN 13: 9789811061417
Language: EN, FR, DE, ES & NL

Pathophysiological Aspects of Proteases Book Review:

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Proteases in Physiology and Pathology

Proteases in Physiology and Pathology
Author: Sajal Chakraborti,Naranjan S. Dhalla
Publsiher: Springer
Total Pages: 619
Release: 2017-09-14
ISBN 10: 9811025134
ISBN 13: 9789811025136
Language: EN, FR, DE, ES & NL

Proteases in Physiology and Pathology Book Review:

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.

The Cancer Degradome

The Cancer Degradome
Author: Dylan Edwards,Gunilla Hoyer-Hansen,Francesco Blasi,B.F. Sloane
Publsiher: Springer Science & Business Media
Total Pages: 926
Release: 2008-09-16
ISBN 10: 0387690573
ISBN 13: 9780387690575
Language: EN, FR, DE, ES & NL

The Cancer Degradome Book Review:

This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.

Proteases in Human Diseases

Proteases in Human Diseases
Author: Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla
Publsiher: Springer
Total Pages: 513
Release: 2017-07-13
ISBN 10: 9811031622
ISBN 13: 9789811031625
Language: EN, FR, DE, ES & NL

Proteases in Human Diseases Book Review:

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Tumor Metastasis

Tumor Metastasis
Author: Ke Xu
Publsiher: Unknown
Total Pages: 266
Release: 2016-09-14
ISBN 10: 953512630X
ISBN 13: 9789535126300
Language: EN, FR, DE, ES & NL

Tumor Metastasis Book Review:

Ovarian Cancer

Ovarian Cancer
Author: Omer Devaja,Andreas Papadopoulos
Publsiher: BoD – Books on Demand
Total Pages: 364
Release: 2018-10-24
ISBN 10: 1789843332
ISBN 13: 9781789843330
Language: EN, FR, DE, ES & NL

Ovarian Cancer Book Review:

Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Urological Cancers

Urological Cancers
Author: Jonathan Waxman
Publsiher: Springer Science & Business Media
Total Pages: 342
Release: 2006-06-26
ISBN 10: 184628015X
ISBN 13: 9781846280153
Language: EN, FR, DE, ES & NL

Urological Cancers Book Review:

Encompasses all areas of urological cancers Combines clinical and molecular advances in one volume Only available book specific to the whole of urological malignancies Appeals equally to urologists and oncologists The well-known author has published over 250 research papers and eleven books on cancer and is also the founder of the "Prostate Cancer Charity"

Cysteine Proteases of Pathogenic Organisms

Cysteine Proteases of Pathogenic Organisms
Author: Mark W. Robinson,John P. Dalton
Publsiher: Springer Science & Business Media
Total Pages: 226
Release: 2011-06-10
ISBN 10: 9781441984142
ISBN 13: 1441984143
Language: EN, FR, DE, ES & NL

Cysteine Proteases of Pathogenic Organisms Book Review:

Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Thus, the biochemistry, molecular biology and structure‐function relationships of these important pathogen enzymes are covered in detail. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research.

Kallikrein related Peptidases

Kallikrein related Peptidases
Author: Viktor Magdolen,Christian P. Sommerhoff,Hans Fritz,Manfred Schmitt
Publsiher: Unknown
Total Pages: 409
Release: 2012
ISBN 10: 9783110260366
ISBN 13: 3110260360
Language: EN, FR, DE, ES & NL

Kallikrein related Peptidases Book Review:

The KLK proteins and their encoding genes are increasingly attracting attention among scientists and clinicians worldwide as they represent interesting and functionally distinct biomarkers both under physiological and pathophysiological conditions. This volume on kallikrein-related peptidases (KLKs) reviews the characterization, regulation, and interactions of these proteases within the protease web.

Prostate Cancer

Prostate Cancer
Author: Ravinder Mohan
Publsiher: BoD – Books on Demand
Total Pages: 258
Release: 2016-09-28
ISBN 10: 953512644X
ISBN 13: 9789535126447
Language: EN, FR, DE, ES & NL

Prostate Cancer Book Review:

Prostate cancer is diagnosed commonly in the course of general health screening. Very often it is difficult to tell whether the cancer will be aggressive and lethal or will be so slow growing that it will not affect the patient's survival. Treatment can have a major impact on the patient's health-related quality of life. This book presents cutting-edge research in predicting the behavior of localized and metastatic cancer, targeted treatment of cancer that has spread minimally, response to newer methods of treatment, and rehabilitation of patients.

Heparanase

Heparanase
Author: Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan
Publsiher: Springer Nature
Total Pages: 885
Release: 2020-04-09
ISBN 10: 3030345211
ISBN 13: 9783030345211
Language: EN, FR, DE, ES & NL

Heparanase Book Review:

Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Proteases and Cancer

Proteases and Cancer
Author: Santiago Cal,Alvaro J. Obaya
Publsiher: Humana
Total Pages: 352
Release: 2019-06-04
ISBN 10: 9781493985319
ISBN 13: 1493985310
Language: EN, FR, DE, ES & NL

Proteases and Cancer Book Review:

This volume explores the role of proteases in various catalytic classes and cellular processes associated with cancer. The chapters in this book cover topics such as encoding proteolytic enzymes, cleavage sites of proteases, functional catalytic domains of MMPs, zymography, angiogenesis and lymphangiogenesis, genetic and epigenetic alterations of metallopeptidases, and methods to target metalloproteinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting edge, Proteases and Cancer: Methods and Protocols is a valuable resource for clinical researchers across numerous fields such as molecular and cellular biology, oncology, biochemistry, and chemistry. This book is also useful for PhD students in the various disciples of health sciences.

Berries and Cancer Prevention

Berries and Cancer Prevention
Author: Gary D. Stoner,Navindra P. Seeram
Publsiher: Springer Science & Business Media
Total Pages: 313
Release: 2010-12-07
ISBN 10: 9781441975546
ISBN 13: 1441975543
Language: EN, FR, DE, ES & NL

Berries and Cancer Prevention Book Review:

Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes associated with cancer development. In addition, diets containing freeze-dried berries have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans.

An Integrated View of the Molecular Recognition and Toxinology

An Integrated View of the Molecular Recognition and Toxinology
Author: Gandhi Radis-Baptista
Publsiher: BoD – Books on Demand
Total Pages: 546
Release: 2013-07-01
ISBN 10: 9535111515
ISBN 13: 9789535111511
Language: EN, FR, DE, ES & NL

An Integrated View of the Molecular Recognition and Toxinology Book Review:

Molecular Toxinology has been consolidated as a scientific area focused on the intertwined description of several aspects of animal toxins. In an inquiring biotechnological world, animal toxins appear as an invaluable source for the discovery of therapeutic polypeptides. Animal toxins rely on specific chemical interactions with their partner molecule to exert their biological actions. The comprehension of how molecules interact and recognize their target is essential for the rational exploration of bioactive polypeptides as therapeutics. Investigation on the mechanism of molecular interaction and recognition offers a window of opportunity for the pharmaceutical industry and clinical medicine. Thus, this book brings examples of two interconnected themes - molecular recognition and toxinology concerning to the integration between analytical procedures and biomedical applications.

Phytochemicals

Phytochemicals
Author: Venketeshwer Rao,Leticia Rao
Publsiher: BoD – Books on Demand
Total Pages: 350
Release: 2015-09-30
ISBN 10: 9535121707
ISBN 13: 9789535121701
Language: EN, FR, DE, ES & NL

Phytochemicals Book Review:

Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.

Anticancer Drug Development

Anticancer Drug Development
Author: Bruce C. Baguley,David J. Kerr
Publsiher: Elsevier
Total Pages: 397
Release: 2001-11-17
ISBN 10: 9780080490441
ISBN 13: 0080490441
Language: EN, FR, DE, ES & NL

Anticancer Drug Development Book Review:

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Cell Surface Proteases

Cell Surface Proteases
Author: Anonim
Publsiher: Academic Press
Total Pages: 452
Release: 2003-04-16
ISBN 10: 9780121531546
ISBN 13: 0121531546
Language: EN, FR, DE, ES & NL

Cell Surface Proteases Book Review:

Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource. * Provides an overview of the entire field of cell surface proteases in a single volume * Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage

Nitric Oxide Synthase

Nitric Oxide Synthase
Author: Seyed Soheil Saeedi Saravi
Publsiher: BoD – Books on Demand
Total Pages: 248
Release: 2017-05-17
ISBN 10: 953513163X
ISBN 13: 9789535131632
Language: EN, FR, DE, ES & NL

Nitric Oxide Synthase Book Review:

Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.

Tight Junctions

Tight Junctions
Author: Marcelino Cereijido,James M. Anderson
Publsiher: CRC Press
Total Pages: 792
Release: 2001-06-26
ISBN 10: 1420038532
ISBN 13: 9781420038538
Language: EN, FR, DE, ES & NL

Tight Junctions Book Review:

As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cell and molecular biology, genetics and physiology. The field has advanced so fast and so far that it influences many areas of biology and now has practical implications for pharmacology of drug delivery and understanding a wide range of diseases altering epithelial permeability.