Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance
Author: Andrew Freywald,Franco Vizeacoumar
Publsiher: Academic Press
Total Pages: 308
Release: 2020-12-04
ISBN 10: 0128213116
ISBN 13: 9780128213117
Language: EN, FR, DE, ES & NL

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance Book Review:

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Overcoming Ovarian Cancer Chemoresistance

Overcoming Ovarian Cancer Chemoresistance
Author: Goli Samimi,Christina Annunziata
Publsiher: Academic Press
Total Pages: 188
Release: 2020-11-19
ISBN 10: 0128198419
ISBN 13: 9780128198414
Language: EN, FR, DE, ES & NL

Overcoming Ovarian Cancer Chemoresistance Book Review:

Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

pH-Interfering Agents as Chemosensitizers in Cancer Therapy

pH-Interfering Agents as Chemosensitizers in Cancer Therapy
Author: Claudiu Supuran,Simone Carradori
Publsiher: Academic Press
Total Pages: 228
Release: 2020-09-15
ISBN 10: 0128209283
ISBN 13: 9780128209288
Language: EN, FR, DE, ES & NL

pH-Interfering Agents as Chemosensitizers in Cancer Therapy Book Review:

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

Kinase Drug Discovery

Kinase Drug Discovery
Author: Richard A. Ward,Frederick W. Goldberg
Publsiher: Royal Society of Chemistry
Total Pages: 414
Release: 2018-10-10
ISBN 10: 1788010833
ISBN 13: 9781788010832
Language: EN, FR, DE, ES & NL

Kinase Drug Discovery Book Review:

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years.

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
Author: Lucia Morbidelli,Benjamin Bonavida
Publsiher: Academic Press
Total Pages: 372
Release: 2019-02-09
ISBN 10: 0128172797
ISBN 13: 9780128172797
Language: EN, FR, DE, ES & NL

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders Book Review:

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

National Conference on the Care of the Child with Cancer

National Conference on the Care of the Child with Cancer
Author: Anonim
Publsiher: Anonim
Total Pages: 200
Release: 1979
ISBN 10:
ISBN 13: UOM:39015015465530
Language: EN, FR, DE, ES & NL

National Conference on the Care of the Child with Cancer Book Review:

Biomaterials for 3D Tumor Modeling

Biomaterials for 3D Tumor Modeling
Author: Subhas Kundu,Rui L. Reis
Publsiher: Elsevier
Total Pages: 772
Release: 2020-08-22
ISBN 10: 012818129X
ISBN 13: 9780128181294
Language: EN, FR, DE, ES & NL

Biomaterials for 3D Tumor Modeling Book Review:

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine. Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery

Ovarian Cancers

Ovarian Cancers
Author: National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on the State of the Science in Ovarian Cancer Research
Publsiher: National Academies Press
Total Pages: 396
Release: 2016-05-25
ISBN 10: 0309380464
ISBN 13: 9780309380461
Language: EN, FR, DE, ES & NL

Ovarian Cancers Book Review:

In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Challenges to Tackling Antimicrobial Resistance

Challenges to Tackling Antimicrobial Resistance
Author: Michael Anderson,Michele Cecchini,Elias Mossialos
Publsiher: Cambridge University Press
Total Pages: 240
Release: 2020-04-30
ISBN 10: 1108799450
ISBN 13: 9781108799454
Language: EN, FR, DE, ES & NL

Challenges to Tackling Antimicrobial Resistance Book Review:

An accessible overview of the challenges in tackling AMR and the economic and policy responses of the 'One Health' approach. It will appeal to policy-makers seeking to strengthen national and local polices tackling AMR, as well as students and academics who want an overview of the latest scientific evidence regarding effective AMR policies.

Nanotheranostics for Cancer Applications

Nanotheranostics for Cancer Applications
Author: Prakash Rai,Stephanie A. Morris
Publsiher: Springer
Total Pages: 480
Release: 2018-11-12
ISBN 10: 3030017753
ISBN 13: 9783030017750
Language: EN, FR, DE, ES & NL

Nanotheranostics for Cancer Applications Book Review:

This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.

Biomedical Chemistry

Biomedical Chemistry
Author: Nuno Vale
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 361
Release: 2015-01-01
ISBN 10: 3110468751
ISBN 13: 9783110468755
Language: EN, FR, DE, ES & NL

Biomedical Chemistry Book Review:

Biomedical Chemistry provides readers with an understanding of how fundamental chemical concepts are used to combat some diseases. The authors explain the interdisciplinary relationship of chemistry with biology, physics, pharmacy and medicine. The results of chemical research can be applied to understand chemical processes in cells and in the body, and new methods for drug transportation. Also, basic chemical ideas and determination of disease etiology are approached by developing techniques to ensure optimum interaction between drugs and human cells. This Book is an excellent resource for students and researchers in health-related fields with frontier topics in medicinal and pharmaceutical chemistry, organic chemistry and biochemistry.

Targeted Therapies

Targeted Therapies
Author: Daniel Gioeli
Publsiher: Springer Science & Business Media
Total Pages: 202
Release: 2011-06-02
ISBN 10: 9781607614784
ISBN 13: 1607614782
Language: EN, FR, DE, ES & NL

Targeted Therapies Book Review:

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Precision Medicine for Investigators, Practitioners and Providers

Precision Medicine for Investigators, Practitioners and Providers
Author: Joel Faintuch,Salomao Faintuch
Publsiher: Academic Press
Total Pages: 640
Release: 2019-11-16
ISBN 10: 0128191791
ISBN 13: 9780128191798
Language: EN, FR, DE, ES & NL

Precision Medicine for Investigators, Practitioners and Providers Book Review:

Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Cancer Drug Design and Discovery

Cancer Drug Design and Discovery
Author: Stephen Neidle
Publsiher: Elsevier
Total Pages: 496
Release: 2011-04-28
ISBN 10: 9780080554952
ISBN 13: 0080554954
Language: EN, FR, DE, ES & NL

Cancer Drug Design and Discovery Book Review:

The ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumors. Unique sections explain the basic underlying principles of cancer drug development and provide a practical introduction to modern methods of drug design. Appealing to a broad audience, this is an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry and clinicians taking oncology options. * Covers both currently available drugs as well as those under development * Provides a clinical perspective on trials of new anticancer agents * Presents drug discovery examples through the use of case histories

Drug Resistance in the Treatment of Cancer

Drug Resistance in the Treatment of Cancer
Author: Herbert M. Pinedo,Giuseppe Giaccone
Publsiher: Cambridge University Press
Total Pages: 340
Release: 2007-01-18
ISBN 10: 9780521030748
ISBN 13: 0521030749
Language: EN, FR, DE, ES & NL

Drug Resistance in the Treatment of Cancer Book Review:

International authorities review the mechanisms and clinical implications of drug resistance in cancer.

Metastatic Cancer: Clinical and Biological Perspectives

Metastatic Cancer: Clinical and Biological Perspectives
Author: Rahul Jandial
Publsiher: CRC Press
Total Pages: 312
Release: 2013-08-08
ISBN 10: 9781587066597
ISBN 13: 1587066599
Language: EN, FR, DE, ES & NL

Metastatic Cancer: Clinical and Biological Perspectives Book Review:

Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Advances in Biological Science Research

Advances in Biological Science Research
Author: Surya Nandan Meena,Milind Naik
Publsiher: Academic Press
Total Pages: 580
Release: 2019-05-17
ISBN 10: 0128174986
ISBN 13: 9780128174982
Language: EN, FR, DE, ES & NL

Advances in Biological Science Research Book Review:

Advances in Biological Science Research: A Practical Approach provides discussions on diverse research topics and methods in the biological sciences in a single platform. This book provides the latest technologies, advanced methods, and untapped research areas involved in diverse fields of biological science research such as bioinformatics, proteomics, microbiology, medicinal chemistry, and marine science. Each chapter is written by renowned researchers in their respective fields of biosciences and includes future advancements in life science research. Discusses various research topics and methods in the biological sciences in a single platform Comprises the latest updates in advanced research techniques, protocols, and methods in biological sciences Incorporates the fundamentals, advanced instruments, and applications of life science experiments Offers troubleshooting for many common problems faced while performing research experiments

Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues

 Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues
Author: Stefania Nobili,Enrico Mini,Chiara Riganti
Publsiher: Anonim
Total Pages: 329
Release: 2015-07-06
ISBN 10: 2889196151
ISBN 13: 9782889196159
Language: EN, FR, DE, ES & NL

Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues Book Review:

More than 40 years ago, the observation that doxorubicin-resistant tumor cells were cross-resistant to several structurally different anticancer agents was the first step in the discovery of P-glycoprotein (P-gp). P-gp belongs to the superfamily of ATP-binding cassette (ABC) transporters;its overexpression has become a therapeutic target for overcoming multidrug resistance in tumors. However, P-gp is also expressed in cells of normal tissues where it plays a physiological role, by protecting them from the toxic effects of xenobiotics. Also, ABCB1 gene polymorphisms may influence the response to anticancer drugs substrate of P-gp. Several strategies to overcome P-gp tumor drug resistance have been suggested. P-gp 'circumvention’ is the most explored and is based on the coadministration of anticancer agents and pump inhibitors (P-gp modulators). Despite the positive findings obtained in preclinical studies, results of clinical trials are not yet successful and clinical research is still ongoing. Other investigational approaches have been studied (e.g. P-gp targeting antibodies, use of antisense strategies or transcriptional regulators targeting ABCB1 gene expression) but their use is still circumscribed to the preclinical setting. A further approach is represented by the encapsulation of P-gp substrate anticancer drugs into liposomes or nanoparticles. This strategy has shown higher efficacy in tumor previously treated with the free drug. The reasons explaining the increased efficacy of liposomal/nanoparticle-based drugs in Pgp-overexpressing tumors include the coating with specific surfactants, the composition changes in the plasma membrane microdomains where P-gp is embedded, the direct impairment of P-gp catalytic mechanisms exerted by specific component of the liposomal shell, but are not yet fully understood. A second strategy to overcome P-gp tumor drug resistance is represented by exploiting the P-gp presence. Actually, P-gp-overexpressing cells show increased sensitivity (collateral sensitivity) to some drugs (e.g. verapamil, narcotic analgesics) and to some investigational compounds (e.g. NSC73306). P-gp-overexpressing cell are hypersensitive to reactive oxygen species, to agents perturbing the energetic metabolic pathways, changing the membrane compositions, reducing the efflux of endogenous toxic catabolites. However, the mechanisms explaining collateral sensitivity have not been fully elucidated. Another approach to exploit P-gp is represented by ABCB1 gene transfer to transform bone marrow progenitor cells into a drug resistant state which may allow conventional or higher doses of anticancer drug substrates of P-gp to be administered safely after transplantation. More recently the development and introduction in the clinics of anticancer drugs which are not substrates of P-gp (e.g. new microtubule modulators, topoisomerase inhibitors) has provided a new and promising strategy to overcome P-gp tumor drug resistance (P-gp 'evasion'). This ‘research topic’ issue aims at exploding the above mentioned matters, in particular by: -retracing the history of the first researches on P-gp - describing the physiological role of P-gp - describing the molecular basis, structural features and mechanism of action of P-gp - describing diagnostic laboratory methods useful to determine the expression of P-gp and its transporter function - describing strategies to overcome tumor drug resistance due to P-gp and other ABC transporters - indicating novel approaches to overcome P-gp multidrug resistance, ranging from basic research studies to pre-clinical/clinical studies.

The Annals of Pharmacotherapy

The Annals of Pharmacotherapy
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 1997
ISBN 10:
ISBN 13: NWU:35558003846926
Language: EN, FR, DE, ES & NL

The Annals of Pharmacotherapy Book Review:

Biosciences 2000

Biosciences 2000
Author: Charles A Pasternak
Publsiher: World Scientific
Total Pages: 284
Release: 1999-08-16
ISBN 10: 1783261889
ISBN 13: 9781783261888
Language: EN, FR, DE, ES & NL

Biosciences 2000 Book Review:

As the new millennium approaches, it is appropriate to ask how far medicine and the life sciences have brought us, and to wonder how specific fields will develop over the next decade or so. This volume gathers together a number of leading scientists to give a bird's eye view of their field. Much of the emphasis is on cancer, microbial infections and immunology, because these are some of the most rapidly advancing areas of research. However, the book is wide-ranging and interdisciplinary, and covers topics as diverse as reproductive health technology, animal-to-human transplants, drug resistance, non-invasive diagnosis by magnetic resonance, novel membrane technology, and carbon nanotubes. The graduate student faced with a decision regarding his or her future topic of research could do worse than browse through this collection of articles by experts in the field. Contents: UNESCO: The Biosciences and Global Perspectives (F Mayor)Growing Infertility and Population Explosion: Challenges for Reproductive Health Technology (G P Talwar & T C A Kumar)The Way Ahead for Virology: Molecular Pathogenesis (W Joklik)Challenges of Chronic Persisting Infections of Global Importance for Vaccine Developers (G Ada)Xenografts and Viruses (R Weiss)Approaches in Treatment of Cancer (A Dalgleish)Overcoming Multidrug Resistance (W Stein)Advances in Anticancer Treatment-Mirage or Reality? (G McVie)The Dual Role of Oxygen in Aerobic Cells (V Skulachev)Non-Invasive Medicine by Magnetic Resonance in the Next Century (I R Young & J R Griffiths)Genetic Testing in the 21st Century (M A Patton & N C Carter)Model Membranes (C L Bashford)Nanotubes of Carbon and Other Materials (C N R Rao et al.) Readership: Biochemists, cell & molecular biologists, immunologists, microbiologists, clinicians and oncologists. Keywords:Cancer;Gene Testing;Infection;Infertility;Membranes;Multi-Drug Resistance;Nanotubes;NMR;Oxygen;Vaccines;Xenografts