Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury
Author: Alan H.B. Wu,W. Frank Peacock
Publsiher: Academic Press
Total Pages: 486
Release: 2020-07-10
ISBN 10: 0128167300
ISBN 13: 9780128167304
Language: EN, FR, DE, ES & NL

Biomarkers for Traumatic Brain Injury Book Review:

Biomarkers for Traumatic Brain Injury provides a comprehensive overview on the selection and implementation of serum-based and saliva-based biomarkers for traumatic brain injury. The book presents an economic analysis for implementing TBI biomarkers into clinical practice. In addition, it discusses the analytical tools needed to implement TBI biomarkers, including specifications for testing instruments and interpretative software. Neurologists, emergency department physicians, intensivists, and clinical laboratorians will find this book a great resource from which to familiarize themselves with the issues and processes regarding TBI biomarkers. Approximately 2 million people in the U.S. sustain a traumatic brain injury (TBI) each year with over 250,000 hospitalizations and 50,000 deaths. There has been a significant rise in interest in diagnosing mild concussions, particularly in the sports world. While imaging has been the gold standard, these procedures are costly and not always available. There is great potential in using serum-based biomarkers, hence the book seeks to enlighten readers on new possibilities. Offers strategies for the selection and implementation of traumatic brain injury biomarkers Discusses the importance of autoantibodies and post translational modifications for TBI Covers the analytical tools needed to implement TBI biomarkers, including the specifications for testing instruments and interpretative software

Biomarkers for Traumatic Brain Injury

Biomarkers for Traumatic Brain Injury
Author: Svetlana Dambinova,Ronald L. Hayes,Kevin K. W. Wang
Publsiher: Royal Society of Chemistry
Total Pages: 226
Release: 2012
ISBN 10: 1849733899
ISBN 13: 9781849733892
Language: EN, FR, DE, ES & NL

Biomarkers for Traumatic Brain Injury Book Review:

Examines current and prospective biomarkers for assessment of traumatic brain injury using a multidisciplinary approach involving biochemistry, molecular biology and clinical chemistry.

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
Author: Daniel Laskowitz,Gerald Grant
Publsiher: CRC Press
Total Pages: 412
Release: 2015-12-01
ISBN 10: 1498766579
ISBN 13: 9781498766579
Language: EN, FR, DE, ES & NL

Translational Research in Traumatic Brain Injury Book Review:

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Biomarkers of Brain Injury and Neurological Disorders

Biomarkers of Brain Injury and Neurological Disorders
Author: Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publsiher: CRC Press
Total Pages: 650
Release: 2014-10-28
ISBN 10: 1482239825
ISBN 13: 9781482239829
Language: EN, FR, DE, ES & NL

Biomarkers of Brain Injury and Neurological Disorders Book Review:

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Brain Neurotrauma

Brain Neurotrauma
Author: Firas H. Kobeissy
Publsiher: CRC Press
Total Pages: 725
Release: 2015-02-25
ISBN 10: 1466565993
ISBN 13: 9781466565999
Language: EN, FR, DE, ES & NL

Brain Neurotrauma Book Review:

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

From Bench to BedsideTrauma Tumors Spine Functional Neurosurgery

From Bench to BedsideTrauma  Tumors  Spine  Functional Neurosurgery
Author: Francesco Signorelli
Publsiher: BoD – Books on Demand
Total Pages: 168
Release: 2016-09-28
ISBN 10: 9535126288
ISBN 13: 9789535126287
Language: EN, FR, DE, ES & NL

From Bench to BedsideTrauma Tumors Spine Functional Neurosurgery Book Review:

This book is written for graduate students, researchers, and practitioners who are interested in learning how the knowledge from research can be implemented in clinical competences. The first section is dedicated to deep brain stimulation, a surgical procedure which is the paramount example of how clinical practice can take advantage from fundamental research. The second section gathers four chapters on four different topics and illustrates how significant is the challenge to translate scientific advances into clinical practice because the route from evidence to action is not always obvious. It is hoped that this book will stimulate the interest in the process of translating research into practice for a broader range of neurosurgical topics than the one covered by this book, which could result in a forthcoming more comprehensive publication.

Traumatic Brain Injury

Traumatic Brain Injury
Author: Jordan Grafman,Andres M. Salazar
Publsiher: Elsevier
Total Pages: 490
Release: 2015-02-19
ISBN 10: 0444634983
ISBN 13: 9780444634986
Language: EN, FR, DE, ES & NL

Traumatic Brain Injury Book Review:

The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI. Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including descriptions of potential biomarkers and indicators of potential targets for treatments to reduce the impact of the injury Explores cellular and molecular mechanisms as well as genetic predictors of outcome Offers coverage of various diagnostic tools – CT, MRI, DDTI, fMRI, EEG, resting functional imaging, and more State-of-the-art traumatic brain injury management and treatment principles are presented for both civilian and military care

Neurotrauma

Neurotrauma
Author: Kevin Wang
Publsiher: Oxford University Press, USA
Total Pages: 528
Release: 2018-12-05
ISBN 10: 0190279435
ISBN 13: 9780190279431
Language: EN, FR, DE, ES & NL

Neurotrauma Book Review:

Neurotrauma: A Comprehensive Textbook on Traumatic Brain Injury and Spinal Cord Injury aims to bring together the latest clinical practice and research in the filed of two forms of trauma to the central nervous system: namely traumatic brain injury (TBI) and spinal cord injury (SCI). Nationally, more 1.9 million Americans sustain a traumatic brain injury annually. In parallel, there are an estimate of 12,000 new cases of SCI in the United States annually. In addition, approximately 1.2 million people live with paralysis due to SCI. In recent years, dramatic advancements in the field have resulted in much improved outcomes for patients and higher standards of care. This volume details the latest research and clinical practice in the treatment of neurotrauma, in a comprehensive but easy-to-follow format. Neurotrauma is a valuable resource for any clinician involved in caring for TBI and SCI patients, clinical research professionals, researchers, medical and graduate students, and nurse specialists.

Traumatic Brain and Spinal Cord Injury

Traumatic Brain and Spinal Cord Injury
Author: Cristina Morganti-Kossmann,Ramesh Raghupathi,Andrew Maas
Publsiher: Cambridge University Press
Total Pages: 329
Release: 2012-07-19
ISBN 10: 1139536354
ISBN 13: 9781139536356
Language: EN, FR, DE, ES & NL

Traumatic Brain and Spinal Cord Injury Book Review:

Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: • The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion • Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury • Overview of major pathophysiological changes • The development of animal models; successes and limitations • Past, current and future therapeutic strategies including rehabilitative opportunities. Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians.

Sports Related Concussion

Sports Related Concussion
Author: Julian E. Bailes,Mark R. Lovell,Joseph Maroon, MD
Publsiher: CRC Press
Total Pages: 261
Release: 1999
ISBN 10:
ISBN 13: UOM:39015045998740
Language: EN, FR, DE, ES & NL

Sports Related Concussion Book Review:

The phenomenon of minor head injury is increasingly being recognized as having both immediate and long-term implications for athletes. Physicians, trainers, and coaches play a vital role in the prevention of injury, on-field diagnosis and management, and treatment of sports related concussion. From early recognition of a concussive event to treatment options and possible long-term side effects, all aspects of the neurologic and neuropsychologic evaluation and management of head injury in the athlete are addressed. The book concludes with a lively and informative round-table discussion among professional athletes who have experienced sports-related concussion.

Annual Update in Intensive Care and Emergency Medicine 2017

Annual Update in Intensive Care and Emergency Medicine 2017
Author: Jean-Louis Vincent
Publsiher: Springer
Total Pages: 545
Release: 2017-03-31
ISBN 10: 3319519085
ISBN 13: 9783319519081
Language: EN, FR, DE, ES & NL

Annual Update in Intensive Care and Emergency Medicine 2017 Book Review:

The Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive reference book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Handbook of Neuroemergency Clinical Trials

Handbook of Neuroemergency Clinical Trials
Author: Brett E. Skolnick,Wayne M. Alves
Publsiher: Academic Press
Total Pages: 400
Release: 2017-11-13
ISBN 10: 0128041013
ISBN 13: 9780128041017
Language: EN, FR, DE, ES & NL

Handbook of Neuroemergency Clinical Trials Book Review:

Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development. Presents a comprehensive overview on clinical trials and drug development challenges in acute neuroscience populations Provides neurologists, neuroscientists and drug developers with a complete understanding of scientific and medical issues related to designing clinical trials Edited by leaders in the field who have designed and managed over 50 neuroemergency clinical trials

Management of Severe Traumatic Brain Injury

Management of Severe Traumatic Brain Injury
Author: Terje Sundstrøm,Per-Olof Grände,Niels Juul,Carsten Kock-Jensen,Bertil Romner,Knut Wester
Publsiher: Springer Science & Business Media
Total Pages: 417
Release: 2012-06-25
ISBN 10: 3642281265
ISBN 13: 9783642281266
Language: EN, FR, DE, ES & NL

Management of Severe Traumatic Brain Injury Book Review:

In order to reduce the number of deaths from severe head injuries, systematic management is essential. This book is a practical, comprehensive guide to the treatment of patients (both adults and children) with such injuries, from the time of initial contact through to the rehabilitation center. Sections are devoted to prehospital treatment, admission and diagnostics, acute management, and neurointensive care and rehabilitation. Evidence-based recommendations are presented for each diagnostic and therapeutic measure, and tips, tricks, and pitfalls are highlighted. Throughout, the emphasis is on the provision of sound clinical advice that will maximize the likelihood of an optimal outcome. Helpful flowcharts designed for use in daily routine are also provided. The authors are all members of the Scandinavian Neurotrauma Committee and have extensive practical experience in the areas they write about.

Neurotrauma

Neurotrauma
Author: Raj K. Narayan,James E. Wilberger,John T. Povlishock
Publsiher: McGraw-Hill
Total Pages: 1558
Release: 1996
ISBN 10: 9780070456624
ISBN 13: 0070456623
Language: EN, FR, DE, ES & NL

Neurotrauma Book Review:

This reference is a comprehensive work in the field of neurotrauma and critical care. It incorporates the fields of head injury, spinal injury and basic neurotrauma research into one source. The major emphasis is on the treatment of patients with head and spinal cord injury, including the management of all other problems that bear upon the care of these patients.

Brain Injury Medicine E Book

Brain Injury Medicine E Book
Author: Blessen C. Eapen,David X. Cifu
Publsiher: Elsevier Health Sciences
Total Pages: 352
Release: 2020-07-17
ISBN 10: 0323779441
ISBN 13: 9780323779449
Language: EN, FR, DE, ES & NL

Brain Injury Medicine E Book Book Review:

The only review book currently available in this complex field, Brain Injury Medicine: Board Review focuses on the prevention, diagnosis, treatment, and management of individuals with varying severity levels of brain injury. Focused, high-yield content prepares you for success on exams and in practice, with up-to-date coverage of traumatic brain injury (TBI), stroke, CNS neoplasms, anoxic brain injury, and other brain disorders. This unique review tool is ideal for residents, fellows, and practitioners studying or working in the field and preparing to take the brain injury medicine exam. Supports self-assessment and review with 200 board-style questions and explanations. Covers the information you need to know on traumatic brain injury by severity and pattern, neurologic disorders, systemic manifestations, rehabilitation problems and outcomes, and basic science. Includes questions on patient management including patient evaluation and diagnosis, prognosis/risk factors, and applied science. Discusses key topics such as neurodegeneration and dementia; proteomic, genetic, and epigenetic biomarkers in TBI; neuromodulation and neuroprosthetics; and assistive technology. Reviews must-know procedures including acute emergency management and critical care; post-concussion syndrome assessment, management and treatment; diagnostic procedures and electrophysiology; neuroimaging, and brain death criteria. Ensures efficient, effective review with content written by experts in physical medicine and rehabilitation, neurology, and psychiatry and a format that mirrors the board exam outline.

Concussion and Traumatic Encephalopathy

Concussion and Traumatic Encephalopathy
Author: Jeff Victoroff,Erin D. Bigler
Publsiher: Cambridge University Press
Total Pages: 890
Release: 2019-02-28
ISBN 10: 1107073952
ISBN 13: 9781107073951
Language: EN, FR, DE, ES & NL

Concussion and Traumatic Encephalopathy Book Review:

Readers will discover how very recent scientific advances have overthrown a century of dogma about concussive brain injury.

Neuroproteomics

Neuroproteomics
Author: Oscar Alzate
Publsiher: CRC Press
Total Pages: 354
Release: 2009-10-26
ISBN 10: 9781420076264
ISBN 13: 1420076264
Language: EN, FR, DE, ES & NL

Neuroproteomics Book Review:

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we begin to unravel the complex mysteries of neurological diseases that less than a generation ago seemed opaque to our inquiries, if not altogether intractable. Edited by Dr. Oscar Alzate, Neuroproteomics is the newest volume in the CRC Press Frontiers of Neuroscience Series. With an extensive background in mathematics and physics, Dr. Alzate exemplifies the newest generation of biological systems researchers. He organizes research and data contributed from all across the world to present an overview of neuroproteomics that is practical and progressive. Bolstered by each new discovery, researchers employing multiple methods of inquiry gain a deeper understanding of the key biological problems related to brain function, brain structure, and the complexity of the nervous system. This in turn is leading to new understanding about diseases of neurological deficit such as Parkinson’s and Alzheimer’s. Approaches discussed in the book include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Writing about their own work, leading researchers detail the principles, approaches, and difficulties of the various techniques, demonstrating the questions that neuroproteomics can answer and those it raises. New challenges wait, not the least of which is the identification of potential methods to regulate the structures and functions of key protein interaction networks. Ultimately, those building on the foundation presented here will advance our understanding of the brain and show us ways to abate the suffering caused by neurological and mental diseases.

Biomarkers of Neuroinflammation

Biomarkers of Neuroinflammation
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 90
Release: 2018-03-16
ISBN 10: 0309463653
ISBN 13: 9780309463652
Language: EN, FR, DE, ES & NL

Biomarkers of Neuroinflammation Book Review:

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.

Leveraging Biomedical and Healthcare Data

Leveraging Biomedical and Healthcare Data
Author: Firas Kobeissy,Kevin Wang,Fadi A. Zaraket,Ali Alawieh
Publsiher: Academic Press
Total Pages: 225
Release: 2018-11-23
ISBN 10: 012809561X
ISBN 13: 9780128095614
Language: EN, FR, DE, ES & NL

Leveraging Biomedical and Healthcare Data Book Review:

Leveraging Biomedical and Healthcare Data: Semantics, Analytics and Knowledge provides an overview of the approaches used in semantic systems biology, introduces novel areas of its application, and describes step-wise protocols for transforming heterogeneous data into useful knowledge that can influence healthcare and biomedical research. Given the astronomical increase in the number of published reports, papers, and datasets over the last few decades, the ability to curate this data has become a new field of biomedical and healthcare research. This book discusses big data text-based mining to better understand the molecular architecture of diseases and to guide health care decision. It will be a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in understanding more about how to process and apply great amounts of data to improve their research. Includes at each section resource pages containing a list of available curated raw and processed data that can be used by researchers in the field Provides demonstrative and relevant examples that serve as a general tutorial Presents a list of algorithm names and computational tools available for basic and clinical researchers

Traumatic Brain Injury

Traumatic Brain Injury
Author: Robert P. Granacher, Jr.
Publsiher: CRC Press
Total Pages: 528
Release: 2003-06-27
ISBN 10: 9780203501740
ISBN 13: 0203501748
Language: EN, FR, DE, ES & NL

Traumatic Brain Injury Book Review:

Numerous books exist on traumatic brain injury, yet none comprehensively cover evaluation from both clinical and forensic standpoints. Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment is the first medical book to guide treatment practitioners not only in methods for evaluating traumatic brain injury in adults and children, but also in the important elements of forensic brain injury assessment. From the clinical aspect, the book details neurobehavioral data analysis and describes how to apply it to treatment planning and pharmacotherapy following traumatic brain injury. From the forensic perspective, it provides methods for detecting deception at examination and emphasizes the important legal concepts of causation, damages, and impairment determination following traumatic brain injury. The text provides multiple explanatory tables, structural and functional brain imaging figures, and liberal case examples of actual traumatic brain injury examinations and reports. The practical and pragmatic approach offered in Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment will aid clinicians and forensic specialists in comprehensively evaluating the TBI patient and successfully presenting the evaluation in the courtroom.