Animal and Translational Models for CNS Drug Discovery 3 Vols Set

Animal and Translational Models for CNS Drug Discovery  3 Vols  Set
Author: Robert A. McArthur,Franco Borsini
Publsiher: Unknown
Total Pages: 135
Release: 2008-12
ISBN 10: 9780123738615
ISBN 13: 012373861X
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery 3 Vols Set Book Review:

Animal and Translational Models for CNS Drug Discovery Psychiatric Disorders

Animal and Translational Models for CNS Drug Discovery  Psychiatric Disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 528
Release: 2008-11-17
ISBN 10: 008092039X
ISBN 13: 9780080920399
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Psychiatric Disorders Book Review:

Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.

Animal and Translational Models for CNS Drug Discovery Neurological Disorders

Animal and Translational Models for CNS Drug Discovery  Neurological Disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 416
Release: 2008-10-20
ISBN 10: 9780123738554
ISBN 13: 0123738555
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Neurological Disorders Book Review:

Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer's disease, Parkinson's disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area

Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders

Animal and Translational Models for CNS Drug Discovery  Reward Deficit Disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 432
Release: 2009-02-24
ISBN 10: 0080920403
ISBN 13: 9780080920405
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders Book Review:

Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.

Improving the Utility and Translation of Animal Models for Nervous System Disorders

Improving the Utility and Translation of Animal Models for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 110
Release: 2013-04-25
ISBN 10: 0309266335
ISBN 13: 9780309266338
Language: EN, FR, DE, ES & NL

Improving the Utility and Translation of Animal Models for Nervous System Disorders Book Review:

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

Translational Neuroimaging

Translational Neuroimaging
Author: Robert A. McArthur
Publsiher: Academic Press
Total Pages: 421
Release: 2012
ISBN 10: 0123869455
ISBN 13: 9780123869456
Language: EN, FR, DE, ES & NL

Translational Neuroimaging Book Review:

With a unique collaborative approach of author teams from industry and academia, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment provides an integrated perspective of small animal and human brain imaging in the development of translational models and biomarkers to understand human neuropsychiatric disorders and to accelerate the development of novel drugs for their treatment. The book provides chapters on methodical issues in human and animal neuroimaging translational research, allowing a beginning researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in studies. Additional chapters cover selected neuropsychiatric disorders, examining the role of neuroimaging in translational model development from the preclinical, animal model perspective as well as from the human experimental medicine perspective. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to researchers working in and studying CNS drug treatment research across industry and academia. Provides a background of translational research and the use of imaging in studies Dicusses the application of imaging in specific disease states Features an accompanying website with additional images and text

Animal and Translational Models for CNS Drug Discovery Neurological Disorders

Animal and Translational Models for CNS Drug Discovery  Neurological Disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 416
Release: 2008-11-18
ISBN 10: 9780080920382
ISBN 13: 0080920381
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Neurological Disorders Book Review:

Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development
Author: George G. Nomikos,Douglas E. Feltner
Publsiher: Academic Press
Total Pages: 458
Release: 2019-06-18
ISBN 10: 0128031646
ISBN 13: 9780128031643
Language: EN, FR, DE, ES & NL

Translational Medicine in CNS Drug Development Book Review:

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
Author: Asfar Azmi,Ramzi M. Mohammad
Publsiher: Academic Press
Total Pages: 470
Release: 2019-04-16
ISBN 10: 0128147059
ISBN 13: 9780128147054
Language: EN, FR, DE, ES & NL

Animal Models in Cancer Drug Discovery Book Review:

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 118
Release: 2014-02-06
ISBN 10: 0309292492
ISBN 13: 9780309292498
Language: EN, FR, DE, ES & NL

Improving and Accelerating Therapeutic Development for Nervous System Disorders Book Review:

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

The Mouse Nervous System

The Mouse Nervous System
Author: Charles Watson
Publsiher: Academic Press
Total Pages: 795
Release: 2012
ISBN 10: 0123694973
ISBN 13: 9780123694973
Language: EN, FR, DE, ES & NL

The Mouse Nervous System Book Review:

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. * Visualization of brain white matter anatomy via 3D diffusion tensor imaging contrasts enhances relationship of anatomy to function * Systematic consideration of the anatomy and connections of all regions of brain and spinal cord by the authors of the most cited rodent brain atlases * A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states, * Full segmentation of 170120+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlasesA detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area. * Full coverage of the role of gene expression during development, and the new field of genetic neuroantomy using site-specific recombinases * Examples of the use of mouse models in the study of neurological illness

Translational Neuroscience

Translational Neuroscience
Author: James E. Barrett,Joseph T. Coyle,Michael Williams
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2012-06-28
ISBN 10: 1139510304
ISBN 13: 9781139510301
Language: EN, FR, DE, ES & NL

Translational Neuroscience Book Review:

Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America

Human and Animal Models for Translational Research on Neurodegeneration  Challenges and Opportunities From South America
Author: Agustín Ibáñez,Lucas Sedeño,Adolfo M. García,Robert M.J. Deacon,Patricia Cogram
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-06-21
ISBN 10: 2889454940
ISBN 13: 9782889454945
Language: EN, FR, DE, ES & NL

Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America Book Review:

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders

Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 94
Release: 2017-05-24
ISBN 10: 0309455162
ISBN 13: 9780309455169
Language: EN, FR, DE, ES & NL

Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders Book Review:

Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders. In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016. Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop.

Models of Seizures and Epilepsy

Models of Seizures and Epilepsy
Author: Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
Publsiher: Academic Press
Total Pages: 1178
Release: 2017-06-14
ISBN 10: 012804067X
ISBN 13: 9780128040676
Language: EN, FR, DE, ES & NL

Models of Seizures and Epilepsy Book Review:

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Contemporary Aspects of Biomedical Research

Contemporary Aspects of Biomedical Research
Author: Anonim
Publsiher: Academic Press
Total Pages: 520
Release: 2009-11-24
ISBN 10: 9780123786432
ISBN 13: 0123786436
Language: EN, FR, DE, ES & NL

Contemporary Aspects of Biomedical Research Book Review:

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. Articles written by leading investigators in the field Informs and updates on all the latest developments

Modern CNS Drug Discovery

Modern CNS Drug Discovery
Author: Rudy Schreiber
Publsiher: Springer Nature
Total Pages: 283
Release: 2021-06-17
ISBN 10: 3030623513
ISBN 13: 9783030623517
Language: EN, FR, DE, ES & NL

Modern CNS Drug Discovery Book Review:

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

Alzheimer s Disease Modernizing Concept Biological Diagnosis and Therapy

Alzheimer s Disease   Modernizing Concept  Biological Diagnosis and Therapy
Author: M.C. Carrillo,H. Hampel
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 200
Release: 2012-04-23
ISBN 10: 3805598033
ISBN 13: 9783805598033
Language: EN, FR, DE, ES & NL

Alzheimer s Disease Modernizing Concept Biological Diagnosis and Therapy Book Review:

Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer’s disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the ‘amyloid’ or ‘tau’ hypotheses.This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Addiction Reviews 2

Addiction Reviews 2
Author: George R. Uhl
Publsiher: John Wiley & Sons
Total Pages: 300
Release: 2010-03-29
ISBN 10: 1573317675
ISBN 13: 9781573317672
Language: EN, FR, DE, ES & NL

Addiction Reviews 2 Book Review:

This volume features expert, refereed reviews of timely topics in each of the areas relevant to addiction science and clinical practice to aid researchers and practitioners interested in addictions. Authors from the United States, EU, Asia and elsewhere provide an international perspective on the problems and practices. Specifically, this volume: - focuses on topics that are relevant to specific substances but also provides important lessons for addiction to all substances - provides reviews that are aimed to be useful to specialists in the field and as useful to students as the first criterion allows. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Unnerved

Unnerved
Author: Jason Schnittker
Publsiher: Columbia University Press
Total Pages: 135
Release: 2021-06-08
ISBN 10: 0231553560
ISBN 13: 9780231553568
Language: EN, FR, DE, ES & NL

Unnerved Book Review:

Anxiety is not new. Yet now more than ever, anxiety seems to define our times. Anxiety disorders are the most common psychiatric disorders in the United States, exceeding mood, impulse-control, and substance-use disorders, and they are especially common among younger cohorts. More and more Americans are taking antianxiety medications. According to polling data, anxiety is experienced more frequently than other negative emotions. Why have we become so anxious? In Unnerved, Jason Schnittker investigates the social, cultural, medical, and scientific underpinnings of the modern state of mind. He explores how anxiety has been understood from the late nineteenth century to the present day and why it has assumed a more central position in how we think about mental health. Contrary to the claims that anxiety reflects large-scale traumas, abrupt social transitions, or technological revolutions, Schnittker argues that the ascent of anxiety has been driven by slow transformations in people, institutions, and social environments. Changes in family formation, religion, inequality, and social relationships have all primed people to be more anxious. At the same time, the scientific and medical understanding of anxiety has evolved, pushing it further to the fore. The rise in anxiety cannot be explained separately from changes in how patients, physicians, and scientists understand the disorder. Ultimately, Schnittker demonstrates that anxiety has carried the imprint of social change more acutely than have other emotions or disorders, including depression. When societies change, anxiety follows.