Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy
Author: Kasuya Hideki,Itzel Bustos Villalobos
Publsiher: Academic Press
Total Pages: 250
Release: 2021-01-15
ISBN 10: 9780128229149
ISBN 13: 0128229144
Language: EN, FR, DE, ES & NL

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy Book Review:

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy discusses current treatment as well as treatment under investigation in pancreatic cancer. It brings information on how to combine current therapy with treatment under development and/or in clinical trials in order to be able to improve pancreatic cancer survival. Pancreatic cancer has a very low survival rate since it is discovered on late phase, when the patient already presents metastases and surgical options are limited. Currently, there are different modalities to treat pancreatic cancer, however its response has been poor and the toxicity of the treatment limits not only the survival rate, but also the patients that are able to get treated. This book reviews new modalities on basic research intending to reach the cure of pancreatic cancer, such as oncolytic viruses and Bi-specific T cell engager (BiTEs) as future clinical treatment, as well as discusses recent researches using those modalities as prospective combination therapy. The book is a valuable source for cancer researchers, oncologists and several members of medical and biomedical field who are interested in learning more about new therapies to treat pancreatic cancer. Reviews current situation of pancreatic cancer before discussing new modalities, so the reader gets knowledge on what it is available and on problems faced on its treatment currently Discusses oncolytic virus in pancreatic cancer use, mainly herpes and adenoviruses, the results obtained on basic research as well as in clinical trials Encompasses knowledge on Bi-specific T cell engager (BiTEs) focusing on its function, development and use on pancreatic cancer Brings information on combination therapies recently developed that allow lower dose of treatment, which means less side effect

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy
Author: Ganji Purnachandra Nagaraju, MSc, PhD
Publsiher: Academic Press
Total Pages: 200
Release: 2019-04-04
ISBN 10: 9780128176610
ISBN 13: 012817661X
Language: EN, FR, DE, ES & NL

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy Book Review:

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy, edited by Dr. Nagaraju focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy
Author: Ganji Purnachandra Nagaraju
Publsiher: Academic Press
Total Pages: 223
Release: 2019-02-26
ISBN 10: 0128176628
ISBN 13: 9780128176627
Language: EN, FR, DE, ES & NL

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy Book Review:

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Immunotherapy in Resistant Cancer From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer  From the Lab Bench Work to Its Clinical Perspectives
Author: Jorge Morales Montor,Mariana Segovia
Publsiher: Academic Press
Total Pages: 286
Release: 2020-10-01
ISBN 10: 0128220295
ISBN 13: 9780128220290
Language: EN, FR, DE, ES & NL

Immunotherapy in Resistant Cancer From the Lab Bench Work to Its Clinical Perspectives Book Review:

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy. Provides basic and clinical evidence based on molecular interactions and clinical studies to address the risks and benefits of cancer immunotherapy Presents the results of new immunotherapy trials, discussing the state-of-the-art in different types of cancer Discusses targeted therapies approved by the FDA, along with therapies with clinical potential used in basic studies

Immunotherapeutic Strategies for the Treatment of Glioma

Immunotherapeutic Strategies for the Treatment of Glioma
Author: Christopher Jackson,Michael Lim
Publsiher: Academic Press
Total Pages: 190
Release: 2021-09-10
ISBN 10: 0128197560
ISBN 13: 9780128197561
Language: EN, FR, DE, ES & NL

Immunotherapeutic Strategies for the Treatment of Glioma Book Review:

Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward. The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics. This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma. Summarizes the work in immunotherapy for glioma to-date, including the available evidence from preclinical studies and clinical trials Reviews the challenges and successes of the most promising strategies for brain tumor immunotherapy Provides a foundation for considering novel and combination therapies moving forward

Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 376
Release: 2019-10-04
ISBN 10: 0128178698
ISBN 13: 9780128178690
Language: EN, FR, DE, ES & NL

Improving the Therapeutic Ratio in Head and Neck Cancer Book Review:

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Theranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer
Author: Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publsiher: Academic Press
Total Pages: 410
Release: 2019-08-19
ISBN 10: 0128194588
ISBN 13: 9780128194584
Language: EN, FR, DE, ES & NL

Theranostic Approach for Pancreatic Cancer Book Review:

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer“/li> Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Theranostics and Precision Medicine For the Management of Hepatocellular Carcinoma Volume 3

Theranostics and Precision Medicine For the Management of Hepatocellular Carcinoma  Volume 3
Author: Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publsiher: Academic Press
Total Pages: 300
Release: 2022-05-01
ISBN 10: 0323992846
ISBN 13: 9780323992848
Language: EN, FR, DE, ES & NL

Theranostics and Precision Medicine For the Management of Hepatocellular Carcinoma Volume 3 Book Review:

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma provides comprehensive information about on-going research as well as clinical data about liver cancer. It presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. The third volume, Clinical assessment, management, and precision medicine, discusses topics such as clinical and safety assessment of HCC patients; liver transplantation as therapeutic option; immunotherapy interventions; and image-based surveillance. In addition, it discusses immunohistology of HCC-enabled precision medicine and artificial intelligence for hepatocellular carcinomas. It is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists, and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting. Provides best practices for management of hepatocellular carcinoma in the clinical setting Discusses emerging treatment approaches based on artificial intelligence and precision medicine tools and techniques Brings updated information on international clinical trials for the treatment of HCC

Cancer Immunotherapy at the Crossroads

Cancer Immunotherapy at the Crossroads
Author: James H. Finke,Ronald M. Bukowski
Publsiher: Springer Science & Business Media
Total Pages: 386
Release: 2003-11-24
ISBN 10: 1592597432
ISBN 13: 9781592597437
Language: EN, FR, DE, ES & NL

Cancer Immunotherapy at the Crossroads Book Review:

Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are outlined with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.

Role of Tyrosine Kinases in Gastrointestinal Malignancies

Role of Tyrosine Kinases in Gastrointestinal Malignancies
Author: Ganji Purnachandra Nagaraju
Publsiher: Springer
Total Pages: 241
Release: 2018-09-27
ISBN 10: 9811314861
ISBN 13: 9789811314865
Language: EN, FR, DE, ES & NL

Role of Tyrosine Kinases in Gastrointestinal Malignancies Book Review:

The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy. Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.

Immunotherapy of Cancer

Immunotherapy of Cancer
Author: Yoshiyuki Yamaguchi
Publsiher: Springer
Total Pages: 358
Release: 2016-02-22
ISBN 10: 4431550313
ISBN 13: 9784431550310
Language: EN, FR, DE, ES & NL

Immunotherapy of Cancer Book Review:

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Role of Transcription Factors in Gastrointestinal Malignancies

Role of Transcription Factors in Gastrointestinal Malignancies
Author: Ganji Purnachandra Nagaraju,Pallaval Veera Bramhachari
Publsiher: Springer
Total Pages: 517
Release: 2018-03-27
ISBN 10: 9811067287
ISBN 13: 9789811067280
Language: EN, FR, DE, ES & NL

Role of Transcription Factors in Gastrointestinal Malignancies Book Review:

This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

Novel Immunotherapeutic Approaches to the Treatment of Cancer

Novel Immunotherapeutic Approaches to the Treatment of Cancer
Author: Paul D. Rennert
Publsiher: Springer
Total Pages: 276
Release: 2016-05-30
ISBN 10: 3319298275
ISBN 13: 9783319298276
Language: EN, FR, DE, ES & NL

Novel Immunotherapeutic Approaches to the Treatment of Cancer Book Review:

Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.

Brunner Suddarth s Textbook of Medical surgical Nursing

Brunner   Suddarth s Textbook of Medical surgical Nursing
Author: Suzanne C. O'Connell Smeltzer,Brenda G. Bare,Janice L. Hinkle,Kerry H. Cheever
Publsiher: Lippincott Williams & Wilkins
Total Pages: 2240
Release: 2010
ISBN 10: 0781785898
ISBN 13: 9780781785891
Language: EN, FR, DE, ES & NL

Brunner Suddarth s Textbook of Medical surgical Nursing Book Review:

Preparing students for successful NCLEX results and strong futures as nurses in today's world. Now in its 12th edition, Brunner and Suddarth's Textbook of Medical-Surgical Nursing is designed to assist nurses in preparing for their roles and responsibilities in the medical-surgical setting and for success on the NCLEX. In the latest edition, the resource suite is complete with a robust set of premium and included ancillaries such as simulation support, adaptive testing, and a variety of digital resources helping prepare today's students for success. This leading textbook focuses on physiological, pathophysiological, and psychosocial concepts as they relate to nursing care. Brunner is known for its strong Nursing Process focus and its readability. This edition retains these strengths and incorporates enhanced visual appeal and better portability for students. Online Tutoring powered by Smarthinking--Free online tutoring, powered by Smarthinking, gives students access to expert nursing and allied health science educators whose mission, like yours, is to achieve success. Students can access live tutoring support, critiques of written work, and other valuable tools.

Regulation of Cancer Immune Checkpoints

Regulation of Cancer Immune Checkpoints
Author: Jie Xu
Publsiher: Springer Nature
Total Pages: 653
Release: 2020-03-17
ISBN 10: 9811532664
ISBN 13: 9789811532665
Language: EN, FR, DE, ES & NL

Regulation of Cancer Immune Checkpoints Book Review:

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

Cancer Research

Cancer Research
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2009-03
ISBN 10: 1928374650XXX
ISBN 13: CORNELL:31924108287321
Language: EN, FR, DE, ES & NL

Cancer Research Book Review:

Tissue Phenomics Profiling Cancer Patients for Treatment Decisions

Tissue Phenomics  Profiling Cancer Patients for Treatment Decisions
Author: Gerd Binnig,Ralf Huss,Günter Schmidt
Publsiher: CRC Press
Total Pages: 224
Release: 2018-01-29
ISBN 10: 1351134264
ISBN 13: 9781351134262
Language: EN, FR, DE, ES & NL

Tissue Phenomics Profiling Cancer Patients for Treatment Decisions Book Review:

In the age of digitization our society is transformed into a new state. In particular, machine intelligence dramatically elevates our capability to create and digest information. Naturally, healthcare is also impacted by this trend and will even be more transformed into a informatic driven discipline in the future. In the most important area of histo-pathology, the interpretation of tissue slices from cancer patients, informatics will have an early and huge impact on treatment decisions and probably will act as the leading discipline for this transformation in medicine. Tissue Phenomics provides a comprehensive methodology aiming at the discovery of the most accurate tissue-based decision support algorithm by close integration of assay development, image analysis and bioinformatics, and optimization feedback loops. In this book the methodology of Tissue Phenomics and its benefits and wealth’s are described. The different components of Tissue Phenomics are explained in the different chapters. In the chapters 2 to 4 of this book different authors describe various approaches on how to convert the wealth of tissue slide pixel data into mineable information using knowledge-based and data-driven image analysis methods. Subsequently, the datafication of images and the bioinformatics part plays a crucial role in generating prognostic and predictive models for disease progression. The integration of other data sources such as genomics, radiomics and patient related information is also important and is described as well. As discussed in chapters 5 and 6, these models may classify patients in distinct groups such as those responding to a given therapy. Since Tissue Phenomics provides a huge set of potentially prognostic features (phenes), one focus of both chapters is robust feature selection methods by advanced Monte-Carlo cross validation algorithms. In chapter 7 we discuss multiple application examples of Tissue Phenomics in academic and commercial settings and its tremendous impact to advances in biomedical sciences. Building on the successes in research, chapters 8 and 9 discuss applications in clinical environments and provide a flavor to the future envision in chapter 10, where tissue datafication and subsequent patient profiling is part of every routine examination, with the goal to best match patients with the most successful therapy, as predicted by tissue phenes.

Physics of Cancer

Physics of Cancer
Author: Claudia Mierke
Publsiher: Iop Publishing Limited
Total Pages: 400
Release: 2015-09-22
ISBN 10: 9780750311359
ISBN 13: 0750311355
Language: EN, FR, DE, ES & NL

Physics of Cancer Book Review:

'Physics of Cancer' emphasizes a novel biophysical-based view on cancer disease and metastasis highlighting the functional role of mechanical properties of cells while describing the biological state of cancer. Originating in part from the author's own courses on tumor biology and cellular biophysics, this book is suitable for students and researchers in this dynamic interdisciplinary field, be they from a physical, biological or medical sciences background.

Colon Cancer Diagnosis and Therapy

Colon Cancer Diagnosis and Therapy
Author: Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
Publsiher: Springer Nature
Total Pages: 369
Release: 2021
ISBN 10: 3030633691
ISBN 13: 9783030633691
Language: EN, FR, DE, ES & NL

Colon Cancer Diagnosis and Therapy Book Review:

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Flow Cytometry and Cell Sorting

Flow Cytometry and Cell Sorting
Author: Andreas Radbruch
Publsiher: Springer Science & Business Media
Total Pages: 355
Release: 2013-03-14
ISBN 10: 3662041294
ISBN 13: 9783662041291
Language: EN, FR, DE, ES & NL

Flow Cytometry and Cell Sorting Book Review:

The analysis and sorting of large numbers of cells with a fluorescence-activated cell sorter (FACS) was first achieved some 30 years ago. Since then, this technology has been rapidly developed and is used today in many laboratories. A Springer Lab Manual Review of the First Edition: "This is a most useful volume which will be a welcome addition for personal use and also for laboratories in a wide range of disciplines. Highly recommended." CYTOBIOS