Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders

Animal and Translational Models for CNS Drug Discovery  Reward Deficit Disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 432
Release: 2009-02-24
ISBN 10: 0080920403
ISBN 13: 9780080920405
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders Book Review:

Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.

Animal and Translational Models for CNS Drug Discovery Psychiatric Disorders

Animal and Translational Models for CNS Drug Discovery  Psychiatric Disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 528
Release: 2008-11-17
ISBN 10: 008092039X
ISBN 13: 9780080920399
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Psychiatric Disorders Book Review:

Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.

Animal and Translational Models for CNS Drug Discovery Neurological disorders

Animal and Translational Models for CNS Drug Discovery  Neurological disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Anonim
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: OCLC:229026149
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Neurological disorders Book Review:

Animal and Translational Models for CNS Drug Discovery Neurological disorders

Animal and Translational Models for CNS Drug Discovery  Neurological disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Anonim
Total Pages: 329
Release: 2008
ISBN 10:
ISBN 13: OCLC:229026149
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Neurological disorders Book Review:

Translational Neuroimaging

Translational Neuroimaging
Author: Robert A. McArthur
Publsiher: Academic Press
Total Pages: 464
Release: 2012-10-05
ISBN 10: 0123869978
ISBN 13: 9780123869975
Language: EN, FR, DE, ES & NL

Translational Neuroimaging Book Review:

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development
Author: George G. Nomikos,Douglas E. Feltner
Publsiher: Academic Press
Total Pages: 458
Release: 2019-06-18
ISBN 10: 0128031646
ISBN 13: 9780128031643
Language: EN, FR, DE, ES & NL

Translational Medicine in CNS Drug Development Book Review:

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
Author: Asfar Azmi,Ramzi M. Mohammad
Publsiher: Academic Press
Total Pages: 470
Release: 2019-04-16
ISBN 10: 0128147059
ISBN 13: 9780128147054
Language: EN, FR, DE, ES & NL

Animal Models in Cancer Drug Discovery Book Review:

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Improving the Utility and Translation of Animal Models for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 110
Release: 2013-04-25
ISBN 10: 0309266335
ISBN 13: 9780309266338
Language: EN, FR, DE, ES & NL

Improving the Utility and Translation of Animal Models for Nervous System Disorders Book Review:

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America

Human and Animal Models for Translational Research on Neurodegeneration  Challenges and Opportunities From South America
Author: Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
Publsiher: Frontiers Media SA
Total Pages: 329
Release: 2018-06-21
ISBN 10: 2889454940
ISBN 13: 9782889454945
Language: EN, FR, DE, ES & NL

Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America Book Review:

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author: P. Michael Conn
Publsiher: Academic Press
Total Pages: 1108
Release: 2013-05-29
ISBN 10: 0124159125
ISBN 13: 9780124159129
Language: EN, FR, DE, ES & NL

Animal Models for the Study of Human Disease Book Review:

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 118
Release: 2014-02-06
ISBN 10: 0309292492
ISBN 13: 9780309292498
Language: EN, FR, DE, ES & NL

Improving and Accelerating Therapeutic Development for Nervous System Disorders Book Review:

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Encyclopedia of Behavioral Neuroscience

Encyclopedia of Behavioral Neuroscience
Author: Anonim
Publsiher: Elsevier
Total Pages: 1816
Release: 2010-06-03
ISBN 10: 0080453961
ISBN 13: 9780080453965
Language: EN, FR, DE, ES & NL

Encyclopedia of Behavioral Neuroscience Book Review:

Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists

Blood Brain Barrier in Drug Discovery

Blood Brain Barrier in Drug Discovery
Author: Li Di,Edward H. Kerns
Publsiher: John Wiley & Sons
Total Pages: 600
Release: 2015-02-02
ISBN 10: 1118788354
ISBN 13: 9781118788356
Language: EN, FR, DE, ES & NL

Blood Brain Barrier in Drug Discovery Book Review:

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Drug Discovery Toxicology

Drug Discovery Toxicology
Author: Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
Publsiher: John Wiley & Sons
Total Pages: 584
Release: 2016-03-22
ISBN 10: 1119053390
ISBN 13: 9781119053392
Language: EN, FR, DE, ES & NL

Drug Discovery Toxicology Book Review:

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
Author: Benjamin Blass
Publsiher: Elsevier
Total Pages: 580
Release: 2015-04-24
ISBN 10: 012411525X
ISBN 13: 9780124115255
Language: EN, FR, DE, ES & NL

Basic Principles of Drug Discovery and Development Book Review:

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries

Drug Discovery for Psychiatric Disorders

Drug Discovery for Psychiatric Disorders
Author: Zoran Rankovic,Richard Hargreaves,Matilda Bingham
Publsiher: Royal Society of Chemistry
Total Pages: 590
Release: 2012
ISBN 10: 1849733651
ISBN 13: 9781849733656
Language: EN, FR, DE, ES & NL

Drug Discovery for Psychiatric Disorders Book Review:

This is a wide scope and in-depth coverage of the state of the art and future directions in drug discovery for major psychiatric disorders.

Peptide Drug Discovery and Development

Peptide Drug Discovery and Development
Author: Miguel Castanho,Nuno Santos
Publsiher: John Wiley & Sons
Total Pages: 390
Release: 2011-10-24
ISBN 10: 3527636749
ISBN 13: 9783527636747
Language: EN, FR, DE, ES & NL

Peptide Drug Discovery and Development Book Review:

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Behavioural Models in Psychopharmacology

Behavioural Models in Psychopharmacology
Author: Paul Willner
Publsiher: Cambridge University Press
Total Pages: 540
Release: 1991-02-21
ISBN 10: 9780521391924
ISBN 13: 052139192X
Language: EN, FR, DE, ES & NL

Behavioural Models in Psychopharmacology Book Review:

Behavioural models in psychopharmacology are used for different purposes. The main concern of industrial psychopharmacologists is specifically to develop new and improved drugs for the treatment of mental disorders, while basic scientists use animal models to investigate the underlying nature of such conditions. The important distinction between these different perspectives is made explicit for the first time in this book. By considering such conditions as anxiety, depression, mania and schizophrenia, feeding disorders, dementia, and drug dependence, this book provides a comprehensive and critical review of the adequacy of the behavioural procedures used by psychopharmacologists to model psychiatric disorders. Graduate students and research workers in pscyhopharmacology, from both academic and industrial spheres, as well as clinicians, will find this book of considerable interest.

The British National Bibliography

The British National Bibliography
Author: Arthur James Wells
Publsiher: Anonim
Total Pages: 329
Release: 2009
ISBN 10:
ISBN 13: STANFORD:36105211722678
Language: EN, FR, DE, ES & NL

The British National Bibliography Book Review:

Drug Delivery to the Brain

Drug Delivery to the Brain
Author: Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
Publsiher: Springer Science & Business Media
Total Pages: 731
Release: 2013-12-03
ISBN 10: 1461491053
ISBN 13: 9781461491057
Language: EN, FR, DE, ES & NL

Drug Delivery to the Brain Book Review:

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​