Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling
Author: Subhas C. Kundu,Rui L Reis
Publsiher: Elsevier
Total Pages: 772
Release: 2020-08-22
ISBN 10: 012818129X
ISBN 13: 9780128181294
Language: EN, FR, DE, ES & NL

Biomaterials for 3D Tumor Modeling Book Review:

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Cell derived Matrices

Cell derived Matrices
Author: Rui L. Reis
Publsiher: Academic Press
Total Pages: 352
Release: 2020-03-24
ISBN 10: 012820172X
ISBN 13: 9780128201725
Language: EN, FR, DE, ES & NL

Cell derived Matrices Book Review:

Cell-Derived Matrices, Part A, Volume 156, provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Biochemical, biophysical and cell biological approaches are presented, along with sample results. Specific chapters cover Anisotropic cell-derived matrices with controlled 3D architecture, Generation of functional fluorescently-labelled cell-derived matrices by means of genetically-modified fibroblasts, Bi-layered cell-derived matrices, Engineering clinically-relevant cell-derived matrices using primary fibroblasts, Decellularized matrices for bioprinting applications, and much more.

Cell Derived Matrices Part B

Cell Derived Matrices Part B
Author: Anonim
Publsiher: Academic Press
Total Pages: 264
Release: 2020-04-23
ISBN 10: 0128201754
ISBN 13: 9780128201756
Language: EN, FR, DE, ES & NL

Cell Derived Matrices Part B Book Review:

Cell-Derived Matrices Part B, Volume 157 provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Chapters in this new release include Glaucomatous cell-derived matrices, Cardiac tissue explants decellularization, Decellularization of skin matrices for wound healing applications, Guiding axonal growth by aligned cell-derived matrices for spinal cord injury regeneration, Human Mesenchymal Stem Cell–Derived Matrices for Enhanced Osteoregeneration, Amniotic decellularized matrices, Three-Dimensional (3-D) Tissue Reconstruction without Scaffold, Tubular cell-derived matrices for TERM applications, and more. Contains contributions from leading experts in the field from across the globe Covers a wide array of topics surrounding the use of cell-derived matrices for tissue engineering and regenerative medicine applications Includes relevant, analysis-based topics, such as the quantification of mechanical properties, decellularization protocols, and innovative matrix engineering methods

Biomaterials and Microfluidics Based Tissue Engineered 3D Models

Biomaterials  and Microfluidics Based Tissue Engineered 3D Models
Author: J. Miguel Oliveira,Rui L. Reis
Publsiher: Springer Nature
Total Pages: 175
Release: 2020-04-13
ISBN 10: 3030365883
ISBN 13: 9783030365882
Language: EN, FR, DE, ES & NL

Biomaterials and Microfluidics Based Tissue Engineered 3D Models Book Review:

This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.

Tumor Organoids

Tumor Organoids
Author: Shay Soker,Aleksander Skardal
Publsiher: Humana Press
Total Pages: 213
Release: 2017-10-20
ISBN 10: 3319605119
ISBN 13: 9783319605111
Language: EN, FR, DE, ES & NL

Tumor Organoids Book Review:

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Biomaterials for Cancer Therapeutics

Biomaterials for Cancer Therapeutics
Author: Kinam Park
Publsiher: Elsevier
Total Pages: 530
Release: 2013-11-23
ISBN 10: 0857096761
ISBN 13: 9780857096760
Language: EN, FR, DE, ES & NL

Biomaterials for Cancer Therapeutics Book Review:

Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction. This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials. A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer Discusses the fundamentals of biomaterials for cancer therapeutics Discusses synthetic vaccines, proteins and polymers for cancer therapeutics

Recent 3D Tumor Models for Testing Immune Mediated Therapies

Recent 3D Tumor Models for Testing Immune Mediated Therapies
Author: Silvia Scaglione,Roberta Castriconi,Jacques Zimmer
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-01-10
ISBN 10: 2889740153
ISBN 13: 9782889740154
Language: EN, FR, DE, ES & NL

Recent 3D Tumor Models for Testing Immune Mediated Therapies Book Review:

Bone and Cancer

Bone and Cancer
Author: Felix Bronner,Mary C. Farach-Carson
Publsiher: Springer Science & Business Media
Total Pages: 246
Release: 2009-06-20
ISBN 10: 9781848820197
ISBN 13: 1848820194
Language: EN, FR, DE, ES & NL

Bone and Cancer Book Review:

The fifth in a series of reviews, centered on a single major topic (vol. 1 Bone Formation, vol. 2 Bone Resorption, vol. 3 Engineering of Functional Skeletal Tissues, vol. 4 Osteoarthritis) written by acknowledged authorities in the field, and aimed at researchers, clinicians and others involved in the bone field.

Tissue engineered Prostate Cancer Xenografts

Tissue engineered Prostate Cancer Xenografts
Author: Thomas Joseph Long
Publsiher: Unknown
Total Pages: 131
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:881834298
Language: EN, FR, DE, ES & NL

Tissue engineered Prostate Cancer Xenografts Book Review:

Despite massive investments in research and development, it is estimated that 95% of oncology compounds that enter clinical trials ultimately fail to receive FDA approval [1]. This disconnect between pre-clinical testing and clinical success points to a need to develop improved pre-clinical model systems for cancer studies that more accurately reflect human disease states. Toward this goal, biomaterial scaffolds have shown promise as the basis for in vitro and in vivo 3D cancer models. Tumors engineered using biomaterials have shown evidence of being more physiologically relevant than some traditional preclinical model systems, and synthetic biomaterials provide the added potential for enhanced microenvironmental control. In this dissertation, we examine sphere-templated poly(2-hydroxyethyl methacrylate) (pHEMA) scaffolds as the basis for engineering in vivo xenografts from human prostate cancer cell lines. Methods were developed to seed, culture, and measure the proliferation of prostate cancer cells in vitro within these porous hydrogels. A novel capillary force-based seeding method is described that improved cell number and distribution within the scaffolds compared to well-established protocols such as static and centrifugation seeding. Dynamic cell culture improved oxygen diffusion in vitro, and a PicoGreen-based DNA assay was used to evaluate cell proliferation. pHEMA scaffolds seeded and pre-cultured with tumorigenic M12 prostate cancer epithelial cells prior to implantation generated tumors in athymic nude mice, demonstrating the ability of the scaffolds to be used as a synthetic vehicle for xenograft generation. The resulting tumors showed no significant differences in tumor growth kinetics or vascularity compared to standard xenografts derived from Matrigel, which is consistent with observations that highly tumorigenic cells are not affected in vivo by 3D culture within biomaterial scaffolds. Because Matrigel-based xenografts expose cells to exogenous growth factors and ECM proteins, it would be of interest to the cancer research field to develop a controllable, synthetic system as a replacement. We attempted to do this using pHEMA scaffolds seeded with LNCaP C4-2 metastatic prostate cancer cells. LNCaP C4-2 cells ordinarily require Matrigel or stromal cell support to form tumors in vivo, but when implanted within pHEMA, the constructs were poorly tumorigenic. Scaffold surface modification with collagen I did not improve tumorigenicity, but the synthetic nature of the scaffold lends itself to further surface modifications and controlled growth factor release in future studies that may allow tumor development within a controllable microenvironment. Finally, M12mac25 cells, an epithelial prostate cancer cell line that is ordinarily rendered non-tumorigenic through the expression of the tumor suppressor insulin-like growth factor binding protein 7 (IGFBP7), displayed a tumorigenic response when implanted within porous pHEMA scaffolds. These findings show the potential for this biomaterials-based model system to be used in the study of in vivo prostate cancer dormancy and dormancy escape. The M12mac25 tumors showed no significant difference in vascularity compared to their dormant Matrigel counterparts, but did demonstrate a significantly higher macrophage infiltration within the scaffolds mediated by the foreign body response to the materials. Cytokine arrays, DNA oligonucleotide arrays, in vitro macrophage-conditioned media studies, and in vivo studies using clondronate liposomes to eliminate macrophages showed evidence that macrophages could be the key cellular player mediating this dormancy escape.

Engineering 3D Tissue Test Systems

Engineering 3D Tissue Test Systems
Author: Karen J.L. Burg,Didier Dréau,Timothy Burg
Publsiher: CRC Press
Total Pages: 412
Release: 2017-07-28
ISBN 10: 1351644548
ISBN 13: 9781351644549
Language: EN, FR, DE, ES & NL

Engineering 3D Tissue Test Systems Book Review:

Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components. The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues.

3D Printing in Medicine

3D Printing in Medicine
Author: Deepak M Kalaskar
Publsiher: Woodhead Publishing
Total Pages: 178
Release: 2017-04-17
ISBN 10: 0081007264
ISBN 13: 9780081007266
Language: EN, FR, DE, ES & NL

3D Printing in Medicine Book Review:

3D Printing in Medicine examines the emerging market of 3D-printed biomaterials and its clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The book begins with a discussion of the fundamentals of 3D printing, including topics such as materials, and hardware. Chapters go on to cover applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing and 3D cell and organ printing. The concluding chapters in the book review the applications of 3D printing in diagnostics, drug development, 3D-printed disease models and 3D printers for surgical practice. With a strong focus on the translation of 3D printing technology to a clinical setting, this book is a valuable resource for scientists and engineers working in biomaterial, biomedical, and nanotechnology based industries and academia. Provides a comprehensive and authoritative overview of all the medical applications of 3D printing biomaterials and technologies Focuses on the emerging market of 3D printed biomaterials in clinical applications Reviews both commercial and under development materials, tools, their applications, and future evolution

Enabling Biomaterials for New Biomedical Technologies and Clinical Therapies

Enabling Biomaterials for New Biomedical Technologies and Clinical Therapies
Author: Hasan Uludag,Abhay Pandit,Liisa Kuhn
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-07-14
ISBN 10: 2889638537
ISBN 13: 9782889638536
Language: EN, FR, DE, ES & NL

Enabling Biomaterials for New Biomedical Technologies and Clinical Therapies Book Review:

Soft Matter for Biomedical Applications

Soft Matter for Biomedical Applications
Author: Helena S Azevedo,João F Mano,João Borges
Publsiher: Royal Society of Chemistry
Total Pages: 766
Release: 2021-06-07
ISBN 10: 1839161132
ISBN 13: 9781839161131
Language: EN, FR, DE, ES & NL

Soft Matter for Biomedical Applications Book Review:

Dynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications. The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.

Multiscale Biomaterials for Cell and Tissue Engineering

Multiscale Biomaterials for Cell and Tissue Engineering
Author: Pranay Agarwal
Publsiher: Unknown
Total Pages: 135
Release: 2017
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1004239635
Language: EN, FR, DE, ES & NL

Multiscale Biomaterials for Cell and Tissue Engineering Book Review:

Next, a bottom-up approach for fabricating 3D vascularized human breast tumor model with the core-shell microencapsulation technology is developed. Microtumors (i.e., 3D aggregates of cancer cells) are generated in core-shell microcapsules and used together with human endothelial cells and human adipose derived stem cells (hADSCs) as building blocks to self-assemble into vascularized tumor in collagen hydrogel. The utility of the platform in drug screening is further demonstrated. It is shown that vascularization can render increased cancer resistance to chemotherapy. This vascularized tumor system may be valuable for in vitro drug screening to better predict the drug efficacy in cancer patients. Lastly, a multiscale system for efficient co-delivery of cells and proteins/growth factors in vivo is developed to address the issue of low cell survival associated with cell delivery in vivo. The multiscale delivery system is comprised of therapeutic agents-laden nanoparticles encapsulated in microcapsules (nano-in-micro), hADSCs, and collagen hydrogel. The nano-in-micro system enables sustained release of therapeutic proteins to interact with their receptors on the hADSCs in the system which significantly improves the survival and proliferation of the hADSCs after implantation. This is shown to greatly facilitate the tissue regeneration in an ischemic disease model. To conclude, this dissertation work demonstrates how microscale encapsulation of cells via microfluidics provides a powerful suite of tools to engineering the cellular microenvironment at micro and macro scales. The technologies and systems described here could potentially help in building tissue engineering constructs that enable treatment of a myriad of human diseases.

Comprehensive Biomaterials II

Comprehensive Biomaterials II
Author: Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publsiher: Elsevier
Total Pages: 4858
Release: 2017-05-18
ISBN 10: 0081006926
ISBN 13: 9780081006924
Language: EN, FR, DE, ES & NL

Comprehensive Biomaterials II Book Review:

Comprehensive Biomaterials II, Second Edition brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Tumor Microenvironment

Tumor Microenvironment
Author: Jacinta Serpa
Publsiher: Springer Nature
Total Pages: 443
Release: 2020-03-04
ISBN 10: 3030340252
ISBN 13: 9783030340254
Language: EN, FR, DE, ES & NL

Tumor Microenvironment Book Review:

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

Biologically responsive Hybrid Biomaterials

Biologically responsive Hybrid Biomaterials
Author: Esmaiel Jabbari,Ali Khademhosseini
Publsiher: World Scientific
Total Pages: 423
Release: 2010
ISBN 10: 981429568X
ISBN 13: 9789814295680
Language: EN, FR, DE, ES & NL

Biologically responsive Hybrid Biomaterials Book Review:

Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral toxicity. Multivalent presentation of tumor-associated antigens on a targeted delivery system containing T and B cell epitopes can result in strong, long-lasting, self-adjuvant immunity against cancer and other diseases in vaccination. These examples demonstrate that cell-responsive conjugate biomaterials have profoundly impacted the medical field. This book is divided into three sections. In the first section, synthesis and characterization, conformation, structure-activity, self-assembly, and host response of conjugate hybrid biomaterials are covered. The second section is dedicated to the applications of conjugate biomaterials in drug delivery and vaccination while the last section is devoted to tissue engineering applications including cell adhesion, control of the stem cell niche, cartilage regeneration, neural and vascular tissue engineering, and dynamic cell culture systems for functionalized biomaterials. There is no doubt that biologically-responsive conjugate biomaterials play a key role in the design of biologics and medical devices, and this pioneering reference book provides a comprehensive review on synthesis, characterization, structure-activity, 3D assembly/fabrication, host response and the emerging applications of conjugate hybrid biomaterials.

Biofabrication and 3D Tissue Modeling

Biofabrication and 3D Tissue Modeling
Author: Dong-Woo Cho
Publsiher: Royal Society of Chemistry
Total Pages: 369
Release: 2019-01-02
ISBN 10: 1788011988
ISBN 13: 9781788011983
Language: EN, FR, DE, ES & NL

Biofabrication and 3D Tissue Modeling Book Review:

3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems
Author: Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao
Publsiher: William Andrew
Total Pages: 452
Release: 2012-12-31
ISBN 10: 143773460X
ISBN 13: 9781437734607
Language: EN, FR, DE, ES & NL

Microfluidic Cell Culture Systems Book Review:

The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture Provides balanced coverage of microsystems engineering and bioengineering

3D Bioprinting in Medicine

3D Bioprinting in Medicine
Author: Murat Guvendiren
Publsiher: Springer
Total Pages: 209
Release: 2019-08-02
ISBN 10: 3030239063
ISBN 13: 9783030239060
Language: EN, FR, DE, ES & NL

3D Bioprinting in Medicine Book Review:

This book provides current and emerging developments in bioprinting with respect to bioprinting technologies, bioinks, applications, and regulatory pathways. Topics covered include 3D bioprinting technologies, materials such as bioinks and bioink design, applications of bioprinting complex tissues, tissue and disease models, vasculature, and musculoskeletal tissue. The final chapter is devoted to clinical applications of bioprinting, including the safety, ethical, and regulatory aspects. This book serves as a go-to reference on bioprinting and is ideal for students, researchers and professionals, including those in academia, government, the medical industry, and healthcare.