Analysis of Type A Botulinum Neurotoxin Expression in Clostridium Botulinum

Analysis of Type A Botulinum Neurotoxin Expression in Clostridium Botulinum
Author: Sean S. Dineen
Publsiher: Anonim
Total Pages: 142
Release: 2003
ISBN 10:
ISBN 13: WISC:89091046367
Language: EN, FR, DE, ES & NL

Analysis of Type A Botulinum Neurotoxin Expression in Clostridium Botulinum Book Review:

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree
Author: Sherly Bellevue
Publsiher: Anonim
Total Pages: 102
Release: 2007
ISBN 10:
ISBN 13: WISC:89095899480
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin Production by Clostridium Botulinum Strain Loch Maree Book Review:

Botulinum Neurotoxins and Nervous System

Botulinum Neurotoxins and Nervous System
Author: Siro Luvisetto
Publsiher: MDPI
Total Pages: 368
Release: 2020-11-06
ISBN 10: 303943456X
ISBN 13: 9783039434565
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxins and Nervous System Book Review:

This book collects 25 scientific articles from laboratories around the world, all of which use botulinum neurotoxins as the main protagonists of their studies. The use of botulinum neurotoxin in medicine, following its ability to inhibit the effects of various disorders of different etiology on the human organism, constitutes the main topic of each article presented here. This book, which is aimed at both students and medical professionals, attempts to summarize current knowledge about the use of botulinum toxin as a therapeutic agent in many diseases, ranging from spasticity to tremor, form motor dysfunction after stroke to neuropathic pain, from hyperactive muscle to migraine, and so on. Thanks to its simplified writing, accessible to an audience who may not be familiar with the mysteries of science, readers will get new insights into this biological toxin and its multiple applications, not simply relegated to its historical use to correct of face wrinkles. Both review and research articles are presented, not only concerning animal studies, but also clinical reports. This book will provide an up-to-date picture of the state-of-the-art of the possible development of novel applications of botulinum neurotoxins for future therapeutic purposes.

Botulinum Neurotoxin Injection Manual

Botulinum Neurotoxin Injection Manual
Author: Katharine E. Alter, MD,Nicole A. Wilson, PhD, MD
Publsiher: Demos Medical Publishing
Total Pages: 110
Release: 2014-12-15
ISBN 10: 1617052094
ISBN 13: 9781617052095
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin Injection Manual Book Review:

The Essential Guide for Clinicians Who Prescribe and Inject BoNTs This is a detailed and practical guide to botulinum neurotoxin therapy (BoNT) and the wide range of applications for neurological and pain disorders. A unique reference source for new injectors and experienced clinicians alike, this indispensable manual provides information on dose, dilution, and indications for all four FDA-approved toxins in one handy text. Following a brief review of relevant pharmacology, the book provides product information and comparative distinctions between the four FDA-approved toxins (BotoxÆ, MyoblocÆ, XeominÆ, and DysportÆ), along with indications and doses for FDA-approved conditions, guidance techniques, and common and emerging clinical applications. The heart of the book is an injection manual, organized anatomically and by condition and covering all applications for medical treatment. For each condition or site, information is provided on typical muscle pattern or muscle groups involved, dosing guidelines and dilution for the applicable toxins, number of injection sites, and potential risks and benefits. Targeting techniques are organized in table format for quick retrieval. Anatomic illustrations and cross-sections are provided to orient injectors and help identify optimal insertion points. An appendix with useful clinical rating scales is also included. Key Features: Presents state-of-the-art information about current indications for all four FDA-approved botulinum neurotoxins Compares and contrasts the four toxins along with common and emerging clinical applications Provides dosing guidelines for various indications and injection sites for each muscle Includes anatomic drawings and cross-sections to illustrate muscle relationships and insertion points Serves as a practical, portable, how-to guide for new and experienced clinicians

Molecular Aspects of Botulinum Neurotoxin

Molecular Aspects of Botulinum Neurotoxin
Author: Keith A. Foster
Publsiher: Springer
Total Pages: 345
Release: 2014-07-08
ISBN 10: 1461494540
ISBN 13: 9781461494546
Language: EN, FR, DE, ES & NL

Molecular Aspects of Botulinum Neurotoxin Book Review:

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Clinical Applications of Botulinum Neurotoxin

Clinical Applications of Botulinum Neurotoxin
Author: Keith A. Foster
Publsiher: Springer
Total Pages: 196
Release: 2014-07-08
ISBN 10: 149390261X
ISBN 13: 9781493902613
Language: EN, FR, DE, ES & NL

Clinical Applications of Botulinum Neurotoxin Book Review:

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxin and Tetanus Toxin

Botulinum Neurotoxin and Tetanus Toxin
Author: Lance Simpson
Publsiher: Elsevier
Total Pages: 436
Release: 2012-12-02
ISBN 10: 0323141609
ISBN 13: 9780323141604
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin and Tetanus Toxin Book Review:

Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

Botulinum Neurotoxin A Multifunctional Protein for the Development of New Therapeutics

Botulinum Neurotoxin  A Multifunctional Protein for the Development of New Therapeutics
Author: Elena Fonfria
Publsiher: Anonim
Total Pages: 329
Release: 2018
ISBN 10:
ISBN 13: OCLC:1154239474
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin A Multifunctional Protein for the Development of New Therapeutics Book Review:

Botulinum neurotoxin (BoNT) is a major therapeutic agent licensed in neurological indications such as dystonia and spasticity. In recent years, its use has steadily increased in other neurological areas and new therapeutic areas and also in the aesthetic setting. Paradoxically, BoNT is also the causative agent of the disease botulism and a potential bioterrorism toxin. The BoNT family of toxins comprised more than 40 individual members, classified into 7 serotypes and are produced by Gram-positive obligate anaerobic bacteria. BoNTs are enzymatic multi-modular proteins with a complex multistep mechanism of action. Their target site is at peripheral neurons, particularly the neuromuscular junction, at which they inhibit acetylcholine neurotransmission. Despite intense activity in the BoNT field, today there are still gaps in knowledge both in clinical practice and in basic research. The discovery of the structure-function of BoNT and its domains has allowed rational design of new features using molecular engineering. The diversity of BoNT molecules, both natural and engineered, is an invaluable pool from which to design future new therapeutics with unique pharmacological properties for current and novel indications.

Botulinum Neurotoxins for Head and Neck Disorders

Botulinum Neurotoxins for Head and Neck Disorders
Author: Andrew Blitzer,Brian E. Benson,Joel Guss
Publsiher: Thieme
Total Pages: 248
Release: 2012-03-28
ISBN 10: 1604065869
ISBN 13: 9781604065862
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxins for Head and Neck Disorders Book Review:

Learn expert injection techniques with this multimedia reference guide to the therapeutic uses of botulinum neurotoxin Containing detailed injection instructions, Botulinum Neurotoxin for Head and Neck Disorders and the associated how-to videos offer otolaryngologists, neurologists, pain specialists, and others a complete guide to the management of motor, sensory and autonomic disorders of the head and neck region with botulinum neurotoxin. It covers treatment methods for conditions ranging from hyperfunctional motor disorders (dystonia, tremor, dysphagia), to afferent pain disorders (temporomandibular joint disorder, migraine, trigeminal neuralgia) to autonomic disorders (hypersalivation, Frey's syndrome). In each of the indications, the written material reviews the effects of the toxin on the nervous system, central pain thresholds, and central motor pathways. Special Features: Reviews the pharmacology, indications, mechanisms of action, and technique for each use of botulinum neurotoxin Provides detailed information on the anatomy, treatment methods, follow-up care, and possible complications for each disorder Includes online access to professionally produced videos in which Dr. Blitzer demonstrates injection techniques for the disorders in the book Contains vivid, full color illustrations and photographs that clarify information in the text Focusing specifically on injection techniques for the therapeutic uses of botulinum neurotoxin for treating head and neck disorders, this manual fills an important gap in the literature. It gives clinicians current, authoritative, and in-depth information on administering botulinum neurotoxin most effectively for the head and neck disorders of their patients.

A Structural Study of Botulinum Neurotoxin

A Structural Study of Botulinum Neurotoxin
Author: Dana Borden Lacy
Publsiher: Anonim
Total Pages: 264
Release: 1999
ISBN 10:
ISBN 13: UCAL:C3442193
Language: EN, FR, DE, ES & NL

A Structural Study of Botulinum Neurotoxin Book Review:

Mechanism of Botulinum Neurotoxin B Entry Into Cells and Novel Ways to Detect Botulinum Neurotoxin Activity

Mechanism of Botulinum Neurotoxin B Entry Into Cells and Novel Ways to Detect Botulinum Neurotoxin Activity
Author: Min Dong
Publsiher: Anonim
Total Pages: 192
Release: 2004
ISBN 10:
ISBN 13: WISC:89090640707
Language: EN, FR, DE, ES & NL

Mechanism of Botulinum Neurotoxin B Entry Into Cells and Novel Ways to Detect Botulinum Neurotoxin Activity Book Review:

The Use of Botulinum Neurotoxin Type A in Aesthetics

The Use of Botulinum Neurotoxin Type A in Aesthetics
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 2017
ISBN 10:
ISBN 13: OCLC:1051353239
Language: EN, FR, DE, ES & NL

The Use of Botulinum Neurotoxin Type A in Aesthetics Book Review:

Abstract : BACKGROUND: The most common aesthetic procedure performed worldwide is the injection of botulinum neurotoxin Type A (BoNT-A). Aesthetic providers must fully comprehend the objective scientific data, theoretical mechanisms of action, and differences between brands of BoNT-A. OBJECTIVE: To determine and review the relevant clinical postulates for the use of botulinum toxin in aesthetics. MATERIALS AND METHODS: The BoNT-A clinical postulates presented here discuss how each brand of BoNT-A acts identically, how the molecular potency may vary between the different products, how patient age, gender, genetics, and muscle mass cause variation in toxin receptor number and density, and how both practitioner and patient can affect toxin distribution. RESULTS: A total of 8 clinical postulates have been identified that are key to understanding the use of botulinum toxin in aesthetics and to obtaining the best clinical results. CONCLUSION: All of these factors affect the potential efficacy of the injected toxin and hence the aesthetic results obtained.

Botulinum Toxin E Book

Botulinum Toxin E Book
Author: Joseph Jankovic,Alberto Albanese,M. Zouhair Atassi,J. Oliver Dolly,Mark Hallett,Nathaniel H. Mayer
Publsiher: Elsevier Health Sciences
Total Pages: 512
Release: 2009-02-18
ISBN 10: 1437711197
ISBN 13: 9781437711196
Language: EN, FR, DE, ES & NL

Botulinum Toxin E Book Book Review:

The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you’ll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.

Botulinum Neurotoxins

Botulinum Neurotoxins
Author: Andreas Rummel,Thomas Binz
Publsiher: Springer Science & Business Media
Total Pages: 324
Release: 2012-12-14
ISBN 10: 3642335705
ISBN 13: 9783642335709
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxins Book Review:

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use
Author: Michael Charles Goodnough
Publsiher: Anonim
Total Pages: 424
Release: 1994
ISBN 10:
ISBN 13: WISC:89052289881
Language: EN, FR, DE, ES & NL

Characterization and Stabilization of Clostridium Botulinum Neurotoxin for Medical Use Book Review:

Hyperhidrosis and Botulinum Toxin in Dermatology

Hyperhidrosis and Botulinum Toxin in Dermatology
Author: Oliver Philip Kreyden,Roland Böni,Günter Burg
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 254
Release: 2002
ISBN 10: 3805573065
ISBN 13: 9783805573061
Language: EN, FR, DE, ES & NL

Hyperhidrosis and Botulinum Toxin in Dermatology Book Review:

In this publication a comprehensive overview on the pathophysiology and treatment of hyperhidrosis with a focus on the new therapy with botulinum toxin is given by renowned experts from Europe and the USA. In the first part the pathophysiology of hyperhidrosis, rare forms of sweating and their symptoms, as well as the different topical and surgical treatments for focal hyperhidrosis are discussed. The second part deals with botulinum toxin. Besides a historic survey of the drug the reader is introduced to the pharmacological particularities and the different modalities of treatment for focal hyperhidrosis. Complications and side effects of the therapy are presented as well. The final chapter is reserved for other dermatological indications like anal fissure and wrinkles.

Botulinum Neurotoxin for Head and Neck Disorders

Botulinum Neurotoxin for Head and Neck Disorders
Author: Andrew Blitzer,Brian Benson,Diana Kirke
Publsiher: Anonim
Total Pages: 226
Release: 2020
ISBN 10: 9781684200955
ISBN 13: 1684200954
Language: EN, FR, DE, ES & NL

Botulinum Neurotoxin for Head and Neck Disorders Book Review:

The most comprehensive, state-of-the-art guide available on the use of botulinum neurotoxin for head & neck disorders! Senior author Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by esteemed co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. The treatment of autonomic nervous system disorders is covered in chapters dedicated to Frey syndrome, facial hyperhydrosis, and sialorrhea. Key Features A 30-year review of spasmodic dysphonia data includes new insights encompassing comprehensive treatment, management and outcomes results, and neuropathophysiology A new chapter details the emerging role of botulinum neurotoxin to treat radiation-induced spasm and pain Updates on the management of palatal myoclonus, temporomandibular joint disorder, and sialorrhea An impressive compendium of professional injection videos, including a new video on sialorrhea and an updated migraine video Clinical pearls throughout the book focus on best practices, how to avoid pitfalls, and achieving the most optimal outcomes This is a must-have resource for otolaryngologists-head and neck surgeons, neurologists, dentists, pain specialists, physical medicine and rehabilitation specialists, and others health professionals who use botulinum neurotoxin to treat motor, sensory, and autonomic disorders of the head and neck region. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Botulinum Toxin for Asians

Botulinum Toxin for Asians
Author: Kyle K Seo
Publsiher: Springer
Total Pages: 182
Release: 2016-12-27
ISBN 10: 9811002045
ISBN 13: 9789811002045
Language: EN, FR, DE, ES & NL

Botulinum Toxin for Asians Book Review:

This book, containing more than 400 photos and illustrations, provides practical guidelines for the cosmetic use of botulinum toxin type A (BTA) in Asians. The differences in BTA treatment of Asians and Caucasians with respect to applicable dose, injection methods, anatomic significance, and indications are clearly described. It is explained how the optimal dose and injection sites for the treatment of wrinkles differ from the guidelines advocated in North America and Europe. Detailed consideration is given to the rapidly expanding role that BTA treatment is playing in facial and body contouring based on leveraging the mechanism of disuse muscle atrophy. Examples that are particularly relevant in Asians include treatment of hypertrophy of the masseter and temporalis muscles and calf muscle reduction. Further chapters are devoted to the use of BTA in the treatment of hyperhidrosis and the intradermal injection of BTA. The book will be an excellent resource for all dermatologists, plastic surgeons, cosmetic Physicians, and other clinicians who employ BTA in Asian patients.

Manual of Botulinum Toxin Therapy

Manual of Botulinum Toxin Therapy
Author: Daniel Truong,Dirk Dressler,Mark Hallett,Christopher Zachary
Publsiher: Cambridge University Press
Total Pages: 304
Release: 2014-01-23
ISBN 10: 1107654335
ISBN 13: 9781107654334
Language: EN, FR, DE, ES & NL

Manual of Botulinum Toxin Therapy Book Review:

Fully updated throughout, the second edition of the Manual of Botulinum Toxin Therapy provides practical guidance on the use of Botox in a wide variety of disorders. New chapters have been added on the use of botulinum toxin in wound healing, in focal hand dystonia and in thoracic outlet syndrome, as well as others. There are new chapters on the use of botulinum toxins in conjunction with ultrasound guidance. Using clear line-drawings the Manual describes the relevant injection sites for each condition and gives comparative dosage tables for the various formulations of toxins used in different muscle groups. Throughout the emphasis is on technique and the book can be used as both a teaching aid and in bedside guidance. The manual will be of use to neurologists, otolaryngologists, urologists, ophthalmologists, dermatologists, internists, pain management specialists, rehabilitation specialists and plastic surgeons, and any other clinicians discovering the potential of botulinum toxin.

A Biophysical Characterization of Botulinum Toxin and Cholera Toxin

A Biophysical Characterization of Botulinum Toxin and Cholera Toxin
Author: Geoffrey Matthew Kuziemko
Publsiher: Anonim
Total Pages: 298
Release: 1997
ISBN 10:
ISBN 13: UCAL:C3407549
Language: EN, FR, DE, ES & NL

A Biophysical Characterization of Botulinum Toxin and Cholera Toxin Book Review: