On line Estimation and Adaptive Control of Bioreactors

On line Estimation and Adaptive Control of Bioreactors
Author: G. Bastin
Publsiher: Elsevier
Total Pages: 394
Release: 2013-10-22
ISBN 10: 1483290980
ISBN 13: 9781483290980
Language: EN, FR, DE, ES & NL

On line Estimation and Adaptive Control of Bioreactors Book Review:

This book deals with monitoring and control of biotechnological processes. Different methods are proposed which are based on the nonlinear structure of the process and do not require any a priori knowledge of the fermentation parameters. The theoretical stability and convergence properties of the proposed algorithms are analysed and their performances are illustrated by simulation results and, in many instances, by real life experiments. The concept of software sensors is introduced; these are algorithms based on the nonlinear model of the process and designed for on-line estimation of the biological variables and/or the fermentation parameters. In order to deal with process nonstationarities and parameter uncertainties, reference is made to adaptive estimation and control techniques. The book is the result of an intensive joint research effort by the authors during the last decade. It is intended as a graduate level text for students of bioengineering as well as a reference text for scientists and engineers involved in the design and optimization of bioprocesses.

Bioreactors

Bioreactors
Author: Lakhveer Singh,Abu Yousuf,Durga Madhab Mahapatra
Publsiher: Academic Press
Total Pages: 368
Release: 2020-04
ISBN 10: 0128212640
ISBN 13: 9780128212646
Language: EN, FR, DE, ES & NL

Bioreactors Book Review:

Bioreactors: Sustainable Design and Industrial Applications in Mitigation of GHG Emissions presents and compares the foundational concepts, state-of-the-art design and fabrication of bioreactors. Solidly based on theoretical fundamentals, the book examines various aspects of the commercially available bioreactors, such as construction and fabrication, design, modeling and simulation, development, operation, maintenance, management and target applications for biofuels production and bio-waste management. Emerging issues in commercial feasibility are explored, constraints and pathways for upscaling, and techno-economic assessment are also covered. This book provides researchers and engineers in the biofuels and waste management sectors a clear, at-a-glance understanding of the actual potential of different advanced bioreactors for their requirements. It is a must-have reference for better-informed decisions when selecting the appropriate technology models for sustainable systems development and commercialization.

Disposable Bioreactors II

Disposable Bioreactors II
Author: Dieter Eibl,Regine Eibl
Publsiher: Springer
Total Pages: 292
Release: 2013-12-17
ISBN 10: 3642451586
ISBN 13: 9783642451584
Language: EN, FR, DE, ES & NL

Disposable Bioreactors II Book Review:

Dynamic Single-Use Bioreactors Used in Modern Liter- and m3- Scale Biotechnological Processes: Engineering Characteristics and Scaling Up, by Christian Löffelholz, Stephan C. Kaiser, Matthias Kraume, Regine Eibl , Dieter Eibl. Orbitally Shaken Single-Use Bioreactors, by Wolf Klöckner, Sylvia Diederichs, Jochen Büchs. Therapeutic Human Cells: Manufacture for Cell Therapy/Regenerative Medicine by Christian van den Bos, Robert Keefe, Carmen Schirmaier, Michael McCaman. Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System: Influenza as Case Study by Regine Eibl, Nina Steiger, Sabine Wellnitz, Tiago Vicente, Corinne John, Dieter Eibl. Microbial High Cell Density Fermentations in a Stirred Single-Use Bioreactor by Thomas Dreher, Bart Walcarius, Ute Husemann, Franziska Klingenberg, Christian Zahnow, Thorsten Adams, Davy de Wilde, Peter Casteels, Gerhard Greller. Quorus Bioreactor: A New Perfusion-Based Technology for Microbial Cultivation by Sheena J. Fraser, Christian Endres. Cultivation of Marine Microorganisms in Single-Use Systems by Friederike Hillig, Maciej Pilarek, Stefan Junne, Peter Neubauer. Flexible Biomanufacturing Processes that Address the Needs of the Future by Bernhard Diel, Christian Manzke, Thorsten Peuker. An Approach to Quality and Security of Supply for Single-Use Bioreactors by Magali Barbaroux, Susanne Gerighausen, Heiko Hackel. A Risk Analysis for Production Processes with Disposable Bioreactors by Tobias Merseburger, Ina Pahl, Daniel Müller, Markus Tanner.

Bioreactors

Bioreactors
Author: Carl-Fredrik Mandenius
Publsiher: John Wiley & Sons
Total Pages: 520
Release: 2016-05-16
ISBN 10: 3527337687
ISBN 13: 9783527337682
Language: EN, FR, DE, ES & NL

Bioreactors Book Review:

In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Bioreactors and Biotransformations

Bioreactors and Biotransformations
Author: G.W. Moody,P.B. Baker
Publsiher: Springer
Total Pages: 406
Release: 1987-11-30
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015012759018
Language: EN, FR, DE, ES & NL

Bioreactors and Biotransformations Book Review:

Bioreactors for Tissue Engineering

Bioreactors for Tissue Engineering
Author: Julian Chaudhuri,Mohamed Al-Rubeai
Publsiher: Springer Science & Business Media
Total Pages: 376
Release: 2006-01-16
ISBN 10: 1402037414
ISBN 13: 9781402037412
Language: EN, FR, DE, ES & NL

Bioreactors for Tissue Engineering Book Review:

For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

Solid State Fermentation Bioreactors

Solid State Fermentation Bioreactors
Author: David A. Mitchell,Nadia Krieger,Marin Berovic
Publsiher: Springer Science & Business Media
Total Pages: 448
Release: 2006-08-02
ISBN 10: 3540312862
ISBN 13: 9783540312864
Language: EN, FR, DE, ES & NL

Solid State Fermentation Bioreactors Book Review:

This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

Bioreactors in Biotechnology

Bioreactors in Biotechnology
Author: Alan H. Scragg
Publsiher: Ellis Horwood Limited
Total Pages: 330
Release: 1991
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015024793948
Language: EN, FR, DE, ES & NL

Bioreactors in Biotechnology Book Review:

Discusses many aspects of bioreactor use and design in biotechnology. There is coverage of conventional and airlift bioreactor design, instrumentation, control and simulation of bioreactor runs, bioreactors for plant and animal culture and a descriptions of experiments.

Bioreactors Process and Analysis

Bioreactors  Process and Analysis
Author: Tapobrata Panda
Publsiher: Tata McGraw-Hill Education
Total Pages: 491
Release: 2011
ISBN 10: 0070704244
ISBN 13: 9780070704244
Language: EN, FR, DE, ES & NL

Bioreactors Process and Analysis Book Review:

6. Bioreactor modeling -- Model - what is it? -- Definition of lumped and distributed parameter models -- Introduction to a few terminologies and theorems -- Modeling principles -- Steps in modeling -- Fundamental laws used in process modeling -- First-order systems -- Second-order systems -- Complexity of the model -- Parameter sensitivity -- Exercises -- References -- Appendix 6 -- 7. Transport processes in bioreactors -- Introduction -- Heat transfer -- Other parameters influencing transfer operations -- Exercises -- References -- 8. Controls in bioreactors -- Introduction -- Control tasks in a bioreactor system -- Instrumentation to control a bioreactor -- Controlled variables and measurement devices -- Procedure for design of efficient control systems -- Conventional control techniques -- Advanced control techniques -- Consistency checks on measurements -- Adaptive online optimizing control of bioreactor system -- Exercises -- References -- Appendix 8 -- 9. Case studies -- Introduction -- Design of packed bed bioreactor -- Airlift bioreactors -- Hollow fiber bioreactor (HFBR) -- Plant cell bioreactor -- Design of bioreactors for solid state fermentation (SSF) -- Mammalian cell bioreactor design -- Exercises -- References -- Appendix 9 -- 10. Application of computational fluid dynamics in bioreactor analysis and design -- Introduction -- Fluid dynamic modeling -- Simulation -- Exercises -- References -- Appendix 10 -- 11. Scale-up of bioreactors -- Introduction -- Additional scale-up problems in bioreactors -- Criteria of scale-up -- Similarity criteria -- Scale-up methods -- Generalized approaches to scale-up in combination of methods -- Examples -- Exercises -- References -- 12. Mechanical aspects of bioreactor design -- Introduction -- Requirements for construction of a bioreactor -- Guidelines for bioreactor design -- Bioreactor vessels -- Agitator assembly -- Exercises -- References -- Appendix 12

Bioreactors

Bioreactors
Author: Luigi Salvay
Publsiher: Unknown
Total Pages: 304
Release: 2017-02
ISBN 10: 9781681176956
ISBN 13: 1681176955
Language: EN, FR, DE, ES & NL

Bioreactors Book Review:

Bioreactor Design Fundamentals

Bioreactor Design Fundamentals
Author: Norton G. McDuffie
Publsiher: Butterworth-Heinemann
Total Pages: 150
Release: 2013-10-22
ISBN 10: 1483221083
ISBN 13: 9781483221083
Language: EN, FR, DE, ES & NL

Bioreactor Design Fundamentals Book Review:

Bioreactor Design Fundamentals presents the development in the bioreactor field. This book discusses the applications of biological kinetics and thermodynamics. Organized into seven chapters, this book begins with an overview of the design of biological reactors that involves determining operating conditions, sizing the reactor, controlling temperature and sterility, and controlling operating variables. This text then examines the significance of pH considerations in biological reactor and process design. Other chapters consider enzyme kinetics and the equations most commonly used as models for overall enzyme kinetics. This book discusses as well the mass transfer rates in bioreactors, which are significant because of their effects on some chemical reaction rates in transformations by enzymes or by living cells. The final chapter deals with the ideal state of the continuous stirred-tank reactors (CSTRs). This book is a valuable resource for biochemical engineers and industrial microbiologists.

Membrane Bioreactors for Municipal Wastewater Treatment

Membrane Bioreactors for Municipal Wastewater Treatment
Author: H. F. van der Roest,D. P. Lawrence,A. G. N. van Bentem
Publsiher: IWA Publishing
Total Pages: 150
Release: 2002-11-01
ISBN 10: 9781843390114
ISBN 13: 1843390116
Language: EN, FR, DE, ES & NL

Membrane Bioreactors for Municipal Wastewater Treatment Book Review:

Recent technical innovations and significant cost reductions have sharply increased the potential for using Membrane Bioreactor (MBR) technology in municipal wastewater treatment. MBR technology displays several advantages compared to the traditional activated sludge processes, such as high effluent quality, limited space requirement and with the possibility of a flexible and phased extension of existing waste water treatment plants. Membrane Bioreactors for Municipal Wastewater Treatment describes the results of a comparative research programme involving four leading membrane suppliers: Kubota (Japan), Mitsubishi (Japan), X-Flow (Netherlands) and Zenon (Canada). Each supplier provided a pilot to represent a suitable scale - right up to full scale. These pilots were operated and optimised in the course of the research programme to achieve the best operating window under different operating regimes. The research focussed on the functionality of the membrane, the biological treatment, membrane fouling, achieved effluent quality, and system operability as well as other factors. In a number of side studies the required pre-treatment, membrane fouling/cleaning, energy usage, effluent quality and sludge processing were also addressed. The comparative pilot research was carried out by DHV Water on location at the wastewater treatment plant at Beverwijk in the Netherlands.

Principles of Membrane Bioreactors for Wastewater Treatment

Principles of Membrane Bioreactors for Wastewater Treatment
Author: Hee-Deung Park,In-Soung Chang,Kwang-Jin Lee
Publsiher: CRC Press
Total Pages: 445
Release: 2015-04-17
ISBN 10: 1466590386
ISBN 13: 9781466590380
Language: EN, FR, DE, ES & NL

Principles of Membrane Bioreactors for Wastewater Treatment Book Review:

Principles of Membrane Bioreactors for Wastewater Treatment covers the basic principles of membrane bioreactor (MBR) technology, including biological treatment, membrane filtration, and MBR applications. The book discusses concrete principles, appropriate design, and operational aspects. It covers a wide variety of MBR topics, including filtration theory, membrane materials and geometry, fouling phenomena and properties, and strategies for minimizing fouling. Also covered are the practical aspects such as operation and maintenance. Case studies and examples in the book help readers understand the basic concepts and principles clearly, while problems presented help advance relevant theories more deeply. Readers will find this book a helpful resource to understand the state of the art in MBR technology.

Animal Cell Bioreactors

Animal Cell Bioreactors
Author: Chester S. Ho
Publsiher: Butterworth-Heinemann
Total Pages: 512
Release: 2013-10-22
ISBN 10: 1483289478
ISBN 13: 9781483289472
Language: EN, FR, DE, ES & NL

Animal Cell Bioreactors Book Review:

Animal Cell Bioreactors provides an introduction to the underlying principles and strategies in the in vitro cell culture biotechnology. It addresses engineering aspects such as mass transfer, instrumentation, and control ensuring successful design and operation of animal cell bioreactors. The goal is to provide a comprehensive analysis and review in the advancement of the bioreactor systems for large-scale animal cell cultures. The book is organized into four parts. Part I traces the historical development of animal cell biotechnology. It presents examples of work in progress that seeks to make animal cell biotechnology processes as productive on a cost per unit of product basis as that achieved by other microbial systems. Part II includes chapters dealing with the implications of cell biology in animal cell biotechnology; protein-bound oligosaccharides and their structures; the development of serum-free media and its use in the production of biologically active substances; and the metabolism of mammalian cells. Part III focuses on animal cell cultivation, covering topics such as the fixed bed immobilized culture; three-dimensional microcarriers; and hydrodynamic phenomena in microcarrier cultures. Part IV discusses the design, operation, and control of animal cell bioreactors.

Fundamentals of Membrane Bioreactors

Fundamentals of Membrane Bioreactors
Author: Bradley Ladewig,Muayad Nadhim Zemam Al-Shaeli
Publsiher: Springer
Total Pages: 150
Release: 2016-10-22
ISBN 10: 9811020140
ISBN 13: 9789811020148
Language: EN, FR, DE, ES & NL

Fundamentals of Membrane Bioreactors Book Review:

This book provides a critical, carefully researched, up-to-date summary of membranes for membrane bioreactors. It presents a comprehensive and self-contained outline of the fundamentals of membrane bioreactors, especially their relevance as an advanced water treatment technology. This outline helps to bring the technology to the readers’ attention, and positions the critical topic of membrane fouling as one of the key impediments to its more widescale adoption. The target readership includes researchers and industrial practitioners with an interest in membrane bioreactors.

Bioreactor Systems for Tissue Engineering

Bioreactor Systems for Tissue Engineering
Author: Cornelia Kasper,Martijn van Griensven,Ralf Pörtner
Publsiher: Springer Science & Business Media
Total Pages: 271
Release: 2009-02-03
ISBN 10: 3540693564
ISBN 13: 9783540693567
Language: EN, FR, DE, ES & NL

Bioreactor Systems for Tissue Engineering Book Review:

The editors of this special volume would first like to thank all authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern b- technology; it combines different subjects ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Therefore, three dimensional biocompatible materials are seeded with cells and cultivated in suitable systems to generate functional tissues. Many different aspects play a role in the formation of 3D tissue structures. In the first place the source of the used cells is of the utmost importance. To prevent tissue rejection or immune response, preferentially autologous cells are now used. In particular, stem cells from different sources are gaining exceptional importance as they can be differentiated into different tissues by using special media and supplements. In the field of biomaterials, numerous scaffold materials already exist but new composites are also being developed based on polymeric, natural or xenogenic sources. Moreover, a very important issue in tissue en- neering is the formation of tissues under well defined, controlled and reprod- ible conditions. Therefore, a substantial number of new bioreactors have been developed.

Bioreactors

Bioreactors
Author: Goutam Saha,Alok Barua,Satyabroto Sinha
Publsiher: CRC Press
Total Pages: 136
Release: 2017-12-01
ISBN 10: 1498736025
ISBN 13: 9781498736022
Language: EN, FR, DE, ES & NL

Bioreactors Book Review:

Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.

Bioreactors for Stem Cell Expansion and Differentiation

Bioreactors for Stem Cell Expansion and Differentiation
Author: Joaquim M.S. Cabral,Claudia Lobato da Silva
Publsiher: CRC Press
Total Pages: 334
Release: 2018-09-03
ISBN 10: 0429841817
ISBN 13: 9780429841811
Language: EN, FR, DE, ES & NL

Bioreactors for Stem Cell Expansion and Differentiation Book Review:

An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art and the future of these fields. Key selling features: Describes various bioreactors or stem cell culturing systems Reviews methods for stem cell expansion and differentiation for neural, cardiac, hemopoietic, mesenchymal, hepatic and other tissues cell types Distinguishes different types of bioreactors intended for different operational scales of tissue engineering and cellular therapies Includes contributions from an international team of leaders in stem cell research

Bioreactors for Stem Cell Expansion and Differentiation

Bioreactors for Stem Cell Expansion and Differentiation
Author: Joaquim M.S. Cabral,Claudia Lobato da Silva
Publsiher: CRC Press
Total Pages: 334
Release: 2018-09-03
ISBN 10: 0429841825
ISBN 13: 9780429841828
Language: EN, FR, DE, ES & NL

Bioreactors for Stem Cell Expansion and Differentiation Book Review:

An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art and the future of these fields. Key selling features: Describes various bioreactors or stem cell culturing systems Reviews methods for stem cell expansion and differentiation for neural, cardiac, hemopoietic, mesenchymal, hepatic and other tissues cell types Distinguishes different types of bioreactors intended for different operational scales of tissue engineering and cellular therapies Includes contributions from an international team of leaders in stem cell research

Eco Engineered Bioreactors

Eco Engineered Bioreactors
Author: James Higgins,Al Mattes,William Stiebel,Brent Wootton
Publsiher: CRC Press
Total Pages: 385
Release: 2017-11-22
ISBN 10: 1351681109
ISBN 13: 9781351681100
Language: EN, FR, DE, ES & NL

Eco Engineered Bioreactors Book Review:

This book provides a comprehensive understanding of a highly innovative method of natural wastewater treatment using advanced in-groundbioreactors called Eco-Engineered Bioreactors (EEBs), and traces their evolution from the earliest aerated gravel bed versions once known as Engineered Wetlands (EWs) and now known as BREW Bioreactors (BBRs) all the way to today’s wide slate of aerobic and anaerobic varieties. Treatment using EEBs involves passing wastewaters through excavated basins in which they contact fixed films of microbial consortia on permeable substrate media. Written from the perspective of ecological engineers designing EEBs, this guide covers updated information on the state-of-the-art for EEBs, covering their morphologies, testing methods, designs, operations, and microbiology.