Biological Chirality

Biological Chirality
Author: Gyula Palyi
Publsiher: Academic Press
Total Pages: 268
Release: 2019-11-06
ISBN 10: 0128123389
ISBN 13: 9780128123386
Language: EN, FR, DE, ES & NL

Biological Chirality Book Review:

Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Progress in Biological Chirality

Progress in Biological Chirality
Author: Gyula Palyi,Claudia Zucchi,Luciano Caglioti
Publsiher: Elsevier
Total Pages: 444
Release: 2004-12-13
ISBN 10: 9780080474038
ISBN 13: 0080474039
Language: EN, FR, DE, ES & NL

Progress in Biological Chirality Book Review:

Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Chiral Drugs

Chiral Drugs
Author: Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2011-08-08
ISBN 10: 9781118075630
ISBN 13: 1118075633
Language: EN, FR, DE, ES & NL

Chiral Drugs Book Review:

An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
Author: Roger J. Crossley
Publsiher: CRC Press
Total Pages: 208
Release: 1995-09-11
ISBN 10: 9780849391408
ISBN 13: 0849391407
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity of Drugs Book Review:

This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Advances in BioChirality

Advances in BioChirality
Author: C. Zucchi,L. Caglioti,Gyula Palyi
Publsiher: Elsevier
Total Pages: 407
Release: 1999-09-08
ISBN 10: 9780080526621
ISBN 13: 0080526624
Language: EN, FR, DE, ES & NL

Advances in BioChirality Book Review:

Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Author: Nilashis Nandi
Publsiher: CRC Press
Total Pages: 209
Release: 2011-07-27
ISBN 10: 1439840024
ISBN 13: 9781439840023
Language: EN, FR, DE, ES & NL

Chirality in Biological Nanospaces Book Review:

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Asymmetry in Biological Homochirality

Asymmetry in Biological Homochirality
Author: David Hochberg
Publsiher: MDPI
Total Pages: 102
Release: 2021-06-04
ISBN 10: 3036504427
ISBN 13: 9783036504421
Language: EN, FR, DE, ES & NL

Asymmetry in Biological Homochirality Book Review:

Chirality, or handedness, is a fundamental physical characteristic, which spans the length scales ranging from elementary particles to the chiral asymmetry of spiral galaxies. The way in which chirality in chemistry, or molecular handedness, may have emerged in a primitive terrestrial environment, and how it can be triggered, amplified, and transferred, are deeply challenging problems rooted in both fundamental scientific interests and the technological potentials for science and society. Chirality constitutes a unifying feature of the living world and is a prime driving force for molecular selection and genetic evolution in biology. In this book, we offer a selection of five distinct approaches to this problem by leading experts in the field. The selected topics range from protein chirality and its relevance to protein ageing, protein aggregation and neurodegeneration, entropy production associated with chiral symmetry breaking in closed systems, chiral oscillations in polymerization models involving higher-order oligomers, the mirror symmetry breaking in liquids and its implications for the development of homochirality in abiogenesis, the role of chirality in the chemical sciences, and some philosophical implications of chirality.

BETA DECAY AND THE ORIGINS OF BIOLOGICAL CHIRALITY POLARIZED POSITRONS POSITRONIUM SLOW

BETA DECAY AND THE ORIGINS OF BIOLOGICAL CHIRALITY  POLARIZED POSITRONS  POSITRONIUM  SLOW
Author: JAMES CHRISTOPHER VAN HOUSE
Publsiher: Unknown
Total Pages: 169
Release: 1984
ISBN 10: 1928374650XXX
ISBN 13: OCLC:68295394
Language: EN, FR, DE, ES & NL

BETA DECAY AND THE ORIGINS OF BIOLOGICAL CHIRALITY POLARIZED POSITRONS POSITRONIUM SLOW Book Review:

an asymmetry in the rate of orthopositronium formation, Ap(,s), when low energy positron beams with a net helicity form positronium in optically active molecules, and quantitatively connect Ap(,s) to asymmetric radiolysis.

Second International Symposium on Biological Chirality

Second International Symposium on Biological Chirality
Author: International Symposium on Biological Chirality
Publsiher: Unknown
Total Pages: 133
Release: 2001
ISBN 10: 1928374650XXX
ISBN 13: OCLC:48052898
Language: EN, FR, DE, ES & NL

Second International Symposium on Biological Chirality Book Review:

Biochirality

Biochirality
Author: Pedro Cintas
Publsiher: Springer
Total Pages: 316
Release: 2014-07-08
ISBN 10: 3642376266
ISBN 13: 9783642376269
Language: EN, FR, DE, ES & NL

Biochirality Book Review:

Early History of the Recognition of Molecular Biochirality, by Joseph Gal, Pedro Cintas Synthesis and Chirality of Amino Acids Under Interstellar Conditions, by Chaitanya Giri, Fred Goesmann, Cornelia Meinert, Amanda C. Evans, Uwe J. Meierhenrich Chemical and Physical Models for the Emergence of Biological Homochirality, by son E. Hein, Dragos Gherase, Donna G. Blackmond Biomolecules at Interfaces: Chiral, Naturally, by Arántzazu González-Campo and David B. Amabilino Stochastic Mirror Symmetry Breaking: Theoretical Models and Simulation of Experiments, by Celia Blanco, David Hochberg Self-Assembly of Dendritic Dipeptides as a Model of Chiral Selection in Primitive Biological Systems, by Brad M. Rosen, Cécile Roche, Virgil Percec Chirality and Protein Biosynthesis, by Sindrila Dutta Banik, Nilashis Nandi

Chirality and Biological Activity

Chirality and Biological Activity
Author: Hartmut Frank,Bo Holmstedt,Bernard Testa
Publsiher: Wiley-Liss
Total Pages: 283
Release: 1990
ISBN 10: 1928374650XXX
ISBN 13: UCAL:B4494559
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity Book Review:

Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.

Bioflavour 87

Bioflavour    87
Author: Peter Schreier
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 596
Release: 2019-11-18
ISBN 10: 3110867125
ISBN 13: 9783110867121
Language: EN, FR, DE, ES & NL

Bioflavour 87 Book Review:

Current Topics in Chirality

Current Topics in Chirality
Author: Takashiro Akitsu
Publsiher: BoD – Books on Demand
Total Pages: 196
Release: 2021-09-01
ISBN 10: 1839689536
ISBN 13: 9781839689536
Language: EN, FR, DE, ES & NL

Current Topics in Chirality Book Review:

Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.

Chirality from Molecular Electronic States

Chirality from Molecular Electronic States
Author: Takashiro Akitsu
Publsiher: BoD – Books on Demand
Total Pages: 128
Release: 2019-02-06
ISBN 10: 1789851556
ISBN 13: 9781789851557
Language: EN, FR, DE, ES & NL

Chirality from Molecular Electronic States Book Review:

In chemistry, biology, and physics, "chirality" is an important concept in nature. Especially in chemistry, not only classical stereochemistry but also asymmetric organic synthesis, supramolecular chemistry, construction of bio-related molecules and molecular recognition became indispensable structural chemical keywords. However, in view of synthetic chemistry and its structural chemistry, chemistry dealing with chirality in relation to the more fundamental electronic state is still a minority. This book is particularly aimed at chiroptical spectroscopy, structural or physical features and theoretical computation of chirality.

Chirality in Drug Design and Development

Chirality in Drug Design and Development
Author: Indra K. Reddy,Reza Mehvar
Publsiher: CRC Press
Total Pages: 1200
Release: 2004-03-15
ISBN 10: 0824751094
ISBN 13: 9780824751098
Language: EN, FR, DE, ES & NL

Chirality in Drug Design and Development Book Review:

Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Comprehensive Chirality Biological significance pharmacology pharmaceutical agrochemical

Comprehensive Chirality  Biological significance    pharmacology  pharmaceutical  agrochemical
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2012
ISBN 10: 1928374650XXX
ISBN 13: OCLC:828894029
Language: EN, FR, DE, ES & NL

Comprehensive Chirality Biological significance pharmacology pharmaceutical agrochemical Book Review:

Chiral Drugs

Chiral Drugs
Author: Cynthia A Challener
Publsiher: Routledge
Total Pages: 662
Release: 2017-10-23
ISBN 10: 1351808052
ISBN 13: 9781351808057
Language: EN, FR, DE, ES & NL

Chiral Drugs Book Review:

This title was first published in 2001: In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Drugs is a comprehensive listing of over 2500 chiral drugs, classified by therapeutic class, and including structures and physical properties for each entry in the listing. Its companion volume, Chiral Intermediates, presents the same detailed information for over 4700 commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part One of each book contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part Two presents entries for over 2500 chiral drugs, classified by therapeutic class. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for researchers in the pharmaceutical and biotechnology sectors as well as to those working in the basic biochemical sciences. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.

Chirality in Drug Design and Synthesis

Chirality in Drug Design and Synthesis
Author: C. Brown
Publsiher: Academic Press
Total Pages: 243
Release: 2013-10-22
ISBN 10: 1483288242
ISBN 13: 9781483288246
Language: EN, FR, DE, ES & NL

Chirality in Drug Design and Synthesis Book Review:

Chirality in Drug Design and Synthesis is a collection of papers that discusses the property of asymmetry in the structural and synthetic chemistry of natural products, including the significance of chirality in medicinal chemistry. These papers examine the need for the preparation and study of pure enantiomers of chiral drug substances and their mechanism of interaction with enzymes and receptors. These papers also investigate the techniques in studying these interactions, as well as analyze the methods for their synthesis in enantiomerically pure form. One paper discusses the pharmacological and pharmacokinetic analyses made that point to the differences in the activity and disposition of enantiometric pairs. Another paper reviews the implications of the neglect of stereoselectivity at the different levels during the examination process of racemic drugs. Since no general guidelines exists for the development of drugs with chiral centers, one paper suggests a case-by-case approach in evaluating the safety and efficacy of drugs, particularly as regards how isomers differ in their effects. This collection is suitable for the pharmacologist, medicinal chemists, toxicologists, mechanistic chemists and synthetic organic chemists.

Possible Scenarios for Homochirality on Earth

Possible Scenarios for Homochirality on Earth
Author: Michiya Fujiki
Publsiher: Buy this from MDPI Books
Total Pages: 318
Release: 2019-11-14
ISBN 10: 3039217224
ISBN 13: 9783039217229
Language: EN, FR, DE, ES & NL

Possible Scenarios for Homochirality on Earth Book Review:

In 1978, Fred Hoyle proposed that interstellar comets carrying several viruses landed on Earth as part of the panspermia hypotheses. With respect to life, the origin of homochirality on Earth has been the greatest mystery because life cannot exist without molecular asymmetry. Many scientists have proposed several possible hypotheses to answer this long-standing L-D question. Previously, Martin Gardner raised the question about mirror symmetry and broken mirror symmetry in terms of the homochirality question in his monographs (1964 and 1990). Possible scenarios for the L-D issue can be categorized into (i) Earth and exoterrestrial origins, (ii) by-chance and necessity mechanisms, and (iii) mirror-symmetrical and non-mirror-symmetrical forces as physical and chemical origins. These scenarios should involve further great amplification mechanisms, enabling a pure L- or D-world.

Chirality and Molecular Interactions

Chirality and Molecular Interactions
Author: Thirumoorthy Krishnan
Publsiher: LAP Lambert Academic Publishing
Total Pages: 248
Release: 2010-10
ISBN 10: 9783843356862
ISBN 13: 3843356866
Language: EN, FR, DE, ES & NL

Chirality and Molecular Interactions Book Review:

This book discusses the influence of chirality and intermolecular interactions in biomimetic (amphiphilic and peptide systems) and biological (amino acids and model biological reactions involving amino acids and peptides) systems using computational chemical methods. Generation and retention of homochirality are fundamentally important in biology. The difference in intermolecular interactions between enantiomeric and racemic pairs (homochiral and heterochiral interactions) and their interactions with the surrounding molecular structures leading to chiral discrimination, which could be responsible for homochiral preference, is also discussed. The nature of intermolecular energy surfaces as a function of molecular mutual orientations dictates the chiral discrimination in biology. The knowledge gained in the biomimetic systems is employed to understand more complex biological reactions like synthesis of amino acids by transamination reaction, synthesis of aminoacyl-tRNA in the aminoacylation process and synthesis of peptides in ribosome. The molecular recognition process in biomimetic amphiphiles and peptides are correlated with the nature of the intermolecular energy surfaces.