Biological Chirality

Biological Chirality
Author: Gyula Palyi
Publsiher: Academic Press
Total Pages: 268
Release: 2019-11-06
ISBN 10: 0128123389
ISBN 13: 9780128123386
Language: EN, FR, DE, ES & NL

Biological Chirality Book Review:

Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Progress in Biological Chirality

Progress in Biological Chirality
Author: Gyula Palyi,Claudia Zucchi,Luciano Caglioti
Publsiher: Elsevier
Total Pages: 444
Release: 2004-12-13
ISBN 10: 9780080474038
ISBN 13: 0080474039
Language: EN, FR, DE, ES & NL

Progress in Biological Chirality Book Review:

Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Author: Nilashis Nandi
Publsiher: CRC Press
Total Pages: 209
Release: 2011-07-27
ISBN 10: 1439840024
ISBN 13: 9781439840023
Language: EN, FR, DE, ES & NL

Chirality in Biological Nanospaces Book Review:

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Chiral Drugs

Chiral Drugs
Author: Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2011-08-08
ISBN 10: 9781118075630
ISBN 13: 1118075633
Language: EN, FR, DE, ES & NL

Chiral Drugs Book Review:

An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
Author: Roger J. Crossley
Publsiher: CRC Press
Total Pages: 208
Release: 1995-09-11
ISBN 10: 9780849391408
ISBN 13: 0849391407
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity of Drugs Book Review:

This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Studies of Chirality Supramolecular Structure Order and Reactivity in and from Biological Systems

Studies of Chirality  Supramolecular Structure  Order and Reactivity in and from Biological Systems
Author: Jie Song
Publsiher: Unknown
Total Pages: 332
Release: 1999
ISBN 10:
ISBN 13: MSU:31293020611723
Language: EN, FR, DE, ES & NL

Studies of Chirality Supramolecular Structure Order and Reactivity in and from Biological Systems Book Review:

Advances in BioChirality

Advances in BioChirality
Author: C. Zucchi,L. Caglioti,Gyula Palyi
Publsiher: Elsevier
Total Pages: 407
Release: 1999-09-08
ISBN 10: 9780080526621
ISBN 13: 0080526624
Language: EN, FR, DE, ES & NL

Advances in BioChirality Book Review:

Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

On Chirality and the Universal Asymmetry

On Chirality and the Universal Asymmetry
Author: Georges H. Wagnière
Publsiher: John Wiley & Sons
Total Pages: 256
Release: 2008-09-26
ISBN 10: 3906390608
ISBN 13: 9783906390604
Language: EN, FR, DE, ES & NL

On Chirality and the Universal Asymmetry Book Review:

Until half a century ago, it was assumed that the forces of nature were symmetric and that they did not distinguish between right and left, between image and mirror image. The discovery of the violation of parity in 1956 was more than a sensation, for some it was a shock. It implied that the universe displays handedness, or chirality, and that it is fundamentally asymmetric. Remarkably, a most striking asymmetry is encountered in the realm of biology. Living organisms contain proteins built almost exclusively from L-amino acids, and nucleic acids derived from D-sugars only. Yet a mirror-image biochemistry, based on D-amino acids and L-sugars is, from a purely chemical standpoint, entirely conceivable. Where, then, does this extraordinary natural selectivity come from? Is it directly, or indirectly, connected to the universal violation of parity? This book is meant as a brief review of the various manifestations of handedness, or chirality, in the universe. It does not attempt to present a solution to basic questions which perhaps will never be unambiguously and conclusively answered. Rather, it is an excursion through nature, to observe and recognize how the chirality manifests itself at different structural levels. The excursion starts in the chemistry and physics laboratory. Then a journey into outer space and back in time is undertaken. After a return to our planet Earth, the focus is on the development of living organisms. The text should be accessible to anyone having the equivalent of a first-year university instruction in physics and chemistry. It is also hoped that a layperson with a more modest scientific formation may gain a general impression of the basic asymmetry in nature and of the fundamental significance of chirality. Mathematical expressions, wherever they occur, may then be overlooked. Some more difficult sections may be skipped. A Glossary preceding the Subject Index should be helpful.

Handbook of Chiral Chemicals Second Edition

Handbook of Chiral Chemicals  Second Edition
Author: David Ager
Publsiher: CRC Press
Total Pages: 664
Release: 2005-10-21
ISBN 10: 9781420027303
ISBN 13: 1420027301
Language: EN, FR, DE, ES & NL

Handbook of Chiral Chemicals Second Edition Book Review:

As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook first elaborates upon starting materials obtained from a 'chiral pool', which can be derived from natural products. Then it explains methods and reactions that can introduce or influence stereogenic centers, particularly asymmetric hydrogenations, oxidations, pericyclic reactions, and enzymatic methods.While hydrogenations have been the most widely employed approach for the large-scale synthesis of several commercial compounds, the search for the ideal catalyst has consistently led researchers to enzymes present in biological systems. Several chapters concentrate on understanding how to manipulate enzymes for catalyzing new reactions for taking new substrates. Other significant topics include chiral auxiliaries, chromatographic techniques, enantiomers-specific reactions, and resolution. This second edition updates all its chapters, illustrating the speed of development in this field, and features new chapters that highlight successful approaches in an industrial setting. "The Handbook of Chiral Chemicals, Second Edition" is a guide to advances in the field that result in more efficient and cost-effective synthesis of chiral chemicals.

Aerospace Medicine and Biology

Aerospace Medicine and Biology
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1984
ISBN 10:
ISBN 13: MINN:30000011046657
Language: EN, FR, DE, ES & NL

Aerospace Medicine and Biology Book Review:

A selection of annotated references to unclassified reports and journal articles that were introduced into the NASA scientific and technical information system and announced in Scientific and technical aerospace reports (STAR) and International aerospace abstracts (IAA).

Chirality in Drug Design and Development

Chirality in Drug Design and Development
Author: Indra K. Reddy,Reza Mehvar
Publsiher: CRC Press
Total Pages: 1200
Release: 2004-03-15
ISBN 10: 0824751094
ISBN 13: 9780824751098
Language: EN, FR, DE, ES & NL

Chirality in Drug Design and Development Book Review:

Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Biochirality

Biochirality
Author: Pedro Cintas
Publsiher: Springer
Total Pages: 316
Release: 2014-07-08
ISBN 10: 3642376266
ISBN 13: 9783642376269
Language: EN, FR, DE, ES & NL

Biochirality Book Review:

Early History of the Recognition of Molecular Biochirality, by Joseph Gal, Pedro Cintas Synthesis and Chirality of Amino Acids Under Interstellar Conditions, by Chaitanya Giri, Fred Goesmann, Cornelia Meinert, Amanda C. Evans, Uwe J. Meierhenrich Chemical and Physical Models for the Emergence of Biological Homochirality, by son E. Hein, Dragos Gherase, Donna G. Blackmond Biomolecules at Interfaces: Chiral, Naturally, by Arántzazu González-Campo and David B. Amabilino Stochastic Mirror Symmetry Breaking: Theoretical Models and Simulation of Experiments, by Celia Blanco, David Hochberg Self-Assembly of Dendritic Dipeptides as a Model of Chiral Selection in Primitive Biological Systems, by Brad M. Rosen, Cécile Roche, Virgil Percec Chirality and Protein Biosynthesis, by Sindrila Dutta Banik, Nilashis Nandi

When Topology Meets Chemistry

When Topology Meets Chemistry
Author: Erica Flapan
Publsiher: Cambridge University Press
Total Pages: 329
Release: 2000-07-31
ISBN 10: 1316583953
ISBN 13: 9781316583951
Language: EN, FR, DE, ES & NL

When Topology Meets Chemistry Book Review:

The applications of topological techniques for understanding molecular structures have become increasingly important over the past thirty years. In this topology text, the reader will learn about knot theory, 3-dimensional manifolds, and the topology of embedded graphs, while learning the role these play in understanding molecular structures. Most of the results that are described in the text are motivated by questions asked by chemists or molecular biologists, though the results themselves often go beyond answering the original question asked. There is no specific mathematical or chemical prerequisite; all the relevant background is provided. The text is enhanced by nearly 200 illustrations and more than 100 exercises. Reading this fascinating book, undergraduate mathematics students can escape the world of pure abstract theory and enter that of real molecules, while chemists and biologists will find simple, clear but rigorous definitions of mathematical concepts they handle intuitively in their work.

Bioflavour 87

Bioflavour    87
Author: Peter Schreier
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 596
Release: 2019-11-18
ISBN 10: 3110867125
ISBN 13: 9783110867121
Language: EN, FR, DE, ES & NL

Bioflavour 87 Book Review:

Chirality and Biological Activity

Chirality and Biological Activity
Author: Hartmut Frank,Bo Holmstedt,Bernard Testa
Publsiher: Wiley-Liss
Total Pages: 283
Release: 1990
ISBN 10:
ISBN 13: UOM:39015015518411
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity Book Review:

Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.

The Role of Chirality in the Olfactory directed Aggregation Behavior of Pine Engraver Beetles in the Genus Ips Coleoptera Scolytidae

The Role of Chirality in the Olfactory directed Aggregation Behavior of Pine Engraver Beetles in the Genus Ips  Coleoptera  Scolytidae
Author: Steven Jon Seybold
Publsiher: Unknown
Total Pages: 710
Release: 1992
ISBN 10:
ISBN 13: UCAL:C3368371
Language: EN, FR, DE, ES & NL

The Role of Chirality in the Olfactory directed Aggregation Behavior of Pine Engraver Beetles in the Genus Ips Coleoptera Scolytidae Book Review:

Chiral Recognition in the Gas Phase

Chiral Recognition in the Gas Phase
Author: Anne Zehnacker
Publsiher: CRC Press
Total Pages: 247
Release: 2010-05-25
ISBN 10: 1420082280
ISBN 13: 9781420082289
Language: EN, FR, DE, ES & NL

Chiral Recognition in the Gas Phase Book Review:

Understanding the molecular interactions responsible for chiral recognition is of primary importance in life chemistry. Gas-phase experiments on either neutral or ionic adducts of chiral molecules allow for the study of intrinsic properties of chiral recognition in solvent-free conditions. With contributions from a panel of international experts exploring a variety of subjects, Chiral Recognition in the Gas Phase describes the structural and energetic aspects of these interactions. Optical spectroscopy The first part of the book focuses on optical spectroscopy in jet-cooled conditions in neutral chiral molecules and complexes. The spectroscopic methods range from microwave, IR, and UV spectroscopy to circular dichroism effects in photoelectron spectroscopy. The book also discusses issues related to the homochirality of life. Mass spectrometry The second section describes mass spectrometry approaches to chiral recognition in ionic complexes. These approaches encompass the study of the stability of supramolecular chiral host-guest adducts, the study of chiral catalysts and chiral selectors, the use of small DNA sequences as auxiliaries for discriminating the enantiomers of amino-acids, and the probe of the chirality of a single amino acid within a peptide chain. Chiral recognition on a molecular level is essential for the rational design of chiral separation media and for understanding the fundamental interactions between biological molecules. It is especially important in all of the life chemistries, particularly in pharmacology, due to the differences in behavior between the enantiomers of a chiral molecule embedded in a chiral surrounding. This volume cogently and comprehensively describes the state-of-the-art work that has been devoted to understanding of the forces at play in chiral recognition.

The Origin of Chirality in the Molecules of Life

The Origin of Chirality in the Molecules of Life
Author: Albert Guijarro,Miguel Yus
Publsiher: Royal Society of Chemistry
Total Pages: 150
Release: 2008-01-01
ISBN 10: 0854041567
ISBN 13: 9780854041565
Language: EN, FR, DE, ES & NL

The Origin of Chirality in the Molecules of Life Book Review:

Few times an unsolved issue in science has dealt with a larger number of approaches or theories intending to shed light on it and few times this has been done from so different, often orthogonal perspectives. This book covers a hot topic, one of the unsolved problems not just in chemistry, but in science.

Amplification of Chirality

Amplification of Chirality
Author: Kenso Soai
Publsiher: Springer Science & Business Media
Total Pages: 205
Release: 2008-07-11
ISBN 10: 9783540778684
ISBN 13: 3540778683
Language: EN, FR, DE, ES & NL

Amplification of Chirality Book Review:

Amplification of Chirality presents critical reviews of the present position and future trends in modern chemical research. The book contains short and concise reports on chemistry. Each is written by the world renowned experts. Still valid and useful after 5 or 10 years, more information as well as the electronic version of the whole content available at: springerlink.com.

Asymmetry in Plants

Asymmetry in Plants
Author: Bir Bahadur,K. V. Krishnamurthy,Monoranjan Ghose,S. John Adams
Publsiher: CRC Press
Total Pages: 387
Release: 2019-03-25
ISBN 10: 0429960719
ISBN 13: 9780429960710
Language: EN, FR, DE, ES & NL

Asymmetry in Plants Book Review:

Plants exhibit forms of asymmetry analogous to "handedness" in bilaterally symmetrical animals. This book explores the evolutionary significance and development of asymmetry. Examples of genetic control include the direction of tendril or stem coiling of many climbing plants; the so-called spiral phyllotaxy and floral taxy; and contorted petal arrangement is another kind of left- right symmetry in plants; the direction of contortion is fixed in some but not in other plants. The book will underscore tha all phenomena related to handedness start during embryogenesis itself, with the occurrence of embryo rotation. Key selling features: First consolidated book on Plant Handedness Relates handedness, asymmetry and chirality to the evolution of different organizational levels in plant biology Emphasizes handedness as a vital governing force in plant functional evolution Provides a new perspective, hitherto ignored, into plant developemtn and evolution Describes how an age-old phenomenon can give scope for investigation from a very modern interdisciplinary approach