Antifungal Compounds Discovery

Antifungal Compounds Discovery
Author: Marina Sokovic,Konstantinos Liaras
Publsiher: Elsevier
Total Pages: 290
Release: 2020-09-30
ISBN 10: 0128158255
ISBN 13: 9780128158258
Language: EN, FR, DE, ES & NL

Antifungal Compounds Discovery Book Review:

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compound Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compound Discovery is a comprehensive guide helping researchers understand the relationship between specific chemicals structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Agents

Antifungal Agents
Author: G. K. Dixon,Leonard G. Copping,Derek W. Hollomon
Publsiher: Bios Scientific Pub Limited
Total Pages: 292
Release: 1995
ISBN 10:
ISBN 13: UCSC:32106012733215
Language: EN, FR, DE, ES & NL

Antifungal Agents Book Review:

Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Antifungal Drug Discovery New Theories and New Therapies

Antifungal Drug Discovery  New Theories and New Therapies
Author: Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2016-09-13
ISBN 10: 2889199509
ISBN 13: 9782889199501
Language: EN, FR, DE, ES & NL

Antifungal Drug Discovery New Theories and New Therapies Book Review:

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Recent Trends in the Discovery Development and Evaluation of Antifungal Agents

Recent Trends in the Discovery  Development and Evaluation of Antifungal Agents
Author: R. A. Fromtling
Publsiher: Anonim
Total Pages: 641
Release: 1987
ISBN 10:
ISBN 13: UOM:39015035784159
Language: EN, FR, DE, ES & NL

Recent Trends in the Discovery Development and Evaluation of Antifungal Agents Book Review:

Antimicrobial Drug Discovery

Antimicrobial Drug Discovery
Author: George Tegos,Eleftherios Mylonakis
Publsiher: CABI
Total Pages: 357
Release: 2012
ISBN 10: 1845939433
ISBN 13: 9781845939434
Language: EN, FR, DE, ES & NL

Antimicrobial Drug Discovery Book Review:

Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Plant Bioactives and Drug Discovery

Plant Bioactives and Drug Discovery
Author: Valdir Cechinel-Filho
Publsiher: John Wiley & Sons
Total Pages: 586
Release: 2012-04-11
ISBN 10: 1118259920
ISBN 13: 9781118259924
Language: EN, FR, DE, ES & NL

Plant Bioactives and Drug Discovery Book Review:

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Antifungal Agents

Antifungal Agents
Author: Erika J. Ernst,P. David Rogers
Publsiher: Springer Science & Business Media
Total Pages: 209
Release: 2005
ISBN 10: 1592599435
ISBN 13: 9781592599431
Language: EN, FR, DE, ES & NL

Antifungal Agents Book Review:

A collection of state-of-the-art molecular methods for studying antifungal resistance, for discovering and evaluating both new and existing antifungal drugs, and for understanding the host response and immunotherapy of such agents. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Antimicrobial Compounds

Antimicrobial Compounds
Author: Tomás G. Villa,Patricia Veiga-Crespo
Publsiher: Springer Science & Business Media
Total Pages: 316
Release: 2013-10-19
ISBN 10: 3642404448
ISBN 13: 9783642404443
Language: EN, FR, DE, ES & NL

Antimicrobial Compounds Book Review:

Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.

Antifungal Therapy

Antifungal Therapy
Author: Mahmoud A. Ghannoum, PhD, EMBA,Mahmoud A. Ghannoum,John R. Perfect,John R. Perfect, MD
Publsiher: CRC Press
Total Pages: 488
Release: 2016-04-19
ISBN 10: 0849387868
ISBN 13: 9780849387869
Language: EN, FR, DE, ES & NL

Antifungal Therapy Book Review:

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment. Divided into four interrelated sections for a cohesive discussion covers: history of antifungals from the discovery of the polyenes to the echinocandins antifungal susceptibility methods patient management animal models in drug development therapeutic strategies pharmacokinetic and pharmacogenomics trends in resistance

Drug Discovery and Design

Drug Discovery and Design
Author: Anonim
Publsiher: Elsevier
Total Pages: 567
Release: 2001-04-18
ISBN 10: 0080493386
ISBN 13: 9780080493381
Language: EN, FR, DE, ES & NL

Drug Discovery and Design Book Review:

Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents.

Chemotherapy of Fungal Diseases

Chemotherapy of Fungal Diseases
Author: John F. Ryley
Publsiher: Springer Science & Business Media
Total Pages: 558
Release: 2012-12-06
ISBN 10: 3642754589
ISBN 13: 9783642754586
Language: EN, FR, DE, ES & NL

Chemotherapy of Fungal Diseases Book Review:

Fungal diseases have been with us from antiquity; interest in the chemo therapy of fungal disease has exploded in the past decade. To plan and pro duce a book on the topic of antifungal chemotherapy has come as a personal challenge - and something of an eye-opener - towards the end of my re search career. A landmark publication which still merits reading is Antifungal Chemotherapy (John Wiley & Sons, Chichester, UK), edited by David Speller, which appeared in 1980. However, the fact that ketoconazole, the first of the modern, orally active, wide-spectrum antifungals, attracted no more than two sentences in it indicates just how far we have come in the 1980s. A steady stream of original papers and a number of conference proceedings have chronicled this progress in drug research; outstanding among the latter are the proceedings of an international telesymposium, entitled Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents, edited by Robert Fromtling (J.R. Prous, Barcelona, 1987) and volume 544 of the Annals of the New York Academy of Sciences, entitled Antifungal Drugs, edited by Vassil St. Georgiev, and containing papers and posters presented at a most enjoyable 3-day conference held at Garden City, New York, in the autumn of 1987.

7

7
Author: J. Wuyts
Publsiher: Anonim
Total Pages: 329
Release: 2017
ISBN 10:
ISBN 13: OCLC:1163813559
Language: EN, FR, DE, ES & NL

7 Book Review:

Impedance-based de-replication of antifungal drug classes High-throughput target-based drug screening of synthetic molecules so far has not resulted in new antifungal drug classes. One of the proposed reasons for this failure is the lack of penetration of synthetic molecules in the fungal cell, the high false-positive rates and the lack of selectivity. Three major classes of antifungal drugs are currently in use; the polyenes, the echinocandins and the azoles. Two of them, the polyenes and the echinocandins, are natural products or based on natural products produced by micro-organisms. Small molecules produced by micro-organisms have several desirable characteristics. First, they are highly specific due to their high degree of chirality. Second, they are intrinsically cell permeable and finally, they occupy a more diverse chemical space. However, natural product-based antifungal drug discovery is associated with a number of technical challenges. Fermentation extracts are composed of complex mixtures containing hundreds or thousands of unknown compounds and concomitantly natural product drug discovery is plagued by a high background of known and/or nuisance compounds. Recent efforts have revealed that the vast majority of micro-organisms are still unable to grow under laboratory conditions, indicating a huge unexplored source of new natural compounds. Mining this so-called u2018microbial dark matteru2019 has recently proven successful in the search for novel antibiotics, but has not been used in the search for novel antifungals. Even though previously uncultured micro-organisms can be a rich source of novel antimicrobials, they still produce known antimicrobials. Therefore, a high-throughput de-replication platform to filter out known or undesirable compounds would decrease costs and time consumption in antifungal drug discovery. We have developed a novel tool that can be used to de-replicate antifungal drug classes in a high-throughput and label-free fashion. This tool is based on multisine electrochemical impedance spectroscopy (EIS). Here, Candida albicans biofilms were grown on modified microtiter plates with gold electrodes coated at the bottom of the plates. Next, the cells were subjected to a small alternating potential inside the wells of the 96 well plates during biofilm development or destruction for 24h. The measurement of the resulting micro-current through the developing biofilm results in a signature profile based on multiple frequency components. When we challenged growing C. albicans biofilms with different antifungals we were able to obtain specific signatures for each class. By comparing the signature profile of unknown compounds with a library of signature profiles of known compounds we were able to identify the antifungal mode-of-action. Impedance based de-replication can become a valuable tool in the next-generation of natural product-based drug discovery platforms.

Drug Discovery from Nature

Drug Discovery from Nature
Author: S. Grabley,R. Thiericke
Publsiher: Springer Science & Business Media
Total Pages: 347
Release: 1998-11-26
ISBN 10: 9783540648444
ISBN 13: 3540648445
Language: EN, FR, DE, ES & NL

Drug Discovery from Nature Book Review:

This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

Nitrogen Phosphorus and Sulphur Utilisation by Fungi

Nitrogen  Phosphorus and Sulphur Utilisation by Fungi
Author: British Mycological Society. Symposium,R. Marchant
Publsiher: Cambridge University Press
Total Pages: 316
Release: 1989-05-11
ISBN 10: 0521374057
ISBN 13: 9780521374057
Language: EN, FR, DE, ES & NL

Nitrogen Phosphorus and Sulphur Utilisation by Fungi Book Review:

The only up-to-date and detailed analysis of nitrogen, phosphorus and sulphur utilization by fungi is presented in this book. Based on the 1988 British Mycological Society symposium, it is broadly based, covering four basic areas: physiology and metabolism of nitrogen, phosphorus and sulphur by fungi; role of these minerals in pathogenic relationships with plants; their role in mutualistic relationships with plants; and the role of saprotrophic fungi in cycling of the elements through ecosystems. This is a useful reference for research workers, advanced students and teachers of mycology, plant pathology, plant nutrition and soil ecology.

Drug Discovery and Evaluation Pharmacological Assays

Drug Discovery and Evaluation  Pharmacological Assays
Author: Hans Vogel
Publsiher: Springer Science & Business Media
Total Pages: 2068
Release: 2007-10-30
ISBN 10: 3540714200
ISBN 13: 9783540714200
Language: EN, FR, DE, ES & NL

Drug Discovery and Evaluation Pharmacological Assays Book Review:

The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

New Approaches for Antifungal Drugs

New Approaches for Antifungal Drugs
Author: FERNANDES,PRABHAVATHI
Publsiher: Springer Science & Business Media
Total Pages: 201
Release: 2013-11-09
ISBN 10: 148996729X
ISBN 13: 9781489967299
Language: EN, FR, DE, ES & NL

New Approaches for Antifungal Drugs Book Review:

Anticandidal Agents

Anticandidal Agents
Author: Awanish Kumar
Publsiher: Academic Press
Total Pages: 94
Release: 2016-09-12
ISBN 10: 012811312X
ISBN 13: 9780128113127
Language: EN, FR, DE, ES & NL

Anticandidal Agents Book Review:

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Combating Fungal Infections

Combating Fungal Infections
Author: Iqbal Ahmad,Mohammad Owais,Mohammed Shahid,Farrukh Aqil
Publsiher: Springer Science & Business Media
Total Pages: 539
Release: 2010-08-03
ISBN 10: 9783642121739
ISBN 13: 364212173X
Language: EN, FR, DE, ES & NL

Combating Fungal Infections Book Review:

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Annual Reports in Medicinal Chemistry

Annual Reports in Medicinal Chemistry
Author: Annette M. Doherty
Publsiher: Academic Press
Total Pages: 478
Release: 2003-09-24
ISBN 10: 9780120405381
ISBN 13: 0120405385
Language: EN, FR, DE, ES & NL

Annual Reports in Medicinal Chemistry Book Review:

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease-orientated and generally report on specific medicinal agents. Sections V-VI continue to emphasize important topics in medicinal chemistry, biology and drug design. In addition to the chapter reviews, a comprehensive set of indices has been included to enable the reader to easily locate topics in Volumes 1-38 of this series.

Emerging Targets in Antibacterial and Antifungal Chemotherapy

Emerging Targets in Antibacterial and Antifungal Chemotherapy
Author: Joyce Sutcliffe,Nafsika Georgopapadakou
Publsiher: Springer Science & Business Media
Total Pages: 606
Release: 2012-12-06
ISBN 10: 1461532744
ISBN 13: 9781461532743
Language: EN, FR, DE, ES & NL

Emerging Targets in Antibacterial and Antifungal Chemotherapy Book Review:

Emerging Targets in Antibacterial and Antifungal Chemotherapy offers constructive ideas to researchers that could lead to the discovery of entirely new classes of drugs. The authors emphasize new topics rather than review work on known antibacterials and antifungals, and identify new targets--either the rate-limiting component of a biochemical pathway or a component of the pathway that is susceptible to a ``screening'' or ``rational drug design'' approach. Each chapter reviews the biochemical pathway and its place in the cellular scheme in order to place the target in perspective. The authors, a mixture of academic researchers and drug-discovery investigators in pharmaceutical companies, also extend these theoretical concerns into practical applications and suggest useful screening methodologies. The importance of this subject area is demonstrated by the increasing number of papers in the literature that point to potential targets and screening methodologies for new antibacterials. This book also deals with antifungals, investigating the inherent limitations in existing antifungals (many of which are extremely toxic or have only limited efficacy), and pointing to major developments in the discovery of novel antifungals. Emerging Targets in Antibacterial and Antifungal Chemotherapy will be of interest to professional microbiologists, biochemists, and cell biologists in both academic and industrial laboratories.