Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury
Author: Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang
Publsiher: Royal Society of Chemistry
Total Pages: 226
Release: 2012
ISBN 10: 1849733899
ISBN 13: 9781849733892
Language: EN, FR, DE, ES & NL

Biomarkers for Traumatic Brain Injury Book Review:

Examines current and prospective biomarkers for assessment of traumatic brain injury using a multidisciplinary approach involving biochemistry, molecular biology and clinical chemistry.

Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury
Author: Alan H.B. Wu, Ph.D.,W. Frank Peacock, MD
Publsiher: Academic Press
Total Pages: 482
Release: 2020-08-03
ISBN 10: 0128163461
ISBN 13: 9780128163467
Language: EN, FR, DE, ES & NL

Biomarkers for Traumatic Brain Injury Book Review:

Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based biomarkers for traumatic brain injury. The book presents an economic analysis for implementing TBI biomarkers into clinical practice. In addition, it discusses the analytical tools needed to implement TBI biomarkers, including specifications for testing instruments and interpretative software. Neurologists, emergency department physicians, intensivists, and clinical laboratorians will find this book a great resource from which to familiarize themselves with the issues and processes regarding TBI biomarkers. Approximately 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year with over 250,000 hospitalizations and 50,000 deaths. There has been a significant rise in interest in diagnosing mild concussions, particularly in the sports world. While imaging has been the gold standard, these procedures are costly and not always available. There is great potential in using serum-based biomarkers, hence the book seeks to enlighten readers on new possibilities. Offers strategies for the selection and implementation of traumatic brain injury biomarkers Discusses the importance of autoantibodies and post translational modifications for TBI Covers the analytical tools needed to implement TBI biomarkers, including the specifications for testing instruments and interpretative software

Brain Neurotrauma

Brain Neurotrauma
Author: Firas H. Kobeissy
Publsiher: CRC Press
Total Pages: 725
Release: 2015-02-25
ISBN 10: 1466565993
ISBN 13: 9781466565999
Language: EN, FR, DE, ES & NL

Brain Neurotrauma Book Review:

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
Author: Daniel Laskowitz,Gerald Grant
Publsiher: CRC Press
Total Pages: 412
Release: 2015-12-01
ISBN 10: 1498766579
ISBN 13: 9781498766579
Language: EN, FR, DE, ES & NL

Translational Research in Traumatic Brain Injury Book Review:

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury
Author: Svetlana Dambinova,Ronald L Hayes,Kevin K.W. Wang
Publsiher: Royal Society of Chemistry
Total Pages: 246
Release: 2012-05-24
ISBN 10: 1849734747
ISBN 13: 9781849734745
Language: EN, FR, DE, ES & NL

Biomarkers for Traumatic Brain Injury Book Review:

Due to injuries sustained in sports and in combat, interest in TBI has never been greater. Biomarkers for Traumatic Brain Injury will fulfil a gap in our understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging. This knowledge will be useful for all researchers and clinicians interested in the biochemical and structural sequelae underpinning clinical manifestations of TBI and help guide appropriate patient management. Current and prospective biomarkers for the assessment of traumatic brain injury (TBI), particularly mild TBI, are examined using a multidisciplinary approach involving biochemistry, molecular biology, and clinical chemistry. The book incorporates presentations from outstanding researchers and clinicians in the area and describes advanced proteomic and degradomic technologies in the development of novel biomarker assays. For practical purposes, the focus of this volume is on detection of blood-based biomarkers to improve diagnostic certainty of mild TBI in conjunction with radiological and clinical findings. It represents contributions from internationally-recognized researchers at the forefront of traumatic brain injury many of whom are recipients of grants and contracts from the United States Department of Defense for research specifically on developing diagnostic tests for TBI. The book will be essential reading for scientists, pharmacologists, chemists, medical and graduate students.

On Biomarkers in Traumatic Brain Injury

On Biomarkers in Traumatic Brain Injury
Author: Anonim
Publsiher: Unknown
Total Pages: 96
Release: 2015
ISBN 10: 9789175498645
ISBN 13: 9175498642
Language: EN, FR, DE, ES & NL

On Biomarkers in Traumatic Brain Injury Book Review:

Biomarkers of Brain Injury and Neurological Disorders

Biomarkers of Brain Injury and Neurological Disorders
Author: Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publsiher: CRC Press
Total Pages: 650
Release: 2014-10-28
ISBN 10: 1482239825
ISBN 13: 9781482239829
Language: EN, FR, DE, ES & NL

Biomarkers of Brain Injury and Neurological Disorders Book Review:

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Traumatic Brain and Spinal Cord Injury

Traumatic Brain and Spinal Cord Injury
Author: Cristina Morganti-Kossmann,Ramesh Raghupathi,Andrew Maas
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2012-07-19
ISBN 10: 1139536354
ISBN 13: 9781139536356
Language: EN, FR, DE, ES & NL

Traumatic Brain and Spinal Cord Injury Book Review:

Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: • The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion • Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury • Overview of major pathophysiological changes • The development of animal models; successes and limitations • Past, current and future therapeutic strategies including rehabilitative opportunities. Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians.

Traumatic Brain Injury

Traumatic Brain Injury
Author: Stephen Honeybul,Angelos G. Kolias
Publsiher: Springer Nature
Total Pages: 355
Release: 2021-09-17
ISBN 10: 3030780759
ISBN 13: 9783030780753
Language: EN, FR, DE, ES & NL

Traumatic Brain Injury Book Review:

This book provides a comprehensive analysis of the contemporary management of all aspects of traumatic brain injury (TBI), combining the findings of several recent randomised controlled trials investigating the role of hypothermia, erythropoietin, intracranial pressure monitoring and decompressive craniectomy in the management of TBI. The book is divided into four sections: the first section covers the epidemiology of TBI, the changing global patterns of presentation, and the basic pathophysiology and classification, while the second discusses contemporary management of TBI, from pre-hospital care, emergency assessment, and medical and surgical management to rehabilitation and social reintegration. The third section then examines the evidence gained from recent clinical trials that have investigated the efficacy of management strategies involving intracranial pressure monitoring, multimodal monitoring, hypothermia, erythropoietin, thromboembolic prophylaxis and decompressive craniectomy. Lastly, the fourth section explores the ethical issues, both at the societal level and on an individual basis. Written by a broad range of experts, this book provides a valuable reference resource for neurosurgeons, intensivists, clinicians with ethical experience and pure bioethicists in their daily work.

Neurotrauma

Neurotrauma
Author: Kevin Wang
Publsiher: Oxford University Press, USA
Total Pages: 528
Release: 2018-12-05
ISBN 10: 0190279435
ISBN 13: 9780190279431
Language: EN, FR, DE, ES & NL

Neurotrauma Book Review:

Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

Blood Biomarkers for Traumatic Brain Injury

Blood Biomarkers for Traumatic Brain Injury
Author: Anonim
Publsiher: Unknown
Total Pages: 70
Release: 2015
ISBN 10: 9789162896706
ISBN 13: 9162896709
Language: EN, FR, DE, ES & NL

Blood Biomarkers for Traumatic Brain Injury Book Review:

Traumatic Brain Injury

Traumatic Brain Injury
Author: Jordan Grafman,Andres M. Salazar
Publsiher: Elsevier
Total Pages: 490
Release: 2015-02-19
ISBN 10: 0444634983
ISBN 13: 9780444634986
Language: EN, FR, DE, ES & NL

Traumatic Brain Injury Book Review:

The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI. Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including descriptions of potential biomarkers and indicators of potential targets for treatments to reduce the impact of the injury Explores cellular and molecular mechanisms as well as genetic predictors of outcome Offers coverage of various diagnostic tools – CT, MRI, DDTI, fMRI, EEG, resting functional imaging, and more State-of-the-art traumatic brain injury management and treatment principles are presented for both civilian and military care

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 74
Release: 2011-07-05
ISBN 10: 0309212243
ISBN 13: 9780309212243
Language: EN, FR, DE, ES & NL

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Book Review:

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Essentials of Neuroanesthesia

Essentials of Neuroanesthesia
Author: Hemanshu Prabhakar
Publsiher: Academic Press
Total Pages: 1036
Release: 2017-03-24
ISBN 10: 0128054301
ISBN 13: 9780128054307
Language: EN, FR, DE, ES & NL

Essentials of Neuroanesthesia Book Review:

Essentials of Neuroanesthesia offers useful insights on the anesthetic management of neurosurgical and neurologic patients. This book covers all topics related to neuroanesthesia, providing essential knowledge on the brain and spinal cord. Sections include chapters on anatomy, physiology, and pharmacology, along with specific chapters related to various neurosurgical and neurological problems and their anesthetic management. This book provides an understanding of related issues, such as palliative care, evidence based practice of neuroanesthesia, sterilization techniques, biostatistics, and ethical issues, and is useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, neuroanesthesia, and neurology. Offers useful insights on the anesthetic management of neurosurgical and neurologic patients Discusses related issues, such as palliative care, evidence based practice of neuroanesthesia, sterilization techniques, biostatistics, and ethical issues Useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, neuroanesthesia, and neurology

Pediatric Traumatic Brain Injury

Pediatric Traumatic Brain Injury
Author: Vicki Anderson,Keith Owen Yeates
Publsiher: Cambridge University Press
Total Pages: 235
Release: 2010-02-04
ISBN 10: 0521763320
ISBN 13: 9780521763325
Language: EN, FR, DE, ES & NL

Pediatric Traumatic Brain Injury Book Review:

"This book, New Frontiers in Pediatric Traumatic Brain Injury, aims to evaluate what we have learned about TBI in childhood to date and, perhaps more importantly to articulate the challenges we face and how we should go forward in the future"--Provided by publisher.

Management of Severe Traumatic Brain Injury

Management of Severe Traumatic Brain Injury
Author: Terje Sundstrøm,Per-Olof Grände,Niels Juul,Carsten Kock-Jensen,Bertil Romner,Knut Wester
Publsiher: Springer Science & Business Media
Total Pages: 417
Release: 2012-06-25
ISBN 10: 3642281265
ISBN 13: 9783642281266
Language: EN, FR, DE, ES & NL

Management of Severe Traumatic Brain Injury Book Review:

In order to reduce the number of deaths from severe head injuries, systematic management is essential. This book is a practical, comprehensive guide to the treatment of patients (both adults and children) with such injuries, from the time of initial contact through to the rehabilitation center. Sections are devoted to prehospital treatment, admission and diagnostics, acute management, and neurointensive care and rehabilitation. Evidence-based recommendations are presented for each diagnostic and therapeutic measure, and tips, tricks, and pitfalls are highlighted. Throughout, the emphasis is on the provision of sound clinical advice that will maximize the likelihood of an optimal outcome. Helpful flowcharts designed for use in daily routine are also provided. The authors are all members of the Scandinavian Neurotrauma Committee and have extensive practical experience in the areas they write about.

Nutrition and Traumatic Brain Injury

Nutrition and Traumatic Brain Injury
Author: Institute of Medicine,Food and Nutrition Board,Committee on Nutrition, Trauma, and the Brain
Publsiher: National Academies Press
Total Pages: 444
Release: 2011-07-01
ISBN 10: 0309210089
ISBN 13: 9780309210089
Language: EN, FR, DE, ES & NL

Nutrition and Traumatic Brain Injury Book Review:

Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.

Peptidomics

Peptidomics
Author: Mikhail Soloviev,Per Andrén,Chris Shaw
Publsiher: John Wiley & Sons
Total Pages: 424
Release: 2007-12-21
ISBN 10: 9780470196496
ISBN 13: 0470196491
Language: EN, FR, DE, ES & NL

Peptidomics Book Review:

The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Handbook of Neuroemergency Clinical Trials

Handbook of Neuroemergency Clinical Trials
Author: Brett E. Skolnick,Wayne M. Alves
Publsiher: Academic Press
Total Pages: 400
Release: 2017-11-13
ISBN 10: 0128041013
ISBN 13: 9780128041017
Language: EN, FR, DE, ES & NL

Handbook of Neuroemergency Clinical Trials Book Review:

Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development. Presents a comprehensive overview on clinical trials and drug development challenges in acute neuroscience populations Provides neurologists, neuroscientists and drug developers with a complete understanding of scientific and medical issues related to designing clinical trials Edited by leaders in the field who have designed and managed over 50 neuroemergency clinical trials

Neuroproteomics

Neuroproteomics
Author: Firas H. Kobeissy,Stanley M. Stevens, Jr.
Publsiher: Humana
Total Pages: 424
Release: 2018-08-08
ISBN 10: 9781493983490
ISBN 13: 1493983490
Language: EN, FR, DE, ES & NL

Neuroproteomics Book Review:

This new edition provides updated and novel protocols of neuroproteomics methods that encompass both global-scale as well as targeted and specialized topics, which are timely additions for the molecular and phenotypic analysis of the central nervous system and CNS-related disorders. The detailed contents of this book include the exploration of several exciting areas of advanced methods used for neuroproteomics research including relative and absolute protein quantitation by mass spectrometry, characterization of post-translational modifications, as well as bioinformatics and computational approaches. Written for the highly successful Methods in Molecular Biology series, methodology chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Updated and accessible, Neuroproteomics: Methods and Protocols, Second Edition serves researchers and clinical scientists involved in the area of biomarker research and protein biochemistry, as well as molecular biologists and biochemists who have been involved in proteomics research already or even for those new to the field.