Biological Chirality

Biological Chirality
Author: Gyula Palyi
Publsiher: Academic Press
Total Pages: 268
Release: 2019-11-06
ISBN 10: 0128123389
ISBN 13: 9780128123386
Language: EN, FR, DE, ES & NL

Biological Chirality Book Review:

Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Chiral Drugs

Chiral Drugs
Author: Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2011-08-08
ISBN 10: 9781118075630
ISBN 13: 1118075633
Language: EN, FR, DE, ES & NL

Chiral Drugs Book Review:

An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Progress in Biological Chirality

Progress in Biological Chirality
Author: Gyula Palyi,Claudia Zucchi,Luciano Caglioti
Publsiher: Elsevier
Total Pages: 444
Release: 2004-12-13
ISBN 10: 9780080474038
ISBN 13: 0080474039
Language: EN, FR, DE, ES & NL

Progress in Biological Chirality Book Review:

Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
Author: Roger J. Crossley
Publsiher: CRC Press
Total Pages: 208
Release: 1995-09-11
ISBN 10: 9780849391408
ISBN 13: 0849391407
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity of Drugs Book Review:

This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
Author: Nilashis Nandi
Publsiher: CRC Press
Total Pages: 209
Release: 2011-07-27
ISBN 10: 1439840024
ISBN 13: 9781439840023
Language: EN, FR, DE, ES & NL

Chirality in Biological Nanospaces Book Review:

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Studies of Chirality Supramolecular Structure Order and Reactivity in and from Biological Systems

Studies of Chirality  Supramolecular Structure  Order and Reactivity in and from Biological Systems
Author: Jie Song
Publsiher: Unknown
Total Pages: 332
Release: 1999
ISBN 10:
ISBN 13: MSU:31293020611723
Language: EN, FR, DE, ES & NL

Studies of Chirality Supramolecular Structure Order and Reactivity in and from Biological Systems Book Review:

Energy Research Abstracts

Energy Research Abstracts
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1994-05
ISBN 10:
ISBN 13: PSU:000052606335
Language: EN, FR, DE, ES & NL

Energy Research Abstracts Book Review:

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
Author: Roger J. Crossley
Publsiher: CRC Press
Total Pages: 208
Release: 1995-09-11
ISBN 10: 9780849391408
ISBN 13: 0849391407
Language: EN, FR, DE, ES & NL

Chirality and Biological Activity of Drugs Book Review:

This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Handbook of Chiral Chemicals Second Edition

Handbook of Chiral Chemicals  Second Edition
Author: David Ager
Publsiher: CRC Press
Total Pages: 664
Release: 2005-10-21
ISBN 10: 9781420027303
ISBN 13: 1420027301
Language: EN, FR, DE, ES & NL

Handbook of Chiral Chemicals Second Edition Book Review:

As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook first elaborates upon starting materials obtained from a 'chiral pool', which can be derived from natural products. Then it explains methods and reactions that can introduce or influence stereogenic centers, particularly asymmetric hydrogenations, oxidations, pericyclic reactions, and enzymatic methods.While hydrogenations have been the most widely employed approach for the large-scale synthesis of several commercial compounds, the search for the ideal catalyst has consistently led researchers to enzymes present in biological systems. Several chapters concentrate on understanding how to manipulate enzymes for catalyzing new reactions for taking new substrates. Other significant topics include chiral auxiliaries, chromatographic techniques, enantiomers-specific reactions, and resolution. This second edition updates all its chapters, illustrating the speed of development in this field, and features new chapters that highlight successful approaches in an industrial setting. "The Handbook of Chiral Chemicals, Second Edition" is a guide to advances in the field that result in more efficient and cost-effective synthesis of chiral chemicals.

Chiral Drugs

Chiral Drugs
Author: Cynthia A Challener
Publsiher: Routledge
Total Pages: 662
Release: 2017-10-23
ISBN 10: 1351808052
ISBN 13: 9781351808057
Language: EN, FR, DE, ES & NL

Chiral Drugs Book Review:

This title was first published in 2001: In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Drugs is a comprehensive listing of over 2500 chiral drugs, classified by therapeutic class, and including structures and physical properties for each entry in the listing. Its companion volume, Chiral Intermediates, presents the same detailed information for over 4700 commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part One of each book contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part Two presents entries for over 2500 chiral drugs, classified by therapeutic class. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for researchers in the pharmaceutical and biotechnology sectors as well as to those working in the basic biochemical sciences. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.

Aerospace Medicine and Biology

Aerospace Medicine and Biology
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1984
ISBN 10:
ISBN 13: MINN:30000011046657
Language: EN, FR, DE, ES & NL

Aerospace Medicine and Biology Book Review:

A selection of annotated references to unclassified reports and journal articles that were introduced into the NASA scientific and technical information system and announced in Scientific and technical aerospace reports (STAR) and International aerospace abstracts (IAA).

Amplification of Chirality

Amplification of Chirality
Author: Kenso Soai
Publsiher: Springer Science & Business Media
Total Pages: 205
Release: 2008-07-11
ISBN 10: 9783540778684
ISBN 13: 3540778683
Language: EN, FR, DE, ES & NL

Amplification of Chirality Book Review:

Amplification of Chirality presents critical reviews of the present position and future trends in modern chemical research. The book contains short and concise reports on chemistry. Each is written by the world renowned experts. Still valid and useful after 5 or 10 years, more information as well as the electronic version of the whole content available at: springerlink.com.

Possible Scenarios for Homochirality on Earth

Possible Scenarios for Homochirality on Earth
Author: Michiya Fujiki
Publsiher: Buy this from MDPI Books
Total Pages: 318
Release: 2019-11-14
ISBN 10: 3039217224
ISBN 13: 9783039217229
Language: EN, FR, DE, ES & NL

Possible Scenarios for Homochirality on Earth Book Review:

In 1978, Fred Hoyle proposed that interstellar comets carrying several viruses landed on Earth as part of the panspermia hypotheses. With respect to life, the origin of homochirality on Earth has been the greatest mystery because life cannot exist without molecular asymmetry. Many scientists have proposed several possible hypotheses to answer this long-standing L-D question. Previously, Martin Gardner raised the question about mirror symmetry and broken mirror symmetry in terms of the homochirality question in his monographs (1964 and 1990). Possible scenarios for the L-D issue can be categorized into (i) Earth and exoterrestrial origins, (ii) by-chance and necessity mechanisms, and (iii) mirror-symmetrical and non-mirror-symmetrical forces as physical and chemical origins. These scenarios should involve further great amplification mechanisms, enabling a pure L- or D-world.

Chirotechnology

Chirotechnology
Author: Roger A. Sheldon
Publsiher: CRC Press
Total Pages: 423
Release: 1993-05-27
ISBN 10: 9780824791438
ISBN 13: 0824791436
Language: EN, FR, DE, ES & NL

Chirotechnology Book Review:

This reference provides an introduction to the phenomenon of chirality and its importance in conjunction with biological activity and offers an easy-to-read examination of practical, industrially relevant methods for the synthesis of optically active compounds.;Furnishing hands-on guidelines for the development of economically viable synthetic compounds, Chirotechnology: explains optical isomerism and stereochemistry; gives a general overview of various methods of synthesis; supplies detailed explications of specific techniques, including fermentation, crystallization, the chirality pool, enzymatic methods, and catalytic asymmetric synthesis; illustrates and compares approaches with examples taken directly from industry such as the synthesis of pharmaceuticals, agrochemicals, flavours, and fragrances; and clarifies the importance of determining which approach to use for the synthesis of particular molecules.;With over 1100 literature citations, tables and figures, Chirotechnology is a reference for chemical engineers; industrial, organic and medicinal chemists; and bioprocess technologists, as well as a text for upper-level undergraduate, graduate and continuing-education students in these disciplines.

When Topology Meets Chemistry

When Topology Meets Chemistry
Author: Erica Flapan
Publsiher: Cambridge University Press
Total Pages: 329
Release: 2000-07-31
ISBN 10: 1316583953
ISBN 13: 9781316583951
Language: EN, FR, DE, ES & NL

When Topology Meets Chemistry Book Review:

The applications of topological techniques for understanding molecular structures have become increasingly important over the past thirty years. In this topology text, the reader will learn about knot theory, 3-dimensional manifolds, and the topology of embedded graphs, while learning the role these play in understanding molecular structures. Most of the results that are described in the text are motivated by questions asked by chemists or molecular biologists, though the results themselves often go beyond answering the original question asked. There is no specific mathematical or chemical prerequisite; all the relevant background is provided. The text is enhanced by nearly 200 illustrations and more than 100 exercises. Reading this fascinating book, undergraduate mathematics students can escape the world of pure abstract theory and enter that of real molecules, while chemists and biologists will find simple, clear but rigorous definitions of mathematical concepts they handle intuitively in their work.

Chirality in Drug Design and Development

Chirality in Drug Design and Development
Author: Indra K. Reddy,Reza Mehvar
Publsiher: CRC Press
Total Pages: 1200
Release: 2004-03-15
ISBN 10: 0824751094
ISBN 13: 9780824751098
Language: EN, FR, DE, ES & NL

Chirality in Drug Design and Development Book Review:

Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Chirality in Drug Design and Synthesis

Chirality in Drug Design and Synthesis
Author: C. Brown
Publsiher: Academic Press
Total Pages: 243
Release: 2013-10-22
ISBN 10: 1483288242
ISBN 13: 9781483288246
Language: EN, FR, DE, ES & NL

Chirality in Drug Design and Synthesis Book Review:

Chirality in Drug Design and Synthesis is a collection of papers that discusses the property of asymmetry in the structural and synthetic chemistry of natural products, including the significance of chirality in medicinal chemistry. These papers examine the need for the preparation and study of pure enantiomers of chiral drug substances and their mechanism of interaction with enzymes and receptors. These papers also investigate the techniques in studying these interactions, as well as analyze the methods for their synthesis in enantiomerically pure form. One paper discusses the pharmacological and pharmacokinetic analyses made that point to the differences in the activity and disposition of enantiometric pairs. Another paper reviews the implications of the neglect of stereoselectivity at the different levels during the examination process of racemic drugs. Since no general guidelines exists for the development of drugs with chiral centers, one paper suggests a case-by-case approach in evaluating the safety and efficacy of drugs, particularly as regards how isomers differ in their effects. This collection is suitable for the pharmacologist, medicinal chemists, toxicologists, mechanistic chemists and synthetic organic chemists.

Chiral Sulfur Reagents

Chiral Sulfur Reagents
Author: Marian Mikolajczyk,Jozef Drabowicz,Piotr Kielbasinski
Publsiher: CRC Press
Total Pages: 288
Release: 1997-06-09
ISBN 10: 9780849391200
ISBN 13: 0849391202
Language: EN, FR, DE, ES & NL

Chiral Sulfur Reagents Book Review:

Over the last three decades, more than 40 different classes of chiral (mirror-image) sulfur compounds have been described, and a number of useful procedures and applications have been developed for their use. Emphasizing modern methodologies, Chiral Sulfur Reagents demonstrates the great potential of enantionmerically pure sulfur reagents in transmitting chirality to other centers. Each chapter highlights the synthesis and synthetic uses of a particular class of chiral sulfur reagent, followed by examples of the most important experimental procedures.

Space Life Sciences Life in the Solar System Prebiotic Chemistry Chirality and Space Biology

Space Life Sciences  Life in the Solar System  Prebiotic Chemistry  Chirality and Space Biology
Author: COSPAR. Scientific Commission F. F3.4-2 Symposium
Publsiher: Unknown
Total Pages: 268
Release: 2001
ISBN 10:
ISBN 13: STANFORD:36105110682767
Language: EN, FR, DE, ES & NL

Space Life Sciences Life in the Solar System Prebiotic Chemistry Chirality and Space Biology Book Review:

Bottom up Nanofabrication Organized films

Bottom up Nanofabrication  Organized films
Author: Katsuhiko Ariga,Hari Singh Nalwa
Publsiher: American Scientific Publishers
Total Pages: 6
Release: 2009
ISBN 10: 9781588830920
ISBN 13: 1588830926
Language: EN, FR, DE, ES & NL

Bottom up Nanofabrication Organized films Book Review: