Botulinum Neurotoxins

Botulinum Neurotoxins
Author: Andreas Rummel,Thomas Binz
Publsiher: Springer Science & Business Media
Total Pages: 324
Release: 2012-12-14
ISBN 10: 3642335705
ISBN 13: 9783642335709
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxins Book Review:

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Clinical Applications of Botulinum Neurotoxin

Clinical Applications of Botulinum Neurotoxin
Author: Keith A. Foster
Publsiher: Springer
Total Pages: 196
Release: 2014-07-08
ISBN 10: 149390261X
ISBN 13: 9781493902613
Language: EN, FR, DE, ES & NL

Clinical Applications of Botulinum Neurotoxin Book Review:

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxin and Tetanus Toxin

Botulinum Neurotoxin and Tetanus Toxin
Author: Lance Simpson
Publsiher: Elsevier
Total Pages: 436
Release: 2012-12-02
ISBN 10: 0323141609
ISBN 13: 9780323141604
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin and Tetanus Toxin Book Review:

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

Botulinum Neurotoxin Complex

Botulinum Neurotoxin Complex
Author: Jiarong Flora Chen
Publsiher: Unknown
Total Pages: 300
Release: 1998
ISBN 10:
ISBN 13: UCAL:C3409179
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin Complex Book Review:

Botulinum Neurotoxins for Head and Neck Disorders

Botulinum Neurotoxins for Head and Neck Disorders
Author: Andrew Blitzer,Brian E. Benson,Joel Guss
Publsiher: Thieme
Total Pages: 248
Release: 2012-03-28
ISBN 10: 1604065869
ISBN 13: 9781604065862
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxins for Head and Neck Disorders Book Review:

Learn expert injection techniques with this multimedia reference guide to the therapeutic uses of botulinum neurotoxin Containing detailed injection instructions, Botulinum Neurotoxin for Head and Neck Disorders and the associated how-to videos offer otolaryngologists, neurologists, pain specialists, and others a complete guide to the management of motor, sensory and autonomic disorders of the head and neck region with botulinum neurotoxin. It covers treatment methods for conditions ranging from hyperfunctional motor disorders (dystonia, tremor, dysphagia), to afferent pain disorders (temporomandibular joint disorder, migraine, trigeminal neuralgia) to autonomic disorders (hypersalivation, Frey's syndrome). In each of the indications, the written material reviews the effects of the toxin on the nervous system, central pain thresholds, and central motor pathways. Special Features: Reviews the pharmacology, indications, mechanisms of action, and technique for each use of botulinum neurotoxin Provides detailed information on the anatomy, treatment methods, follow-up care, and possible complications for each disorder Includes online access to professionally produced videos in which Dr. Blitzer demonstrates injection techniques for the disorders in the book Contains vivid, full color illustrations and photographs that clarify information in the text Focusing specifically on injection techniques for the therapeutic uses of botulinum neurotoxin for treating head and neck disorders, this manual fills an important gap in the literature. It gives clinicians current, authoritative, and in-depth information on administering botulinum neurotoxin most effectively for the head and neck disorders of their patients.

Design and Assay of Inhibitors of Botulinum Neurotoxin Serotypes A and B

Design and Assay of Inhibitors of Botulinum Neurotoxin Serotypes A and B
Author: Chanokporn Sukopan
Publsiher: Unknown
Total Pages: 312
Release: 2002
ISBN 10:
ISBN 13: WISC:89084449289
Language: EN, FR, DE, ES & NL

Design and Assay of Inhibitors of Botulinum Neurotoxin Serotypes A and B Book Review:

Mechanism of Botulinum Neurotoxin B Entry Into Cells and Novel Ways to Detect Botulinum Neurotoxin Activity

Mechanism of Botulinum Neurotoxin B Entry Into Cells and Novel Ways to Detect Botulinum Neurotoxin Activity
Author: Min Dong
Publsiher: Unknown
Total Pages: 192
Release: 2004
ISBN 10:
ISBN 13: WISC:89090640707
Language: EN, FR, DE, ES & NL

Mechanism of Botulinum Neurotoxin B Entry Into Cells and Novel Ways to Detect Botulinum Neurotoxin Activity Book Review:

Cumulated Index Medicus

Cumulated Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1999
ISBN 10:
ISBN 13: UIUC:30112048174681
Language: EN, FR, DE, ES & NL

Cumulated Index Medicus Book Review:

Index Medicus

Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2004
ISBN 10:
ISBN 13: OSU:32436011091889
Language: EN, FR, DE, ES & NL

Index Medicus Book Review:

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree
Author: Sherly Bellevue
Publsiher: Unknown
Total Pages: 102
Release: 2007
ISBN 10:
ISBN 13: WISC:89095899480
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree Book Review:

Botulinum Toxin Treatment

Botulinum Toxin Treatment
Author: Bahman Jabbari
Publsiher: Springer
Total Pages: 217
Release: 2018-11-13
ISBN 10: 3319999451
ISBN 13: 9783319999456
Language: EN, FR, DE, ES & NL

Botulinum Toxin Treatment Book Review:

Very few therapeutic agents in clinical medicine have found indication for so many clinical conditions, and in such a short time as did botulinum neurotoxins (Botox and others). Chronic migraine, bladder dysfunction , dystonia, hemifacial spasm , blepharospasm , drooling, excessive sweating and spasticity are all approved by FDA and many other indications are in the near horizon . The aesthetic/cosmetic use of Botox and other BoNTs already has a huge market worldwide. Stroke, Multiple sclerosis, Parkinson’s disease, Cerebral palsy as well as brain and spinal injury are among clinical conditions in which some of patients’ major symptoms can respond to botulinum toxin therapy Several books have been written on the subject of Botox and other neurotoxins for treatment of medical disorders ( including two books by Jabbari both published by Springer 2015 & 2017). However, despite the huge interest and enthusiasm of the public to learn more about Botox and other toxins, there is currently no book in the market on this subject which is specifically designed to inform and educate the public on botulinum toxin therapy. Botulinum Toxin Treatment explains and discusses in simple language the structure and function of botulinum toxin and other neurotoxins as well as the rational for its utility in different disease conditions. Safety, factors affecting efficacy and duration of action, as well as cost and insurance issues are also addressed.

Synthesis of Mechanism based Inhibitors of Botulinum Neurotoxin Serotypes A and B

Synthesis of Mechanism based Inhibitors of Botulinum Neurotoxin Serotypes A and B
Author: Matthias Brewer
Publsiher: Unknown
Total Pages: 255
Release: 2002
ISBN 10:
ISBN 13: WISC:89084036656
Language: EN, FR, DE, ES & NL

Synthesis of Mechanism based Inhibitors of Botulinum Neurotoxin Serotypes A and B Book Review:

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use
Author: Michael Charles Goodnough
Publsiher: Unknown
Total Pages: 424
Release: 1994
ISBN 10:
ISBN 13: WISC:89052289881
Language: EN, FR, DE, ES & NL

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use Book Review:

Botulinum Toxin E Book

Botulinum Toxin E Book
Author: Joseph Jankovic,Alberto Albanese,M. Zouhair Atassi,J. Oliver Dolly,Mark Hallett,Nathaniel H. Mayer
Publsiher: Elsevier Health Sciences
Total Pages: 512
Release: 2009-02-18
ISBN 10: 1437711197
ISBN 13: 9781437711196
Language: EN, FR, DE, ES & NL

Botulinum Toxin E Book Book Review:

The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you’ll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.

A Biophysical Characterization of Botulinum Toxin and Cholera Toxin

A Biophysical Characterization of Botulinum Toxin and Cholera Toxin
Author: Geoffrey Matthew Kuziemko
Publsiher: Unknown
Total Pages: 298
Release: 1997
ISBN 10:
ISBN 13: UCAL:C3407549
Language: EN, FR, DE, ES & NL

A Biophysical Characterization of Botulinum Toxin and Cholera Toxin Book Review:

Botulinum Toxin Therapy Manual for Dystonia and Spasticity

Botulinum Toxin Therapy Manual for Dystonia and Spasticity
Author: Raymond Rosales,Dirk Dressler
Publsiher: Unknown
Total Pages: 182
Release: 2016-12-28
ISBN 10: 9535128515
ISBN 13: 9789535128519
Language: EN, FR, DE, ES & NL

Botulinum Toxin Therapy Manual for Dystonia and Spasticity Book Review:

Botulinum Neurotoxin Injection Manual

Botulinum Neurotoxin Injection Manual
Author: Katharine E. Alter, MD,Nicole A. Wilson, PhD, MD
Publsiher: Demos Medical Publishing
Total Pages: 110
Release: 2014-12-15
ISBN 10: 1617052094
ISBN 13: 9781617052095
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin Injection Manual Book Review:

The Essential Guide for Clinicians Who Prescribe and Inject BoNTs This is a detailed and practical guide to botulinum neurotoxin therapy (BoNT) and the wide range of applications for neurological and pain disorders. A unique reference source for new injectors and experienced clinicians alike, this indispensable manual provides information on dose, dilution, and indications for all four FDA-approved toxins in one handy text. Following a brief review of relevant pharmacology, the book provides product information and comparative distinctions between the four FDA-approved toxins (BotoxÆ, MyoblocÆ, XeominÆ, and DysportÆ), along with indications and doses for FDA-approved conditions, guidance techniques, and common and emerging clinical applications. The heart of the book is an injection manual, organized anatomically and by condition and covering all applications for medical treatment. For each condition or site, information is provided on typical muscle pattern or muscle groups involved, dosing guidelines and dilution for the applicable toxins, number of injection sites, and potential risks and benefits. Targeting techniques are organized in table format for quick retrieval. Anatomic illustrations and cross-sections are provided to orient injectors and help identify optimal insertion points. An appendix with useful clinical rating scales is also included. Key Features: Presents state-of-the-art information about current indications for all four FDA-approved botulinum neurotoxins Compares and contrasts the four toxins along with common and emerging clinical applications Provides dosing guidelines for various indications and injection sites for each muscle Includes anatomic drawings and cross-sections to illustrate muscle relationships and insertion points Serves as a practical, portable, how-to guide for new and experienced clinicians

Botulinum Toxin Therapy

Botulinum Toxin Therapy
Author: Scott M. Whitcup,Mark Hallett
Publsiher: Springer Nature
Total Pages: 289
Release: 2021-01-05
ISBN 10: 303066306X
ISBN 13: 9783030663063
Language: EN, FR, DE, ES & NL

Botulinum Toxin Therapy Book Review:

In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use and the development of novel therapeutic toxins for the future. Part 2 reviews the use of botulinum toxins in clinical practice. It discusses the clinical pharmacology of botulinum toxin drugs and their use in a wide variety of clinical conditions including headache, spasticity, pain, disorders of the genitourinary and gastrointestinal tract, strabismus, and medical aesthetics.

Molecular Aspects of Botulinum Neurotoxin

Molecular Aspects of Botulinum Neurotoxin
Author: Keith A. Foster
Publsiher: Springer
Total Pages: 345
Release: 2014-07-08
ISBN 10: 1461494540
ISBN 13: 9781461494546
Language: EN, FR, DE, ES & NL

Molecular Aspects of Botulinum Neurotoxin Book Review:

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Clinical Applications of Botulinum Neurotoxin

Clinical Applications of Botulinum Neurotoxin
Author: Keith A. Foster
Publsiher: Springer
Total Pages: 196
Release: 2014-07-08
ISBN 10: 149390261X
ISBN 13: 9781493902613
Language: EN, FR, DE, ES & NL

Clinical Applications of Botulinum Neurotoxin Book Review:

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.