Antimalarial Agents

Antimalarial Agents
Author: Graham L. Patrick
Publsiher: Elsevier
Total Pages: 622
Release: 2020-05-30
ISBN 10: 0081012411
ISBN 13: 9780081012413
Language: EN, FR, DE, ES & NL

Antimalarial Agents Book Review:

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work towards antimalarial solution, providing practical guidance on current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a focus on biological aspects of malaria, this book highlights the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. The book also includes detailed study of the medicinal chemistry of antimalarial agents and a focus on the design of antimalarial drugs. Drawing on the knowledge of its expert authors and coupling historic research with current findings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs, including academic researchers, medicinal chemists, malaria researchers and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

Hepatotoxicity

Hepatotoxicity
Author: Hyman J. Zimmerman
Publsiher: Lippincott Williams & Wilkins
Total Pages: 789
Release: 1999
ISBN 10: 9780781719520
ISBN 13: 0781719526
Language: EN, FR, DE, ES & NL

Hepatotoxicity Book Review:

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Antimalarial Agents

Antimalarial Agents
Author: Poul Thompson
Publsiher: Elsevier
Total Pages: 408
Release: 2012-12-02
ISBN 10: 032315168X
ISBN 13: 9780323151689
Language: EN, FR, DE, ES & NL

Antimalarial Agents Book Review:

Medicinal Chemistry, Volume 12: Antimalarial Agents: Chemistry and Pharmacology presents the essentials of both biology and chemistry pertinent to the chemotherapy of malaria. This book discusses the nature of the disease, the physiology and biochemistry of the plasmodia, and the mode of action of drugs. Organized into 19 chapters, this volume begins with an overview of the most intensive efforts to develop synthetic antimalarial drugs. This text then examines how drugs are evaluated as well as the specific chemotherapy in malaria. Other chapters consider the diversity of chemical structures exhibiting antimalarial activity with emphasis on structure–activity relationships and methods of synthesis. This book discusses as well the plasmodial effects by quinine in vivo. The final chapter deals with the miscellaneous structures known to have activity against some types of plasmodial infection in animals. This book is a valuable resource for chemists and biologists involved in the development of antimalarial drugs.

Saving Lives Buying Time

Saving Lives  Buying Time
Author: Institute of Medicine,Board on Global Health,Committee on the Economics of Antimalarial Drugs
Publsiher: National Academies Press
Total Pages: 384
Release: 2004-10-09
ISBN 10: 0309092183
ISBN 13: 9780309092180
Language: EN, FR, DE, ES & NL

Saving Lives Buying Time Book Review:

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called “artemisinins†are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Antimalarial Chemotherapy

Antimalarial Chemotherapy
Author: Philip J. Rosenthal
Publsiher: Springer Science & Business Media
Total Pages: 396
Release: 2001-04-01
ISBN 10: 1592591116
ISBN 13: 9781592591114
Language: EN, FR, DE, ES & NL

Antimalarial Chemotherapy Book Review:

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Malaria Control During Mass Population Movements and Natural Disasters

Malaria Control During Mass Population Movements and Natural Disasters
Author: Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University,National Research Council,Committee on Population,Roundtable on the Demography of Forced Migration,Holly A. Williams,Peter B. Bloland
Publsiher: National Academies Press
Total Pages: 180
Release: 2003-01-16
ISBN 10: 0309086159
ISBN 13: 9780309086158
Language: EN, FR, DE, ES & NL

Malaria Control During Mass Population Movements and Natural Disasters Book Review:

Admittedly, the world and the nature of forced migration have changed a great deal over the last two decades. The relevance of data accumulated during that time period can now be called into question. The roundtable and the Program on Forced Migration at the Mailman School of Public Health of Columbia University have commissioned a series of epidemiological reviews on priority public health problems for forced migrants that will update the state of knowledge. Malaria Control During Mass Population Movements and Natural Disasters -- the first in the series, provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice
Publsiher: National Academies Press
Total Pages: 426
Release: 2020-03-24
ISBN 10: 0309672139
ISBN 13: 9780309672139
Language: EN, FR, DE, ES & NL

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis Book Review:

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

Guidelines for the Treatment of Malaria

Guidelines for the Treatment of Malaria
Author: World Health Organization
Publsiher: World Health Organization
Total Pages: 194
Release: 2010
ISBN 10: 9241547928
ISBN 13: 9789241547925
Language: EN, FR, DE, ES & NL

Guidelines for the Treatment of Malaria Book Review:

"The purpose of this document is to provide comprehensible, global, evidence-based guidelines to help formulate policies and protocols for the treatment of malaria. Information is presented on the treatment of uncomplicated malaria, including disease in special groups (young children, pregnant women, people who are HIV positive, travellers from non-malaria endemic regions) and in complex emergency situations and severe malaria."--Publisher's description.

Antimalarial Agents Advances in Research and Application 2011 Edition

Antimalarial Agents  Advances in Research and Application  2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 26
Release: 2012-01-09
ISBN 10: 1464949859
ISBN 13: 9781464949852
Language: EN, FR, DE, ES & NL

Antimalarial Agents Advances in Research and Application 2011 Edition Book Review:

Antimalarial Agents: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Antimalarial Agents in a compact format. The editors have built Antimalarial Agents: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antimalarial Agents in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antimalarial Agents: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Treatment and Prevention of Malaria

Treatment and Prevention of Malaria
Author: Henry M. Staines,Sanjeev Krishna
Publsiher: Springer Science & Business Media
Total Pages: 318
Release: 2012-01-05
ISBN 10: 3034604807
ISBN 13: 9783034604802
Language: EN, FR, DE, ES & NL

Treatment and Prevention of Malaria Book Review:

Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.

CDC Yellow Book 2018 Health Information for International Travel

CDC Yellow Book 2018  Health Information for International Travel
Author: Centers for Disease Control and Prevention CDC
Publsiher: Oxford University Press
Total Pages: 672
Release: 2017-04-17
ISBN 10: 0190628634
ISBN 13: 9780190628635
Language: EN, FR, DE, ES & NL

CDC Yellow Book 2018 Health Information for International Travel Book Review:

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

STERIC HINDRANCE AND SYNERGISM IN THE DESIGN OF ANTIMALARIAL AGENTS

STERIC HINDRANCE AND SYNERGISM IN THE DESIGN OF ANTIMALARIAL AGENTS
Author: DOUGLAS CLIFFORD MORRISON
Publsiher: Unknown
Total Pages: 68
Release: 1964
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015032276696
Language: EN, FR, DE, ES & NL

STERIC HINDRANCE AND SYNERGISM IN THE DESIGN OF ANTIMALARIAL AGENTS Book Review:

Antimalarial Natural Products

Antimalarial Natural Products
Author: A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch
Publsiher: Springer
Total Pages: 170
Release: 2022-01-13
ISBN 10: 9783030898724
ISBN 13: 3030898725
Language: EN, FR, DE, ES & NL

Antimalarial Natural Products Book Review:

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.

Synthesis of New Antimalarial Agents

Synthesis of New Antimalarial Agents
Author: F. I. Carroll,John A. Kepler,RESEARCH TRIANGLE INST RESEARCH TRIANGLE PARK NC.
Publsiher: Unknown
Total Pages: 130
Release: 1986
ISBN 10: 1928374650XXX
ISBN 13: OCLC:227988347
Language: EN, FR, DE, ES & NL

Synthesis of New Antimalarial Agents Book Review:

This study is concerned with the preparation of: a) peroxides based on qinghaosu, b) peptide pro-drug derivatives of primaquine, and c) thymidylate synthetase inhibitors as potentially new antimalarial agents. During this study, thirty (30) target compounds were prepared and submitted for antimalarial evaluation. The thirty compounds included twenty-four (24) qinghaosu analogs, three (3) primaquine derivative and three (3) thymidylate synthetase inhibitors. Twenty-one of the qinghaosu analogs and all three of the thymidylate synthetase inhibitors were evaluated in the malaria in vitro drug screen. All but three of the qinghaosu analogs showed activity in this screen, whereas the thymidylate synthetase inhibitors were inactive. The three peptide pro-drug derivatives of primaquine were tested for radical curative activity against Plasmodium cynomologi in rhesus monkeys, All three compounds showed cures greater than that expected for the primaquine content of each pro-drug. Twenty-three target compounds were evaluated for blood schizonticidal suppressive activity against P. berghei in mice, and ten compounds were tested for causal prophylactic activity against P. berghei yoelii in mice. None of the compounds tested showed significant activity in these screens. Keywords: Malaria; Antimalarial Drugs; Heterocycles; Synthesis(Chemistry).

Malaria

Malaria
Author: Institute of Medicine,Division of International Health,Committee for the Study on Malaria Prevention and Control
Publsiher: National Academies Press
Total Pages: 328
Release: 1991-02-01
ISBN 10: 9780309045278
ISBN 13: 0309045274
Language: EN, FR, DE, ES & NL

Malaria Book Review:

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

Antimalarial Drug II

Antimalarial Drug II
Author: Anonim
Publsiher: Springer Science & Business Media
Total Pages: 520
Release: 2012-12-06
ISBN 10: 3642692540
ISBN 13: 9783642692543
Language: EN, FR, DE, ES & NL

Antimalarial Drug II Book Review:

The construction of this volume has been guided by two personal convictions. Experience in the field of experimental chemotherapy, both in the pharmaceutical industry and academia, has convinced us that recent quantum technological advances in biochemistry, molecular biology, and immunology will permit and, indeed, necessitate an increasingly greater use of rational drug development in the future than has been the custom up to now. In Part l, therefore, we asked our contributors to provide detailed reviews covering the biology of the malaria parasites and their relation with their hosts, the experimental procedures including culture techniques that are necessary to take a drug from primary screening to clinical trial, and an account of antimalarial drug resistance. Our second conviction is that many research workers are all too loath to learn from the lessons of the past. For this reason we asked the contributors to Part 2 of this volume to review very thoroughly the widely scattered but voluminous literature on those few chemical groups that have provided the antimalarial drugs in clinical use at the present time. Much can be learned from the history of their development and the problems that have arisen with them in man. Some indeed may still have much to offer if they can be deployed in better ways than they are at present. This question has been taken up by several authors.

Survey of Antimalarial Agents

Survey of Antimalarial Agents
Author: George Robert Coatney
Publsiher: Unknown
Total Pages: 323
Release: 1953
ISBN 10: 1928374650XXX
ISBN 13: CORNELL:31924018502942
Language: EN, FR, DE, ES & NL

Survey of Antimalarial Agents Book Review:

Guidelines for the Treatment of Malaria Third Edition

Guidelines for the Treatment of Malaria  Third Edition
Author: World Health Organization
Publsiher: World Health Organization
Total Pages: 313
Release: 2015-08-13
ISBN 10: 9241549122
ISBN 13: 9789241549127
Language: EN, FR, DE, ES & NL

Guidelines for the Treatment of Malaria Third Edition Book Review:

Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.

From Artemisia Annua L to Artemisinins Hindi Edition

From Artemisia Annua L  to Artemisinins  Hindi Edition
Author: Youyou Tu
Publsiher: Unknown
Total Pages: 456
Release: 2021-10-31
ISBN 10: 9781487804459
ISBN 13: 1487804458
Language: EN, FR, DE, ES & NL

From Artemisia Annua L to Artemisinins Hindi Edition Book Review:

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research.

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice
Publsiher: National Academies Press
Total Pages: 426
Release: 2020-04-24
ISBN 10: 0309672104
ISBN 13: 9780309672108
Language: EN, FR, DE, ES & NL

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis Book Review:

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.