Biometals in Autism Spectrum Disorders

Biometals in Autism Spectrum Disorders
Author: Andreas Grabrucker
Publsiher: Academic Press
Total Pages: 222
Release: 2020-07-08
ISBN 10: 0128211334
ISBN 13: 9780128211335
Language: EN, FR, DE, ES & NL

Biometals in Autism Spectrum Disorders Book Review:

Biometals in Autism Spectrum Disorders will be the first to focus on trace metals and autism. Compared to other references examining ASDs or metallomics, a focused presentation of the findings of abnormal metal homeostasis in ASD has not yet come to be. This book provides for readers an overview of current findings on trace metal biology with respect to its role in ASD etiology and discusses how abnormal trace metal biology may be a common factor of several genetic and non-genetic causes of ASDs considered unrelated in the past. This will open new vistas for the development of new therapies based on targeted manipulation of trace metal homeostasis and generate awareness that trace metal levels during pregnancy must be tightly monitored. Reviews the role of trace metals in brain development Summarizes research linking trace metals and autism Explores heterogenous phenotypes as a factor of genetic and non-genetic factors Includes animal and human stem research Contains many diagrams, tables, and flow charts Proposes future therapies based on biometal homeostasis

Biometals in Neurodegenerative Diseases

Biometals in Neurodegenerative Diseases
Author: Anthony R. White,Michael Aschner,Lucio G. Costa,Ashley I. Bush
Publsiher: Academic Press
Total Pages: 462
Release: 2017-04-28
ISBN 10: 0128045639
ISBN 13: 9780128045633
Language: EN, FR, DE, ES & NL

Biometals in Neurodegenerative Diseases Book Review:

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets Written for academic researchers, clinicians and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

Thimerosal Let the Science Speak

Thimerosal  Let the Science Speak
Author: Robert F. Kennedy
Publsiher: Simon and Schuster
Total Pages: 500
Release: 2015-09-01
ISBN 10: 1634504437
ISBN 13: 9781634504430
Language: EN, FR, DE, ES & NL

Thimerosal Let the Science Speak Book Review:

Over a decade ago, following a sharp rise in developmental disorders such as autism and ADHD, the mercury-containing preservative Thimerosal was widely believed to have been eliminated from vaccine supplies in the US and abroad. However, dangerous quantities of Thimerosal continue to be used, posing a significant threat to public health and leading to a crisis of faith in vaccine safety. In this groundbreaking book, Robert F. Kennedy, Jr., and Dr. Mark Hyman examine the research literature on Thimerosal and make a very clear statement about its potentially dangerous effects. In the past, the CDC, FDA, NIH, and AAP, as well as the US Congress, the American Academy of Family Physicians, the US Department of Agriculture, the European Medicines Agency, and the California Environmental Protection Agency have expressed concerns over the use of Thimerosal in vaccines. But despite the many voices calling for action, the media and policy makers have repeatedly failed to adequately address the issue. Now, with Thimerosal: Let the Science Speak, the goals are to educate parents, doctors, and health policy makers; to eliminate this toxic chemical from the world’s vaccine supplies; to move toward safer alternatives; and to maintain or increase vaccination rates critical to the United States and developing nations. With safer options available, parents shouldn’t have to worry about the devastating effects of vaccinating their children.

Brighton Baby a Revolutionary Organic Approach to Having an Extraordinary Child

Brighton Baby a Revolutionary Organic Approach to Having an Extraordinary Child
Author: Roy Dittmann Omd Mh
Publsiher: Balboa Press
Total Pages: 1006
Release: 2012-10
ISBN 10: 1452555567
ISBN 13: 9781452555560
Language: EN, FR, DE, ES & NL

Brighton Baby a Revolutionary Organic Approach to Having an Extraordinary Child Book Review:

Brighton Baby: A Revolutionary Organic Approach to Having an Extraordinary Child - The Complete Guide to Preconception & Conception is about helping couples achieve optimal health - mentally, physically, emotionally, and spiritually - before you conceive your future child. Author and perinatal expert, Roy Dittmann, OMD, MH takes couples on a journey that celebrates the power of love as the intangible blueprint of life . Dr. Dittmann exposes the dangers of conceiving in our toxic world and focuses couples on how to prepare body, mind, and spirit for the moment of conception. Using integral wisdom, Dr. Dittmann helps couples go from overwhelm to taking practical steps to realize their goals of having an extraordinary child. Brighton Baby is about the art and science of gifting the best of who we are to our future children. It is about reducing human suffering by preventing subtle and overt birth defects before they occur. It is about transforming the context inside of which we conceive and birth children. - Roy Dittmann, OMD, MH, author Throughout the book, Dr. Dittmann turns the spotlight on the hidden dangers of: heavy metals and other toxins, genetically modified foods, pesticides, artificial sweeteners, rancid oils, antibiotics, processed foods, contaminated drinking water, electrosmog, and the pluses & minuses of vaccines - merging science and common sense to compel couples to take action today to prevent birth defects in their future child. Brighton Baby is a call to action for couples to commit now to consciously preparing for your future child together.

The Autism Puzzle

The Autism Puzzle
Author: Brita Belli
Publsiher: Seven Stories Press
Total Pages: 208
Release: 2012-03-27
ISBN 10: 1609803922
ISBN 13: 9781609803926
Language: EN, FR, DE, ES & NL

The Autism Puzzle Book Review:

The alarming spike in autism in recent years has sent doctors and parents on a search for answers. And while many controversies have erupted around the issue, none have gotten us any closer to a definitive explanation, and many key concerns remain unexplored. Moving beyond the distractions of the vaccine debate, The Autism Puzzle is the first book to address the compelling evidence that it is the pairing of environmental exposures with genetic susceptibilities that may be impacting the brain development of children. Journalist Brita Belli brings us into the lives of three families with autistic children, each with different ideas about autism, as she explores the possible causes. She interprets for readers compelling evidence that environmental toxins—including common exposures from chemicals mounting in our everyday lives—may be sparking this disorder in vulnerable children. Belli calls for an end to the use of hazardous materials—like toxic flame retardants used in electronics and furniture, which have been banned elsewhere--insisting that we cannot afford to experiment with our children. The Autism Puzzle puts a human face on the families caught in between the debates, and offers a refreshingly balanced perspective.

Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management

Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management
Author: M. Mohamed Essa,M. Walid Qoronfleh
Publsiher: Springer Nature
Total Pages: 693
Release: 2020-01-31
ISBN 10: 3030304027
ISBN 13: 9783030304027
Language: EN, FR, DE, ES & NL

Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management Book Review:

The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.

Shankopathies Shank Protein Deficiency Induced Synaptic Diseases

Shankopathies  Shank Protein Deficiency Induced Synaptic Diseases
Author: Elodie Ey,Thomas Bourgeron,Tobias Maria Boeckers,Eunjoon Kim,Kihoon Han
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-03-10
ISBN 10: 2889635678
ISBN 13: 9782889635672
Language: EN, FR, DE, ES & NL

Shankopathies Shank Protein Deficiency Induced Synaptic Diseases Book Review:

Translational Anatomy and Cell Biology of Autism Spectrum Disorder

Translational Anatomy and Cell Biology of Autism Spectrum Disorder
Author: Michael J. Schmeisser,Tobias M. Boeckers
Publsiher: Springer
Total Pages: 211
Release: 2017-05-25
ISBN 10: 3319524984
ISBN 13: 9783319524986
Language: EN, FR, DE, ES & NL

Translational Anatomy and Cell Biology of Autism Spectrum Disorder Book Review:

Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are still at the very beginning to understand this enormously complex neurodevelopmental condition. This special volume is focused on translational anatomy and cell biology of ASD. International experts from the field including several members of the EU-AIMS initiative launched by the European Union to develop novel treatments for ASD have contributed chapters on several topics covering all crucial aspects of translational ASD research with a special emphasis on ASD model systems including stem cells and animals. Primary objective is to clarify how anatomical and cell biological phenotypes of ASD will help to translate basic mechanisms to clinical practice and to efficiently treat affected individuals in the near future.

Neural Engineering Techniques for Autism Spectrum Disorder

Neural Engineering Techniques for Autism Spectrum Disorder
Author: Ayman S. El-Baz,Jasjit S. Suri
Publsiher: Academic Press
Total Pages: 400
Release: 2021-07-20
ISBN 10: 0128230657
ISBN 13: 9780128230657
Language: EN, FR, DE, ES & NL

Neural Engineering Techniques for Autism Spectrum Disorder Book Review:

Neural Engineering for Autism Spectrum Disorder, Volume One: Imaging and Signal Analysis Techniques presents the latest advances in neural engineering and biomedical engineering as applied to the clinical diagnosis and treatment of Autism Spectrum Disorder (ASD). Advances in the role of neuroimaging, infrared spectroscopy, sMRI, fMRI, DTI, social behaviors and suitable data analytics useful for clinical diagnosis and research applications for Autism Spectrum Disorder are covered, including relevant case studies. The application of brain signal evaluation, EEG analytics, feature selection, and analysis of blood oxygen level-dependent (BOLD) signals are presented for detection and estimation of the degree of ASD. Presents applications of Neural Engineering and other Machine Learning techniques for the diagnosis of Autism Spectrum Disorder (ASD) Includes in-depth technical coverage of imaging and signal analysis techniques, including coverage of functional MRI, neuroimaging, infrared spectroscopy, sMRI, fMRI, DTI, and neuroanatomy of autism Covers Signal Analysis for the detection and estimation of Autism Spectrum Disorder (ASD), including brain signal analysis, EEG analytics, feature selection, and analysis of blood oxygen level-dependent (BOLD) signals for ASD Written to help engineers, computer scientists, researchers and clinicians understand the technology and applications of Neural Engineering for the detection and diagnosis of Autism Spectrum Disorder (ASD)

Nutrition and the Developing Brain

Nutrition and the Developing Brain
Author: Victoria Hall Moran,Nicola M. Lowe
Publsiher: CRC Press
Total Pages: 265
Release: 2016-08-05
ISBN 10: 1315355140
ISBN 13: 9781315355146
Language: EN, FR, DE, ES & NL

Nutrition and the Developing Brain Book Review:

Nutrients play a significant role in brain development throughout fetal and postnatal life. This book reviews the evidence from animal and human research, highlighting the influence of specific nutrients on brain function and cognitive development. With a unique, integrative approach to the nutritional, environmental, and genetic influences on brain development, the book examines issues such as single versus multiple limiting nutrients, critical periods of deficiency, and the impact of the child-parent relationship on the architecture of the developing brain. The effect of undernutrition on the developing brain of infants and young children can be devastating and enduring. It can impede behavioural and cognitive development and educability, thereby undermining future work productivity. Chapter authors are experts in this field of research and provide an up-to-date insight into the role of the individual nutrients in brain development and function.

Radio Frequency and Microwave Effects on Biological Tissues

Radio Frequency and Microwave Effects on Biological Tissues
Author: Jitendra Behari
Publsiher: CRC Press
Total Pages: 288
Release: 2019-10-30
ISBN 10: 1000707083
ISBN 13: 9781000707083
Language: EN, FR, DE, ES & NL

Radio Frequency and Microwave Effects on Biological Tissues Book Review:

Focussing on engineering aspects of RF/Microwave interaction with biological tissues This book discusses the advancement in bio-electromagnetics pertaining to this important issue of electromagentic field-bio interaction vis-a-vis the emission of electromagnetic radiations from mobile phones and their biological fallout. Divided into six chapters, it discusses basic issues in Electromagnetic Field-Biointeraction, dosimetery, instrumentation, and methods of measurement of specific absorption rate, criteria and magnitude of safe exposure and measurements of field in an open (unobstructed) environment.

The Latest Research and Development of Minerals in Human Nutrition

The Latest Research and Development of Minerals in Human Nutrition
Author: Michael N.A. Eskin
Publsiher: Academic Press
Total Pages: 442
Release: 2021-06-08
ISBN 10: 012823184X
ISBN 13: 9780128231845
Language: EN, FR, DE, ES & NL

The Latest Research and Development of Minerals in Human Nutrition Book Review:

The Latest Research and Development of Minerals in Human Nutrition, Volume 96 in the Advances in Food and Nutrition Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Food and Nutrition Research series Updated release includes the Latest Research and Development of Minerals in Human Nutrition

Integrative Medicine E Book

Integrative Medicine   E Book
Author: David Rakel
Publsiher: Elsevier Health Sciences
Total Pages: 1072
Release: 2017-03-21
ISBN 10: 0323496172
ISBN 13: 9780323496179
Language: EN, FR, DE, ES & NL

Integrative Medicine E Book Book Review:

Stay on the cutting edge of today’s most promising trends in complementary and alternative medical treatments with Dr. David Rakel’s Integrative Medicine, 4th Edition. Written by physicians who are experts in both traditional and integrative medicine, this highly regarded, evidence-based reference covers therapies such as botanicals, supplements, mind-body, lifestyle choices, nutrition, exercise, spirituality, and more. Integrative Medicine, 4th Edition uses a clinical, disease-oriented approach, offering practical guidance for reducing costs and improving patient care. Helps you safely and effectively incorporate complementary and alternative therapies into your everyday practice, while focusing on prevention and wellness for a better quality of life. Uses the reliable SORT method (Strength of Recommendation Taxonomy) to provide evidence-based ratings, grading both the evidence and the relative potential harm. Explains how to make the best use of integrative medicine and the mechanisms by which these therapeutic modalities work, keeping you at the forefront of the trend toward integrative health care. Includes 13 brand-new chapters, covering hot topics such as personalized medicine, MTHFR mutation, food allergy and intolerance, the gut-immune influence on systemic inflammation and disease, chelation therapy, testosterone deficiency, adrenal fatigue, and much more. Features more than 100 significantly revised chapters and hundreds of new figures and tables throughout.

Nutritional Deficiency

Nutritional Deficiency
Author: Pinar Erkekoglu,Belma Kocer-Gumusel
Publsiher: BoD – Books on Demand
Total Pages: 206
Release: 2016-07-20
ISBN 10: 9535124374
ISBN 13: 9789535124375
Language: EN, FR, DE, ES & NL

Nutritional Deficiency Book Review:

Intake of a sufficient diet will provide an individual to live a healthy and functional life. However, poor intake of different nutritional components, such as proteins, vitamins, minerals, and trace elements, may lead to health problems that can cause morbidity and finally mortality. Assessment of nutritional status involves physical examination, comprehensive evaluation of biochemical tests, body composition, and organ functions. Both high and low intake of nutritional elements may lead to significant health impairment. The main aim of the book Nutritional Deficiency is to determine the relationships between nutritional status and general health. The authors, who are contributing to the book, particularly focused on iron, vitamin D, and zinc deficiencies, which are global health problems. Besides, some chapters mention the impact of different nutritional deficiencies in susceptible periods of life, such as pregnancy and elderly. Besides, as a result of these deficiencies, different health conditions, such as depression, anemia, loss of neuronal plasticity, and cancer, are widely scrutinized in the book. One chapter mainly focuses on the effects of disasters on nutrition and disaster-caused malnutrition in underdeveloped countries. This book will widen the knowledge store of the readers on the effects of nutrition on general health, how nutritional deficiencies arise when there is a health problem, and how the nutritional status affects susceptible populations.

The Age of Autism

The Age of Autism
Author: Dan Olmsted,Mark Blaxill
Publsiher: Macmillan
Total Pages: 448
Release: 2010-09-14
ISBN 10: 9781429941181
ISBN 13: 1429941189
Language: EN, FR, DE, ES & NL

The Age of Autism Book Review:

A groundbreaking book, THE AGE OF AUTISM explores how mankind has unwittingly poisoned itself for half a millennium For centuries, medicine has made reckless use of one of earth's most toxic substances: mercury—and the consequences, often invisible or ignored, continue to be tragic. Today, background pollution levels, including global emissions of mercury as well as other toxicants, make us all more vulnerable to its effects. From the worst cases of syphilis to Sigmund Freud's first cases of hysteria, from baffling new disorders in 19th century Britain to the modern scourge of autism, THE AGE OF AUTISM traces the long overlooked history of mercury poisoning. Now, for the first time, authors Dan Olmsted and Mark Blaxill uncover that history. Within this context, they present startling findings: investigating the first cases of autism diagnosed in the 1940s revealed an unsuspected link to a new form of mercury in seed disinfectants, lumber fungicides and vaccines. In the tradition of Silent Spring and An Inconvenient Truth, Olmsted and Blaxill demonstrate with clarity how chemical and environmental clues may have been missed as medical "experts," many of them blinded by decades of systemic bias, instead placed blamed on parental behavior or children's biology. By exposing the roots and rise of The Age of Autism, this book attempts to point the way out – to a safer future for our children and the planet.

Autism

Autism
Author: Abha Chauhan,Ved Chauhan,Ted Brown
Publsiher: CRC Press
Total Pages: 452
Release: 2009-10-26
ISBN 10: 9781420068870
ISBN 13: 1420068873
Language: EN, FR, DE, ES & NL

Autism Book Review:

In 2007, the Centers for Disease Control and Prevention issued an autism alarm, estimating that one in 150 children may be affected by autism spectrum disorder. Autism has been treated mainly with technical approaches: principally applied behavior analysis and psychopharmacology. The findings in this book implicate oxidative stress as a common feature in autism, and support the claim that oxidative stress and intracellular redox imbalance can be induced or triggered in autism by exposure to certain environmental agents. Such findings could point the way to new treatment approaches in autism. Autism: Oxidative Stress, Inflammation, and Immune Abnormalities brings together a wealth of cutting-edge evidence that is already influencing how we treat this serious condition. It looks at the role of neuropathological abnormalities, genetics, and those factors common to oxidative stress such as inflammation, immune dysfunction, aberrant cellular signaling, and gene-environment interactions. Among dozens of research topics, this volume — Looks at interactions between genetic and environmental factors such as the maternal immune environment and prenatal/postnatal environmental stressors Summarizes evidence for oxidative damage and inflammation in autism Introduces a PDD behavior inventory as a tool for assessing autism Considers autism as an aberrant adaptive response to neuroinflammation and oxidative stress Examines the role of abnormal calcium signaling and the hypothesis that it may represent a target for novel therapeutics Presents a hypothesis that autism arises from the dysregulation of a unified gut/brain system rather than originating in the brain alone Proposes the utility of using a biopsychosocial method to treat autism This book shows us that autism is not only developmental but also a chronic condition based on active pathophysiology, and that it is not only behavioral but also presents somatic and systemic features. The findings in these chapters support the theory that oxidative stress plays an important role in autism. They also point to the value of conducting in-depth mechanistic studies as a way to uncover new targets for therapeutic intervention in autism.

Endocrine Toxicology Third Edition

Endocrine Toxicology  Third Edition
Author: J. Charles Eldridge,James T. Stevens
Publsiher: CRC Press
Total Pages: 424
Release: 2016-04-19
ISBN 10: 142009310X
ISBN 13: 9781420093100
Language: EN, FR, DE, ES & NL

Endocrine Toxicology Third Edition Book Review:

With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology’s increased importance in environmental safety issues due to legislative directives established over the past ten years. Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides: putative endocrine disruptors and mechanisms of endocrine toxicity the history and status of the regulatory process mechanisms of toxic effects in various hormonal systems comparisons of the endocrine responses in humans, livestock, and wildlife testing methods in mammalian, fish, avian, and amphibian models valuable insight into the approaches of various personnel in the field, including: government officials who make and oversee policy; scientists in charge of development and validation of testing methods; basic researchers who identify toxic mechanisms; and manufacturers responsible for environmentally benign product certification

Autism

Autism
Author: Valsamma Eapen
Publsiher: BoD – Books on Demand
Total Pages: 500
Release: 2011-08-17
ISBN 10: 9533074930
ISBN 13: 9789533074931
Language: EN, FR, DE, ES & NL

Autism Book Review:

The book covers some of the key research developments in autism and brings together the current state of evidence on the neurobiologic understanding of this intriguing disorder. The pathogenetic mechanisms are explored by contributors from diverse perspectives including genetics, neuroimaging, neuroanatomy, neurophysiology, neurochemistry, neuroimmunology, neuroendocrinology, functional organization of the brain and clinical applications from the role of diet to vaccines. It is hoped that understanding these interconnected neurobiological systems, the programming of which is genetically modulated during neurodevelopment and mediated through a range of neuropeptides and interacting neurotransmitter systems, would no doubt assist in developing interventions that accommodate the way the brains of individuals with autism function. In keeping with the multimodal and diverse origins of the disorder, a wide range of topics is covered and these include genetic underpinnings and environmental modulation leading to epigenetic changes in the aetiology; neural substrates, potential biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions.

Nutraceutical and Functional Foods in Disease Prevention

Nutraceutical and Functional Foods in Disease Prevention
Author: Keservani, Raj K.,Sharma, Anil K.,Kesharwani, Rajesh K.
Publsiher: IGI Global
Total Pages: 569
Release: 2018-07-13
ISBN 10: 1522532684
ISBN 13: 9781522532682
Language: EN, FR, DE, ES & NL

Nutraceutical and Functional Foods in Disease Prevention Book Review:

Current research on health, nutrition, and preventative care will always be in demand. As the battles against ailments such as diabetes and heart disease continue, medical professionals are seeking to create a healthier society through nutrition and dietary-based tactics. Nutraceutical and Functional Foods in Disease Prevention is a comprehensive publication providing current research on the dynamic fields of pharmaceutical and biomedical science in relation to nutrition. This book examines the interactions and associations between nutritive value and its therapeutic applications in human health. Touching on topics such as the impact of probiotics in human health and disease treatment, recent trends in functional foods for obesity management, and the clinical role of antioxidants in the treatment of diseases, this title proves a valuable resource for academicians, healthcare practitioners, medical researchers, and higher education students preparing for careers as health professionals.

Protein Homeostasis Diseases

Protein Homeostasis Diseases
Author: Angel L. Pey
Publsiher: Academic Press
Total Pages: 450
Release: 2020-02-13
ISBN 10: 0128191333
ISBN 13: 9780128191330
Language: EN, FR, DE, ES & NL

Protein Homeostasis Diseases Book Review:

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance