Antifungal Compounds Discovery

Antifungal Compounds Discovery
Author: Marina Sokovic,Konstantinos Liaras
Publsiher: Elsevier
Total Pages: 290
Release: 2020-09-30
ISBN 10: 0128158255
ISBN 13: 9780128158258
Language: EN, FR, DE, ES & NL

Antifungal Compounds Discovery Book Review:

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compound Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compound Discovery is a comprehensive guide helping researchers understand the relationship between specific chemicals structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Drug Discovery New Theories and New Therapies

Antifungal Drug Discovery  New Theories and New Therapies
Author: Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2016-09-13
ISBN 10: 2889199509
ISBN 13: 9782889199501
Language: EN, FR, DE, ES & NL

Antifungal Drug Discovery New Theories and New Therapies Book Review:

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Antifungal Agents

Antifungal Agents
Author: G. K. Dixon,Leonard G. Copping,Derek W. Hollomon
Publsiher: Bios Scientific Pub Limited
Total Pages: 292
Release: 1995
ISBN 10:
ISBN 13: UCSC:32106012733215
Language: EN, FR, DE, ES & NL

Antifungal Agents Book Review:

Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Antimicrobial Drug Discovery

Antimicrobial Drug Discovery
Author: George Tegos,Eleftherios Mylonakis
Publsiher: CABI
Total Pages: 357
Release: 2012
ISBN 10: 1845939433
ISBN 13: 9781845939434
Language: EN, FR, DE, ES & NL

Antimicrobial Drug Discovery Book Review:

Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Recent Trends in the Discovery Development and Evaluation of Antifungal Agents

Recent Trends in the Discovery  Development and Evaluation of Antifungal Agents
Author: Robert A. Fromtling
Publsiher: Unknown
Total Pages: 641
Release: 1987
ISBN 10:
ISBN 13: UOM:39015035784159
Language: EN, FR, DE, ES & NL

Recent Trends in the Discovery Development and Evaluation of Antifungal Agents Book Review:

Plant Bioactives and Drug Discovery

Plant Bioactives and Drug Discovery
Author: Valdir Cechinel-Filho
Publsiher: John Wiley & Sons
Total Pages: 586
Release: 2012-04-11
ISBN 10: 1118259920
ISBN 13: 9781118259924
Language: EN, FR, DE, ES & NL

Plant Bioactives and Drug Discovery Book Review:

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Antifungal Therapy

Antifungal Therapy
Author: Mahmoud A. Ghannoum, PhD, EMBA,Mahmoud A. Ghannoum,John R. Perfect,John R. Perfect, MD
Publsiher: CRC Press
Total Pages: 488
Release: 2016-04-19
ISBN 10: 0849387868
ISBN 13: 9780849387869
Language: EN, FR, DE, ES & NL

Antifungal Therapy Book Review:

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment. Divided into four interrelated sections for a cohesive discussion covers: history of antifungals from the discovery of the polyenes to the echinocandins antifungal susceptibility methods patient management animal models in drug development therapeutic strategies pharmacokinetic and pharmacogenomics trends in resistance

Antimicrobial Compounds

Antimicrobial Compounds
Author: Tomás G. Villa,Patricia Veiga-Crespo
Publsiher: Springer Science & Business Media
Total Pages: 316
Release: 2013-10-19
ISBN 10: 3642404448
ISBN 13: 9783642404443
Language: EN, FR, DE, ES & NL

Antimicrobial Compounds Book Review:

Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.

New Antifungal Compounds from Marine Fungi

New Antifungal Compounds from Marine Fungi
Author: Akkharawit Kanjana-opas
Publsiher: Unknown
Total Pages: 360
Release: 2002
ISBN 10:
ISBN 13: UCSD:31822020690665
Language: EN, FR, DE, ES & NL

New Antifungal Compounds from Marine Fungi Book Review:

Anticandidal Agents

Anticandidal Agents
Author: Awanish Kumar
Publsiher: Academic Press
Total Pages: 94
Release: 2016-09-12
ISBN 10: 012811312X
ISBN 13: 9780128113127
Language: EN, FR, DE, ES & NL

Anticandidal Agents Book Review:

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Antifungal Agents

Antifungal Agents
Author: Erika J. Ernst,P. David Rogers
Publsiher: Springer Science & Business Media
Total Pages: 209
Release: 2005
ISBN 10: 1592599435
ISBN 13: 9781592599431
Language: EN, FR, DE, ES & NL

Antifungal Agents Book Review:

A collection of state-of-the-art molecular methods for studying antifungal resistance, for discovering and evaluating both new and existing antifungal drugs, and for understanding the host response and immunotherapy of such agents. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Medicinal Chemistry and Drug Discovery Chemotherapeutic agents

Medicinal Chemistry and Drug Discovery  Chemotherapeutic agents
Author: Alfred Burger
Publsiher: Unknown
Total Pages: 329
Release: 2003
ISBN 10:
ISBN 13: UOM:39015056276903
Language: EN, FR, DE, ES & NL

Medicinal Chemistry and Drug Discovery Chemotherapeutic agents Book Review:

The Discovery of Natural Products with Therapeutic Potential

The Discovery of Natural Products with Therapeutic Potential
Author: Vincent Philip Gullo
Publsiher: Unknown
Total Pages: 461
Release: 1994
ISBN 10:
ISBN 13: UCSD:31822016462590
Language: EN, FR, DE, ES & NL

The Discovery of Natural Products with Therapeutic Potential Book Review:

Although science has discovered effective drugs for many of the diseases that afflict mankind, many human health problems remain untreatable. The search for novel therapeutic agents is always ongoing. This book will describe some of the diverse sources of natural products, such as terrestrial and marine environments; and will review how research has increased knowledge of biological systems and human disease, leading to the design of targeted asssays, amenable to high volume screening.

Fungicides

Fungicides
Author: Mizuho Nita
Publsiher: BoD – Books on Demand
Total Pages: 342
Release: 2013-05-15
ISBN 10: 9535111302
ISBN 13: 9789535111306
Language: EN, FR, DE, ES & NL

Fungicides Book Review:

This book comprised of three sections that focus various aspects of fungicide usages and its consequences. In the eight-chapter first section, authors discuss implementation of Integrated Plant Disease Management on a wide array of crops grown in different parts of the world: wheat productions in Argentina and in the US; corn, cotton and Eucalyptus productions in Brazil; rice productions in India; peanut productions in the southern US; and pine seedling nurseries in Serbia. The second section is composed of two chapters that explore the possibility of natural products as fungicides. The final section discusses two interesting and important topics on the fungicide-fungus interaction that can influence the implementation of plant disease management practices, fungicide resistance and hormesis.

Conference on Drug Design and Discovery Technologies

Conference on Drug Design and Discovery Technologies
Author: Manikanta Murahari,Lakshmi Sundar,Soma Chaki,Vasanthanathan Poongavanam,Pritesh Bhat,Usha Y Nayak
Publsiher: Royal Society of Chemistry
Total Pages: 350
Release: 2019-11-20
ISBN 10: 1788018621
ISBN 13: 9781788018623
Language: EN, FR, DE, ES & NL

Conference on Drug Design and Discovery Technologies Book Review:

This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.

Pathogenic Yeasts

Pathogenic Yeasts
Author: Ruth Ashbee,Elaine M. Bignell
Publsiher: Springer Science & Business Media
Total Pages: 365
Release: 2009-10-27
ISBN 10: 9783642031502
ISBN 13: 3642031501
Language: EN, FR, DE, ES & NL

Pathogenic Yeasts Book Review:

Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods in many clinical mycology laboratories continues to provide information for the diagnosis and treatment of patients. This volume reviews various aspects of pathogenic yeasts and what is known about their molecular and cellular biology and virulence, in addition to looking at clinical and laboratory findings. As each chapter is written by a leading expert in the field, this book summarizes in one volume much of the latest research on several pathogenic yeasts, including Candida, Cryptococcus, Malassezia and yeasts of emerging importance. The importance of laboratory diagnosis, antifungal susceptibility testing, antifungal resistance and yeast diseases in animals are reviewed.

Current Topics in Marine Biotechnology

Current Topics in Marine Biotechnology
Author: Shigetō Miyaji,I. Karube,Y. Ishida
Publsiher: Unknown
Total Pages: 437
Release: 1989
ISBN 10:
ISBN 13: UCSD:31822007882830
Language: EN, FR, DE, ES & NL

Current Topics in Marine Biotechnology Book Review:

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery
Author: Jens-Uwe Peters
Publsiher: John Wiley & Sons
Total Pages: 510
Release: 2012-03-13
ISBN 10: 0470590904
ISBN 13: 9780470590904
Language: EN, FR, DE, ES & NL

Polypharmacology in Drug Discovery Book Review:

"Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology"--Provided by publisher.

The Evolution of Drug Discovery

The Evolution of Drug Discovery
Author: Enrique Ravina
Publsiher: John Wiley & Sons
Total Pages: 504
Release: 2011-01-11
ISBN 10: 3527326693
ISBN 13: 9783527326693
Language: EN, FR, DE, ES & NL

The Evolution of Drug Discovery Book Review:

Based on his profound knowledge of past and present paradigms in the development of medicines, the author takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people who discovered them, he brings abstract science to life in anecdotal form. The book is beautifully illustrated, containing historical photographs of drugs and their discoverers, and abounds with references to the primary literature, listing seminal publications alongside more modern reviews for readers seeking further details. For anyone with a more than superficial interest in the science of drugs: instructive and enjoyable for a broad audience of students, instructors and professionals in pharmacy, the pharmaceutical chemistry and related fields.

Validamycin and Its Derivatives

Validamycin and Its Derivatives
Author: Xiaolong Chen,Yuele Lu,Yongxian Fan,Yinchu Shen
Publsiher: Elsevier
Total Pages: 340
Release: 2017-03-31
ISBN 10: 008101113X
ISBN 13: 9780081011133
Language: EN, FR, DE, ES & NL

Validamycin and Its Derivatives Book Review:

Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds. Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production. Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored. Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications. Offers complete coverage of validamycin chemistry from a highly experienced team of authors Encourages the discovery of further novel drugs based on validamycin derivatives Presents an interesting model for establishing new pharmaceutical leads from agricultural sources Includes coverage of the total chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine and validoxylamines