Cancer Leading Proteases

Cancer Leading Proteases
Author: Satya Prakash Gupta
Publsiher: Academic Press
Total Pages: 523
Release: 2020-01-09
ISBN 10: 0128181699
ISBN 13: 9780128181690
Language: EN, FR, DE, ES & NL

Cancer Leading Proteases Book Review:

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

Cancer Leading Proteases

Cancer Leading Proteases
Author: Satya Prakash Gupta
Publsiher: Academic Press
Total Pages: 526
Release: 2020-02-03
ISBN 10: 0128181680
ISBN 13: 9780128181683
Language: EN, FR, DE, ES & NL

Cancer Leading Proteases Book Review:

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples

Pathophysiological Aspects of Proteases

Pathophysiological Aspects of Proteases
Author: Sajal Chakraborti,Naranjan S. Dhalla
Publsiher: Springer
Total Pages: 671
Release: 2017-11-15
ISBN 10: 9811061416
ISBN 13: 9789811061417
Language: EN, FR, DE, ES & NL

Pathophysiological Aspects of Proteases Book Review:

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Proteases and Their Inhibitors in Cancer Metastasis

Proteases and Their Inhibitors in Cancer Metastasis
Author: J-M. Foidart,R.J. Muschel
Publsiher: Springer Science & Business Media
Total Pages: 256
Release: 2002
ISBN 10: 9781402009235
ISBN 13: 1402009232
Language: EN, FR, DE, ES & NL

Proteases and Their Inhibitors in Cancer Metastasis Book Review:

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication.

Proteases and Cancer

Proteases and Cancer
Author: Toni M. Antalis,Thomas H. Bugge
Publsiher: Humana Press
Total Pages: 221
Release: 2014-10-30
ISBN 10: 9781627039444
ISBN 13: 1627039449
Language: EN, FR, DE, ES & NL

Proteases and Cancer Book Review:

Proteases decisively contribute to cancer development and promotion by regulating the activities of growth factors/cytokines and signaling receptors, as well as the composition of the extracellular matrix, thereby suppressing cell death pathways and activating cell survival pathways. In Proteases and Cancer: Methods and Protocols, expert researchers bring together a wide range of current, complimentary techniques that have been developed for the specific detection and analysis of proteases and their activities in cancer biology. The volume covers vital topics including the application of proteomics technologies for the detection of protease expression in tumors, imaging proteases by activity profiling, proteomics technologies for the identification of biological substrates, detection of cell surface proteolysis, imaging of protease activity, the use of transgenic mice to determine protease function in tumor initiation and progression, and the development of anti-protease therapies for cancer. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Proteases and Cancer: Methods and Protocols is an ideal guide for scientists who wish to pursue the study of this important branch of cancer research and the development of unique innovative technologies to aid in that study.

The Cancer Degradome

The Cancer Degradome
Author: Dylan Edwards,Gunilla Hoyer-Hansen,Francesco Blasi,B.F. Sloane
Publsiher: Springer Science & Business Media
Total Pages: 926
Release: 2008-09-16
ISBN 10: 0387690573
ISBN 13: 9780387690575
Language: EN, FR, DE, ES & NL

The Cancer Degradome Book Review:

This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.

Urological Cancers

Urological Cancers
Author: Jonathan Waxman
Publsiher: Springer Science & Business Media
Total Pages: 342
Release: 2006-06-26
ISBN 10: 184628015X
ISBN 13: 9781846280153
Language: EN, FR, DE, ES & NL

Urological Cancers Book Review:

Encompasses all areas of urological cancers Combines clinical and molecular advances in one volume Only available book specific to the whole of urological malignancies Appeals equally to urologists and oncologists The well-known author has published over 250 research papers and eleven books on cancer and is also the founder of the "Prostate Cancer Charity"

Kallikrein related Peptidases

Kallikrein related Peptidases
Author: Viktor Magdolen
Publsiher: De Gruyter
Total Pages: 409
Release: 2012
ISBN 10: 9783110260366
ISBN 13: 3110260360
Language: EN, FR, DE, ES & NL

Kallikrein related Peptidases Book Review:

The KLK proteins and their encoding genes are increasingly attracting attention among scientists and clinicians worldwide as they represent interesting and functionally distinct biomarkers both under physiological and pathophysiological conditions. This volume on kallikrein-related peptidases (KLKs) reviews the characterization, regulation, and interactions of these proteases within the protease web.

Ovarian Cancer

Ovarian Cancer
Author: Omer Devaja,Andreas Papadopoulos
Publsiher: BoD – Books on Demand
Total Pages: 364
Release: 2018-10-24
ISBN 10: 1789843332
ISBN 13: 9781789843330
Language: EN, FR, DE, ES & NL

Ovarian Cancer Book Review:

Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Prostate Cancer

Prostate Cancer
Author: Ravinder Mohan
Publsiher: BoD – Books on Demand
Total Pages: 258
Release: 2016-09-28
ISBN 10: 953512644X
ISBN 13: 9789535126447
Language: EN, FR, DE, ES & NL

Prostate Cancer Book Review:

Prostate cancer is diagnosed commonly in the course of general health screening. Very often it is difficult to tell whether the cancer will be aggressive and lethal or will be so slow growing that it will not affect the patient's survival. Treatment can have a major impact on the patient's health-related quality of life. This book presents cutting-edge research in predicting the behavior of localized and metastatic cancer, targeted treatment of cancer that has spread minimally, response to newer methods of treatment, and rehabilitation of patients.

Proteases in Physiology and Pathology

Proteases in Physiology and Pathology
Author: Sajal Chakraborti,Naranjan S. Dhalla
Publsiher: Springer
Total Pages: 619
Release: 2017-09-14
ISBN 10: 9811025134
ISBN 13: 9789811025136
Language: EN, FR, DE, ES & NL

Proteases in Physiology and Pathology Book Review:

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.

Matrix Proteases in Health and Disease

Matrix Proteases in Health and Disease
Author: Niels Behrendt
Publsiher: John Wiley & Sons
Total Pages: 416
Release: 2012-07-10
ISBN 10: 3527329919
ISBN 13: 9783527329915
Language: EN, FR, DE, ES & NL

Matrix Proteases in Health and Disease Book Review:

Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.

Extracellular Matrix Degradation

Extracellular Matrix Degradation
Author: William C. Parks,Robert Mecham
Publsiher: Springer Science & Business Media
Total Pages: 255
Release: 2011-04-07
ISBN 10: 3642168612
ISBN 13: 9783642168611
Language: EN, FR, DE, ES & NL

Extracellular Matrix Degradation Book Review:

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Cell Death

Cell Death
Author: Tobias Ntuli
Publsiher: BoD – Books on Demand
Total Pages: 446
Release: 2015-12-16
ISBN 10: 9535122363
ISBN 13: 9789535122364
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

The Role of Force Generation in Metastatic Cancer Progression

The Role of Force Generation in Metastatic Cancer Progression
Author: Casey Marie Kraning-Rush
Publsiher: Unknown
Total Pages: 205
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:913719294
Language: EN, FR, DE, ES & NL

The Role of Force Generation in Metastatic Cancer Progression Book Review:

Metastasis, or the process by which cancer cells escape a primary tumor and travel through the body to form secondary tumors, is believed to be responsible for over 90% of the 7.9 million annual cancer-related fatalities reported worldwide. To migrate from the original tumor, cancer cells must navigate an extremely dense and heterogeneous stromal environment to arrive at a blood or lymph vessel, which they can then penetrate to enter the circulatory or lymphatic system. Each of these steps requires cells to pull on its matrix using contractile, or traction, forces. However, the precise relationship of force generation to metastatic cell structure and function remains largely unknown. Herein, I demonstrate that metastatic cells exert increased contractile forces which facilitate the invasion of the extracellular microenvironment (ECM). Using traction force microscopy, I show that human metastatic breast, prostate, and lung cancer cell lines exhibit increased traction stresses compared to non-metastatic counterparts on physiologically-relevant substrates. Additionally, I find that the increased collagen density and matrix stiffness previously shown to be a hallmark of the tumor microenvironment promote increased traction forces through cell spread area-dependent and independent mechanisms. Finally, I develop a novel 3D model for one mode of metastatic migration in which secondary cancer cells follow microtracks that are formed by leading tumor cells secreting proteases and cleaving ECM fibers. iii By using physiologically relevant 3D collagen channels to study cancer cell migration, I specifically assessed the role of force in protease-independent migration, and, surprisingly, found that contractile force was dispensable for this form of protease independent migration. Instead, my results point to focal adhesion, actin filaments, and microtubules being key mediators of protease-independent migration within patterned collagen microtracks. Ultimately, these studies help to define the role that cellular force generation plays in metastatic invasion, and also yield insight into the biophysical mechanisms that tumor cells use to migrate. These insights could potentially lead to a targeted therapeutic approach to combating those mechanisms to delay or prevent metastasis and its subsequent fatal damage. iv.

Essentials of Glycobiology

Essentials of Glycobiology
Author: Ajit Varki,Maarten J. Chrispeels
Publsiher: CSHL Press
Total Pages: 653
Release: 1999
ISBN 10: 9780879696818
ISBN 13: 0879696818
Language: EN, FR, DE, ES & NL

Essentials of Glycobiology Book Review:

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Physics of Cancer

Physics of Cancer
Author: Claudia Mierke
Publsiher: Iop Publishing Limited
Total Pages: 400
Release: 2015-09-22
ISBN 10: 9780750311359
ISBN 13: 0750311355
Language: EN, FR, DE, ES & NL

Physics of Cancer Book Review:

'Physics of Cancer' emphasizes a novel biophysical-based view on cancer disease and metastasis highlighting the functional role of mechanical properties of cells while describing the biological state of cancer. Originating in part from the author's own courses on tumor biology and cellular biophysics, this book is suitable for students and researchers in this dynamic interdisciplinary field, be they from a physical, biological or medical sciences background.

Extracellular Targeting of Cell Signaling in Cancer

Extracellular Targeting of Cell Signaling in Cancer
Author: James W. Janetka,Roseann M. Benson
Publsiher: John Wiley & Sons
Total Pages: 488
Release: 2018-05-10
ISBN 10: 1119300215
ISBN 13: 9781119300212
Language: EN, FR, DE, ES & NL

Extracellular Targeting of Cell Signaling in Cancer Book Review:

International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.

Anticancer Drug Development

Anticancer Drug Development
Author: Bruce C. Baguley,David J. Kerr
Publsiher: Elsevier
Total Pages: 397
Release: 2001-11-17
ISBN 10: 0080490441
ISBN 13: 9780080490441
Language: EN, FR, DE, ES & NL

Anticancer Drug Development Book Review:

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Functional Imaging of Cysteine Proteases in Cancer and Inflammation Using Novel Activity based Probes

Functional Imaging of Cysteine Proteases in Cancer and Inflammation Using Novel Activity based Probes
Author: Laura Elizabeth Edgington
Publsiher: Unknown
Total Pages: 135
Release: 2012
ISBN 10: 1928374650XXX
ISBN 13: OCLC:794730518
Language: EN, FR, DE, ES & NL

Functional Imaging of Cysteine Proteases in Cancer and Inflammation Using Novel Activity based Probes Book Review:

Cysteine proteases use a catalytic thiol to cleave amide bonds of protein substrates. This activity serves as an important regulatory mechanism for diverse cellular processes necessary for normal physiology. Dysregulated protease activity is a hallmark of numerous diseases, including atherosclerosis, arthritis, stroke, macular degeneration, neurodegenerative disorders, inflammatory diseases, and cancer. In the last decades, the field of activity-based proteomics has produced a number of tools for dissecting protease function. In the introductory chapter, I will discuss the current state of the field and describe the two main classes of probes for cysteine proteases: substrate-based and activity-based probes. I will then describe my own contribution to the field, which includes the design and characterization of several new and improved activity-based probes. We have applied these probes to optical imaging and biochemical characterization of three families of cysteine proteases: caspases, cathepsins and legumain. In particular, I have used these tools to aid in understanding the regulation of complex signaling pathways associated with cancer and inflammation. Caspases are key mediators of a programmed form of cell death called apoptosis. One of the key features of tumor cells is their ability to evade apoptosis, and therefore, a major therapeutic goal is to reactivate latent death pathways. We have developed fluorescent activity-based probes to image the induction of caspase activity in tumors in response to chemotherapy. In addition to non-invasive optical imaging, we have utilized these new probes to assess the kinetics of caspase activation in response to various death stimuli and identified a unique activation mechanism for the caspase-6 enzyme. Another emerging hallmark of cancer is infiltration of stromal-derived immune cells into the tumor, resulting in an inflammatory microenvironment. Crosstalk between tumor and immune cells can lead to enhanced proliferation, angiogenesis, and metastasis of tumor cells. The cysteine proteases legumain and cathepsins have been shown to play critical roles within the tumor microenvironment. I have developed new tools for optical imaging of their proteolytic activity in several cancer models as well as inflammation associated with pancreatitis. In the future, these new probes will have great value in further dissecting the roles of cysteine proteases in basic biology and disease. Since legumain and cathepsins are used as biomarkers for cancer, the ability to detect their proteolytic activity has much diagnostic and prognostic value in both pre-clinical and clinical settings. Furthermore, these new agents will be integral in validating these enzymes, particularly legumain, as drug targets.