Mass Spectrometry in Biophysics

Mass Spectrometry in Biophysics
Author: Igor A. Kaltashov,Stephen J. Eyles
Publsiher: John Wiley & Sons
Total Pages: 320
Release: 2005-05-06
ISBN 10: 0471705160
ISBN 13: 9780471705161
Language: EN, FR, DE, ES & NL

Mass Spectrometry in Biophysics Book Review:

The first systematic summary of biophysical mass spectrometrytechniques Recent advances in mass spectrometry (MS) have pushed the frontiersof analytical chemistry into the biophysical laboratory. As aresult, the biophysical community's acceptance of MS-based methods,used to study protein higher-order structure and dynamics, hasaccelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presentedthe full array of MS-based experimental techniques and strategiesfor biophysics. Mass Spectrometry in Biophysics expertly closesthis gap in the literature. Covering the theoretical background and technical aspects of eachmethod, this much-needed reference offers an unparalleled overviewof the current state of biophysical MS. Mass Spectrometry inBiophysics begins with a helpful discussion of general biophysicalconcepts and MS-related techniques. Subsequent chaptersaddress: * Modern spectrometric hardware * High-order structure and dynamics as probed by various MS-basedmethods * Techniques used to study structure and behavior of non-nativeprotein states that become populated under denaturingconditions * Kinetic aspects of protein folding and enzyme catalysis * MS-based methods used to extract quantitative information onprotein-ligand interactions * Relation of MS-based techniques to other experimental tools * Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physicsof electrospray mass spectrometry, Mass Spectrometry in Biophysicsalso offers a compelling look at the current challenges facingbiomolecular MS and the potential applications that will likelyshape its future.

Mass Spectrometry in Structural Biology and Biophysics

Mass Spectrometry in Structural Biology and Biophysics
Author: Igor A. Kaltashov,Stephen J. Eyles
Publsiher: John Wiley & Sons
Total Pages: 312
Release: 2012-02-27
ISBN 10: 1118232089
ISBN 13: 9781118232088
Language: EN, FR, DE, ES & NL

Mass Spectrometry in Structural Biology and Biophysics Book Review:

The definitive guide to mass spectrometry techniques in biologyand biophysics The use of mass spectrometry (MS) to study the architecture anddynamics of proteins is increasingly common within the biophysicalcommunity, and Mass Spectrometry in Structural Biology andBiophysics: Architecture, Dynamics, and Interaction ofBiomolecules, Second Edition provides readers with detailed,systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentariumthat can be used to solve the most challenging problems inbiophysics, structural biology, and biopharmaceuticals, the book isa practical guide to understanding the role of MS techniques inbiophysical research. Designed to meet the needs of both academicand industrial researchers, it makes mass spectrometry accessibleto professionals in a range of fields, includingbiopharmaceuticals. This new edition has been significantly expanded and updated toinclude the most recent experimental methodologies and techniques,MS applications in biophysics and structural biology, methods forstudying higher order structure and dynamics of proteins, anexamination of other biopolymers and synthetic polymers, such asnucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate theconcepts described in the text, as well as extensive referencesthat enable the reader to pursue further study, Mass Spectrometryin Structural Biology and Biophysics is an indispensable resourcefor researchers and graduate students working in biophysics,structural biology, protein chemistry, and related fields.

Biophysical Techniques in Drug Discovery

Biophysical Techniques in Drug Discovery
Author: Angeles Canales
Publsiher: Royal Society of Chemistry
Total Pages: 320
Release: 2017-11-14
ISBN 10: 1788012860
ISBN 13: 9781788012867
Language: EN, FR, DE, ES & NL

Biophysical Techniques in Drug Discovery Book Review:

Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

Mass Spectrometry in Structural Biology and Biophysics

Mass Spectrometry in Structural Biology and Biophysics
Author: Igor A. Kaltashov,Stephen J. Eyles
Publsiher: John Wiley & Sons
Total Pages: 289
Release: 2012-04-03
ISBN 10: 0470937793
ISBN 13: 9780470937792
Language: EN, FR, DE, ES & NL

Mass Spectrometry in Structural Biology and Biophysics Book Review:

With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues. The book presents a discussion of general biophysical concepts and a brief overview of traditional biophysical techniques before outlining the more advanced concepts of mass spectrometry. The new edition gives an up-to-date and expanded coverage of experimental methodologies and a clear look at MS-based methods for studying higher order structures and biopolymers. A must for researchers in the field of biophysics, structural biology, and protein chemistry.

Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Biophysical Characterization of Proteins in Developing Biopharmaceuticals
Author: Damian J. Houde,Steven A. Berkowitz
Publsiher: Elsevier
Total Pages: 586
Release: 2019-11-13
ISBN 10: 0444641742
ISBN 13: 9780444641748
Language: EN, FR, DE, ES & NL

Biophysical Characterization of Proteins in Developing Biopharmaceuticals Book Review:

Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical’s developability and the technical decision-making process needed when dealing with biophysical characterization data. Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development Highlights the capabilities and limitations of each technique Discusses the underlining science of each tool Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry

Methods in Modern Biophysics

Methods in Modern Biophysics
Author: Bengt Nölting
Publsiher: Springer Science & Business Media
Total Pages: 254
Release: 2013-03-09
ISBN 10: 3662053675
ISBN 13: 9783662053676
Language: EN, FR, DE, ES & NL

Methods in Modern Biophysics Book Review:

Incorporating dramatic recent advances, "Methods in Modern Biophysics" presents a fresh and timely introduction to modern biophysical methods. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobility spectrometry, mass spectrometry, and proteomics. Containing much information previously unavailable in tutorial form, "Methods in Modern Biophysics" employs worked examples and more than 260 illustrations to fully detail the techniques and their underlying mechanisms. The book was written for advanced undergraduate and graduate students, postdocs, researchers, lecturers and professors in biophysics, biochemistry, general biology and related fields.

Introduction to Biophysical Methods for Protein and Nucleic Acid Research

Introduction to Biophysical Methods for Protein and Nucleic Acid Research
Author: Jay A. Glasel,Murray P. Deutscher
Publsiher: Academic Press
Total Pages: 510
Release: 1995-11-20
ISBN 10: 9780080534985
ISBN 13: 0080534988
Language: EN, FR, DE, ES & NL

Introduction to Biophysical Methods for Protein and Nucleic Acid Research Book Review:

The first of its kind, Introduction to Biophysical Methods for Protein and Nucleic Acid Research serves as a text for the experienced researcher and student requiring an introduction to the field. Each chapter presents a description of the physical basis of the method, the type of information that may be obtained with the method, how data should be analyzed and interpreted and, where appropriate, practical tips about procedures and equipment. Key Features * Modern Use of Mass Spectroscopy * NMR Spectroscopy * Molecular Modeling and Graphics * Macintosh and DOS/Windows 3.x disks

Biophysical Methods for Biotherapeutics

Biophysical Methods for Biotherapeutics
Author: Tapan K. Das
Publsiher: John Wiley & Sons
Total Pages: 376
Release: 2014-02-27
ISBN 10: 1118354680
ISBN 13: 9781118354681
Language: EN, FR, DE, ES & NL

Biophysical Methods for Biotherapeutics Book Review:

With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.

Biophysical Techniques

Biophysical Techniques
Author: Iain Campbell
Publsiher: Oxford University Press
Total Pages: 353
Release: 2012-02-16
ISBN 10: 0199642141
ISBN 13: 9780199642144
Language: EN, FR, DE, ES & NL

Biophysical Techniques Book Review:

Biophysical Techniques explains in a readily-accessible way the basics of the various biophysical methods available so students can understand the principles behind the different methods used, and begin to appreciate which tools can be used to probe different biological questions, and the pros and cons of each.

Biophysical Chemistry

Biophysical Chemistry
Author: Alan Cooper
Publsiher: Royal Society of Chemistry
Total Pages: 184
Release: 2004
ISBN 10: 9780854044801
ISBN 13: 0854044809
Language: EN, FR, DE, ES & NL

Biophysical Chemistry Book Review:

This book will be ideal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study.

Methods in Molecular Biophysics

Methods in Molecular Biophysics
Author: Nathan R. Zaccai,Igor N. Serdyuk,Joseph Zaccai
Publsiher: Cambridge University Press
Total Pages: 702
Release: 2017-05-18
ISBN 10: 1107056373
ISBN 13: 9781107056374
Language: EN, FR, DE, ES & NL

Methods in Molecular Biophysics Book Review:

A comprehensive graduate textbook explaining key physical methods in biology, reflecting the very latest research in this fast-moving field.

Biomedical Applications of Biophysics

Biomedical Applications of Biophysics
Author: Thomas Jue
Publsiher: Springer Science & Business Media
Total Pages: 237
Release: 2010-08-18
ISBN 10: 9781603272339
ISBN 13: 160327233X
Language: EN, FR, DE, ES & NL

Biomedical Applications of Biophysics Book Review:

In keeping with goal and style of the Handbook in Modern Biophysics series, the proposed book will maintain a chapter structure that contains two parts: concepts and biological application. The book also integrates all the chapters into a smooth, continuous discourse. The first and second chapters establish the mathematical methods and theoretical framework underpinning the different topics in the rest if the book. Other chapters will use the theoretical framework as a basis to discuss optical and NMR approaches. Each chapter will contain innovative didactic elements that facilitate teaching, self-study, and research preparation (key points, summary, exercise, references).

Protein Interactions

Protein Interactions
Author: Peter Schuck
Publsiher: Springer Science & Business Media
Total Pages: 532
Release: 2007-03-20
ISBN 10: 0387359664
ISBN 13: 9780387359663
Language: EN, FR, DE, ES & NL

Protein Interactions Book Review:

This volume successfully and clearly examines how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It deals with the methodology behind the research and shows how to synergistically incorporate several methodologies for use. Each chapter treats and introduces the reader to different biological systems, includes a brief summary of the physical principles, and mentions practical requirements.

Modern Biophysical Chemistry

Modern Biophysical Chemistry
Author: Peter Jomo Walla
Publsiher: John Wiley & Sons
Total Pages: 360
Release: 2015-09-10
ISBN 10: 3527683550
ISBN 13: 9783527683550
Language: EN, FR, DE, ES & NL

Modern Biophysical Chemistry Book Review:

This updated and up-to-date version of the first edition continues with the really interesting stuff to spice up a standard biophysics and biophysical chemistry course. All relevant methods used in current cutting edge research including such recent developments as super-resolution microscopy and next-generation DNA sequencing techniques, as well as industrial applications, are explained. The text has been developed from a graduate course taught by the author for several years, and by presenting a mix of basic theory and real-life examples, he closes the gap between theory and experiment. The first part, on basic biophysical chemistry, surveys fundamental and spectroscopic techniques as well as biomolecular properties that represent the modern standard and are also the basis for the more sophisticated technologies discussed later in the book. The second part covers the latest bioanalytical techniques such as the mentioned super-resolution and next generation sequencing methods, confocal fluorescence microscopy, light sheet microscopy, two-photon microscopy and ultrafast spectroscopy, single molecule optical, electrical and force measurements, fluorescence correlation spectroscopy, optical tweezers, quantum dots and DNA origami techniques. Both the text and illustrations have been prepared in a clear and accessible style, with extended and updated exercises (and their solutions) accompanying each chapter. Readers with a basic understanding of biochemistry and/or biophysics will quickly gain an overview of cutting edge technology for the biophysical analysis of proteins, nucleic acids and other biomolecules and their interactions. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented. Questions of differing complexity testing the reader's understanding can be found at the end of each chapter with clearly described solutions available on the Wiley-VCH textbook homepage under: www.wiley-vch.de/textbooks

Biophysical Chemistry

Biophysical Chemistry
Author: Alan Cooper
Publsiher: Royal Society of Chemistry
Total Pages: 184
Release: 2004
ISBN 10: 9780854044801
ISBN 13: 0854044809
Language: EN, FR, DE, ES & NL

Biophysical Chemistry Book Review:

This book will be ideal for early undergraduates studying chemical or physical sciences and will act as a basis for more advanced study.

Applied Biophysics for Drug Discovery

Applied Biophysics for Drug Discovery
Author: Donald Huddler,Edward R. Zartler
Publsiher: John Wiley & Sons
Total Pages: 312
Release: 2017-10-02
ISBN 10: 111909948X
ISBN 13: 9781119099482
Language: EN, FR, DE, ES & NL

Applied Biophysics for Drug Discovery Book Review:

13.2.1 Protein Dynamics of SA WT and S1 Mutant DHFR in Apo and Bound States

Biophysical Techniques in Photosynthesis

Biophysical Techniques in Photosynthesis
Author: Thijs Aartsma,Jörg Matysik
Publsiher: Springer Science & Business Media
Total Pages: 520
Release: 2008-02-01
ISBN 10: 1402082509
ISBN 13: 9781402082504
Language: EN, FR, DE, ES & NL

Biophysical Techniques in Photosynthesis Book Review:

Since the first volume on Biophysical Techniques in Photosynthesis Research, published in 1996, new experimental techniques and methods have been devised at a rapid pace. The present book is a sequel which complements the publication of the first volume by providing a comprehensive overview of the most important new techniques developed over the past ten years, especially those that are relevant for research on the mechanism and fundamental aspects of photosynthesis.

Introduction to Biomolecular Structure and Biophysics

Introduction to Biomolecular Structure and Biophysics
Author: Gauri Misra
Publsiher: Springer
Total Pages: 274
Release: 2017-09-07
ISBN 10: 9811049688
ISBN 13: 9789811049682
Language: EN, FR, DE, ES & NL

Introduction to Biomolecular Structure and Biophysics Book Review:

This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon with the underlying physical concepts. The content is divided into nine chapters summarizing the structural details of proteins, including recently discovered novel folds, higher order structures of nucleic acids, as well as lipids and the physical forces governing the macromolecular interactions which are essential for the various biological processes. It also provides insights into the recent advances in biophysical techniques including Hydrogen Deuterium Exchange with Mass Spectrometry (HDX-MS), Small angle X-ray scattering (SAXS) and Cryo Electron Microscopy (cryo EM), supplemented with interesting experimental data. It is a valuable reference resource for anyone with a desire to gain a better understanding of the fundamentals of biophysical concepts and techniques of important biomolecules.

Structural Biology in Drug Discovery

Structural Biology in Drug Discovery
Author: Jean-Paul Renaud
Publsiher: John Wiley & Sons
Total Pages: 688
Release: 2020-01-27
ISBN 10: 1118900405
ISBN 13: 9781118900406
Language: EN, FR, DE, ES & NL

Structural Biology in Drug Discovery Book Review:

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Biophysical Approaches Determining Ligand Binding to Biomolecular Targets

Biophysical Approaches Determining Ligand Binding to Biomolecular Targets
Author: Alberto Podjarny,Annick Dejaegere,Bruno Kieffer
Publsiher: Royal Society of Chemistry
Total Pages: 356
Release: 2011
ISBN 10: 1849730091
ISBN 13: 9781849730099
Language: EN, FR, DE, ES & NL

Biophysical Approaches Determining Ligand Binding to Biomolecular Targets Book Review:

This book provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand binding mechanisms. Suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available.