Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics
Author: Allan Matte
Publsiher: Elsevier
Total Pages: 222
Release: 2020-09-07
ISBN 10: 0081030193
ISBN 13: 9780081030196
Language: EN, FR, DE, ES & NL

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics Book Review:

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Protein and Peptide Mass Spectrometry in Drug Discovery

Protein and Peptide Mass Spectrometry in Drug Discovery
Author: Michael L. Gross,Guodong Chen,Birendra Pramanik
Publsiher: John Wiley & Sons
Total Pages: 484
Release: 2011-09-26
ISBN 10: 1118116542
ISBN 13: 9781118116548
Language: EN, FR, DE, ES & NL

Protein and Peptide Mass Spectrometry in Drug Discovery Book Review:

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.

Development of Antibody-Based Therapeutics

Development of Antibody-Based Therapeutics
Author: Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp
Publsiher: Springer Science & Business Media
Total Pages: 426
Release: 2012-04-24
ISBN 10: 1441959556
ISBN 13: 9781441959553
Language: EN, FR, DE, ES & NL

Development of Antibody-Based Therapeutics Book Review:

Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.

Monoclonal Antibodies

Monoclonal Antibodies
Author: Philip Shepherd,Christopher J. Dean
Publsiher: Practical Approach (Paperback)
Total Pages: 479
Release: 2000
ISBN 10: 9780199637225
ISBN 13: 0199637229
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.

Advances in Clinical Chemistry

Advances in Clinical Chemistry
Author: Anonim
Publsiher: Academic Press
Total Pages: 296
Release: 2017-06-16
ISBN 10: 0128121777
ISBN 13: 9780128121771
Language: EN, FR, DE, ES & NL

Advances in Clinical Chemistry Book Review:

Advances in Clinical Chemistry, Volume 81, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientist Presents the international benchmark for novel analytical approaches in the clinical laboratory

Where Song Began

Where Song Began
Author: Tim Low
Publsiher: Yale University Press
Total Pages: 405
Release: 2016
ISBN 10: 0300221665
ISBN 13: 9780300221664
Language: EN, FR, DE, ES & NL

Where Song Began Book Review:

Originally published: Melbourne, Vic.: Penguin Group (Australia), 2014. With new preface.

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 1985
ISBN 10:
ISBN 13: STANFORD:36105119624778
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
Author: Zhiqiang An
Publsiher: John Wiley & Sons
Total Pages: 896
Release: 2011-09-20
ISBN 10: 1118210263
ISBN 13: 9781118210260
Language: EN, FR, DE, ES & NL

Therapeutic Monoclonal Antibodies Book Review:

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Cancer Immunology: Innovative Approaches to Therapy

Cancer Immunology: Innovative Approaches to Therapy
Author: Ronald B. Herberman
Publsiher: Springer Science & Business Media
Total Pages: 230
Release: 2012-12-06
ISBN 10: 146132629X
ISBN 13: 9781461326298
Language: EN, FR, DE, ES & NL

Cancer Immunology: Innovative Approaches to Therapy Book Review:

This volume is the second in the 'Cancer Treatment and Research' series focussing on basic and clinical tumor immunology. It has a rather different focus or emphasis from that of the first volume, published two years ago. That work (Basic and Clinical Tumor Immunology, R.B. Herberman, ed., Martinus Nijhoff Publishers, 1983) devoted considerable attention to up dated summaries in various areas of classical tumor immunology: specific antitumor immunity, the immunologic competence of cancer patietns, char acterization of human tumor-associated antigens, the ability to propagate specifically immune T cells in culture in the presence of interleukin 2, and the use of such cells for adoptive immunotherapy of established tumors. of evidence concerning the immune However, it also reviewed the status surveillance hypothesis and pointed out the need to consider non-T cell mediated mechanisms of host resistance. In particular, one chapter sum marized information on the role of macrophages in host resistance against tumors. The present volume continues to emphasize one of the major themes of the first volume, innovative approaches to the therapy of cancer. It involves contributions from leading investigators on several primary types of therapeutic interventions related to monoclonal antibodies, the col laboration of monoclonal antibodies with macro phages to mediate antibody dependent cellular cytotoxicity, lymphokines, tumor vaccines, and natural killer cells. It also has an up-to-date summary of the immunologic aspects of the exciting and promising work being performed on human T cell leukemia virus in the laboratory of Dr. Robert Gallo.

HPLC of Peptides and Proteins

HPLC of Peptides and Proteins
Author: Marie-Isabel Aguilar
Publsiher: Springer Science & Business Media
Total Pages: 413
Release: 2004
ISBN 10: 1592597424
ISBN 13: 9781592597420
Language: EN, FR, DE, ES & NL

HPLC of Peptides and Proteins Book Review:

Hands-on experts from academia and industry comprehensively describe how to successfully perform all the critical HPLC techniques needed for the analysis of peptides and proteins. The methods range from commonly used techniques to those for capillary to large-scale preparative isolation. The authors have also presented a number of specific applications as case studies to illustrate the analytical approaches to a particular separation or assay challenge, with examples drawn from contemporary fields in biochemistry and biotechnology. Follow step-by-step instructions that ensure experimental success Develop your own separation and analytical protocols for peptide and protein analysis.

Antibody Engineering

Antibody Engineering
Author: Benny K. C. Lo
Publsiher: Springer Science & Business Media
Total Pages: 561
Release: 2004
ISBN 10: 1592596665
ISBN 13: 9781592596669
Language: EN, FR, DE, ES & NL

Antibody Engineering Book Review:

A core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics. Use cutting-edge techniques for generating and optimizing recombinant antibodies Generate antibodies by humanization, molecular display technologies and transgenic mice Perform epitope mapping with mass spectrometry, bioinformatics, and array technologies Learn about novel applications in cancer, drug addiction, and proteomics Express recombinant antibodies in bacterial, yeast, insect, mammalian and plant systems.

Cancer Research

Cancer Research
Author: Anonim
Publsiher: Anonim
Total Pages: 329
Release: 2009-07
ISBN 10:
ISBN 13: CORNELL:31924108295647
Language: EN, FR, DE, ES & NL

Cancer Research Book Review:

Development of Antibody-Based Therapeutics

Development of Antibody-Based Therapeutics
Author: Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp
Publsiher: Springer
Total Pages: 248
Release: 2018-09-11
ISBN 10: 9811304963
ISBN 13: 9789811304965
Language: EN, FR, DE, ES & NL

Development of Antibody-Based Therapeutics Book Review:

With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.

Current Research on Pre-clinical Aspects of Cancer Therapy

Current Research on Pre-clinical Aspects of Cancer Therapy
Author: Anonim
Publsiher: Anonim
Total Pages: 259
Release: 1975
ISBN 10:
ISBN 13: MINN:31951000075170L
Language: EN, FR, DE, ES & NL

Current Research on Pre-clinical Aspects of Cancer Therapy Book Review:

Current Research on Pre-clinical Aspects of Cancer Therapy

Current Research on Pre-clinical Aspects of Cancer Therapy
Author: Smithsonian Science Information Exchange. Current Cancer Research Project Analysis Center
Publsiher: Anonim
Total Pages: 259
Release: 1975
ISBN 10:
ISBN 13: PURD:32754081177598
Language: EN, FR, DE, ES & NL

Current Research on Pre-clinical Aspects of Cancer Therapy Book Review:

1038 references to research projects being conducted in the United States and elsewhere. Entries arranged under 5 topics, e.g., Preclinical studies of anticancer drugs, Preclinical radiation therapy, and Preclinical immunotherapy. Entriesinclude title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.

Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book

Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book
Author: Richard A. McPherson,Matthew R. Pincus
Publsiher: Elsevier Health Sciences
Total Pages: 1568
Release: 2011-09-06
ISBN 10: 1455726842
ISBN 13: 9781455726844
Language: EN, FR, DE, ES & NL

Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book Book Review:

Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.

ABC of Clinical Haematology

ABC of Clinical Haematology
Author: Drew Provan
Publsiher: John Wiley & Sons
Total Pages: 112
Release: 2009-04-08
ISBN 10: 1444312685
ISBN 13: 9781444312683
Language: EN, FR, DE, ES & NL

ABC of Clinical Haematology Book Review:

This ABC has established itself as a popular introduction toClinical Haematology, relevant both for postgraduate students andprimary care practitioners. Now in its third edition, the ABC ofClinical Haematology has been thoroughly revised, featuring thelatest treatments for leukemia, antithrombotics and drugs forlymphoma and covering the latest advances in hematology and bonemarrow transplantation. With each chapter written by specialists in their respectivefields, this is an ideal basic text for general practice andhospital staff with patients who have blood related problems, inparticular GPs, hematology nurses, junior doctors, hematologists,and trainees in hematology.

State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization

State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization
Author: Oleg Borisov
Publsiher: Anonim
Total Pages: 329
Release: 2014
ISBN 10: 9780841230262
ISBN 13: 0841230269
Language: EN, FR, DE, ES & NL

State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Book Review:

Process Scale Purification of Antibodies

Process Scale Purification of Antibodies
Author: Uwe Gottschalk
Publsiher: John Wiley & Sons
Total Pages: 752
Release: 2017-04-03
ISBN 10: 1119126916
ISBN 13: 9781119126911
Language: EN, FR, DE, ES & NL

Process Scale Purification of Antibodies Book Review:

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing

Abeloff's Clinical Oncology E-Book

Abeloff's Clinical Oncology E-Book
Author: John E. Niederhuber,James O. Armitage,James H Doroshow,Michael B. Kastan,Joel E. Tepper
Publsiher: Elsevier Health Sciences
Total Pages: 2224
Release: 2013-09-12
ISBN 10: 1455728810
ISBN 13: 9781455728817
Language: EN, FR, DE, ES & NL

Abeloff's Clinical Oncology E-Book Book Review:

Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.