Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy
Author: Ganji Purnachandra Nagaraju
Publsiher: Academic Press
Total Pages: 223
Release: 2019-02-26
ISBN 10: 0128176628
ISBN 13: 9780128176627
Language: EN, FR, DE, ES & NL

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy Book Review:

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

A Theranostic and Precision Medicine Approach for Female Specific Cancers

A Theranostic and Precision Medicine Approach for Female Specific Cancers
Author: Rama Rao Malla,Ganji Purnachandra Nagaraju
Publsiher: Academic Press
Total Pages: 318
Release: 2020-11-06
ISBN 10: 0128226927
ISBN 13: 9780128226926
Language: EN, FR, DE, ES & NL

A Theranostic and Precision Medicine Approach for Female Specific Cancers Book Review:

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Theranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer
Author: Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publsiher: Academic Press
Total Pages: 410
Release: 2019-08-19
ISBN 10: 0128194588
ISBN 13: 9780128194584
Language: EN, FR, DE, ES & NL

Theranostic Approach for Pancreatic Cancer Book Review:

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer“/li> Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Role of Transcription Factors in Gastrointestinal Malignancies

Role of Transcription Factors in Gastrointestinal Malignancies
Author: Ganji Purnachandra Nagaraju,Pallaval Veera Bramhachari
Publsiher: Springer
Total Pages: 513
Release: 2018-03-27
ISBN 10: 9811067287
ISBN 13: 9789811067280
Language: EN, FR, DE, ES & NL

Role of Transcription Factors in Gastrointestinal Malignancies Book Review:

This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

Special listing International Cancer Research Data Bank v 334 1980

Special listing  International Cancer Research Data Bank   v  334  1980
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1980
ISBN 10:
ISBN 13: STANFORD:24501854122
Language: EN, FR, DE, ES & NL

Special listing International Cancer Research Data Bank v 334 1980 Book Review:

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy
Author: Benjamin Bonavida
Publsiher: Springer Science & Business Media
Total Pages: 260
Release: 2013-07-04
ISBN 10: 1461470706
ISBN 13: 9781461470700
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy Book Review:

​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

Role of Nutraceuticals in Cancer Chemosensitization

Role of Nutraceuticals in Cancer Chemosensitization
Author: Anonim
Publsiher: Academic Press
Total Pages: 398
Release: 2017-10-18
ISBN 10: 0128123745
ISBN 13: 9780128123744
Language: EN, FR, DE, ES & NL

Role of Nutraceuticals in Cancer Chemosensitization Book Review:

Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations

100 Cases in Clinical Medicine Second Edition

100 Cases in Clinical Medicine  Second Edition
Author: John Rees,James Pattison,Gwyn Williams
Publsiher: CRC Press
Total Pages: 272
Release: 2011-12-09
ISBN 10: 1444166557
ISBN 13: 9781444166552
Language: EN, FR, DE, ES & NL

100 Cases in Clinical Medicine Second Edition Book Review:

100 Cases in Clinical Medicine is an indispensable revision tool for medical students preparing for clinical examinations or OSCEs. Using scenarios which mimic daily life, the cases will interest students in clinical problems and help them develop their clinical reasoning skills, with each case presenting details of a patient's medical history and the key findings of a clinical examination, together with initial investigation results for evaluation. Key questions then prompt the student to evaluate the patient, and reach a decision regarding their condition and the possible management plan, while the answer pages will help the student to understand the processes that a clinician goes through in dealing with the problems presented. Contents are organised to provide a quick review of each body system, with a selection of cases relevant to that specific system, then the majority are presented randomly to mimic real life in a GP surgery or emergency department. New to this edition: a review of each body system as well as random cases; new page design with a second colour used throughout; and brought up-to-date with 25% new cases.

Essentials of Interventional Cancer Pain Management

Essentials of Interventional Cancer Pain Management
Author: Amitabh Gulati,Vinay Puttanniah,Brian M. Bruel,William S. Rosenberg,Joseph C. Hung
Publsiher: Springer
Total Pages: 530
Release: 2018-12-28
ISBN 10: 3319996843
ISBN 13: 9783319996844
Language: EN, FR, DE, ES & NL

Essentials of Interventional Cancer Pain Management Book Review:

This text provides a comprehensive review and expertise on various interventional cancer pain procedures. The first part of the text addresses the lack of consistency seen in the literature regarding interventional treatment options for specific cancer pain syndromes. Initially, it discusses primary cancer and treatment-related cancer pain syndromes that physicians may encounter when managing cancer patients. The implementation of paradigms that can be used in treating specific groups of cancer such as breast cancer, follows. The remainder of the text delves into a more common approach to addressing interventional cancer pain medicine. After discussing interventional options that are commonly employed by physicians, the text investigates how surgeons may address some of the more severe pain syndromes, and covers the most important interventional available for our patients, intrathecal drug delivery. Chapters also cover radiologic options in targeted neurolysis and ablative techniques, specifically for bone metastasis, rehabilitation to address patients’ quality of life and function, and integrative and psychological therapies. Essentials of Interventional Cancer Pain Management globally assesses and addresses patients’ needs throughout the cancer journey. Written by experts in the field, and packed with copious tables, figures, and flow charts, this book is a must-have for pain physicians, residents, and fellows.

Oncologic Therapies

Oncologic Therapies
Author: Everett E. Vokes,Harvey M. Golomb
Publsiher: Springer Science & Business Media
Total Pages: 659
Release: 2011-06-28
ISBN 10: 3642557805
ISBN 13: 9783642557804
Language: EN, FR, DE, ES & NL

Oncologic Therapies Book Review:

This second edition has been updated in a user-friendly layout that makes its comprehensive information extremely accessible. The handbook, written for all physicians who treat cancer patients, provides a survey of current therapeutic concepts of solid tumors and hematologic malignancies in internal oncology. Each individual chapter of this shortened new edition is structured in the same way and features a brief outline or tabular summary of the main aspects of epidemiology, pathology, staging, and diagnosis. The main focus is on the therapeutic strategy, i.e., an interdisciplinary approach to systemic drug therapy. Surgical and radiological concepts of treatment are also covered, as are supportive care, pain relief methods and ethical problems. This title is a must for clinicians and practitioners as well as interns, residents and postgraduate students.

Molecular Therapies of Cancer

Molecular Therapies of Cancer
Author: Georg F. Weber
Publsiher: Springer
Total Pages: 488
Release: 2015-07-22
ISBN 10: 3319132784
ISBN 13: 9783319132785
Language: EN, FR, DE, ES & NL

Molecular Therapies of Cancer Book Review:

Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.

Progress in Cancer Immunotherapy

Progress in Cancer Immunotherapy
Author: Shuren Zhang
Publsiher: Springer
Total Pages: 283
Release: 2016-05-30
ISBN 10: 9401775559
ISBN 13: 9789401775557
Language: EN, FR, DE, ES & NL

Progress in Cancer Immunotherapy Book Review:

This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.

The Emperor of All Maladies

The Emperor of All Maladies
Author: Siddhartha Mukherjee
Publsiher: Simon and Schuster
Total Pages: 571
Release: 2011-08-09
ISBN 10: 1439170916
ISBN 13: 9781439170915
Language: EN, FR, DE, ES & NL

The Emperor of All Maladies Book Review:

An assessment of cancer addresses both the courageous battles against the disease and the misperceptions and hubris that have compromised modern understandings, providing coverage of such topics as ancient-world surgeries and the development of present-day treatments. Reprint. Best-selling winner of the Pulitzer Prize. Includes reading-group guide.

Theranostics Approaches to Gastric and Colon Cancer

Theranostics Approaches to Gastric and Colon Cancer
Author: Ganji Seeta Rama Raju,L.V.K.S. Bhaskar
Publsiher: Springer Nature
Total Pages: 250
Release: 2020-03-04
ISBN 10: 9811520178
ISBN 13: 9789811520174
Language: EN, FR, DE, ES & NL

Theranostics Approaches to Gastric and Colon Cancer Book Review:

This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.

Marijuana and the Cannabinoids

Marijuana and the Cannabinoids
Author: Mahmoud A. ElSohly
Publsiher: Springer Science & Business Media
Total Pages: 322
Release: 2007-11-15
ISBN 10: 1592599478
ISBN 13: 9781592599479
Language: EN, FR, DE, ES & NL

Marijuana and the Cannabinoids Book Review:

Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.

Approaches to Design and Synthesis of Antiparasitic Drugs

Approaches to Design and Synthesis of Antiparasitic Drugs
Author: N. Anand,S. Sharma†
Publsiher: Elsevier
Total Pages: 510
Release: 1997-07-10
ISBN 10: 9780080527529
ISBN 13: 0080527523
Language: EN, FR, DE, ES & NL

Approaches to Design and Synthesis of Antiparasitic Drugs Book Review:

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Anti cancer Drugs

Anti cancer Drugs
Author: Jasna Bankovic
Publsiher: BoD – Books on Demand
Total Pages: 196
Release: 2016-12-07
ISBN 10: 9535128132
ISBN 13: 9789535128137
Language: EN, FR, DE, ES & NL

Anti cancer Drugs Book Review:

We are in constant search for new therapeutic options to cure cancer. In this book, you can find out how scientists throughout the world deal with this problem. Readers will learn how to engage nature, chemical synthesis, and cell machinery to design new anticancer agents. Nature has already been very generous in providing us different compounds which are in widespread application. Starting from these resources, various synthetic processes are applied to create synthetic drugs which can be then obtained in large quantities. Also, the cell by itself provides different possibilities to meet the constantly increasing requirements for successful therapy. Explore the book and find out what are the new ways to fight cancer.

Nanocarriers for Cancer Diagnosis and Targeted Chemotherapy

Nanocarriers for Cancer Diagnosis and Targeted Chemotherapy
Author: Muhammad Raza Shah,Muhammad Imran,Shafi Ullah
Publsiher: Elsevier
Total Pages: 310
Release: 2019-07-13
ISBN 10: 0128163119
ISBN 13: 9780128163115
Language: EN, FR, DE, ES & NL

Nanocarriers for Cancer Diagnosis and Targeted Chemotherapy Book Review:

Nanocarriers for Cancer Diagnosis and Targeted Chemotherapy reviews the principles and applications of nanocarriers for targeted drug delivery. Drug targeting involves active and passive strategies that exploit both the use of ligands for interactions and the physical and chemical properties of nanocarriers and micro-environments at target sites. Multidrug resistance and adverse side effects associated with anticancer drugs have attracted greater scientific attention and led formulation scientists to specifically target these drugs to target sites. Nanocarriers like liposomes, niosomes, gold nanorods, carbon nanotubes, and micelles are discussed for the delivery of drugs to specific disease sites. This is an important reference source for researchers in the biomedical and biomaterials fields who want to gain an understanding on how nanotechnology is used for earlier diagnoses and more effective cancer treatment. Explores the fundamental principles of drug targeting through different nano-carriers, highlighting major applications Shows how the use of nanocarriers is leading to quicker cancer diagnosis and more effective treatment Discusses the major challenges of using nanocarriers for drug delivery and assesses how to overcome these barriers

Preoperative Neoadjuvant Chemotherapy

Preoperative  Neoadjuvant  Chemotherapy
Author: Joseph Ragaz,Pierre R. Band,James H. Goldie
Publsiher: Springer Science & Business Media
Total Pages: 162
Release: 2012-12-06
ISBN 10: 3642826717
ISBN 13: 9783642826719
Language: EN, FR, DE, ES & NL

Preoperative Neoadjuvant Chemotherapy Book Review:

Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.

Immune Response Activation

Immune Response Activation
Author: Guy Huynh Thien Duc
Publsiher: BoD – Books on Demand
Total Pages: 276
Release: 2014-05-29
ISBN 10: 9535113747
ISBN 13: 9789535113744
Language: EN, FR, DE, ES & NL

Immune Response Activation Book Review:

The book Immune Response Activation is aiming to analyse the multifaceted aspects of the immune response, treating a number of representative cases in which the immune response is, on one hand, activated against pathogens, and, on the other hand, involved in pathologic settings, leading to allograft rejection, allergy and autoimmunity. The regulatory mechanisms in which the immune response can be modulated for rendering its effector components more efficient and/or not harmful to the organism is also dissected in translational purposes in cancer immunotherapy, local immunity against bacteria and viruses, as well as in allergy and autoimmunity.