Botulinum Toxin

Botulinum Toxin in Clinical Dermatology explores botulinum toxin, from its early recognition as a food borne toxin to its current form as a pharmaceutical injectible. This high quality, well-illustrated, practical manual presents the latest on the clinical use of the different types of botulinum toxins available and presents in a clear and concise way all the pertinent and up-to-date information on how to inject botulinum toxin and avoid complications. Packed with clinical photographs and scientific drawings, each chapter addresses a different aspect of the topic. This is the most comprehensive and authoritative reference for cosmetic injections of botulinum toxin for removal of facial and neck wrinkles.

This book surveys the use of botulinum toxin A in aesthetic medicine, including patient selection and evaluation, as well as rules and requirements. A section with tips and tricks makes this an invaluable resource for practicing dermatologists and plastic surgeons.

This volume outlines and examines current understanding of botulinum toxin and its various therapeutic applications. It presents therapeutic uses across a variety of medical subspecialties and patient populations. Each chapter focuses on a particular symptom and explains how botulinum toxin is currently used for treatment. Coverage also examines questions of immunity and explores economic issues. Written by leaders in their fields respected for their progressive approach to treatment, the book encourages responsible research into new and novel uses of botulinum toxin.

In this publication a comprehensive overview on the pathophysiology and treatment of hyperhidrosis with a focus on the new therapy with botulinum toxin is given by renowned experts from Europe and the USA. In the first part the pathophysiology of hyperhidrosis, rare forms of sweating and their symptoms, as well as the different topical and surgical treatments for focal hyperhidrosis are discussed. The second part deals with botulinum toxin. Besides a historic survey of the drug the reader is introduced to the pharmacological particularities and the different modalities of treatment for focal hyperhidrosis. Complications and side effects of the therapy are presented as well. The final chapter is reserved for other dermatological indications like anal fissure and wrinkles.

The exceptionally successful history of botulinum toxin and its likely future has hardly an equivalent. Initially, it was used in strabismus, blepharospasm and hemifacial spasm, later also in focal dystonia and spasticity and it has been shown to effectively treat wrinkles, hyperhidrosis and a great number of ensuing indications. By treating symptoms or disorders associated with pain, its analgesic effect was first noticed. The efficacy and reasons for this side effect have since been investigated and a number of models explaining the mode of action have been presented. However, even if we know that botulinum toxin undoubtedly helps in certain pain syndromes, there is still much work to do to identify the major ones, define the optimum dose and the preferred site of injection. Indicating current positions and kindling the growing interest in this extraordinary therapeutic agent this book presents a timely overview on pain management with botulinum toxin. Thus, it will be of great interest especially for anesthesiologists and neurologists in their clinical work and medical research.

Botulinum toxins now play a very significant role in the management of a wide variety of medical conditions; from headaches to hypersalivation, and from spasticity to sweating. In this book, a strong, international team of experts outline the basic neurochemistry of botulinum toxins and chart the progress of the drug from laboratory to clinic. Then individual chapters summarize their use for the main clinical indications in the context of other available treatments. This book will be of interest to neuroscientists and practising clinicians working in a wide range of specialities, from neurology and dermatology to pediatrics, plastic surgery and rehabilitation medicine.

The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you’ll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.

This title in the PROCEDURES IN COSMETIC DERMATOLOGY SERIES presents up-to-the-minute, practical guidance on botulinum toxin injection techniques shaping today's practice. Succinctly written and lavishly illustrated, it focuses on procedural how-to's and offers step-by-step advice on proper techniques, pitfalls, and tricks of the trade—so you can refine and hone your skills...and expand your surgical repertoire. You'll find current, to-the-point guidance on the cosmetic use of the toxin — edited by pioneers in the field, Drs. Jean and Alastair Carruthers. Implement the newest procedures into your practice immediately and confidently—with the outstanding guidance you'll find in this volume of the PROCEDURES IN COSMETIC DERMATOLOGY SERIES. Covers the hottest topics—including botox aesthetics, facial treatments, neck treatment, adjunctive treatment, pain relief, and facial asymmetry—all in one concise, accessible volume. Features a wealth of color illustrations and photographs that depict cases as they present in practice. Discusses common pitfalls and emphasizes how to optimize outcomes, enabling readers to improve their technique. Highlights emerging topics in the field, with guidance on the newest developments in cosmetic surgery. Includes a comprehensive, instructional DVD containing video clips of techniques and procedures as well as the experts' hints and tips. Use of fillers in combination with Botox to better sculpt the lower face Coverage of new fillers like Juvederm, Evolence, Radiesse and Perlane to keep you on the cutting edge New and expanded coverage of periocular treatment Highest quality video footage of procedures on the bonus DVD

Provides practical guidance on the use of botulinum toxin in a wide variety of disorders, in many areas of medicine. Using clear line drawings, it describes the relevant injection sites for each condition and gives comparative dosage tables for the various formulations of toxin used in different muscle groups.

Even those clinicians who feel themselves far from aesthetic dermatology now recognise that BoNT-A is an extraordinary tool in their therapeutic armamentarium for treating complex disorders such as focal idiopathic hyperhidrosis. This has opened a therapeutic scenario for a group of patients very difficult to treat previously. Since the introduction of BoNT-A in the dermatological therapeutic armamentarium, in 1990, things have changed to the point that any dermatologist should now have knowledge of BoNT-A basics, and the practicalities of BoNT-A vial reconstitution and injection. Moreover, in the last years, a widespread availability of multiple different commercially available forms of BoNT-A has been for sale, thus the clinicians must now really know and consider the advantages and disadvantages of the different available products. These would include dosing/duration, immunogenicity, and spread of effect. What has not changed over the years is the safety profile of BoNT-A. The knowledge regarding its side effects and complications have greatly increased, confirming that, despite the attempts of some individuals to assert otherwise, BoNT-A remains one of the safest forms of treatment available to us as physicians. This edited collection provides a comprehensive practical guide on the use of botulinum toxin in several dermatological disorders, including focal idiopathic, axillary, palmar and plantar, craniofacial or segmental hyperhidrosis, chrono-aging, hidradenitis, and gives some suggestion on the use of BoNT-A for the treatment of several orphan skin diseases, not responding to conventional treatments like benign Hailey-Hiley disease, lichen simplex, osmidrosis. Using clear explanations, simple line drawings, diagrams and clinical pictures, it provides suggestions to improve practical knowledge on the use of BTX-A in dermatology. Hot topics include practical information for clinicians regarding the correct counselling of the patients to be treated; methods and ready to use tests to select patients to be treated; the optimal dosage and dilution according to the site of injection and the indication of use; the relevant injection sites for each condition; the correct technique of injection in the different areas of body surface; comparative dosage tables for the various formulations of toxin used; how to manage and prevent side effects related to the use of BoNT-A; common pitfalls and how to optimize outcomes; timing for the follow-up of treated patients. The authors hope that this book may be a starting point for the use of a drug that is still growing, and a useful tool for those clinicians who want to improve their knowledge about the use of BoNT-A in dermatology.

Bladder injection of onabotulinumtoxinA for the treatment of urinary incontinence due to neurogenic detrusor overactivity has recently been approved by regulatory agencies in several EU countries and by the FDA in the United States. This is the first book to focus on the practical application of botulinum toxin (BoNT) in the genitourinary tract. It covers in detail applications of BoNT in the bladder and the prostate and pelvic floor, with reviews of the latest clinical series and techniques in both adults and children. Appendices containing easy-to-read instructions for patients undergoing bladder and prostate BoNT injections are included, in addition to procedural guidelines for nursing staff. The book is written in a concise, clinically relevant style by two leading pioneers in the field, who were the first to undertake comprehensive basic research into the mechanisms underlying the efficacy and potential uses of BoNT within the lower urinary tract.

This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 14 pain categories with an evidence based literature review on each pain disorder, illustrative figures along with brief video clips showing the techniques and patient interviews. Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories. Botulinum Toxin Treatment of Pain Disorders will prove an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.

A Practical Guide to Botulinum Toxin Procedures is one of four books in the new Cosmetic Procedures for Primary Care series. This series offers guidance to primary care practitioners who wish to expand their practice to minimally invasive cosmetic procedures. Whether the physician is just getting started or well versed in aesthetic medicine, this series can be used as a routine quick reference for current aesthetic procedures that can be readily incorporated into office practice. The series will put these cosmetic treatments into the hands of the physician the patient knows and trusts the most, and will bring primary care practitioners increased autonomy, improved patient satisfaction, and added reimbursement. This book provides thoroughly illustrated step-by-step instructions on botulinum toxin injection procedures and advice on managing common issues seen in follow-up visits. Each chapter focuses on a single procedure and reviews all relevant anatomy, including target muscles and their functions and muscles to be avoided. Injection points and the injection Safety Zones are highlighted to help practitioners perform the procedures more effectively and minimize complication risks. Initial chapters cover treatment in the upper third of the face for frown lines, horizontal forehead lines, and crow's feet—procedures suited for practitioners who are getting started with cosmetic botulinum toxin treatments. Subsequent chapters cover more advanced face and neck procedures and treatment of axillary hyperhidrosis.

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

BOTULINUM TOXIN - The complete guide Reverse the effects of aging and achieve the cosmetic effects that clients are seeking. With this superficial muscles Botulinum Toxin injections training book, you can offer

Presents up-to-the-minute, practical guidance on the cosmetic and medical uses of botulinum toxin. Succinctly written and lavishly illustrated, this resource focuses on the how to's of botox injection and offers step-by-step guidance on proper techniques, pitfalls, and tricks of the trade. An accompanying DVD shows clips of key techniques so readers can implement the newest procedures into their practice immediately.

Botulinum Toxins—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built Botulinum Toxins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Botulinum Toxins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Highlights: BTX-A could retrograde axonal transport to the dorsal horn after peripheral application. BTX-A could decrease the expression and function of AMPA receptor in dorsal horn neurons. Pretreatment with BTX-A decrease formalin-evoked release of glutamate in dorsal horn neurons. Abstract: The use of botulinum toxin A (BTX-A) for various clinical therapeutic applications is increasing. It is widely believed that peripheral therapeutic or toxic effects of BTX-A are exclusively mediated by SNAP-25 cleavage. There is growing evidence of long-distance retrograde axonal transport of BTX-A on entering the central nervous system, subsequent to a local injection of the toxin. However, the prevalence of central antinociceptive effects after BTX-A peripheral application and its underlying mechanisms are unclear. Our results show that (1) BTX-A can undergo retrograde axonal transport to the dorsal horn after peripheral application; (2) Peripheral pretreatment with BTX-A decreases the expression and function of AMPA receptors in the spinal cord dorsal horn neurons; (3) Peripheral pretreatment with BTX-A does not change basal glutamate release, but decreases the effect of formalin-evoked release of glutamate in spinal cord dorsal horn neurons. These results suggest that peripheral application of BTX-A can change AMPA receptor expression in, and glutamate release from, spinal dorsal horn neurons, which may have significance in its central antinociceptive effects.