Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics

Approaches to the Purification  Analysis and Characterization of Antibody Based Therapeutics
Author: Allan Matte
Publsiher: Elsevier
Total Pages: 222
Release: 2020-09-07
ISBN 10: 0081030193
ISBN 13: 9780081030196
Language: EN, FR, DE, ES & NL

Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics Book Review:

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Development of Antibody Based Therapeutics

Development of Antibody Based Therapeutics
Author: Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp
Publsiher: Springer Science & Business Media
Total Pages: 426
Release: 2012-04-24
ISBN 10: 1441959556
ISBN 13: 9781441959553
Language: EN, FR, DE, ES & NL

Development of Antibody Based Therapeutics Book Review:

Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the ‘unit dose’ and ‘unit effect’ with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective novel and next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of biosuperior antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.

Monoclonal Antibodies

Monoclonal Antibodies
Author: Philip Shepherd,Christopher J. Dean
Publsiher: Practical Approach (Paperback)
Total Pages: 479
Release: 2000
ISBN 10: 9780199637225
ISBN 13: 0199637229
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.

Subject Index of Current Extramural Research Administered by the National Cancer Institute

Subject Index of Current Extramural Research Administered by the National Cancer Institute
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1978
ISBN 10:
ISBN 13: UOM:39015010012667
Language: EN, FR, DE, ES & NL

Subject Index of Current Extramural Research Administered by the National Cancer Institute Book Review:

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 1984
ISBN 10:
ISBN 13: MINN:31951000193619S
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Index Medicus

Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: OSU:32436011091202
Language: EN, FR, DE, ES & NL

Index Medicus Book Review:

FDA s Drug Review Process and the Package Label

FDA s Drug Review Process and the Package Label
Author: Tom Brody
Publsiher: Academic Press
Total Pages: 670
Release: 2017-12-13
ISBN 10: 0128146486
ISBN 13: 9780128146484
Language: EN, FR, DE, ES & NL

FDA s Drug Review Process and the Package Label Book Review:

FDA's Drug Review Process and the Package Label provides guidance to pharmaceutical companies for writing FDA-submissions, such as the NDA, BLA, Clinical Study Reports, and Investigator's Brochures. The book provides guidance to medical writers for drafting FDA-submissions in a way more likely to persuade FDA reviewers to grant approval of the drug. In detail, the book reproduces data on efficacy and safety from one hundred different FDA-submissions (NDAs, BLAs). The book reproduces comments and complaints from FDA reviewers regarding data that are fragmentary, ambiguous, or that detract from the drug's approvability, and the book reveals how sponsors overcame FDA's concerns and how sponsors succeeded in persuading FDA to grant approval of the drug. The book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely text and data from NDAs and BLAs, as published on FDA's website. The source material for writing this book included about 80,000 pages from FDA's Medical Reviews, FDA's Clinical Pharmacology Reviews, and FDA's Pharmacology Reviews, from one hundred different NDAs or BLAs for one hundred different drugs. Each chapter focuses on a different section of the package label, e.g., the Dosage and Administration section or the Drug Interactions section, and demonstrates how the sponsor's data supported that section of the package label. Reveals strategies for winning FDA approval and for drafting the package label Examples are from one hundred FDA-submissions (NDAs, BLAs) for one hundred different drugs, e.g., for oncology, metabolic diseases, autoimmune diseases, and neurological diseases This book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely, the data from NDAs and BLAs as published on FDA's website at the time FDA grants approval to the drug

State of the Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization

State of the Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization
Author: Oleg Borisov
Publsiher: Unknown
Total Pages: 329
Release: 2014
ISBN 10: 9780841230262
ISBN 13: 0841230269
Language: EN, FR, DE, ES & NL

State of the Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Book Review:

Science

Science
Author: John Michels
Publsiher: Unknown
Total Pages: 329
Release: 2001-09
ISBN 10:
ISBN 13: UIUC:30112037736953
Language: EN, FR, DE, ES & NL

Science Book Review:

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
Author: Zhiqiang An
Publsiher: John Wiley & Sons
Total Pages: 896
Release: 2011-09-20
ISBN 10: 1118210263
ISBN 13: 9781118210260
Language: EN, FR, DE, ES & NL

Therapeutic Monoclonal Antibodies Book Review:

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Cancer Immunology Innovative Approaches to Therapy

Cancer Immunology  Innovative Approaches to Therapy
Author: Ronald B. Herberman
Publsiher: Springer Science & Business Media
Total Pages: 230
Release: 2012-12-06
ISBN 10: 146132629X
ISBN 13: 9781461326298
Language: EN, FR, DE, ES & NL

Cancer Immunology Innovative Approaches to Therapy Book Review:

This volume is the second in the 'Cancer Treatment and Research' series focussing on basic and clinical tumor immunology. It has a rather different focus or emphasis from that of the first volume, published two years ago. That work (Basic and Clinical Tumor Immunology, R.B. Herberman, ed., Martinus Nijhoff Publishers, 1983) devoted considerable attention to up dated summaries in various areas of classical tumor immunology: specific antitumor immunity, the immunologic competence of cancer patietns, char acterization of human tumor-associated antigens, the ability to propagate specifically immune T cells in culture in the presence of interleukin 2, and the use of such cells for adoptive immunotherapy of established tumors. of evidence concerning the immune However, it also reviewed the status surveillance hypothesis and pointed out the need to consider non-T cell mediated mechanisms of host resistance. In particular, one chapter sum marized information on the role of macrophages in host resistance against tumors. The present volume continues to emphasize one of the major themes of the first volume, innovative approaches to the therapy of cancer. It involves contributions from leading investigators on several primary types of therapeutic interventions related to monoclonal antibodies, the col laboration of monoclonal antibodies with macro phages to mediate antibody dependent cellular cytotoxicity, lymphokines, tumor vaccines, and natural killer cells. It also has an up-to-date summary of the immunologic aspects of the exciting and promising work being performed on human T cell leukemia virus in the laboratory of Dr. Robert Gallo.

Monoclonal Antibodies

Monoclonal Antibodies
Author: Maher Albitar
Publsiher: Springer Science & Business Media
Total Pages: 228
Release: 2007
ISBN 10: 1597453234
ISBN 13: 9781597453233
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

Monoclonal Antibodies: Methods and Protocols examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting with opening chapters focusing on the gold standard method for generating mouse monoclonal antibodies through hybridoma technology, future methods for engineering recombinant and humanized antibodies, methods for engineering soluble Fc fusion protein, and the use of antibodies and flow cytometry in the quantification of cell signaling proteins. Specific chapters describe how antibodies are used for the diagnosis and classification of hematologic diseases. Subsequent chapters examine the advantages and most recent advances of using bead-based immunoassays, including the ability of bead-based technology to multiplex and analyze several analytes simultaneously, and the use of beads in detecting fusion proteins resulting from chromosomal translocations. Concluding chapters provide additional examples of methodologies that employ monoclonal antibodies.

Development of Antibody Based Therapeutics

Development of Antibody Based Therapeutics
Author: Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp
Publsiher: Springer
Total Pages: 248
Release: 2018-09-11
ISBN 10: 9811304963
ISBN 13: 9789811304965
Language: EN, FR, DE, ES & NL

Development of Antibody Based Therapeutics Book Review:

With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.

Monoclonal Antibodies

Monoclonal Antibodies
Author: Christian Klein
Publsiher: MDPI
Total Pages: 238
Release: 2018-04-27
ISBN 10: 3038428752
ISBN 13: 9783038428756
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies Book Review:

This book is a printed edition of the Special Issue "Monoclonal Antibodies" that was published in Antibodies

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability
Author: Anthony R. Mire-Sluis
Publsiher: S Karger Ag
Total Pages: 213
Release: 2005
ISBN 10:
ISBN 13: UOM:39015062415834
Language: EN, FR, DE, ES & NL

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability Book Review:

With the latest advances in analytical technologies, most biological products can now be extensively characterized in terms of their identity, heterogeneity and impurity profile. The currently available analytical methods (both physicochemical and biological) can characterize the primary, secondary and to some extent, the higher order structure of proteins. The sensitivity and selectivity of these methods allow for the identification and characterization not only of the desired protein component, but also many product-related substances and impurities as well as process-related impurities present in the drug preparations. Using an appropriate selection of analytical tools, it may be possible to demonstrate physicochemical and functional comparability between protein products manufactured before and after a manufacturing change or during product development. However, the extent of demonstrable comparability depends on the tests used, on the nature of the product and on the basic understanding of structure-function relationships. Assessment of immunogenicity is also a critical component of product characterization and is highly dependent on the types of assays used.

Federation Proceedings

Federation Proceedings
Author: Federation of American Societies for Experimental Biology
Publsiher: Unknown
Total Pages: 329
Release: 1987
ISBN 10:
ISBN 13: UOM:39015010280215
Language: EN, FR, DE, ES & NL

Federation Proceedings Book Review:

Vols. for 1942- include proceedings of the American Physiological Society.

Basic Methods in Antibody Production and Characterization

Basic Methods in Antibody Production and Characterization
Author: Gary C. Howard,Delia R. Bethell
Publsiher: CRC Press
Total Pages: 288
Release: 2000-09-21
ISBN 10: 9781420036534
ISBN 13: 142003653X
Language: EN, FR, DE, ES & NL

Basic Methods in Antibody Production and Characterization Book Review:

Written for researchers and professionals in the fields of biomedical research, immunology, biochemistry, molecular biology, pathology, and biotechnology, Basic Methods in Antibody Production and Characterization uses a cookbook approach to presenting the methods for the production, characterization, and use of antibodies. Antibodies described include polyclonal and monoclonal and those made by the phage display. Basic Methods in Antibody Production and Characterization focuses on specific aspects of antibodies and takes readers on a step-by-step process from antigen preparation to immunizations, adjuvants, screening, purification, storage, and applications. Introductory material accompanies each chapter, giving readers a better understanding of the methods and applications. Ample references arm researchers with many applications pertaining to the particular technology.

Scientific Report

Scientific Report
Author: Ohio State University. Comprehensive Cancer Center
Publsiher: Unknown
Total Pages: 329
Release: 1988
ISBN 10:
ISBN 13: OSU:32435027704311
Language: EN, FR, DE, ES & NL

Scientific Report Book Review:

Antibody Engineering

Antibody Engineering
Author: Thomas Böldicke
Publsiher: BoD – Books on Demand
Total Pages: 312
Release: 2018-02-21
ISBN 10: 9535138251
ISBN 13: 9789535138259
Language: EN, FR, DE, ES & NL

Antibody Engineering Book Review:

Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets.

Process Scale Purification of Antibodies

Process Scale Purification of Antibodies
Author: Uwe Gottschalk
Publsiher: John Wiley & Sons
Total Pages: 752
Release: 2017-04-03
ISBN 10: 1119126916
ISBN 13: 9781119126911
Language: EN, FR, DE, ES & NL

Process Scale Purification of Antibodies Book Review:

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing